CA2128243A1 - Process for the Manufacture of Soft Gelatin Capsules by a Drip-Feed Method - Google Patents
Process for the Manufacture of Soft Gelatin Capsules by a Drip-Feed MethodInfo
- Publication number
- CA2128243A1 CA2128243A1 CA 2128243 CA2128243A CA2128243A1 CA 2128243 A1 CA2128243 A1 CA 2128243A1 CA 2128243 CA2128243 CA 2128243 CA 2128243 A CA2128243 A CA 2128243A CA 2128243 A1 CA2128243 A1 CA 2128243A1
- Authority
- CA
- Canada
- Prior art keywords
- soft gelatin
- drip
- gelatin capsules
- manufacture
- feed method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007903 gelatin capsule Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 108010010803 Gelatin Proteins 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 229920000159 gelatin Polymers 0.000 abstract 2
- 239000008273 gelatin Substances 0.000 abstract 2
- 235000019322 gelatine Nutrition 0.000 abstract 2
- 235000011852 gelatine desserts Nutrition 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000011837 pasties Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
Abstract
In a drip-feed process for the production of soft gelatin capsules in which the preferably pasty or liquid filling material is covered with a soft gelatin composition, the soft gelatin composition is solidified in a cooling bath comprising a chemically inert, deep-cooled liquefied gas which does not leave behind any biologically unacceptable or harmful residue on the soft gelatin capsule. The cooling bath used is preferably liquid nitrogen.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4201178A DE4201178C2 (en) | 1992-01-17 | 1992-01-17 | Process for the production of soft gelatin capsules by a dropping process |
DEP4201178.7 | 1992-01-17 | ||
US07/876,863 | 1992-04-30 | ||
US07/876,863 US5254294A (en) | 1992-01-17 | 1992-04-30 | Soft gelatin capsules |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2128243A1 true CA2128243A1 (en) | 1993-07-22 |
CA2128243C CA2128243C (en) | 1998-09-22 |
Family
ID=25911045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002128243A Expired - Fee Related CA2128243C (en) | 1992-01-17 | 1993-01-18 | Process for the manufacture of soft gelatin capsules by a drip-feed method |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0623018B1 (en) |
JP (1) | JPH07502912A (en) |
AT (1) | ATE132036T1 (en) |
AU (1) | AU670771B2 (en) |
CA (1) | CA2128243C (en) |
DE (1) | DE59301262D1 (en) |
DK (1) | DK0623018T3 (en) |
ES (1) | ES2083846T3 (en) |
GR (1) | GR3019424T3 (en) |
WO (1) | WO1993013761A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU679906B2 (en) | 1992-01-17 | 1997-07-17 | Alfatec-Pharma Gmbh | Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies |
WO1999002136A1 (en) * | 1997-07-09 | 1999-01-21 | Peter Greither | Method and device for producing a multi-layer, physiologically tolerated presentation form |
DE19930030B4 (en) * | 1999-06-30 | 2004-02-19 | Meduna Arzneimittel Gmbh | Oral dosage form containing CO-3-unsaturated fatty acids |
US7264824B1 (en) | 2000-04-13 | 2007-09-04 | Meduna Arzneimittel Gmbh | Oral dosage form |
JP5876695B2 (en) * | 2011-09-29 | 2016-03-02 | 森下仁丹株式会社 | Seamless capsule and method for producing the same |
JP5989953B1 (en) * | 2015-12-28 | 2016-09-07 | 森下仁丹株式会社 | Seamless capsule containing powdery component and method for producing the same |
CN110090599B (en) * | 2019-05-20 | 2024-09-17 | 武汉大坦智能装备科技有限公司 | Multi-station pill dropping machine |
DE102021107251A1 (en) | 2021-03-23 | 2022-09-29 | Technische Universität Dortmund | Process for coating particles |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1080822A (en) * | 1952-05-26 | 1954-12-14 | Trifax N V Chemisch Pharmaceut | Method and device for the production of seamless capsules |
US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
JPH08511559A (en) * | 1993-06-18 | 1996-12-03 | スミスクライン・ビーチャム・コーポレイション | Particles encapsulated in soft crust gelatin |
SI1033128T2 (en) * | 1993-09-28 | 2012-02-29 | Scherer Gmbh R P | Soft gelatin capsule manufacture |
-
1993
- 1993-01-18 CA CA002128243A patent/CA2128243C/en not_active Expired - Fee Related
- 1993-01-18 DK DK93901686.1T patent/DK0623018T3/en active
- 1993-01-18 DE DE59301262T patent/DE59301262D1/en not_active Expired - Fee Related
- 1993-01-18 EP EP93901686A patent/EP0623018B1/en not_active Expired - Lifetime
- 1993-01-18 JP JP5512076A patent/JPH07502912A/en active Pending
- 1993-01-18 AU AU32546/93A patent/AU670771B2/en not_active Ceased
- 1993-01-18 WO PCT/DE1993/000035 patent/WO1993013761A1/en active IP Right Grant
- 1993-01-18 AT AT93901686T patent/ATE132036T1/en not_active IP Right Cessation
- 1993-01-18 ES ES93901686T patent/ES2083846T3/en not_active Expired - Lifetime
-
1996
- 1996-03-26 GR GR960400808T patent/GR3019424T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0623018B1 (en) | 1995-12-27 |
ES2083846T3 (en) | 1996-04-16 |
GR3019424T3 (en) | 1996-06-30 |
EP0623018A1 (en) | 1994-11-09 |
WO1993013761A1 (en) | 1993-07-22 |
DE59301262D1 (en) | 1996-02-08 |
CA2128243C (en) | 1998-09-22 |
AU670771B2 (en) | 1996-08-01 |
AU3254693A (en) | 1993-08-03 |
JPH07502912A (en) | 1995-03-30 |
DK0623018T3 (en) | 1996-03-04 |
ATE132036T1 (en) | 1996-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |