CA2139169A1 - Antiherpes peptidomimetic compounds - Google Patents

Antiherpes peptidomimetic compounds

Info

Publication number
CA2139169A1
CA2139169A1 CA002139169A CA2139169A CA2139169A1 CA 2139169 A1 CA2139169 A1 CA 2139169A1 CA 002139169 A CA002139169 A CA 002139169A CA 2139169 A CA2139169 A CA 2139169A CA 2139169 A1 CA2139169 A1 CA 2139169A1
Authority
CA
Canada
Prior art keywords
antiherpes
peptidomimetic compounds
alkyl
compounds
peptidomimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002139169A
Other languages
French (fr)
Other versions
CA2139169C (en
Inventor
Robert Deziel
Montse Llinas Brunet
Neil Moss
Raymond Plante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Priority to CA002139169A priority Critical patent/CA2139169C/en
Priority to CA002230750A priority patent/CA2230750C/en
Priority to US08/460,957 priority patent/US5846941A/en
Priority to AU37395/95A priority patent/AU3739595A/en
Priority to MX9704548A priority patent/MX9704548A/en
Priority to DE69514388T priority patent/DE69514388T2/en
Priority to JP8520086A priority patent/JPH10511362A/en
Priority to EP95935318A priority patent/EP0800512B1/en
Priority to AT95935318T priority patent/ATE188468T1/en
Priority to PCT/CA1995/000626 priority patent/WO1996020171A1/en
Priority to TW084112900A priority patent/TW432035B/en
Priority to IL11655795A priority patent/IL116557A0/en
Priority to ZA9510964A priority patent/ZA9510964B/en
Publication of CA2139169A1 publication Critical patent/CA2139169A1/en
Application granted granted Critical
Publication of CA2139169C publication Critical patent/CA2139169C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Storing, Repeated Paying-Out, And Re-Storing Of Elongated Articles (AREA)

Abstract

Disclosed herein are compounds of the formula
CA002139169A 1992-03-12 1994-12-28 Antiherpes peptidomimetic compounds Expired - Fee Related CA2139169C (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002139169A CA2139169C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds
CA002230750A CA2230750C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds
US08/460,957 US5846941A (en) 1992-03-12 1995-06-05 Isosteric antiherpes peptide derivatives II
JP8520086A JPH10511362A (en) 1994-12-28 1995-10-31 Anti-herpes peptidomimetic compound
MX9704548A MX9704548A (en) 1994-12-28 1995-10-31 Antiherpes peptidomimetic compounds.
DE69514388T DE69514388T2 (en) 1994-12-28 1995-10-31 ANTIHERPETIC PEPTIDOMIMETIC COMPOUNDS
AU37395/95A AU3739595A (en) 1994-12-28 1995-10-31 Antiherpes peptidomimetic compounds
EP95935318A EP0800512B1 (en) 1994-12-28 1995-10-31 Antiherpes peptidomimetic compounds
AT95935318T ATE188468T1 (en) 1994-12-28 1995-10-31 ANTIHERPETIC PEPTIDOMIMMETIC COMPOUNDS
PCT/CA1995/000626 WO1996020171A1 (en) 1994-12-28 1995-10-31 Antiherpes peptidomimetic compounds
TW084112900A TW432035B (en) 1994-12-28 1995-12-04 Antiherpes peptidomimetic compounds
IL11655795A IL116557A0 (en) 1994-12-28 1995-12-26 Antiherpes peptidomimetic compounds their preparation and pharmaceutical compositions containing them
ZA9510964A ZA9510964B (en) 1994-12-28 1995-12-27 Antiherpes peptidomimetic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002139169A CA2139169C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002230750A Division CA2230750C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds

Publications (2)

Publication Number Publication Date
CA2139169A1 true CA2139169A1 (en) 1996-06-29
CA2139169C CA2139169C (en) 2001-05-01

Family

ID=4154943

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002230750A Expired - Fee Related CA2230750C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds
CA002139169A Expired - Fee Related CA2139169C (en) 1992-03-12 1994-12-28 Antiherpes peptidomimetic compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002230750A Expired - Fee Related CA2230750C (en) 1994-12-28 1994-12-28 Antiherpes peptidomimetic compounds

Country Status (11)

Country Link
EP (1) EP0800512B1 (en)
JP (1) JPH10511362A (en)
AT (1) ATE188468T1 (en)
AU (1) AU3739595A (en)
CA (2) CA2230750C (en)
DE (1) DE69514388T2 (en)
IL (1) IL116557A0 (en)
MX (1) MX9704548A (en)
TW (1) TW432035B (en)
WO (1) WO1996020171A1 (en)
ZA (1) ZA9510964B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE169931T1 (en) * 1992-03-12 1998-09-15 Boehringer Ingelheim Ca Ltd ISOSTERIC PEPTIDE DERIVATIVES AGAINST HERPES
CA2095408A1 (en) * 1993-05-03 1994-11-04 James Gus Chafouleas Method of combating acyclovir-resistant herpes simplex viral infections

Also Published As

Publication number Publication date
CA2230750A1 (en) 1996-06-29
DE69514388D1 (en) 2000-02-10
EP0800512A1 (en) 1997-10-15
MX9704548A (en) 1998-02-28
DE69514388T2 (en) 2000-07-27
TW432035B (en) 2001-05-01
CA2139169C (en) 2001-05-01
JPH10511362A (en) 1998-11-04
WO1996020171A1 (en) 1996-07-04
CA2230750C (en) 2002-05-21
AU3739595A (en) 1996-07-19
EP0800512B1 (en) 2000-01-05
ATE188468T1 (en) 2000-01-15
IL116557A0 (en) 1996-03-31
ZA9510964B (en) 1996-06-08

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed