CA2141056A1 - Treatment of dentoalveolar infections with taurolidine and/or taurultam - Google Patents
Treatment of dentoalveolar infections with taurolidine and/or taurultamInfo
- Publication number
- CA2141056A1 CA2141056A1 CA002141056A CA2141056A CA2141056A1 CA 2141056 A1 CA2141056 A1 CA 2141056A1 CA 002141056 A CA002141056 A CA 002141056A CA 2141056 A CA2141056 A CA 2141056A CA 2141056 A1 CA2141056 A1 CA 2141056A1
- Authority
- CA
- Canada
- Prior art keywords
- taurultam
- taurolidine
- treatment
- dentoalveolar
- infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 title abstract 4
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004267 taurolidine Drugs 0.000 title abstract 4
- 229950007343 taurultam Drugs 0.000 title abstract 4
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010063066 Dental gangrene Diseases 0.000 abstract 1
- 206010067268 Post procedural infection Diseases 0.000 abstract 1
- 206010000269 abscess Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention provides a new means of combatting severe dentoalveolar infections such as dental gangrene, parodontitis and abscesses which involves the administration of the methylol-transfer agents taurolidine and/or taurultam. In one embodiment the taurolidine and/or taurultam compositions may be administered prophylactically to combat post-operative infection. Certain novel compositions comprising taurolidine and or taurultam are also described.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9216155.3 | 1992-07-30 | ||
GB929216155A GB9216155D0 (en) | 1992-07-30 | 1992-07-30 | Treatment of dentoalveolar infections |
PCT/GB1993/001607 WO1994003174A1 (en) | 1992-07-30 | 1993-07-29 | Treatment of dentoalveolar infections with taurolidine and/or taurultam |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2141056A1 true CA2141056A1 (en) | 1994-02-17 |
CA2141056C CA2141056C (en) | 2005-02-15 |
Family
ID=10719520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002141056A Expired - Lifetime CA2141056C (en) | 1992-07-30 | 1993-07-29 | Treatment of dentoalveolar infections with taurolidine and/or taurultam |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0652753A1 (en) |
JP (1) | JPH07509483A (en) |
CA (1) | CA2141056C (en) |
GB (1) | GB9216155D0 (en) |
WO (1) | WO1994003174A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2180852C2 (en) * | 1994-12-12 | 2002-03-27 | Омерос Медикл Системс, Инк. | Inhibitory solution and method of suppression of pain, inflammation or spasm |
KR100517210B1 (en) * | 1994-12-12 | 2006-06-07 | 오메로스 코포레이션 | Infusion solution for pain, inflammation and spasm |
AU4467396A (en) * | 1994-12-12 | 1996-07-10 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
NZ333872A (en) * | 1996-06-24 | 2000-08-25 | Bio Safe Entpr Inc | Barrier forming antibacterial composition comprising polyvinylpyrrolidone, hydroxyethylcellulonse, an antibacterial agent and an emulsifier |
US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
US6166007A (en) * | 1998-07-02 | 2000-12-26 | Sodemann; Klaus | Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof |
CN100519525C (en) | 1999-12-06 | 2009-07-29 | 葛兰素集团有限公司 | Aromatic sulfones and their medical use |
ES2438535T3 (en) | 1999-12-06 | 2014-01-17 | Geistlich Pharma Ag | Taurolidine or taurultamo for use in the treatment of prostate, colon, lung tumors and for the treatment of recurrent glioblastoma multiforme |
EP1797884B1 (en) * | 1999-12-06 | 2013-09-11 | Geistlich Pharma AG | Taurolidine or taurultam for use in the treatment of tumors of the prostate, colon, lung and for the treatment of recurrent glioblastoma multiforme |
JP5280603B2 (en) | 2001-10-01 | 2013-09-04 | ガイストリッヒ ファーマ アーゲー | Methods for metastasis inhibition |
DE10261241A1 (en) * | 2002-12-20 | 2004-07-15 | 3M Espe Ag | Dental material with bacteriostatic and / or bactericidal substances |
ATE354380T1 (en) * | 2003-02-03 | 2007-03-15 | Polaschegg Hans-Dietrich Dr Te | COMPOSITION FOR THE PREVENTION OF INFECTIONS THROUGH SUBCUTANEOUS PROSTHESIS |
JP2007537200A (en) * | 2004-05-14 | 2007-12-20 | ハンス−ディートリヒ・ポラシェグ | Taurolidine formulation and administration: therapeutic treatment and antibacterial protection against bacterial microfilm formation |
US7696182B2 (en) | 2004-11-02 | 2010-04-13 | Nd Partners, Llc | Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin |
EP1787627A1 (en) | 2005-11-17 | 2007-05-23 | 3M Innovative Properties Company | Anti-microbial dental impression material |
WO2012042349A1 (en) * | 2010-09-27 | 2012-04-05 | Geistlich Pharma Ag | Antimicrobial dental care preparation |
KR20180105115A (en) * | 2015-10-07 | 2018-09-27 | 코르메딕스, 인코포레이티드 | Skin-permeable formulations of taurolidine |
US11738120B1 (en) | 2022-04-14 | 2023-08-29 | Cormedix Inc. | Synthesis of taurolidine, purity profiles and polymorphs |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH600878A5 (en) * | 1975-04-28 | 1978-06-30 | Gaba Ag | |
GB1557163A (en) * | 1975-06-24 | 1979-12-05 | Geistlich Soehne Ag | Dental care preparations |
GB8328073D0 (en) * | 1983-10-20 | 1983-11-23 | Geistlich Soehne Ag | Chemical compounds |
EP0521225B1 (en) * | 1991-07-04 | 1994-10-12 | Hawe Neos Dental Dr. H. v. Weissenfluh SA | Pharmaceutical preparation for treatment of periodontitis, containing clavulanic acid |
-
1992
- 1992-07-30 GB GB929216155A patent/GB9216155D0/en active Pending
-
1993
- 1993-07-29 WO PCT/GB1993/001607 patent/WO1994003174A1/en not_active Application Discontinuation
- 1993-07-29 CA CA002141056A patent/CA2141056C/en not_active Expired - Lifetime
- 1993-07-29 EP EP93917947A patent/EP0652753A1/en not_active Ceased
- 1993-07-29 JP JP6505094A patent/JPH07509483A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH07509483A (en) | 1995-10-19 |
WO1994003174A1 (en) | 1994-02-17 |
EP0652753A1 (en) | 1995-05-17 |
GB9216155D0 (en) | 1992-09-09 |
CA2141056C (en) | 2005-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130730 |
|
MKEC | Expiry (correction) |
Effective date: 20131009 |