CA2141056A1 - Treatment of dentoalveolar infections with taurolidine and/or taurultam - Google Patents

Treatment of dentoalveolar infections with taurolidine and/or taurultam

Info

Publication number
CA2141056A1
CA2141056A1 CA002141056A CA2141056A CA2141056A1 CA 2141056 A1 CA2141056 A1 CA 2141056A1 CA 002141056 A CA002141056 A CA 002141056A CA 2141056 A CA2141056 A CA 2141056A CA 2141056 A1 CA2141056 A1 CA 2141056A1
Authority
CA
Canada
Prior art keywords
taurultam
taurolidine
treatment
dentoalveolar
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002141056A
Other languages
French (fr)
Other versions
CA2141056C (en
Inventor
Rolf Wilhelm Pfirrmann
Peter Geistlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ed Geistlich Soehne AG fuer Chemische Industrie
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2141056A1 publication Critical patent/CA2141056A1/en
Application granted granted Critical
Publication of CA2141056C publication Critical patent/CA2141056C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides a new means of combatting severe dentoalveolar infections such as dental gangrene, parodontitis and abscesses which involves the administration of the methylol-transfer agents taurolidine and/or taurultam. In one embodiment the taurolidine and/or taurultam compositions may be administered prophylactically to combat post-operative infection. Certain novel compositions comprising taurolidine and or taurultam are also described.
CA002141056A 1992-07-30 1993-07-29 Treatment of dentoalveolar infections with taurolidine and/or taurultam Expired - Lifetime CA2141056C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9216155.3 1992-07-30
GB929216155A GB9216155D0 (en) 1992-07-30 1992-07-30 Treatment of dentoalveolar infections
PCT/GB1993/001607 WO1994003174A1 (en) 1992-07-30 1993-07-29 Treatment of dentoalveolar infections with taurolidine and/or taurultam

Publications (2)

Publication Number Publication Date
CA2141056A1 true CA2141056A1 (en) 1994-02-17
CA2141056C CA2141056C (en) 2005-02-15

Family

ID=10719520

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002141056A Expired - Lifetime CA2141056C (en) 1992-07-30 1993-07-29 Treatment of dentoalveolar infections with taurolidine and/or taurultam

Country Status (5)

Country Link
EP (1) EP0652753A1 (en)
JP (1) JPH07509483A (en)
CA (1) CA2141056C (en)
GB (1) GB9216155D0 (en)
WO (1) WO1994003174A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2180852C2 (en) * 1994-12-12 2002-03-27 Омерос Медикл Системс, Инк. Inhibitory solution and method of suppression of pain, inflammation or spasm
KR100517210B1 (en) * 1994-12-12 2006-06-07 오메로스 코포레이션 Infusion solution for pain, inflammation and spasm
AU4467396A (en) * 1994-12-12 1996-07-10 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
NZ333872A (en) * 1996-06-24 2000-08-25 Bio Safe Entpr Inc Barrier forming antibacterial composition comprising polyvinylpyrrolidone, hydroxyethylcellulonse, an antibacterial agent and an emulsifier
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
US6166007A (en) * 1998-07-02 2000-12-26 Sodemann; Klaus Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof
CN100519525C (en) 1999-12-06 2009-07-29 葛兰素集团有限公司 Aromatic sulfones and their medical use
ES2438535T3 (en) 1999-12-06 2014-01-17 Geistlich Pharma Ag Taurolidine or taurultamo for use in the treatment of prostate, colon, lung tumors and for the treatment of recurrent glioblastoma multiforme
EP1797884B1 (en) * 1999-12-06 2013-09-11 Geistlich Pharma AG Taurolidine or taurultam for use in the treatment of tumors of the prostate, colon, lung and for the treatment of recurrent glioblastoma multiforme
JP5280603B2 (en) 2001-10-01 2013-09-04 ガイストリッヒ ファーマ アーゲー Methods for metastasis inhibition
DE10261241A1 (en) * 2002-12-20 2004-07-15 3M Espe Ag Dental material with bacteriostatic and / or bactericidal substances
ATE354380T1 (en) * 2003-02-03 2007-03-15 Polaschegg Hans-Dietrich Dr Te COMPOSITION FOR THE PREVENTION OF INFECTIONS THROUGH SUBCUTANEOUS PROSTHESIS
JP2007537200A (en) * 2004-05-14 2007-12-20 ハンス−ディートリヒ・ポラシェグ Taurolidine formulation and administration: therapeutic treatment and antibacterial protection against bacterial microfilm formation
US7696182B2 (en) 2004-11-02 2010-04-13 Nd Partners, Llc Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin
EP1787627A1 (en) 2005-11-17 2007-05-23 3M Innovative Properties Company Anti-microbial dental impression material
WO2012042349A1 (en) * 2010-09-27 2012-04-05 Geistlich Pharma Ag Antimicrobial dental care preparation
KR20180105115A (en) * 2015-10-07 2018-09-27 코르메딕스, 인코포레이티드 Skin-permeable formulations of taurolidine
US11738120B1 (en) 2022-04-14 2023-08-29 Cormedix Inc. Synthesis of taurolidine, purity profiles and polymorphs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH600878A5 (en) * 1975-04-28 1978-06-30 Gaba Ag
GB1557163A (en) * 1975-06-24 1979-12-05 Geistlich Soehne Ag Dental care preparations
GB8328073D0 (en) * 1983-10-20 1983-11-23 Geistlich Soehne Ag Chemical compounds
EP0521225B1 (en) * 1991-07-04 1994-10-12 Hawe Neos Dental Dr. H. v. Weissenfluh SA Pharmaceutical preparation for treatment of periodontitis, containing clavulanic acid

Also Published As

Publication number Publication date
JPH07509483A (en) 1995-10-19
WO1994003174A1 (en) 1994-02-17
EP0652753A1 (en) 1995-05-17
GB9216155D0 (en) 1992-09-09
CA2141056C (en) 2005-02-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130730

MKEC Expiry (correction)

Effective date: 20131009