CA2137755A1 - Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical - Google Patents

Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical

Info

Publication number
CA2137755A1
CA2137755A1 CA 2137755 CA2137755A CA2137755A1 CA 2137755 A1 CA2137755 A1 CA 2137755A1 CA 2137755 CA2137755 CA 2137755 CA 2137755 A CA2137755 A CA 2137755A CA 2137755 A1 CA2137755 A1 CA 2137755A1
Authority
CA
Canada
Prior art keywords
substituted
phenylethylurea
benzylurea
phenylurea
palliation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2137755
Other languages
French (fr)
Other versions
CA2137755C (en
Inventor
William H. Waugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2137755A1 publication Critical patent/CA2137755A1/en
Application granted granted Critical
Publication of CA2137755C publication Critical patent/CA2137755C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention is directed to the novel use of arylurea compounds and aralkylura compounds consisting of phenylurea, benzylurea, and phenylethylurea or by a meta-or para-positioned, ring-substituted homolog of each in which one hydrogen is substituted by one methoxyl, methyl, or hydroxyl radical, for the palliation of sickle cell anemia and other human sickling disease.
The invention is also directed to pharmaceutical formulations containing these aromatic urea compounds.
CA 2137755 1994-06-07 1994-12-09 Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical Expired - Fee Related CA2137755C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25575594A 1994-06-07 1994-06-07
US08/255,755 1994-06-07

Publications (2)

Publication Number Publication Date
CA2137755A1 true CA2137755A1 (en) 1995-12-08
CA2137755C CA2137755C (en) 2002-07-02

Family

ID=22969714

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2137755 Expired - Fee Related CA2137755C (en) 1994-06-07 1994-12-09 Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical

Country Status (2)

Country Link
CA (1) CA2137755C (en)
GB (1) GB2290235B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
EP1514867A3 (en) * 1998-10-22 2005-03-23 NeuroSearch A/S Substituted phenyl derivatives, their preparation and use
DE102012007558A1 (en) 2012-04-14 2013-10-17 Alf Hammes Use of diarylurea-derivatives for treating the symptoms of anemia, thalassemia, sickle cell anemia and Diamond-Blackfan anemia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56131516A (en) * 1980-03-18 1981-10-15 Koutaku Hayashi Immunochemotherapy, prevention of resistance to drug, and carcinostatic agent

Also Published As

Publication number Publication date
CA2137755C (en) 2002-07-02
GB2290235A (en) 1995-12-20
GB9500442D0 (en) 1995-03-01
GB2290235B (en) 1998-03-25

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Legal Events

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MKLA Lapsed