CA2128243A1 - Process for the Manufacture of Soft Gelatin Capsules by a Drip-Feed Method - Google Patents

Process for the Manufacture of Soft Gelatin Capsules by a Drip-Feed Method

Info

Publication number
CA2128243A1
CA2128243A1 CA 2128243 CA2128243A CA2128243A1 CA 2128243 A1 CA2128243 A1 CA 2128243A1 CA 2128243 CA2128243 CA 2128243 CA 2128243 A CA2128243 A CA 2128243A CA 2128243 A1 CA2128243 A1 CA 2128243A1
Authority
CA
Canada
Prior art keywords
soft gelatin
drip
gelatin capsules
manufacture
feed method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2128243
Other languages
French (fr)
Other versions
CA2128243C (en
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Alfatec-Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4201178A external-priority patent/DE4201178C2/en
Application filed by Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich, Alfatec-Pharma Gmbh filed Critical Jens-Christian Wunderlich
Publication of CA2128243A1 publication Critical patent/CA2128243A1/en
Application granted granted Critical
Publication of CA2128243C publication Critical patent/CA2128243C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Abstract

In a drip-feed process for the production of soft gelatin capsules in which the preferably pasty or liquid filling material is covered with a soft gelatin composition, the soft gelatin composition is solidified in a cooling bath comprising a chemically inert, deep-cooled liquefied gas which does not leave behind any biologically unacceptable or harmful residue on the soft gelatin capsule. The cooling bath used is preferably liquid nitrogen.
CA002128243A 1992-01-17 1993-01-18 Process for the manufacture of soft gelatin capsules by a drip-feed method Expired - Fee Related CA2128243C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4201178A DE4201178C2 (en) 1992-01-17 1992-01-17 Process for the production of soft gelatin capsules by a dropping process
DEP4201178.7 1992-01-17
US07/876,863 US5254294A (en) 1992-01-17 1992-04-30 Soft gelatin capsules
US07/876,863 1992-04-30

Publications (2)

Publication Number Publication Date
CA2128243A1 true CA2128243A1 (en) 1993-07-22
CA2128243C CA2128243C (en) 1998-09-22

Family

ID=25911045

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002128243A Expired - Fee Related CA2128243C (en) 1992-01-17 1993-01-18 Process for the manufacture of soft gelatin capsules by a drip-feed method

Country Status (10)

Country Link
EP (1) EP0623018B1 (en)
JP (1) JPH07502912A (en)
AT (1) ATE132036T1 (en)
AU (1) AU670771B2 (en)
CA (1) CA2128243C (en)
DE (1) DE59301262D1 (en)
DK (1) DK0623018T3 (en)
ES (1) ES2083846T3 (en)
GR (1) GR3019424T3 (en)
WO (1) WO1993013761A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128244C (en) 1992-01-17 1998-09-22 Jens-Christian Wunderlich Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
ES2235337T3 (en) * 1997-07-09 2005-07-01 Swiss Caps Rechte Und Lizenzen Ag PROCEDURE AND DEVICE FOR MANUFACTURING A MULTI-PATH PHARMACEUTICAL FORM, PHYSIOLOGICALLY TOLERABLE.
DE19930030B4 (en) * 1999-06-30 2004-02-19 Meduna Arzneimittel Gmbh Oral dosage form containing CO-3-unsaturated fatty acids
US7264824B1 (en) 2000-04-13 2007-09-04 Meduna Arzneimittel Gmbh Oral dosage form
JP5876695B2 (en) * 2011-09-29 2016-03-02 森下仁丹株式会社 Seamless capsule and method for producing the same
JP5989953B1 (en) * 2015-12-28 2016-09-07 森下仁丹株式会社 Seamless capsule containing powdery component and method for producing the same
CN110090599A (en) * 2019-05-20 2019-08-06 武汉大坦智能装备科技有限公司 Multistation pill dripping machine
DE102021107251A1 (en) 2021-03-23 2022-09-29 Technische Universität Dortmund Process for coating particles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1080822A (en) * 1952-05-26 1954-12-14 Trifax N V Chemisch Pharmaceut Method and device for the production of seamless capsules
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
RU2134105C1 (en) * 1993-06-18 1999-08-10 Смитклайн Бичам Корпорейшн Soft gelatine capsule
EP1029538A3 (en) * 1993-09-28 2003-10-15 R.P. Scherer GmbH Soft gelatin capsule manufacture

Also Published As

Publication number Publication date
JPH07502912A (en) 1995-03-30
GR3019424T3 (en) 1996-06-30
ATE132036T1 (en) 1996-01-15
ES2083846T3 (en) 1996-04-16
CA2128243C (en) 1998-09-22
WO1993013761A1 (en) 1993-07-22
DE59301262D1 (en) 1996-02-08
DK0623018T3 (en) 1996-03-04
AU670771B2 (en) 1996-08-01
EP0623018A1 (en) 1994-11-09
EP0623018B1 (en) 1995-12-27
AU3254693A (en) 1993-08-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed