CA2129986A1 - Amphiphile nucleosidphosphatanaloga - Google Patents

Amphiphile nucleosidphosphatanaloga

Info

Publication number
CA2129986A1
CA2129986A1 CA002129986A CA2129986A CA2129986A1 CA 2129986 A1 CA2129986 A1 CA 2129986A1 CA 002129986 A CA002129986 A CA 002129986A CA 2129986 A CA2129986 A CA 2129986A CA 2129986 A1 CA2129986 A1 CA 2129986A1
Authority
CA
Canada
Prior art keywords
formula
radical
stands
hydroxyl
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002129986A
Other languages
French (fr)
Other versions
CA2129986C (en
Inventor
Albert Reto Schwendener
Frederique Guerin
Herbert Schott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19924204211 external-priority patent/DE4204211A1/en
Priority claimed from DE19924224878 external-priority patent/DE4224878A1/en
Application filed by Individual filed Critical Individual
Publication of CA2129986A1 publication Critical patent/CA2129986A1/en
Application granted granted Critical
Publication of CA2129986C publication Critical patent/CA2129986C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

The present invention relates to amphiphilic nucleosidephosphate analogues of Formula I
(See formula I) wherein R1 stands for a hydroxyl-, amino-, acylated, or alkylized amino group or one substituted by polyoxyethylene, whose acyl- or alkyl rest is linear or branched, have 1 to 24 C-atoms and up to 2 double bonds, and which can be substituted by an aromatic radicals R2 stands for H, F, a 2-bromvinyl radical or a linear or branched C1-C24 alkyl radical;
R3 and R4 are identical or different and stand for H, hydroxyl, halogen and azido;
R5 is a nucleoside radical of Formula II
(See formula II) that is connected through R8, R9, or R10 to the nucleotide of Formula I. R5 can also stand for OH.
A procedure for producing these, and pharmaceutical means are also described.
CA002129986A 1992-02-13 1993-02-12 Amphiphile nucleosidphosphatanaloga Expired - Fee Related CA2129986C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP4204211.9 1992-02-13
DE19924204211 DE4204211A1 (en) 1992-02-13 1992-02-13 New azido-thymidine derivs. - are AZT pro-drugs used as antiviral agents, esp. against AIDS, and to treat cancer
DEP4224878.7 1992-07-28
DE19924224878 DE4224878A1 (en) 1992-07-28 1992-07-28 Amphiphilic nucleoside phosphate analogues
PCT/EP1993/000346 WO1993016093A1 (en) 1992-02-13 1993-02-12 Amphiphilic nucleoside phosphate analogs

Publications (2)

Publication Number Publication Date
CA2129986A1 true CA2129986A1 (en) 1993-08-14
CA2129986C CA2129986C (en) 2003-12-09

Family

ID=25911795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129986A Expired - Fee Related CA2129986C (en) 1992-02-13 1993-02-12 Amphiphile nucleosidphosphatanaloga

Country Status (6)

Country Link
US (1) US5679652A (en)
EP (1) EP0642527B1 (en)
AT (1) ATE132873T1 (en)
CA (1) CA2129986C (en)
DE (1) DE59301421D1 (en)
WO (1) WO1993016093A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9608180D0 (en) * 1996-04-19 1996-06-26 Cancer Res Campaign Tech Phosphate analogues
DE19855963A1 (en) 1998-12-04 2000-06-08 Herbert Schott Amphiphilic glyceryl nucleotides, process for their preparation and their use
DE10228059B4 (en) * 2002-06-19 2005-12-29 Eberhard-Karls-Universität Tübingen Use of amphiphilic nucleoside-phosphonoformic acid derivatives for the treatment of viral infectious diseases
CN1304408C (en) * 2004-03-04 2007-03-14 清华大学 Derivative of vibothymidine and its preparation process and application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0642527B1 (en) 1996-01-10
DE59301421D1 (en) 1996-02-22
ATE132873T1 (en) 1996-01-15
US5679652A (en) 1997-10-21
WO1993016093A1 (en) 1993-08-19
CA2129986C (en) 2003-12-09
EP0642527A1 (en) 1995-03-15

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