CA2149062A1 - Immunoassays using a carbon sol label - Google Patents

Immunoassays using a carbon sol label

Info

Publication number
CA2149062A1
CA2149062A1 CA002149062A CA2149062A CA2149062A1 CA 2149062 A1 CA2149062 A1 CA 2149062A1 CA 002149062 A CA002149062 A CA 002149062A CA 2149062 A CA2149062 A CA 2149062A CA 2149062 A1 CA2149062 A1 CA 2149062A1
Authority
CA
Canada
Prior art keywords
analyte
carbon
sample
din
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002149062A
Other languages
French (fr)
Other versions
CA2149062C (en
Inventor
Aart Van Amerongen
Jan Herman Wichers
Lucienne Bernardina Johanna Maria Berendsen
Albert Willem Jacob Van Doorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Dienst Landbouwkundig Onderzoek DLO
Original Assignee
Aart Van Amerongen
Jan Herman Wichers
Lucienne Bernardina Johanna Maria Berendsen
Albert Willem Jacob Van Doorn
Staat Der Nederlanden (Dienst Landbouwkundig Onderzoek (Dlo))
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/241,734 external-priority patent/US5529901A/en
Application filed by Aart Van Amerongen, Jan Herman Wichers, Lucienne Bernardina Johanna Maria Berendsen, Albert Willem Jacob Van Doorn, Staat Der Nederlanden (Dienst Landbouwkundig Onderzoek (Dlo)) filed Critical Aart Van Amerongen
Publication of CA2149062A1 publication Critical patent/CA2149062A1/en
Application granted granted Critical
Publication of CA2149062C publication Critical patent/CA2149062C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0026—Preparation of sols containing a liquid organic phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/922—Colloid systems having specified particle size, range, or distribution, e.g. bimodal particle distribution

Abstract

Method for determining the presence or amount of an analyte in a sample by contacting the sample with a carbon-labeled constituent comprising an essentially non-stabilized aqueous sol of a carbon black having a linear predictor value V > 0, wherein V = - 138.954 - 0.987xDBP + 15.609xVC + 3.994xPPD; DBP is the dibutylphthalate adsorption in ml/100g, as determined according to DIN 53601; VC is the volatile content in %, as determined according to DIN 53552; and PPD is the average primary particle diameter in nanometers; the colloidal carbon particles having directly conjugated to their surface a binding component capable of specifically recognizing said analyte and determining the presence or absence of a resulting analyte/carbon particle complex as an indication of the presence or a measure of the amount of analyte in said sample. Composition suited for use in the method, and method for preparing same.
CA002149062A 1994-05-12 1995-05-10 Immunoassays using a carbon sol label Expired - Fee Related CA2149062C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US241,734 1988-09-08
US08/241,734 US5529901A (en) 1987-11-19 1994-05-12 Method for determining the presence or amount of analyte using a stable colloidal carbon sol
EP94201817A EP0682255A1 (en) 1994-05-12 1994-06-23 Immunoassays using a carbon sol label
EP94201817.7 1994-06-23

Publications (2)

Publication Number Publication Date
CA2149062A1 true CA2149062A1 (en) 1995-11-13
CA2149062C CA2149062C (en) 2007-03-13

Family

ID=26136372

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002149062A Expired - Fee Related CA2149062C (en) 1994-05-12 1995-05-10 Immunoassays using a carbon sol label

Country Status (7)

Country Link
JP (1) JPH08184597A (en)
CN (1) CN1120986C (en)
AU (1) AU693523B2 (en)
CA (1) CA2149062C (en)
FI (1) FI952281A (en)
IL (1) IL113682A (en)
NZ (1) NZ272119A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3407065A4 (en) * 2016-01-22 2018-11-28 Tanaka Kikinzoku Kogyo K.K. Chromatograph medium

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20115285A0 (en) * 2011-03-24 2011-03-24 Reagena Ltd Oy Method for performing a rapid test
CN103134933B (en) * 2013-02-05 2015-07-01 江西中德生物工程有限公司 Test strip used for detecting vibrio parahemolytocus and purpose thereof
CN106153936A (en) * 2015-03-26 2016-11-23 中国农业科学院油料作物研究所 A kind of Bt-Cry1Ab/Ac colloidal-carbon Rapid detection test strip
CN107543933A (en) * 2016-06-24 2018-01-05 江苏雷森生物科技有限公司 A kind of preparation method of carbon nano-particle of antibody labeling and the early pregnancy test strips using its preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760030A (en) * 1984-09-10 1988-07-26 Syntex (U.S.A.) Inc. Quantitative opaque particle agglutination assay
US5252496A (en) * 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3407065A4 (en) * 2016-01-22 2018-11-28 Tanaka Kikinzoku Kogyo K.K. Chromatograph medium

Also Published As

Publication number Publication date
IL113682A0 (en) 1995-08-31
CN1114423A (en) 1996-01-03
FI952281A (en) 1995-11-13
AU693523B2 (en) 1998-07-02
JPH08184597A (en) 1996-07-16
CA2149062C (en) 2007-03-13
NZ272119A (en) 1997-08-22
IL113682A (en) 2000-10-31
CN1120986C (en) 2003-09-10
FI952281A0 (en) 1995-05-10
AU1797995A (en) 1995-11-23

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150511