CA2146192A1 - Polyionic Insoluble Hydrogels Comprising Xanthan - Google Patents

Polyionic Insoluble Hydrogels Comprising Xanthan

Info

Publication number
CA2146192A1
CA2146192A1 CA2146192A CA2146192A CA2146192A1 CA 2146192 A1 CA2146192 A1 CA 2146192A1 CA 2146192 A CA2146192 A CA 2146192A CA 2146192 A CA2146192 A CA 2146192A CA 2146192 A1 CA2146192 A1 CA 2146192A1
Authority
CA
Canada
Prior art keywords
xanthan
chitosan
hydrogels
prepared
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2146192A
Other languages
French (fr)
Other versions
CA2146192C (en
Inventor
Esteban Chornet
Severian Dumitriu
Pierre Vidal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kemestrie Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002146192A priority Critical patent/CA2146192C/en
Publication of CA2146192A1 publication Critical patent/CA2146192A1/en
Application granted granted Critical
Publication of CA2146192C publication Critical patent/CA2146192C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method for the preparation of insoluble hydrogels from the complexation of polycations and xanthan is reported. Stable hydrogels capable of retaining between 65 and 95% weight water were prepared particularly with chitosan and xanthan. The water retention and properties of the hydrogels were studied as a function of the degree of acetylation of chitosan and the ratio chitosan/xanthan used in the preparation of the gel.
The chitosan-xanthan complex was used to immobilize biological material. Hydrogels containing enzymes (for example endo-1,4-.beta.-xylanase and protease) either as single enzymes or as a binary system have been prepared.
Immobilization varied between 85 and 98%. The immobilized xylanase activity was significantly greater with respect to the free enzyme while the binary enzyme system promoted protease activity. Other hydrogels prepared with polybasic drugs complexed to xanthan with or without chitosan have been prepared. These complexes slowly dissociate in acidic media and provide for sustained release of compounds in near neutral pHs.
Gels containing chitosan are stable in all physiological pHs and the immobilized molecules are released therefrom by diffusion.
CA002146192A 1995-04-03 1995-04-03 Polyionic insoluble hydrogels comprising xanthan Expired - Fee Related CA2146192C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002146192A CA2146192C (en) 1995-04-03 1995-04-03 Polyionic insoluble hydrogels comprising xanthan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002146192A CA2146192C (en) 1995-04-03 1995-04-03 Polyionic insoluble hydrogels comprising xanthan

Publications (2)

Publication Number Publication Date
CA2146192A1 true CA2146192A1 (en) 1996-10-04
CA2146192C CA2146192C (en) 1999-04-06

Family

ID=4155559

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002146192A Expired - Fee Related CA2146192C (en) 1995-04-03 1995-04-03 Polyionic insoluble hydrogels comprising xanthan

Country Status (1)

Country Link
CA (1) CA2146192C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710107B2 (en) 2006-04-05 2014-04-29 Woodland Biofuels Inc. System and method for converting biomass to ethanol via syngas
CN114990100A (en) * 2022-06-24 2022-09-02 陕西科技大学 Lactase microcapsule preparation method and low-lactose liquid goat milk prepared by using lactase microcapsule

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710107B2 (en) 2006-04-05 2014-04-29 Woodland Biofuels Inc. System and method for converting biomass to ethanol via syngas
CN114990100A (en) * 2022-06-24 2022-09-02 陕西科技大学 Lactase microcapsule preparation method and low-lactose liquid goat milk prepared by using lactase microcapsule
CN114990100B (en) * 2022-06-24 2024-01-30 陕西科技大学 Lactase microcapsule preparation method and low-lactose liquid goat milk prepared by using lactase microcapsule

Also Published As

Publication number Publication date
CA2146192C (en) 1999-04-06

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Legal Events

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