CA2149875A1 - Wound dressings - Google Patents
Wound dressingsInfo
- Publication number
- CA2149875A1 CA2149875A1 CA 2149875 CA2149875A CA2149875A1 CA 2149875 A1 CA2149875 A1 CA 2149875A1 CA 2149875 CA2149875 CA 2149875 CA 2149875 A CA2149875 A CA 2149875A CA 2149875 A1 CA2149875 A1 CA 2149875A1
- Authority
- CA
- Canada
- Prior art keywords
- layer
- adhesive
- hydrogel
- backing layer
- dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00795—Plasters special helping devices
- A61F2013/00829—Plasters special helping devices rigid or semi-rigid backing
Abstract
There is described an adhesive dressing (1) comprising a backing layer (2) having a pressure sensitive adhesive layer (3) over one surface thereof, a hydrogel layer (6) over part of the adhesive surface, a removable protector (7) which covers the exposed adhesive layer (3) and the hydrogel layer (6); and a continuous conformable support layer (4) which is reversibly attached to the non-adhesive surface of the backing layer and extends beyond the backing layer at one or more edges.
Description
WO 94/12134 ~ PCT/GB93/û2382 21~9875 WO~ND DRESSINGS
This invention relates to a novel form of wound dressing and a novel method of treatment of wounds.
The accummulation of wound exudate in secreting 5- ~kin wounds such as decubitus ulcers and surgical wounds promotes the growth of bacteria and other organisms which may delay heaIing o~ the wound and in some casea cause infection of~the wound. It is well established that wound healing may ~e accele.rated lf lO- the wound is kept in a 'moist condition' but that excess exudate must be remQved from the wound.
: ~ :
Polyurethane films have~been used as dressings in recent years, such films have~a moisture vapour 15`- transmission rate (MVTR) which allows excess exudate to permeate`whilst keeping a residual amount of ; ; moisture around the;wound~area. More recently ;~ hydxogel;~at~erials have~;been~used, sometimes in~
; conjunction wi~th a polyurethane film dressing to 20- further control the 'moisture'~ content of the wound.
However, the application of a~hydrogel and~ ~
subsequently a~olyurethane dressing proves~wkward ~o manipuIate. ~A further~disadvantage is that for falrly `~ ! 25- superficial wounds only relati~ely small amounts of hydrogei are required~thus a sachet~of hydrogel m!ay only~be part used~and~the~remainder di~scarded.
Recent~ developments~have sought to overcome this 30O~ problem. ;For~example, European Patent Application No.42416~describes~ a~reservoir of a hydrogel in a vacuum;formed well in~a thin~film dressing layer provided~wlth~an adhesive perimeter portion. The thin WO~4/12134 PCT/GB93l0~8'
This invention relates to a novel form of wound dressing and a novel method of treatment of wounds.
The accummulation of wound exudate in secreting 5- ~kin wounds such as decubitus ulcers and surgical wounds promotes the growth of bacteria and other organisms which may delay heaIing o~ the wound and in some casea cause infection of~the wound. It is well established that wound healing may ~e accele.rated lf lO- the wound is kept in a 'moist condition' but that excess exudate must be remQved from the wound.
: ~ :
Polyurethane films have~been used as dressings in recent years, such films have~a moisture vapour 15`- transmission rate (MVTR) which allows excess exudate to permeate`whilst keeping a residual amount of ; ; moisture around the;wound~area. More recently ;~ hydxogel;~at~erials have~;been~used, sometimes in~
; conjunction wi~th a polyurethane film dressing to 20- further control the 'moisture'~ content of the wound.
However, the application of a~hydrogel and~ ~
subsequently a~olyurethane dressing proves~wkward ~o manipuIate. ~A further~disadvantage is that for falrly `~ ! 25- superficial wounds only relati~ely small amounts of hydrogei are required~thus a sachet~of hydrogel m!ay only~be part used~and~the~remainder di~scarded.
Recent~ developments~have sought to overcome this 30O~ problem. ;For~example, European Patent Application No.42416~describes~ a~reservoir of a hydrogel in a vacuum;formed well in~a thin~film dressing layer provided~wlth~an adhesive perimeter portion. The thin WO~4/12134 PCT/GB93l0~8'
2~ 49 87 . I
film layer is provided with a support layer around the perimeter of the vacuum formed well. However, such dressings have only limited stability since the support layer does nst add to the support of the hydrogelO In the embodiment-described therein the dressing layer may be provided with a grid pattern to permit measurement of wound healing.
European Patent Application No.42~422 discloses a 10- number of hydrogel dressings which include;
(i) a hydrogel mater1al maintained in à cavity formed in a flexible film membrane; and (ii) a hydrogel layer maintained in position on a flexible film by a perimeter defining adhesive coated lSo foam dam.
However, such dressings although advantageous ~ over the methods of applying hydrogels and dressings: , separately, suffer from~a:number of disadvantages.
. 20.
The ~oam dam dressings of the prior art have th disadvantage that the shouldsr of the dam is aligned.
with the edge of the dressing, the shoulder ea~ily : catches when a patient moves, thus dislodging the 25- dressing and/or causing discomfort to the patient.
` This is found to be a particular~problem with sacral : dres~ings. :~Moreover, it is common for the appearance . of a small:wound~in th ~orm of a pressure ~ore in thP
dermis or epidermis to merely be an i~ndication of a ~ 30 :much larger subcutaneous wound sore. Thus it may be :: : undesirable to adhere a dre5sing to tissue directly adja nt to the visible wound.
~ . ~
, ~'094/12134 PCT/GB93l0~82 , .. , 21~987~
Also, because of the need to create a vacuum ormed well, particularly with the dressings of European Patent Application No.426422, the dressings I of the prior art are difficult and expensive to 1 5 manufacture and would tend to re~uire a less conformable backing layer.
Although the dressings of the prior art are described as optionally having a grid marked on a 10- backing in order to measura wound healing, this particular aspec~ of the prior art is disadvantageous since the grid cannot be easily entered into the patients records.
: ~ lS. We have now found a form of dressing which overc4mes or mitigates these problems.
, According to the invention, we provide an adhesive dressing comprising a backing layer having a : 2~- pressure sensiti~e adhesive layer over one surface thereo~, a hydrogel layer over part of the adAPsive ; surface, a removable pro~ector which covers the . exposed~adhesi~e layer and the hydrogeI layer; and a ~; continuous con~ormable support~layer which is ~; 25- reversibly attached to the non-adhesive ~urface of the backing layer and ex~ends ~eyond the backing layer at l one or more edges.
: The amount which the support layer ex~ends beyond ;~ 30 the outer~edge of the backing layer may vary according to the size and nature of t~e wound to be treatedO
: ~ However, in:general we prefer the support layer to ~: : extend beyond the backing layer by approximately 1 - 5 ~, , `
W09~/12134 ~ ~ $ 7 PCT/GB93/0238~
cm, more preferably by l - 4 cm and most preferably by l - 3 cm. The support layer may extend over one edge, two edges or all four edges of the backing 'ayer.
~' The pressure sensitive adhesive may be a ¦ continuous adhesive layer or may be non-continuous.
In a preferred em~odiement of the present invention the pressure sensitive adhesive layer is non-conti~uous, eg. a~pattern spread adhe~ive. In lO- particularly the portion of the b cking layer around ; the periphery of hydrogel layer may be adhesive free.
Such adhesive free re~ions may be manu~acturPd by coating the bar.king layer with an adhesive in the presenc~ of a template. The adhesive f-ee region of l;~ the backing layer may be from O.l to 5.0mm wide, preferably from 0.1 to 20mm wide, more preferably from : 1 to lOmmi wide~
, The:hydrogel layer may optionally be provided j 20~ with a support member. The support member may be I in~igral to the hydr~el layer:or may be adjacent:the periphery of the hydrogel 1ayer:such peripheral support members may surround aIl:or par~ o~ the :~ hydrvgelO ~Preferably, a:peripheral sup~ort member iS
a foam dam member which preferably surrounds the whole ~, oflthç~hydrogel layer.
The dam~member may~surround the whole of the hydrogel lay:er~: Tha~exposed surface of the dam member : 3~ may also optiona11y be coated with a pressure : sensitive adhesi~e layer,~but preferably, the wound :~ facing side of the dam member is adhesi~e ~ree.
: . :
~ 1 ~L 9 ~ 7 ~
The dam member may def ine any con~entional shape, eg. circular, square or rectangular. Alternatively, the dam member may def ine an internal well ~hich is dif f erent in shape ~o that def ined by it ' s external walls. Thus the d m member may be rectangular snaped on it ' s external walls whilst def ining a circular shaped well. When the outer walls of the dam member define a square or rectangular shape the corners of the dam member and/ or the backing layer may be rounded 10. in order to further alleviate the problem o~ the dressing, when applied, catching and causing discomf ort to the patient . In addition, the shoulder of the dam mem~er adjacent to the backing layer may be . ~evelled in order to alleviate 'dressing lift'. Such 15- 'dressing lift' may also be alleviated by profilirlg the dam member such that it ' s thickness at it ' s outer : edge may be less than tha~ at its inner edge. In a : similar fashion 'dressing }ift' may be alle~riated in: the support free dressing by prof iling the hydrogel :; 2 ~ layer . Thus, when ~h~ hydrogel layer is a square or recta~gular slab, the corners of the sla~ may be of less thickness ~han the remainder. Alternatively, the ; : whole of the outer edge o~ the slab may be o~ less ~` :~ thickne s than the remainder. Such edge profiling 2;- wouId of cource be applicable to all shapes of hydrogel layer.
::~ ~
When the hydrogel layer is provided with an :: : integral support member, the support member may he a 30 reticulated ~member~ or may :comprise a scrim or gauze of material~. ~ The lntegral suppcrt layer may be a sc:rim, gauze or net of mat~rial. The integral support member ma~r comprise a conf ormable sheet, eg . a - ~
I ~'094/12134 PCT/GB9310~8' 9 8 ~
! - 6 -plastics sheet provided with a plurali~y of apertures or, for example, a polyurethane net, eg. a ~EYPOL net.
Further, the integral support member preferably comprises material whic~ absorbs wound exudate, eg~
cotton, although non-absorbent materials may also be used. The integral support member will be within th~
hydrogel layer but may be adjacent either the wound facing or the backing layer facing surface~ It is preferable`however that the integral support will lie 10- substantially in the middle, measured by depth, of the hydrogel layer, that it is, substantially in equal proximity to the wound facing and the backing layer . facing surface. The integral support preferably extends substantially to the edges:of the hydrogel : 1~- layer, althou~h provided the hydrogel layer is :~ su~ficiently stable this is not essen~ial.
~;
Suitably the backing layer may comprise any of : ~ : those materials which are conventionally employed ~o 20- form thin film surgical dressing. Suitable ma~erials include those described in~UK Patent No. 1280631.
European Patents Nos. 51935j 91800 and ~78740.
:~ Particularly apt materials are polyurethanes, for example polyester or polyether polyurethanes known as :, ~5 Estanes (Trade Mark)~ Other apt materials are elastomeric pdlyether polyesters~ or e~ample tholse known as ~ytrels (Trade Mark) and polyether polyamides, for example tho:se known as Pebaxes ~Trade Mark)O Other favoured materials include ~ydrophilic ~ 30^ ~ po~l~mers ~such as~hy~drophilic polyure~hanes including :~ : : those~described in~UK Patent ~o. 2093190B, esp~cially the polyurethane d scribed in Example 2 therein. Such materials~will typically take up from 5 to 95~ by `:`: :
: :
: :
WO ~4/12134 PCT/GB93/02382 ,. . , ,21,~987a ~ .
weight of water.
The materials employed in the dressings of the inven~ion may be moisture vapour permeable. The 5 moisture vapour transmission rate of the materials employed in the present invention may be measured by a procedure known as the Payne Cup m~thod, which method is described in European Patent Application No.
360458.: The method:uses a cup 1.5cm deep with a lO flanged top. The inner diameter of ~ the flange is such to provide an area for moi ture vapour transmission of . 10cm2. In this method lOml of chilled water is added to the cup and:a sample o~ the materia1 under test, large enough to completely co~e~ the flange, is }5 clamped o~er the cup. The comp1ete~assembly is then weighed and placed in a~cabinet where the temperature and relati~e humidity ~re maintained at 37C and 10%
~ r~5pectîvely. After 17 hours the cup is~removed from :;, the ca~inet and allowed to coo1 at room temper ture.
20- After re-weighing, the mass of water lost by vapour ;~ transmission is ca1cula~ed and the resul~ expressed as in gm 2 24hrs 1 at ~7C at~100~ to lOS;relative:
humidity:dif~erence. H~reinafter the:units for : ~
: moisture~vapour transmission will be abbreviated ~o~ -25 . gll~ 2 24hrs l. ~ : ~ ~
i ore importantly, the~overa11 moiskure vapour:
tran mi~ssion rate (MVTR)~of the~dress~ing should eguate : to 500~- 7000~gm ~24h based on composite ;30'~ ;properties:, ie in heavl1y;exudin~ wounds the gel may act~as~a~'sink' and~enab1e ~he~moisture~ vapour permea~le film~;to~" lash off"~excess fluid~ In : lightly~-xudlng wounds the MVTR shouId be sufficleh~
W094/12134 PCTIGB93/0~82 2~,498~S
to maintain a moist environment and prevent the wound drying out.
The backing layer may comprise a polyurethane film or alternatively the backing layer may comprise a HYTREL (TM). The backing layer may have a thickness of from 15 to lOO~m, preferably 20 to 80~m and more preferably 25 to 50~m, for example 27.5~, 30~m, 35~m, 40~m.
! 10 The pressure sensitive adhesive layer may b~
formed from an adhesive which is conventionally used for contact with the skin. Suitable adhe~ives include : polyvinyl alkyl ether adhesiva and acrylate ester 15 copolymer a~hesives. Suitable adhesives are described in ~K Patent No. 1280631 and Europe.n Pat~nts Nos.
3S399 and 51935. Preferably the adhesi~e is a ~ polyvinyl ether adhesive or an:acrylate ester ; ~ copolymer adhesive formed b~ the copolymerisation of 20- 2-ethylhexyl acrylate,: butyl acrylate and acrylic acid~
: The adhesive layer may be from 15 to 65~m thick, for example 20 to 40~m thick and is applied at a . ~J- weight per un}t area of 10 to 75gsm, more suitably 15 to~65gsm and preferably 25 to 40gsm. I ~;
: The rémovable protector is preferably a 5il icone :~ Goatsd relea~e paper.: Sui~ably ~he removable ~: 30 ~ protector may have a weight per unit area of 1~0 ~o : ~140gsm,~and preferably 110 tjo 130gsm, for example ` ~120gsm. The remova~le protector may be divided in~o tWQ ~r more pieces. Preferably at least one of the WO94/12 W 1 ~9 8 73 PCT/GB93/0238 . _ 9 _ :
, ! protector pieces is significantly 1arger than the ¦ other or others and covers a major proportion of the adhesive layer. It is desirable that the stripping 1Oad of the support layer from the bac~ing 1ayer is great~r than:that of the protector from the adhesive layer otherwise there is a risk that the support layer would peel from the backing layer before the protector can be remov2d.:
10 The hydrogel layer may be any polymer which is characterised by it's hydrophilicity and insoIubi1ity ;: ~ in water. Such polymers~ preferab1y:comprise a cross: ~ linked macromolecular n~twork. Such hydrophilic po1ymers may~ be amphoteric,~eg:. contai~ing anionic and 15- cationic~monomers; anionic,~eg. containing ~: : carboxy1ate,~su1phonate, phosphonate group~; cationic, : eg~ containing quaternary ammonium ions; zwitterionic, : eg. conta~ining monomers with:a cationic and ~anionicgroup;~or non-ionic,~eg.~containing ~mide, hydroxyl, : lactam,~polyether, polyhydroxyethy1methacrylate or ~: ~ ; polyvinyl~pyrrolidone~(PVP) groups.
;Preferred hydrogel materials are those containing~
: ~ polyethylene oxide or PVP.~ Such hydroge~s~pr~ferab1y : ~ contain ~rom~5:to 30% w/w of~the hydrophilir pol ~ er,~
praferab:ly~rom 5 to 20% w/w, most pre~erab1y 5 to 15 ; w/w, ~eg.~ lO~ V/W. ;~
:;T~he~hydrogel~ material may be~ an aqueous;or:~a~
sa1ine~:~so1ution~in a gel-like phase and~may comprise from about~5% to~about 3~0% by weight of~a polyhydrlc alcohol selected from~the group:consisting of polypropylene g1ycol~, polye~hylene g1yco1 and WO94/12l34 PCT/G~93/0~&2 Zl 498~
, -- 10 --glycerine.
The hydrogel may also contain from about 8% to about 14% by wei~ht of an isophorone disocyanate . ;^ terminated prepolymer/ and, when saline, up to about 1 1% by weight of a salt such as sodium chloride, and I ~he balance water. ~ :
¦ The hydrogel comprisas a water-insoluble, 10 water-swellable cross-linked cellulose derivative, , water and a polyol component and the cellulose ~erivative compri~es less:~han 10% by weight of the gel. `
:
::~ 15- In particular, hydrogels which may he mentioned : include those described in~patent applica~ion no. WQ
92tl6245~ When the dressing~according to the invention includes a support member,:the hydrogel may be relatively more mobile than other pre~rred ~:~ ~ 20- hydrogels althoug~ the less mobile hydrogels may al~o : : bè used.
:`; : It is~a:further feature:of this invention to provide~an a~hesive dressing as hereinbefore de~cribed 25- wherein the removable protector ~xtends beyond the backing layer at one or more~edges, preferably at both edges and comprises first and second parts, the first part having a:portion~:~ext~nding away:from the adhesive surface and ben~ ~ack to :form a v shap~ an~ the second ~ part;having a portion~extending:away ~rom the adhesi~e : and overlying the v-shaped firs~ part.
According to~a further feature o~ the invention ~ the conformable support layer may be provlded with a : :
: :
i WO94/12134 9 PCT/GB93/0~82 ^` ~1~987S
~.........
grid mar~ing in order to enable wound healing to be observed. The extensions of the conformable support layer beyond one or more edges of the backing layer are preferably non-adhesive and thus facilitate the 5- removal of the conformable suppo~t layer from the backing layer.: ~
In another aspect therefore the present invention provides a method of treatiDg a wound which omprises lO- applying thereto an adhesive dressing as hereinbefore described by removing the removable protector, ;~ app~lying ~he hydrogel layer to the wound and the exposed adhesive:layer to the skin and then removing ~` : . the con~inuous conformable support layer.
;~ ~ ~ 15. - ` : : :
~: :We ~urthe~ provide~a method of manufacturing an a~hesive dressing as;hereinbefore described. This ; I method comprises taking a;backing layer provided with a support layer on a fixst side. The support layer : 20- preferably be~lng:provided with a grid pattern, a ~: ~ second side of the backing ~layer is coat d~with an ~` adhesive layer and then a protector is applied to ~he . ~ adhesive using conventional methods knnwn ~ se. In ; an automate~ pro~ess, the dressing may optionally be ~, ~ 25~ wound-:~nto a reel~ Subseguently, the reel~is unrolled~ the protector is remsved from the adhesive ;~ ~ layer~,~ the~hydrogel layer, which: may be in;the form of ;~: ~ a 'sl~b' is po~itioned onto the adhesive.:~ ~he protector~is,then~reapplied and~the~:dressings may be 30- cu~ t~;siæe.
When;~the~ hydrogel l:ayer comprises an integral support me~ber~the process~of manufacture will be as ~ ~ : : ` : ` : :
WO94/12134 PCTIGB93/Q238~
9~,~15 .- 12 -hereinbefore described. When the dressing according to the invention comprises a dam member, the dam member may be applied after the hydrogel la~er or the hydroge~ layer may be supported in the dam me~ber prior to applying the supported hydrogel layer to the backing layer. ~:Preferably however, the dam member is applied to~the backing layer;and then the hydrogel . layer is appl~ied.
10. The dressing may be plac~d in a bacteria-proof pack, sealed and sterilised by conventional methods, : including, for example,:using ethylene oxide or ~:; . irradiation.
: :;
: : 15. Preferred embodiments~of adhesive dressings of :: the present~invantion will now be:described by way of :~ ~ exampIe only and w1th reference to~the accompanying :. drawings, in which , , I :: .
~ ~ 20- Figure 1 is a cross section through an ambodiment :~: ~ ~ of a:dressing according to the invention, ~;`
~ Figure 2~is an expanded perspective view of the~
:~ ~: embodiment of Figure~l.~ ` ::
2~.
~Figure 3 is a cross section of an~embodlmen~ of tAe invention:provided~w1th~a~peripheral dam member, Figure 4 is~a cross section of a embodiment of 30: ::the invention~provided with an integral support : : member.
;Figures l and 2`shows~an adh sive dressing ~1 : :
.'O~./12134 PCT/GB93/02382 . 21~987,~ , ¦ which comprises a backing layer (2) formed from a fil~
of polyether polyurethane. ThP backing layex (2) has on one surface a pressure sensitive adhe~ive layer t3) formed from polyacrylate ester adhesive. On the non-adhesive surface of the backing layer (2) is a support layer (4). The support layer (4) may compxise a silicone or polyethylene coated papex or a : transparent film of polyethylene ox polypropylene.
The support layer (4,) is marked with a ~rid (5) to l0- enable wound haaling to be measured. A hydrogel (6) is attached to the adhesi~e layex ~3)~ The adhesive :; layer (3) and the hydrogel~(6~ are provided with a protector (7) made from a~silicone coatPd:release ~~~ paper.
~ 15. ~ :
! The protec~or (7) comprises two components. A
large protector (8~ is essentially:flat and overlap.s the smaller protector (9) which smaller pr~tector (9) ~ is folded into:a v-shape.:
:~ ~ : 20. ~ :
~ ~ :
~: ~ The support layer (4). is provided with edges (lO~
which;extend beyo~d the edge~(11) of t~he backing layer (2)~ and adhesive layer~(3).~
, ~ l In Figure 3 the d~essin~ is provided with a;dam . . :member (12) around the periphery of:the:hydro~el layer In: Figure~ 4 the hydrogel: layer (6) is providPd:
; 30wlth~an lntegral :support member ~(13j being a scrim.
In use~the larger~plecé (8) of the;protector is removed:first and: the dressing held by the overlylng ::
~'094/12134 PCT/GB93/023B?
.
2~98~S
portion of piece (9) and edge of the support layer (4). In such a case the larger area of the dressing ! is adhered to the skin, then the smaller piece (9) and the support layer (4) may be removed. Alternatively, 5- the smaller protector piece (9~ may be removed before application and the dressing handled asectically by the edges of the support layer (4) which project beyond the adhesive (3) and film (2) layers.
: 10.
lS.
:
:~ :
20.
:
.: ' 25.
~ ~ I
.
30.
, ;
~ .
:
film layer is provided with a support layer around the perimeter of the vacuum formed well. However, such dressings have only limited stability since the support layer does nst add to the support of the hydrogelO In the embodiment-described therein the dressing layer may be provided with a grid pattern to permit measurement of wound healing.
European Patent Application No.42~422 discloses a 10- number of hydrogel dressings which include;
(i) a hydrogel mater1al maintained in à cavity formed in a flexible film membrane; and (ii) a hydrogel layer maintained in position on a flexible film by a perimeter defining adhesive coated lSo foam dam.
However, such dressings although advantageous ~ over the methods of applying hydrogels and dressings: , separately, suffer from~a:number of disadvantages.
. 20.
The ~oam dam dressings of the prior art have th disadvantage that the shouldsr of the dam is aligned.
with the edge of the dressing, the shoulder ea~ily : catches when a patient moves, thus dislodging the 25- dressing and/or causing discomfort to the patient.
` This is found to be a particular~problem with sacral : dres~ings. :~Moreover, it is common for the appearance . of a small:wound~in th ~orm of a pressure ~ore in thP
dermis or epidermis to merely be an i~ndication of a ~ 30 :much larger subcutaneous wound sore. Thus it may be :: : undesirable to adhere a dre5sing to tissue directly adja nt to the visible wound.
~ . ~
, ~'094/12134 PCT/GB93l0~82 , .. , 21~987~
Also, because of the need to create a vacuum ormed well, particularly with the dressings of European Patent Application No.426422, the dressings I of the prior art are difficult and expensive to 1 5 manufacture and would tend to re~uire a less conformable backing layer.
Although the dressings of the prior art are described as optionally having a grid marked on a 10- backing in order to measura wound healing, this particular aspec~ of the prior art is disadvantageous since the grid cannot be easily entered into the patients records.
: ~ lS. We have now found a form of dressing which overc4mes or mitigates these problems.
, According to the invention, we provide an adhesive dressing comprising a backing layer having a : 2~- pressure sensiti~e adhesive layer over one surface thereo~, a hydrogel layer over part of the adAPsive ; surface, a removable pro~ector which covers the . exposed~adhesi~e layer and the hydrogeI layer; and a ~; continuous con~ormable support~layer which is ~; 25- reversibly attached to the non-adhesive ~urface of the backing layer and ex~ends ~eyond the backing layer at l one or more edges.
: The amount which the support layer ex~ends beyond ;~ 30 the outer~edge of the backing layer may vary according to the size and nature of t~e wound to be treatedO
: ~ However, in:general we prefer the support layer to ~: : extend beyond the backing layer by approximately 1 - 5 ~, , `
W09~/12134 ~ ~ $ 7 PCT/GB93/0238~
cm, more preferably by l - 4 cm and most preferably by l - 3 cm. The support layer may extend over one edge, two edges or all four edges of the backing 'ayer.
~' The pressure sensitive adhesive may be a ¦ continuous adhesive layer or may be non-continuous.
In a preferred em~odiement of the present invention the pressure sensitive adhesive layer is non-conti~uous, eg. a~pattern spread adhe~ive. In lO- particularly the portion of the b cking layer around ; the periphery of hydrogel layer may be adhesive free.
Such adhesive free re~ions may be manu~acturPd by coating the bar.king layer with an adhesive in the presenc~ of a template. The adhesive f-ee region of l;~ the backing layer may be from O.l to 5.0mm wide, preferably from 0.1 to 20mm wide, more preferably from : 1 to lOmmi wide~
, The:hydrogel layer may optionally be provided j 20~ with a support member. The support member may be I in~igral to the hydr~el layer:or may be adjacent:the periphery of the hydrogel 1ayer:such peripheral support members may surround aIl:or par~ o~ the :~ hydrvgelO ~Preferably, a:peripheral sup~ort member iS
a foam dam member which preferably surrounds the whole ~, oflthç~hydrogel layer.
The dam~member may~surround the whole of the hydrogel lay:er~: Tha~exposed surface of the dam member : 3~ may also optiona11y be coated with a pressure : sensitive adhesi~e layer,~but preferably, the wound :~ facing side of the dam member is adhesi~e ~ree.
: . :
~ 1 ~L 9 ~ 7 ~
The dam member may def ine any con~entional shape, eg. circular, square or rectangular. Alternatively, the dam member may def ine an internal well ~hich is dif f erent in shape ~o that def ined by it ' s external walls. Thus the d m member may be rectangular snaped on it ' s external walls whilst def ining a circular shaped well. When the outer walls of the dam member define a square or rectangular shape the corners of the dam member and/ or the backing layer may be rounded 10. in order to further alleviate the problem o~ the dressing, when applied, catching and causing discomf ort to the patient . In addition, the shoulder of the dam mem~er adjacent to the backing layer may be . ~evelled in order to alleviate 'dressing lift'. Such 15- 'dressing lift' may also be alleviated by profilirlg the dam member such that it ' s thickness at it ' s outer : edge may be less than tha~ at its inner edge. In a : similar fashion 'dressing }ift' may be alle~riated in: the support free dressing by prof iling the hydrogel :; 2 ~ layer . Thus, when ~h~ hydrogel layer is a square or recta~gular slab, the corners of the sla~ may be of less thickness ~han the remainder. Alternatively, the ; : whole of the outer edge o~ the slab may be o~ less ~` :~ thickne s than the remainder. Such edge profiling 2;- wouId of cource be applicable to all shapes of hydrogel layer.
::~ ~
When the hydrogel layer is provided with an :: : integral support member, the support member may he a 30 reticulated ~member~ or may :comprise a scrim or gauze of material~. ~ The lntegral suppcrt layer may be a sc:rim, gauze or net of mat~rial. The integral support member ma~r comprise a conf ormable sheet, eg . a - ~
I ~'094/12134 PCT/GB9310~8' 9 8 ~
! - 6 -plastics sheet provided with a plurali~y of apertures or, for example, a polyurethane net, eg. a ~EYPOL net.
Further, the integral support member preferably comprises material whic~ absorbs wound exudate, eg~
cotton, although non-absorbent materials may also be used. The integral support member will be within th~
hydrogel layer but may be adjacent either the wound facing or the backing layer facing surface~ It is preferable`however that the integral support will lie 10- substantially in the middle, measured by depth, of the hydrogel layer, that it is, substantially in equal proximity to the wound facing and the backing layer . facing surface. The integral support preferably extends substantially to the edges:of the hydrogel : 1~- layer, althou~h provided the hydrogel layer is :~ su~ficiently stable this is not essen~ial.
~;
Suitably the backing layer may comprise any of : ~ : those materials which are conventionally employed ~o 20- form thin film surgical dressing. Suitable ma~erials include those described in~UK Patent No. 1280631.
European Patents Nos. 51935j 91800 and ~78740.
:~ Particularly apt materials are polyurethanes, for example polyester or polyether polyurethanes known as :, ~5 Estanes (Trade Mark)~ Other apt materials are elastomeric pdlyether polyesters~ or e~ample tholse known as ~ytrels (Trade Mark) and polyether polyamides, for example tho:se known as Pebaxes ~Trade Mark)O Other favoured materials include ~ydrophilic ~ 30^ ~ po~l~mers ~such as~hy~drophilic polyure~hanes including :~ : : those~described in~UK Patent ~o. 2093190B, esp~cially the polyurethane d scribed in Example 2 therein. Such materials~will typically take up from 5 to 95~ by `:`: :
: :
: :
WO ~4/12134 PCT/GB93/02382 ,. . , ,21,~987a ~ .
weight of water.
The materials employed in the dressings of the inven~ion may be moisture vapour permeable. The 5 moisture vapour transmission rate of the materials employed in the present invention may be measured by a procedure known as the Payne Cup m~thod, which method is described in European Patent Application No.
360458.: The method:uses a cup 1.5cm deep with a lO flanged top. The inner diameter of ~ the flange is such to provide an area for moi ture vapour transmission of . 10cm2. In this method lOml of chilled water is added to the cup and:a sample o~ the materia1 under test, large enough to completely co~e~ the flange, is }5 clamped o~er the cup. The comp1ete~assembly is then weighed and placed in a~cabinet where the temperature and relati~e humidity ~re maintained at 37C and 10%
~ r~5pectîvely. After 17 hours the cup is~removed from :;, the ca~inet and allowed to coo1 at room temper ture.
20- After re-weighing, the mass of water lost by vapour ;~ transmission is ca1cula~ed and the resul~ expressed as in gm 2 24hrs 1 at ~7C at~100~ to lOS;relative:
humidity:dif~erence. H~reinafter the:units for : ~
: moisture~vapour transmission will be abbreviated ~o~ -25 . gll~ 2 24hrs l. ~ : ~ ~
i ore importantly, the~overa11 moiskure vapour:
tran mi~ssion rate (MVTR)~of the~dress~ing should eguate : to 500~- 7000~gm ~24h based on composite ;30'~ ;properties:, ie in heavl1y;exudin~ wounds the gel may act~as~a~'sink' and~enab1e ~he~moisture~ vapour permea~le film~;to~" lash off"~excess fluid~ In : lightly~-xudlng wounds the MVTR shouId be sufficleh~
W094/12134 PCTIGB93/0~82 2~,498~S
to maintain a moist environment and prevent the wound drying out.
The backing layer may comprise a polyurethane film or alternatively the backing layer may comprise a HYTREL (TM). The backing layer may have a thickness of from 15 to lOO~m, preferably 20 to 80~m and more preferably 25 to 50~m, for example 27.5~, 30~m, 35~m, 40~m.
! 10 The pressure sensitive adhesive layer may b~
formed from an adhesive which is conventionally used for contact with the skin. Suitable adhe~ives include : polyvinyl alkyl ether adhesiva and acrylate ester 15 copolymer a~hesives. Suitable adhesives are described in ~K Patent No. 1280631 and Europe.n Pat~nts Nos.
3S399 and 51935. Preferably the adhesi~e is a ~ polyvinyl ether adhesive or an:acrylate ester ; ~ copolymer adhesive formed b~ the copolymerisation of 20- 2-ethylhexyl acrylate,: butyl acrylate and acrylic acid~
: The adhesive layer may be from 15 to 65~m thick, for example 20 to 40~m thick and is applied at a . ~J- weight per un}t area of 10 to 75gsm, more suitably 15 to~65gsm and preferably 25 to 40gsm. I ~;
: The rémovable protector is preferably a 5il icone :~ Goatsd relea~e paper.: Sui~ably ~he removable ~: 30 ~ protector may have a weight per unit area of 1~0 ~o : ~140gsm,~and preferably 110 tjo 130gsm, for example ` ~120gsm. The remova~le protector may be divided in~o tWQ ~r more pieces. Preferably at least one of the WO94/12 W 1 ~9 8 73 PCT/GB93/0238 . _ 9 _ :
, ! protector pieces is significantly 1arger than the ¦ other or others and covers a major proportion of the adhesive layer. It is desirable that the stripping 1Oad of the support layer from the bac~ing 1ayer is great~r than:that of the protector from the adhesive layer otherwise there is a risk that the support layer would peel from the backing layer before the protector can be remov2d.:
10 The hydrogel layer may be any polymer which is characterised by it's hydrophilicity and insoIubi1ity ;: ~ in water. Such polymers~ preferab1y:comprise a cross: ~ linked macromolecular n~twork. Such hydrophilic po1ymers may~ be amphoteric,~eg:. contai~ing anionic and 15- cationic~monomers; anionic,~eg. containing ~: : carboxy1ate,~su1phonate, phosphonate group~; cationic, : eg~ containing quaternary ammonium ions; zwitterionic, : eg. conta~ining monomers with:a cationic and ~anionicgroup;~or non-ionic,~eg.~containing ~mide, hydroxyl, : lactam,~polyether, polyhydroxyethy1methacrylate or ~: ~ ; polyvinyl~pyrrolidone~(PVP) groups.
;Preferred hydrogel materials are those containing~
: ~ polyethylene oxide or PVP.~ Such hydroge~s~pr~ferab1y : ~ contain ~rom~5:to 30% w/w of~the hydrophilir pol ~ er,~
praferab:ly~rom 5 to 20% w/w, most pre~erab1y 5 to 15 ; w/w, ~eg.~ lO~ V/W. ;~
:;T~he~hydrogel~ material may be~ an aqueous;or:~a~
sa1ine~:~so1ution~in a gel-like phase and~may comprise from about~5% to~about 3~0% by weight of~a polyhydrlc alcohol selected from~the group:consisting of polypropylene g1ycol~, polye~hylene g1yco1 and WO94/12l34 PCT/G~93/0~&2 Zl 498~
, -- 10 --glycerine.
The hydrogel may also contain from about 8% to about 14% by wei~ht of an isophorone disocyanate . ;^ terminated prepolymer/ and, when saline, up to about 1 1% by weight of a salt such as sodium chloride, and I ~he balance water. ~ :
¦ The hydrogel comprisas a water-insoluble, 10 water-swellable cross-linked cellulose derivative, , water and a polyol component and the cellulose ~erivative compri~es less:~han 10% by weight of the gel. `
:
::~ 15- In particular, hydrogels which may he mentioned : include those described in~patent applica~ion no. WQ
92tl6245~ When the dressing~according to the invention includes a support member,:the hydrogel may be relatively more mobile than other pre~rred ~:~ ~ 20- hydrogels althoug~ the less mobile hydrogels may al~o : : bè used.
:`; : It is~a:further feature:of this invention to provide~an a~hesive dressing as hereinbefore de~cribed 25- wherein the removable protector ~xtends beyond the backing layer at one or more~edges, preferably at both edges and comprises first and second parts, the first part having a:portion~:~ext~nding away:from the adhesive surface and ben~ ~ack to :form a v shap~ an~ the second ~ part;having a portion~extending:away ~rom the adhesi~e : and overlying the v-shaped firs~ part.
According to~a further feature o~ the invention ~ the conformable support layer may be provlded with a : :
: :
i WO94/12134 9 PCT/GB93/0~82 ^` ~1~987S
~.........
grid mar~ing in order to enable wound healing to be observed. The extensions of the conformable support layer beyond one or more edges of the backing layer are preferably non-adhesive and thus facilitate the 5- removal of the conformable suppo~t layer from the backing layer.: ~
In another aspect therefore the present invention provides a method of treatiDg a wound which omprises lO- applying thereto an adhesive dressing as hereinbefore described by removing the removable protector, ;~ app~lying ~he hydrogel layer to the wound and the exposed adhesive:layer to the skin and then removing ~` : . the con~inuous conformable support layer.
;~ ~ ~ 15. - ` : : :
~: :We ~urthe~ provide~a method of manufacturing an a~hesive dressing as;hereinbefore described. This ; I method comprises taking a;backing layer provided with a support layer on a fixst side. The support layer : 20- preferably be~lng:provided with a grid pattern, a ~: ~ second side of the backing ~layer is coat d~with an ~` adhesive layer and then a protector is applied to ~he . ~ adhesive using conventional methods knnwn ~ se. In ; an automate~ pro~ess, the dressing may optionally be ~, ~ 25~ wound-:~nto a reel~ Subseguently, the reel~is unrolled~ the protector is remsved from the adhesive ;~ ~ layer~,~ the~hydrogel layer, which: may be in;the form of ;~: ~ a 'sl~b' is po~itioned onto the adhesive.:~ ~he protector~is,then~reapplied and~the~:dressings may be 30- cu~ t~;siæe.
When;~the~ hydrogel l:ayer comprises an integral support me~ber~the process~of manufacture will be as ~ ~ : : ` : ` : :
WO94/12134 PCTIGB93/Q238~
9~,~15 .- 12 -hereinbefore described. When the dressing according to the invention comprises a dam member, the dam member may be applied after the hydrogel la~er or the hydroge~ layer may be supported in the dam me~ber prior to applying the supported hydrogel layer to the backing layer. ~:Preferably however, the dam member is applied to~the backing layer;and then the hydrogel . layer is appl~ied.
10. The dressing may be plac~d in a bacteria-proof pack, sealed and sterilised by conventional methods, : including, for example,:using ethylene oxide or ~:; . irradiation.
: :;
: : 15. Preferred embodiments~of adhesive dressings of :: the present~invantion will now be:described by way of :~ ~ exampIe only and w1th reference to~the accompanying :. drawings, in which , , I :: .
~ ~ 20- Figure 1 is a cross section through an ambodiment :~: ~ ~ of a:dressing according to the invention, ~;`
~ Figure 2~is an expanded perspective view of the~
:~ ~: embodiment of Figure~l.~ ` ::
2~.
~Figure 3 is a cross section of an~embodlmen~ of tAe invention:provided~w1th~a~peripheral dam member, Figure 4 is~a cross section of a embodiment of 30: ::the invention~provided with an integral support : : member.
;Figures l and 2`shows~an adh sive dressing ~1 : :
.'O~./12134 PCT/GB93/02382 . 21~987,~ , ¦ which comprises a backing layer (2) formed from a fil~
of polyether polyurethane. ThP backing layex (2) has on one surface a pressure sensitive adhe~ive layer t3) formed from polyacrylate ester adhesive. On the non-adhesive surface of the backing layer (2) is a support layer (4). The support layer (4) may compxise a silicone or polyethylene coated papex or a : transparent film of polyethylene ox polypropylene.
The support layer (4,) is marked with a ~rid (5) to l0- enable wound haaling to be measured. A hydrogel (6) is attached to the adhesi~e layex ~3)~ The adhesive :; layer (3) and the hydrogel~(6~ are provided with a protector (7) made from a~silicone coatPd:release ~~~ paper.
~ 15. ~ :
! The protec~or (7) comprises two components. A
large protector (8~ is essentially:flat and overlap.s the smaller protector (9) which smaller pr~tector (9) ~ is folded into:a v-shape.:
:~ ~ : 20. ~ :
~ ~ :
~: ~ The support layer (4). is provided with edges (lO~
which;extend beyo~d the edge~(11) of t~he backing layer (2)~ and adhesive layer~(3).~
, ~ l In Figure 3 the d~essin~ is provided with a;dam . . :member (12) around the periphery of:the:hydro~el layer In: Figure~ 4 the hydrogel: layer (6) is providPd:
; 30wlth~an lntegral :support member ~(13j being a scrim.
In use~the larger~plecé (8) of the;protector is removed:first and: the dressing held by the overlylng ::
~'094/12134 PCT/GB93/023B?
.
2~98~S
portion of piece (9) and edge of the support layer (4). In such a case the larger area of the dressing ! is adhered to the skin, then the smaller piece (9) and the support layer (4) may be removed. Alternatively, 5- the smaller protector piece (9~ may be removed before application and the dressing handled asectically by the edges of the support layer (4) which project beyond the adhesive (3) and film (2) layers.
: 10.
lS.
:
:~ :
20.
:
.: ' 25.
~ ~ I
.
30.
, ;
~ .
:
Claims (10)
1. An adhesive dressing (1) comprising a backing layer (2) having a pressure sensitive adhesive layer (3) over one surface thereof and a continuous conformable support layer (4) which is reversibly attached to the non-adhesive surface of the backing layer and extends beyond the backing layer at one or more edges and a removable protector (7) characterised in that the dressing comprises a hydrogel layer (6) over part of the adhesive surface and the removable protector (7) covers the exposed adhesive layer and the hydrogel layer (6).
2. An adhesive dressing according to claim 1 in which the support layer (4) extends beyond the backing layer by 1 to 5cm.
3. An adhesive dressing according to claims 1 or 2 in which the adhesive layer (3) is non-continuous.
4. An adhesive dressing according to claim 3 wherein the backing layer (2) possesses an adhesive free zone around the periphery of the hydrogel layer (6).
5. An adhesive dressing according to claim 1 in which the hydrogel layer (6) is provided with a support member.
6. An adhesive dressing according to claim 5 wherein the support member is a dam member (12).
7. An adhesive dressing according to claim 5 wherein the support member is a scrim (13) and the scrim is based away from the edge of the hydrogel.
8. An adhesive dressing according to claim 1 in wherein the protector (7) comprises first and second parts (8 and 9), the first part (8) having a portion extending away from the adhesive surface and bent back to form a v-shape and the second part (9) having a portion extending away from the adhesive surface and overlaying the v-shaped first part.
9. A dressing according to claim 1 wherein the backing layer is a hydrophilic polyurethane.
10. The use of a hydrogel in the manufacture of a dressing according to claim 1.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929224444A GB9224444D0 (en) | 1992-11-21 | 1992-11-21 | Dressing |
| GB929224445A GB9224445D0 (en) | 1992-11-21 | 1992-11-21 | Dressing |
| GB9224444.1 | 1992-11-21 | ||
| GB9224445.8 | 1992-11-21 | ||
| GB929225312A GB9225312D0 (en) | 1992-12-03 | 1992-12-03 | Dressing |
| GB9225312.9 | 1992-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2149875A1 true CA2149875A1 (en) | 1994-06-09 |
Family
ID=27266474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2149875 Abandoned CA2149875A1 (en) | 1992-11-21 | 1993-11-19 | Wound dressings |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0674498A1 (en) |
| JP (1) | JPH08506028A (en) |
| AU (1) | AU5530694A (en) |
| CA (1) | CA2149875A1 (en) |
| GB (1) | GB2287409A (en) |
| WO (1) | WO1994012134A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69323975T2 (en) * | 1992-12-15 | 1999-08-19 | Johnson & Johnson Consumer | Hydrogel laminate, wound dressings and composite materials and processes for their manufacture |
| WO1997025012A1 (en) * | 1996-01-12 | 1997-07-17 | Smith & Nephew Plc | Wound dressing |
| US5846214A (en) * | 1996-03-29 | 1998-12-08 | Nichiban Company Limited | PVA hydrogel, hydrogel laminate using the same and hydrogel wound-dressing material using the same |
| US5897516A (en) * | 1996-09-27 | 1999-04-27 | Bristol-Myers Squibb Company | Method of treating a wound by monitoring the swelling of a hydrocolloid layer in a wound dressing |
| US6927315B1 (en) | 1999-07-30 | 2005-08-09 | 3M Innovative Properties Company | Adhesive composite having distinct phases |
| DE60011775T2 (en) * | 1999-07-30 | 2005-07-14 | 3M Innovative Properties Co., St. Paul | STICKY OBJECT WITH DIFFERENT PHASES |
| DK200000278A (en) * | 2000-02-22 | 2001-02-24 | Coloplast As | Wound bandage |
| DE10047673A1 (en) * | 2000-09-22 | 2002-04-11 | Beiersdorf Ag | Association |
| DE10047884A1 (en) * | 2000-09-22 | 2002-04-11 | Beiersdorf Ag | Self-adhesive wound dressings with an adhesive wound care area |
| US9457123B2 (en) | 2008-09-24 | 2016-10-04 | 3M Innovative Properties Company | Hydrogels with release element |
| US10034799B2 (en) | 2014-07-31 | 2018-07-31 | Johnson & Johnson Consumer Inc. | Two-stage wound dressing assembly |
| US10016310B2 (en) | 2014-07-31 | 2018-07-10 | Johnson & Johnson Consumer Inc. | Wound dressing assembly |
| US10456497B2 (en) | 2014-09-10 | 2019-10-29 | C. R. Bard, Inc. | Protective dressing for skin-placed medical device |
| IL245656B (en) | 2016-05-16 | 2018-02-28 | Technion Res & Dev Foundation | Superabsorbent polymeric structures |
| EP3491028A4 (en) | 2016-06-26 | 2020-02-19 | Technion Research & Development Foundation Limited | Polyhipes by interfacial step-growth polymerization |
| IL247302B (en) | 2016-08-16 | 2019-03-31 | Technion Res & Dev Foundation | Polyhipe-based substance-releasing systems |
| WO2019016816A1 (en) | 2017-07-19 | 2019-01-24 | Technion Research & Development Foundation Limited | Doubly-crosslinked, emulsion-templated hydrogels through reversible metal coordination |
| IL255404B (en) | 2017-11-02 | 2018-10-31 | Technion Res & Dev Foundation | Hipe-templated zwitterionic hydrogels, process of preparation and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE17191T1 (en) * | 1982-04-08 | 1986-01-15 | Smith & Nephew Ass | SURGICAL STAPS. |
| CA1320087C (en) * | 1988-09-07 | 1993-07-13 | Smith & Nephew Plc | Adhesive dressing, its preparation and use |
| US5059424A (en) * | 1989-11-01 | 1991-10-22 | Ndm Acquisition Corp. | Hydrogel wound dressing product |
| US5160328A (en) * | 1991-08-07 | 1992-11-03 | Ndm Acquisition Corp. | Hydrogel bandage |
-
1993
- 1993-11-19 JP JP6512885A patent/JPH08506028A/en active Pending
- 1993-11-19 EP EP94900233A patent/EP0674498A1/en not_active Withdrawn
- 1993-11-19 GB GB9510011A patent/GB2287409A/en not_active Withdrawn
- 1993-11-19 CA CA 2149875 patent/CA2149875A1/en not_active Abandoned
- 1993-11-19 WO PCT/GB1993/002382 patent/WO1994012134A1/en not_active Application Discontinuation
- 1993-11-19 AU AU55306/94A patent/AU5530694A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08506028A (en) | 1996-07-02 |
| GB9510011D0 (en) | 1995-07-19 |
| GB2287409A (en) | 1995-09-20 |
| WO1994012134A1 (en) | 1994-06-09 |
| AU5530694A (en) | 1994-06-22 |
| EP0674498A1 (en) | 1995-10-04 |
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