CA2148942A1 - M-edta pharmaceutical preparations and uses thereof - Google Patents

M-edta pharmaceutical preparations and uses thereof

Info

Publication number
CA2148942A1
CA2148942A1 CA002148942A CA2148942A CA2148942A1 CA 2148942 A1 CA2148942 A1 CA 2148942A1 CA 002148942 A CA002148942 A CA 002148942A CA 2148942 A CA2148942 A CA 2148942A CA 2148942 A1 CA2148942 A1 CA 2148942A1
Authority
CA
Canada
Prior art keywords
edta
glycocalyx
formation
solution
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002148942A
Other languages
French (fr)
Other versions
CA2148942C (en
Inventor
Issam Raad
Robert J. Sherertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Issam Raad
Robert J. Sherertz
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/975,486 external-priority patent/US5362754A/en
Application filed by Issam Raad, Robert J. Sherertz, Board Of Regents, The University Of Texas System filed Critical Issam Raad
Publication of CA2148942A1 publication Critical patent/CA2148942A1/en
Application granted granted Critical
Publication of CA2148942C publication Critical patent/CA2148942C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Disclosed are pharmaceutical compositions of a mixture of minocycline and EDTA (M-EDTA) and methods of using the compositions in maintaining the patency of a catheter port. Methods for inhibiting the formation of polysaccharide-rich glycocalyx (such as the glycocalyx of staphylococcal organisms) are also provided using an M-EDTA
solution. A solution including minocycline, EDTA
or both, may also be used to pretreat a medical device to prevent adherence of infectious organisms, such as S. epidermidis and S. aureus. The compositions destroy and prevent the formation of polysaccharide-rich glycocalyx. Methods for treating infections of S. epidermidis and S. aureus where glycocalyx formation are provided with an M-EDTA
solution. The minocycline and EDTA solutions are included together within a pharmacologically acceptable carrier solution, such as saline.
CA002148942A 1992-11-12 1993-11-12 M-edta pharmaceutical preparations and uses thereof Expired - Fee Related CA2148942C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/975,486 1992-11-12
US07/975,486 US5362754A (en) 1992-11-12 1992-11-12 M-EDTA pharmaceutical preparations and uses thereof
PCT/US1993/010893 WO1994010838A1 (en) 1992-11-12 1993-11-12 M-edta pharmaceutical preparations and uses thereof

Publications (2)

Publication Number Publication Date
CA2148942A1 true CA2148942A1 (en) 1994-05-26
CA2148942C CA2148942C (en) 2006-10-03

Family

ID=37101718

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002148942A Expired - Fee Related CA2148942C (en) 1992-11-12 1993-11-12 M-edta pharmaceutical preparations and uses thereof

Country Status (1)

Country Link
CA (1) CA2148942C (en)

Also Published As

Publication number Publication date
CA2148942C (en) 2006-10-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed