CA2127514A1 - Autoclave - Google Patents
AutoclaveInfo
- Publication number
- CA2127514A1 CA2127514A1 CA002127514A CA2127514A CA2127514A1 CA 2127514 A1 CA2127514 A1 CA 2127514A1 CA 002127514 A CA002127514 A CA 002127514A CA 2127514 A CA2127514 A CA 2127514A CA 2127514 A1 CA2127514 A1 CA 2127514A1
- Authority
- CA
- Canada
- Prior art keywords
- transfer chamber
- autoclave
- vessel
- post
- objects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/015—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress or cavitation
- A23L3/0155—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress or cavitation using sub- or super-atmospheric pressures, or pressure variations transmitted by a liquid or gas
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/10—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by heating materials in packages which are not progressively transported through the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/04—Pressure vessels, e.g. autoclaves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/0227—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using pressure vessels, e.g. autoclaves, vulcanising pans
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
An autoclave 10 has a first vessel 12 in which objects are heated, and a second vessel 14 in which the objects are cooled down. A container 24 containing the objects is introduced via a preheating chamber 30 into a chamber 20, and thence into the cavity 16 of the vessel 12. Similarly, at the downstream end of the second vessel 14, a container is removed from a cavity 18 via a chamber 22. Transfer of containers is effected lock fashion to limit loss of pressure. When a container is thus removed and a fresh container is loaded, containers in the cavity 16 are advanced upwardly and containers in the cavity 18 are advanced downwardly. A container at the top of the cavity 16 is laterally displaced to the top of the cavity 18, via a chamber 19. The autoclave is thus operated continuously, stepwise. Pressures and temperatures are monitored via an interface 32 and a computer 34.
Sterilization values for the objects are computed and advance of the containers are dependant on appropriate sterilization values being obtained.
Sterilization values for the objects are computed and advance of the containers are dependant on appropriate sterilization values being obtained.
Description
2I2751~
THIS INVENTION relates to an autoclave.
In an autoclave, matter is heated to high temperature under conditions of high pressure. In one kind of application, matter or objects are thus heated to sterilize the matter or objects.
When an autoclave is batch operated, it is charged with the matter or filled with the objects, closed, and pressurized and heated. After the pressurizing and heating operation, the autoclave is cooled and depressurized, opened and then unloaded.
In continuous operated autoclaves known to the Inventor, flowable matter is continuously pumped under high pressure into the autoclave while flowable matter is correspondingly continuously exhausted out of the autoclave.
In accordance with this invention, broadly, there is provided a method of operating an autoclave for sequentially 212751~
heating separate objects under pressure and cooling said objects, the method including providing an autoclave having, lock fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate respectively the pre-transfer chamber and the post-transfer chamber with and to isolate respectively the pre-transfer chamber and the post-transfer chamber from an operative cavity of the autoclave, and means for selectively pressurizing and depressurizing the respective pre-transfer chamber and post-transfer chamber;
loading an object to be treated into the autoclave by, sequentially, isolating the pre-transfer chamber from the autoclave cavity, depressurizing the pre-transfer chamber, introducing the object into the pre-transfer chamber, isolating the pre-transfer chamber from atmosphere, pressurizing the pre-transfer chamber, communicating the pre-transfer chamber with the autoclave cavity and transferring the object from the pre-transfer chamber into the autoclave cavity; and unloading another object which has been treated from the autoclave by, sequentially, isolating the post-transfer chamber from atmosphere, pressurizing the post-transfer chamber, communicating the post-transfer chamber with the autoclave cavity, transferring said other object into the post-transfer chamber, isolating the post-transfer chamber from the autoclave cavity, depressurizing the post-transfer chamber and removing said other object from the post-transfer chamber.
21275~ ~
It is to be appreciated that in respect of both of the pre-transfer chamber and the post-transfer chamber, pressurizing is to a pressure substantially equal to the prevailing pressure in the autoclave cavity.
Isolating the respective pre-transfer chamber and post-transfer chamber from the autoclave cavity may be by closing pressure tight closures between the respective pre-transfer chamber and post-transfer chamber and the autoclave cavity.
Communicating the respective pre-transfer chamber and post-transfer chamber with the autoclave cavity may be by opening said pressure tight closures, and transferring the respective objects may thus be via openings left open by opening of said pressure tight closures.
Pressurizing each respective chamber may be by intercommunicating it via a restrictive passage with the autoclave cavity.
Advantageously, loading and unloading may be synchronized to take place simultaneously.
In a preferred method, applied in a composite autoclave which includes a first vessel and a second vessel, the pre-transfer chamber being associated with the first vessel and the post-transfer chamber being associated with the second vessel, the method may include progressively moving objects from the pre-transfer chamber through the first vessel, heating said objects 212751~
in the first vessel, intermittently transferring said objects to the second vessel, cooling said objects in the second vessel and progressively moving said objects through the second vessel toward the post-transfer chamber.
Such intermittently transferring said objects from the first vessel to the second vessel may be via an intermediate transfer chamber. The method may thus include isolating the intermediate transfer chamber from the second vessel, communicating the intermediate transfer chamber with the first vessel, transferring a respective object from the first vessel to the intermediate transfer chamber, isolating the intermediate transfer chamber from the first vessel, communicating the intermediate transfer chamber with the second vessel and transferring said respective object from the intermediate transfer chamber to the second vessel.
If desired or if required, the method may include operating the second vessel at a pressure different to the pressure of the first vessel. Then, the method may include, after isolating the intermediate transfer chamber from the first vessel, and before communicating the intermediate transfer chamber with the second vessel, equalizing pressures between the second vessel and the i~termediate chamber. Equalizing pressures may be effected by exposing the intermediate transfer chamber to the second vessel via a restricted passage.
By way of development, introducing said object into the pre-transfer chamber may be via a pre-heating chamber. The method may thus include the steps of introducing a respective object into the pre-heating chamber and pre-heating said respective object in the pre-heating chamber. Depressurizing the pre-transfer chamber may include isolating the pre-heating chamber from atmosphere, exposing the pre-transfer chamber to the pre-heating chamber, and relieving the pre-transfer chamber into the pre-heating chamber.
The method may include measuring, at predetermined time intervals, a temperature in the autoclave cavity, comparing the measured temperature with a predetermined base temperature, and adjusting energy input into the autoclave cavity appropriately in response to the difference between the measured temperature and the predetermined base temperature.
Further by way of advantageous development, the method may include establishing repeatedly, at predetermined time intervals, a temperature of a respective object, computing a sterilization value Fo for said object in accordance with the formula ~ t; - t~
n \ 10 J
Fo = ~T * ~ 10 i=1 in which ~T is a convenient time interval, for example 10 seconds;
ti is the average temperature of a product in the i-th time interval;
t~ is a reference temperature namely 121.1C;
~_ 21~7!~1~
n is determined such that the sterilization value Fo is bigger than a pre-defined set-point value, comparing the computed value for Fo with a predetermined base value for Fo~ and unloading said respective object only when the calculated value for Fo of said respective object is at least equal to the base value for Fo~
The method may include measuring the average steam temperature in the or each chamber or cavity in which the respective objects are heated, i.e. in the preheating chamber and in the cavity of the first vessel, repeatedly at predetermined time intervals, and computing the value of t; in accordance with the formula (tj_l + C * ~T * tS~m i) t; =
(1 + C * ~T) in which t; is the average temperature of a product in the i-th time interval;
~T is a convenient time interval, for example 10 seconds;
tS~m; is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
tjl is the average temperature of a product in the i-1 interval.
The method may include recording the Fo value of each object and identifying each object with said Fo value.
The method may then include advancing the objects through the autoclave under control of a computer in accordance with predetermined criteria in respect of positions of respective ` 212751~
objects in the autoclave and the values of Fo of the respective objects.
Each object may be in the form of a product contained in a container forming part of the autoclave.
The invention extends to an autoclave for heating, under pressure, separate objects, the autoclave including, lock-fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate each of the pre-transfer chamber and post-transfer chamber with and to isolate each of the pre-transfer chamber and post-transfer chamber from atmosphere and from an operative cavity of the autoclave, pressurizing means for selectively pressurizing and depressurizing means for selectively depressurizing the respective pre-transfer chamber and post-transfer chamber, loading means suitable for loading the objects into the pre-transfer chamber, unloading means suitable for unloading the objects from the post-transfer chamber, and transport means suitable for transporting the objects from the pre-transfer chamber through the autoclave cavity to the post-transfer chamber.
Advantageously, the autoclave may be a composite autoclave which includes a first vessel and a second vessel, the operative cavity being defined as sub-cavities in said first vessel and said second vessel, the pre-transfer chamber being associated with the first vessel, and the post-transfer chamber being associated with the second vessel, the autoclave including ~1275~
an intermediate transfer chamber arranged to operate lock-fashion intermediate the first vessel and the second vessel, and means selectively respectively to communicate the intermediate transfer chamber with each of the first vessel and the second vessel and to isolate the intermediate transfer chamber from each of the first vessel and the second vessel.
The second vessel may be adapted selectively to be operated at a pressure different to the pressure of the first vessel, the autoclave having pressure equalizing means selectively operable between the intermediate transfer chamber and the second vessel.
The autoclave may include a plurality of containers suitable to contain the objects, the transport means being adapted for progressively, intermittently in stepped manner, transporting the containers from the pre-transfer chamber through the first vessel, and thence via the intermediate transfer chamber to the second vessel and through the second vessel to the post-transfer chamber. The transport means may be arranged to effect transport along the first vessel upwardly and to effect transport along the second vessel downwardly, the intermediate transfer chamber being arranged intermediate the first vessel and the second vessel at a high level.
The pressurizing means may include pressurizing passages between the autoclave cavity and respectively the pre-transfer chamber and post-transfer chamber and valve means selectively to open and close said pressurizing passages.
` ~l27sl 1 The means selectively to communicate each of the pre-transfer chamber and the post-transfer chamber with and to isolate each of the pre-transfer chamber and the post-transfer chamber from the operative cavity of the autoclave may be in the form of openable closures, which are pressure-tight when closed, intermediate the autoclave cavity and respectively the pre-transfer chamber and the post-transfer chamber.
By way of development, the autoclave may include a pre-heating chamber upstream of the pre-transfer chamber, isolating means arranged selectively to isolate the pre-heating chamber from atmosphere, and lock means arranged selectively to communicate the pre-heating chamber and the pre-transfer chamber and to isolate the pre-heating chamber from the pre-transfer chamber.
By way of advantageous development, the autoclave may include temperature measuring means arranged to measure temperature repeatedly, at predetermined time intervals, in the autoclave, computing means for computing a sterilization value Fo for an object in accordance with the formula ~ ti - t~f~
n ~ 10 J
Fo = ~T * ~ 10 i=1 in which ~T is a convenient time interval, for example 10 seconds;
tj is the average temperature of a product in the i-th time interval;
t~f is a reference temperature namely 121.1C;
n is determined such that the sterilization value Fo is bigger than a pre-defined set-point value, 212751~
and comparing means for comparing the computed value for Fo with a predetermined base value for Fo/ the unloading means being adapted in response to the result of comparing the computed and base values for Fo~ to unload the object only when the computed value for Fo is at least equal to the base value for Fo~
The computing means may be adapted to compute a value for t; in accordance with the formula (tjl + C * ~T * tS,e~ ;) t; = .
(1 + C * ~T) in which t; is the average temperature of a product in the i-th time interval;
~T is a convenient time interval, for example 10 seconds;
tS~m; is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
tj1 is the average temperature of a product in the i-1 interval.
The autoclave may include computerized control means adapted to actuate the transport means to advance the objects through the autoclave in accordance with predetermined criteria in respect of positions of respective objects in the autoclave and the values of Fo of the respective objects.
The autoclave may include a plurality of containers.
The invention is now described by way of example with reference to the accompanying diagrammatic drawing which shows, 212751~
schematically, in side view, an autoclave in accordance with this invention.
With reference to the drawing, an autoclave in accordance with the invention is generally indicated by reference numeral 10. The autoclave 10 is a composite autoclave comprising a first pressure vessel 12 and a second pressure vessel 14. The vessels 12, 14 respectively enclose autoclave cavities generally indicated respectively by reference numerals 16 and 18 which cavities are adapted to be operated under pressure at high temperature. In the embodiment shown, the autoclave is adapted to be operated with steam.
A transversely extending intermediate transfer chamber 19 interconnects the first and second vessels 12, 14 at positions toward upper ends of the vessels.
The vessel 12, more specifically associated with the cavity 16, incorporates heating means for heating the cavity 16.
The vessel 14, more specifically associated with the cavity 18, incorporates cooling means for cooling the cavity 18.
Pressurizing means (not shown) is provided to pressurize the vessels 12, 14.
External to and adjacent to the vessel 12, at a low level and associated with a lower end of the first vessel 12, there is provided a pre-transfer chamber 20. Likewise, external 21~751~
to, and adjacent to the second vessel 14 and associated with a lower end thereof, there is provided a post-transfer chamber 22.
The autoclave 10 has displacement means including a plurality of drawer-like containers 24 and mechanized transport means progressively to displace the containers upwardly in the cavity 16, into the intermediate transfer chamber 19, transversely along the intermediate transfer chamber 19 to the top of the cavity 18 and downwardly along the cavity 18 to the post-transfer chamber 22. For use with small or flat objects, a container may be divided in upper and lower compartments, each compartment then containing one or more objects.
The pre-transfer chamber 20 and post-transfer chamber 22 are shaped commensurate with and such as to contain containers 24. The containers 24 in use contain objects which are to be heated under pressure in the autoclave 10. Such objects may, for example, be surgical instruments which are to be sterilized for use in an operating theatre, drip bags containing water to be sterilized, and the like.
Each of the pre-transfer chamber 20 and the post-transfer 22 has a pressure-tight, openable closure 26.1, 26.2 selectively to open the respective chambers externally or to atmosphere respectively to allow a container 24 to be introduced or loaded into the pre-transfer chamber 20 and such a container to be removed or unloaded from the post-transfer chamber 22.
~ 7 5 1 ~
Furthermore, intermediate the respective autoclave cavities 16, 18 and respectively the pre-transfer chamber 20 and the post-transfer chamber 22, there are provided openable closures 26.3, 26.4 which are pressure tight and which, when open, afford communication between the respective autoclave cavities and respectively the pre-transfer chamber 20 and the post-transfer chamber 22.
It is to be appreciated that, when closed, all of the closures mentioned above are substantially pressure tight.
Pressurizing means is provided in the form of pressurizing passages between the respective autoclave cavities 16, 18 and respectively the pre-transfer chamber 20 and the post-transfer chamber 22 together with valve means selectively to render the passages open and closed. Similarly, depressurizing means is provided in the form of depressurizing passages leading respectively from the pre-transfer chamber 20 and from the post-transfer chamber 22 to vent the respective chambers. The depressurizing passages are provided together with valve means selectively to render the depressurizing passages open and closed.
When objects to be heated under pressure are to be introduced into the autoclave 10, they are placed within the container 24. The containers 24 are progressively loaded into the autoclave 10. Visualize a specific container 24 containing objects. It is introduced or loaded via the pre-transfer chamber 212751~
20 into the cavity 16. In synchronization, a similar container is removed or unloaded from the lower end of the cavity 18 via the post-transfer chamber 22 to remove objects 26 which have already undergone heating under pressure.
Assume that the pre-transfer chamber 20 is in communication with the autoclave cavity 16 and is isolated from atmosphere while the pos~-transfer chamber 22 is isolated from the autoclave cavity 18 and is open to atmosphere. As a first step, the post-transfer chamber is isolated from atmosphere and the pre-transfer chamber 20 is isolated from the autoclave cavity 16.
To effect loading, the pre-transfer chamber 20 is depressurized by opening the respective depressurizing passage.
The openable closure 26.1 giving external access is then opened, the container 24 is introduced into the chamber 20 and the closure 26.1 is closed.
Unloading is effected by venting the autoclave cavity 18 via the pressurizing passage into the post-transfer chamber 22. When the pressures have been equalized, the closure 26.4 giving access from the autoclave cavity 18 into the chamber 22 is opened, and a container 24 is displaced from a bottom of the cavity 18 into the chamber 22. The closure 26.4 is closed.
212751~
At that stage, both the chamber 20 and the chamber 22 contain containers and both are isolated from the respective autoclave cavities 16, 18 and from atmosphere.
The pre-transfer chamber 20 is then pressurized to autoclave pressure via the respective pressurizing passage by venting the autoclave cavity 16 into the chamber 20. When pressures are equal, the closure 26.3 intermediate the autoclave cavity 16 and the chamber 20 can be-opened and the container 24 containing the objects 26 is introduced into the autoclave cavity 16 at the bottom thereof.
More or less simultaneously, the chamber 22 is depressurized by venting it to atmosphere and the drawer is unloaded by opening the external closure 26.2.
Associated with loading and unloading, in the cavity 16, the containers 24 have been moved up one position each and the containers 24 in the cavity 18 have been moved down one position each. The top container in the cavity 16 has been displaced into the intermediate transfer chamber 19, has been displaced laterally through the intermediate transfer chamber 19 and has been displaced downwardly to the top of the second portion 16. Such displacing is effected lock-fashion via the closures 26.5 and 26.6 and, if required, by equalizing pressures firstly between the chamber 19 and the cavity 16, and secondly between the chamber 19 and the cavity 18.
212751~
The above procedure is intermittently repeated, to introduce containers containing fresh objects into the autoclave and to remove containers containing treated objects from the autoclave. The procedure is controlled, as described below, to ensure the required degree of sterilizing.
The autoclave cavity is repressurized from time to time to maintain its pressure within predetermined limits. Heating is controlled to maintain appropriately high temperatures.
By way of development, there is provided a preheating chamber 30 upstream of the pre-transfer chamber 20. The preheating chamber 30 has capacity to contain a plurality of containers 24. The closure 26.1 is arranged selectively to communicate the preheating chamber 30 and the pre-transfer chamber 20, and to isolate them. In addition, there is provided a closure 26.7 intermediate the preheating chamber 30 and atmosphere.
Thus, by closing the closure 26.1, the preheating chamber 30 is isolated from the autoclave 10 to allow loading of fresh containers 24. After loading, the preheating chamber 30 is isolated from atmosphere by closing the closure 26.7 to allow the containers in waiting to be preheated prior to being loaded into the autoclave 10 via the pre-transfer chamber 20.
Preheating is effected, if desired, by providing heating means associated with the preheating chamber. Preheating is facilitated conveniently by depressurizing the pre-transfer chamber 20 via an appropriate passage and valve means into the preheating chamber 30 to re-use the energy which would otherwise have been lost.
Apart from using waste energy, the use of the preheating chamber has the advantages that the thermal shock on the autoclave cavity 16 when loading takes place is diminished and that the objects preheated are brought to elevated temperatures in the cavity 16 quicker than would otherwise have been possible thus enhancing the capacity of the autoclave 10.
The Inventor regards it as extremely important that operation of the autoclave 10 is managed or controlled automatically by means of a computer. The Inventor further regards it as of paramount importance that such control is based primarily on computing a sterilization value Fo (as described above) in respect of the objects in each container and controlling advance of the objects or the containers through the autoclave on actual sterilization values achieved in use.
Furthermore, temperature control in the autoclave cavity 16 is based on the sterilization values measured in comparison to base sterilization values.
Thus, control of operation of the autoclave 10 is via an interface 32 by means of a computer 34.
~127514 Control commences with compiling of information regarding pressure and temperature at strategic positions through the autoclave, more specifically, in respect of temperature, in the preheating chamber, in the autoclave cavity 16, and the autoclave cavity 18. Monitoring of pressure is important in respect of transport, lock fashion, of the containers and is monitored in the autoclave cavity 16, the intermediate transfer chamber 19, the autoclave cavity 18 and the post-transfer chamber 22.
As described above, the sterilization value or Fo value for each container is computed based on data actually measured and progression of the sterilization process, or advance of the containers through the autoclave 10, is controlled in accordance with comparisons between actual sterilization values achieved and predetermined base values fcr sterilization values which are predetermined.
By means of the computer 34, via the interface 32, the valves for controlling pressurization and depressurization, hydraulic or pneumatic cylinders for opening and closing closures, and the transport means, are controlled.
It is an advantage of the invention that an autoclave in accordance with the invention can receive fresh objects and can exhaust treated objects on a substantially continuous albeit stepwise fashion. It is further an advantage that less energy is required to maintain the pressure in the autoclave cavity as, 212751~
first, only a relatively small chamber is depressurized and pressurized in respect of each loading and unloading operation.
It is an important advantage that the autoclave can be operated on a continuous basis as opposed to batch operation.
It is further an advantage that objects to be sterilized are advanced and are ultimately unloaded from the autoclave only in response to appropriate results obtained from automated monitoring of the sterilization value to ensure adequate or appropriate sterilization of the products.
THIS INVENTION relates to an autoclave.
In an autoclave, matter is heated to high temperature under conditions of high pressure. In one kind of application, matter or objects are thus heated to sterilize the matter or objects.
When an autoclave is batch operated, it is charged with the matter or filled with the objects, closed, and pressurized and heated. After the pressurizing and heating operation, the autoclave is cooled and depressurized, opened and then unloaded.
In continuous operated autoclaves known to the Inventor, flowable matter is continuously pumped under high pressure into the autoclave while flowable matter is correspondingly continuously exhausted out of the autoclave.
In accordance with this invention, broadly, there is provided a method of operating an autoclave for sequentially 212751~
heating separate objects under pressure and cooling said objects, the method including providing an autoclave having, lock fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate respectively the pre-transfer chamber and the post-transfer chamber with and to isolate respectively the pre-transfer chamber and the post-transfer chamber from an operative cavity of the autoclave, and means for selectively pressurizing and depressurizing the respective pre-transfer chamber and post-transfer chamber;
loading an object to be treated into the autoclave by, sequentially, isolating the pre-transfer chamber from the autoclave cavity, depressurizing the pre-transfer chamber, introducing the object into the pre-transfer chamber, isolating the pre-transfer chamber from atmosphere, pressurizing the pre-transfer chamber, communicating the pre-transfer chamber with the autoclave cavity and transferring the object from the pre-transfer chamber into the autoclave cavity; and unloading another object which has been treated from the autoclave by, sequentially, isolating the post-transfer chamber from atmosphere, pressurizing the post-transfer chamber, communicating the post-transfer chamber with the autoclave cavity, transferring said other object into the post-transfer chamber, isolating the post-transfer chamber from the autoclave cavity, depressurizing the post-transfer chamber and removing said other object from the post-transfer chamber.
21275~ ~
It is to be appreciated that in respect of both of the pre-transfer chamber and the post-transfer chamber, pressurizing is to a pressure substantially equal to the prevailing pressure in the autoclave cavity.
Isolating the respective pre-transfer chamber and post-transfer chamber from the autoclave cavity may be by closing pressure tight closures between the respective pre-transfer chamber and post-transfer chamber and the autoclave cavity.
Communicating the respective pre-transfer chamber and post-transfer chamber with the autoclave cavity may be by opening said pressure tight closures, and transferring the respective objects may thus be via openings left open by opening of said pressure tight closures.
Pressurizing each respective chamber may be by intercommunicating it via a restrictive passage with the autoclave cavity.
Advantageously, loading and unloading may be synchronized to take place simultaneously.
In a preferred method, applied in a composite autoclave which includes a first vessel and a second vessel, the pre-transfer chamber being associated with the first vessel and the post-transfer chamber being associated with the second vessel, the method may include progressively moving objects from the pre-transfer chamber through the first vessel, heating said objects 212751~
in the first vessel, intermittently transferring said objects to the second vessel, cooling said objects in the second vessel and progressively moving said objects through the second vessel toward the post-transfer chamber.
Such intermittently transferring said objects from the first vessel to the second vessel may be via an intermediate transfer chamber. The method may thus include isolating the intermediate transfer chamber from the second vessel, communicating the intermediate transfer chamber with the first vessel, transferring a respective object from the first vessel to the intermediate transfer chamber, isolating the intermediate transfer chamber from the first vessel, communicating the intermediate transfer chamber with the second vessel and transferring said respective object from the intermediate transfer chamber to the second vessel.
If desired or if required, the method may include operating the second vessel at a pressure different to the pressure of the first vessel. Then, the method may include, after isolating the intermediate transfer chamber from the first vessel, and before communicating the intermediate transfer chamber with the second vessel, equalizing pressures between the second vessel and the i~termediate chamber. Equalizing pressures may be effected by exposing the intermediate transfer chamber to the second vessel via a restricted passage.
By way of development, introducing said object into the pre-transfer chamber may be via a pre-heating chamber. The method may thus include the steps of introducing a respective object into the pre-heating chamber and pre-heating said respective object in the pre-heating chamber. Depressurizing the pre-transfer chamber may include isolating the pre-heating chamber from atmosphere, exposing the pre-transfer chamber to the pre-heating chamber, and relieving the pre-transfer chamber into the pre-heating chamber.
The method may include measuring, at predetermined time intervals, a temperature in the autoclave cavity, comparing the measured temperature with a predetermined base temperature, and adjusting energy input into the autoclave cavity appropriately in response to the difference between the measured temperature and the predetermined base temperature.
Further by way of advantageous development, the method may include establishing repeatedly, at predetermined time intervals, a temperature of a respective object, computing a sterilization value Fo for said object in accordance with the formula ~ t; - t~
n \ 10 J
Fo = ~T * ~ 10 i=1 in which ~T is a convenient time interval, for example 10 seconds;
ti is the average temperature of a product in the i-th time interval;
t~ is a reference temperature namely 121.1C;
~_ 21~7!~1~
n is determined such that the sterilization value Fo is bigger than a pre-defined set-point value, comparing the computed value for Fo with a predetermined base value for Fo~ and unloading said respective object only when the calculated value for Fo of said respective object is at least equal to the base value for Fo~
The method may include measuring the average steam temperature in the or each chamber or cavity in which the respective objects are heated, i.e. in the preheating chamber and in the cavity of the first vessel, repeatedly at predetermined time intervals, and computing the value of t; in accordance with the formula (tj_l + C * ~T * tS~m i) t; =
(1 + C * ~T) in which t; is the average temperature of a product in the i-th time interval;
~T is a convenient time interval, for example 10 seconds;
tS~m; is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
tjl is the average temperature of a product in the i-1 interval.
The method may include recording the Fo value of each object and identifying each object with said Fo value.
The method may then include advancing the objects through the autoclave under control of a computer in accordance with predetermined criteria in respect of positions of respective ` 212751~
objects in the autoclave and the values of Fo of the respective objects.
Each object may be in the form of a product contained in a container forming part of the autoclave.
The invention extends to an autoclave for heating, under pressure, separate objects, the autoclave including, lock-fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate each of the pre-transfer chamber and post-transfer chamber with and to isolate each of the pre-transfer chamber and post-transfer chamber from atmosphere and from an operative cavity of the autoclave, pressurizing means for selectively pressurizing and depressurizing means for selectively depressurizing the respective pre-transfer chamber and post-transfer chamber, loading means suitable for loading the objects into the pre-transfer chamber, unloading means suitable for unloading the objects from the post-transfer chamber, and transport means suitable for transporting the objects from the pre-transfer chamber through the autoclave cavity to the post-transfer chamber.
Advantageously, the autoclave may be a composite autoclave which includes a first vessel and a second vessel, the operative cavity being defined as sub-cavities in said first vessel and said second vessel, the pre-transfer chamber being associated with the first vessel, and the post-transfer chamber being associated with the second vessel, the autoclave including ~1275~
an intermediate transfer chamber arranged to operate lock-fashion intermediate the first vessel and the second vessel, and means selectively respectively to communicate the intermediate transfer chamber with each of the first vessel and the second vessel and to isolate the intermediate transfer chamber from each of the first vessel and the second vessel.
The second vessel may be adapted selectively to be operated at a pressure different to the pressure of the first vessel, the autoclave having pressure equalizing means selectively operable between the intermediate transfer chamber and the second vessel.
The autoclave may include a plurality of containers suitable to contain the objects, the transport means being adapted for progressively, intermittently in stepped manner, transporting the containers from the pre-transfer chamber through the first vessel, and thence via the intermediate transfer chamber to the second vessel and through the second vessel to the post-transfer chamber. The transport means may be arranged to effect transport along the first vessel upwardly and to effect transport along the second vessel downwardly, the intermediate transfer chamber being arranged intermediate the first vessel and the second vessel at a high level.
The pressurizing means may include pressurizing passages between the autoclave cavity and respectively the pre-transfer chamber and post-transfer chamber and valve means selectively to open and close said pressurizing passages.
` ~l27sl 1 The means selectively to communicate each of the pre-transfer chamber and the post-transfer chamber with and to isolate each of the pre-transfer chamber and the post-transfer chamber from the operative cavity of the autoclave may be in the form of openable closures, which are pressure-tight when closed, intermediate the autoclave cavity and respectively the pre-transfer chamber and the post-transfer chamber.
By way of development, the autoclave may include a pre-heating chamber upstream of the pre-transfer chamber, isolating means arranged selectively to isolate the pre-heating chamber from atmosphere, and lock means arranged selectively to communicate the pre-heating chamber and the pre-transfer chamber and to isolate the pre-heating chamber from the pre-transfer chamber.
By way of advantageous development, the autoclave may include temperature measuring means arranged to measure temperature repeatedly, at predetermined time intervals, in the autoclave, computing means for computing a sterilization value Fo for an object in accordance with the formula ~ ti - t~f~
n ~ 10 J
Fo = ~T * ~ 10 i=1 in which ~T is a convenient time interval, for example 10 seconds;
tj is the average temperature of a product in the i-th time interval;
t~f is a reference temperature namely 121.1C;
n is determined such that the sterilization value Fo is bigger than a pre-defined set-point value, 212751~
and comparing means for comparing the computed value for Fo with a predetermined base value for Fo/ the unloading means being adapted in response to the result of comparing the computed and base values for Fo~ to unload the object only when the computed value for Fo is at least equal to the base value for Fo~
The computing means may be adapted to compute a value for t; in accordance with the formula (tjl + C * ~T * tS,e~ ;) t; = .
(1 + C * ~T) in which t; is the average temperature of a product in the i-th time interval;
~T is a convenient time interval, for example 10 seconds;
tS~m; is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
tj1 is the average temperature of a product in the i-1 interval.
The autoclave may include computerized control means adapted to actuate the transport means to advance the objects through the autoclave in accordance with predetermined criteria in respect of positions of respective objects in the autoclave and the values of Fo of the respective objects.
The autoclave may include a plurality of containers.
The invention is now described by way of example with reference to the accompanying diagrammatic drawing which shows, 212751~
schematically, in side view, an autoclave in accordance with this invention.
With reference to the drawing, an autoclave in accordance with the invention is generally indicated by reference numeral 10. The autoclave 10 is a composite autoclave comprising a first pressure vessel 12 and a second pressure vessel 14. The vessels 12, 14 respectively enclose autoclave cavities generally indicated respectively by reference numerals 16 and 18 which cavities are adapted to be operated under pressure at high temperature. In the embodiment shown, the autoclave is adapted to be operated with steam.
A transversely extending intermediate transfer chamber 19 interconnects the first and second vessels 12, 14 at positions toward upper ends of the vessels.
The vessel 12, more specifically associated with the cavity 16, incorporates heating means for heating the cavity 16.
The vessel 14, more specifically associated with the cavity 18, incorporates cooling means for cooling the cavity 18.
Pressurizing means (not shown) is provided to pressurize the vessels 12, 14.
External to and adjacent to the vessel 12, at a low level and associated with a lower end of the first vessel 12, there is provided a pre-transfer chamber 20. Likewise, external 21~751~
to, and adjacent to the second vessel 14 and associated with a lower end thereof, there is provided a post-transfer chamber 22.
The autoclave 10 has displacement means including a plurality of drawer-like containers 24 and mechanized transport means progressively to displace the containers upwardly in the cavity 16, into the intermediate transfer chamber 19, transversely along the intermediate transfer chamber 19 to the top of the cavity 18 and downwardly along the cavity 18 to the post-transfer chamber 22. For use with small or flat objects, a container may be divided in upper and lower compartments, each compartment then containing one or more objects.
The pre-transfer chamber 20 and post-transfer chamber 22 are shaped commensurate with and such as to contain containers 24. The containers 24 in use contain objects which are to be heated under pressure in the autoclave 10. Such objects may, for example, be surgical instruments which are to be sterilized for use in an operating theatre, drip bags containing water to be sterilized, and the like.
Each of the pre-transfer chamber 20 and the post-transfer 22 has a pressure-tight, openable closure 26.1, 26.2 selectively to open the respective chambers externally or to atmosphere respectively to allow a container 24 to be introduced or loaded into the pre-transfer chamber 20 and such a container to be removed or unloaded from the post-transfer chamber 22.
~ 7 5 1 ~
Furthermore, intermediate the respective autoclave cavities 16, 18 and respectively the pre-transfer chamber 20 and the post-transfer chamber 22, there are provided openable closures 26.3, 26.4 which are pressure tight and which, when open, afford communication between the respective autoclave cavities and respectively the pre-transfer chamber 20 and the post-transfer chamber 22.
It is to be appreciated that, when closed, all of the closures mentioned above are substantially pressure tight.
Pressurizing means is provided in the form of pressurizing passages between the respective autoclave cavities 16, 18 and respectively the pre-transfer chamber 20 and the post-transfer chamber 22 together with valve means selectively to render the passages open and closed. Similarly, depressurizing means is provided in the form of depressurizing passages leading respectively from the pre-transfer chamber 20 and from the post-transfer chamber 22 to vent the respective chambers. The depressurizing passages are provided together with valve means selectively to render the depressurizing passages open and closed.
When objects to be heated under pressure are to be introduced into the autoclave 10, they are placed within the container 24. The containers 24 are progressively loaded into the autoclave 10. Visualize a specific container 24 containing objects. It is introduced or loaded via the pre-transfer chamber 212751~
20 into the cavity 16. In synchronization, a similar container is removed or unloaded from the lower end of the cavity 18 via the post-transfer chamber 22 to remove objects 26 which have already undergone heating under pressure.
Assume that the pre-transfer chamber 20 is in communication with the autoclave cavity 16 and is isolated from atmosphere while the pos~-transfer chamber 22 is isolated from the autoclave cavity 18 and is open to atmosphere. As a first step, the post-transfer chamber is isolated from atmosphere and the pre-transfer chamber 20 is isolated from the autoclave cavity 16.
To effect loading, the pre-transfer chamber 20 is depressurized by opening the respective depressurizing passage.
The openable closure 26.1 giving external access is then opened, the container 24 is introduced into the chamber 20 and the closure 26.1 is closed.
Unloading is effected by venting the autoclave cavity 18 via the pressurizing passage into the post-transfer chamber 22. When the pressures have been equalized, the closure 26.4 giving access from the autoclave cavity 18 into the chamber 22 is opened, and a container 24 is displaced from a bottom of the cavity 18 into the chamber 22. The closure 26.4 is closed.
212751~
At that stage, both the chamber 20 and the chamber 22 contain containers and both are isolated from the respective autoclave cavities 16, 18 and from atmosphere.
The pre-transfer chamber 20 is then pressurized to autoclave pressure via the respective pressurizing passage by venting the autoclave cavity 16 into the chamber 20. When pressures are equal, the closure 26.3 intermediate the autoclave cavity 16 and the chamber 20 can be-opened and the container 24 containing the objects 26 is introduced into the autoclave cavity 16 at the bottom thereof.
More or less simultaneously, the chamber 22 is depressurized by venting it to atmosphere and the drawer is unloaded by opening the external closure 26.2.
Associated with loading and unloading, in the cavity 16, the containers 24 have been moved up one position each and the containers 24 in the cavity 18 have been moved down one position each. The top container in the cavity 16 has been displaced into the intermediate transfer chamber 19, has been displaced laterally through the intermediate transfer chamber 19 and has been displaced downwardly to the top of the second portion 16. Such displacing is effected lock-fashion via the closures 26.5 and 26.6 and, if required, by equalizing pressures firstly between the chamber 19 and the cavity 16, and secondly between the chamber 19 and the cavity 18.
212751~
The above procedure is intermittently repeated, to introduce containers containing fresh objects into the autoclave and to remove containers containing treated objects from the autoclave. The procedure is controlled, as described below, to ensure the required degree of sterilizing.
The autoclave cavity is repressurized from time to time to maintain its pressure within predetermined limits. Heating is controlled to maintain appropriately high temperatures.
By way of development, there is provided a preheating chamber 30 upstream of the pre-transfer chamber 20. The preheating chamber 30 has capacity to contain a plurality of containers 24. The closure 26.1 is arranged selectively to communicate the preheating chamber 30 and the pre-transfer chamber 20, and to isolate them. In addition, there is provided a closure 26.7 intermediate the preheating chamber 30 and atmosphere.
Thus, by closing the closure 26.1, the preheating chamber 30 is isolated from the autoclave 10 to allow loading of fresh containers 24. After loading, the preheating chamber 30 is isolated from atmosphere by closing the closure 26.7 to allow the containers in waiting to be preheated prior to being loaded into the autoclave 10 via the pre-transfer chamber 20.
Preheating is effected, if desired, by providing heating means associated with the preheating chamber. Preheating is facilitated conveniently by depressurizing the pre-transfer chamber 20 via an appropriate passage and valve means into the preheating chamber 30 to re-use the energy which would otherwise have been lost.
Apart from using waste energy, the use of the preheating chamber has the advantages that the thermal shock on the autoclave cavity 16 when loading takes place is diminished and that the objects preheated are brought to elevated temperatures in the cavity 16 quicker than would otherwise have been possible thus enhancing the capacity of the autoclave 10.
The Inventor regards it as extremely important that operation of the autoclave 10 is managed or controlled automatically by means of a computer. The Inventor further regards it as of paramount importance that such control is based primarily on computing a sterilization value Fo (as described above) in respect of the objects in each container and controlling advance of the objects or the containers through the autoclave on actual sterilization values achieved in use.
Furthermore, temperature control in the autoclave cavity 16 is based on the sterilization values measured in comparison to base sterilization values.
Thus, control of operation of the autoclave 10 is via an interface 32 by means of a computer 34.
~127514 Control commences with compiling of information regarding pressure and temperature at strategic positions through the autoclave, more specifically, in respect of temperature, in the preheating chamber, in the autoclave cavity 16, and the autoclave cavity 18. Monitoring of pressure is important in respect of transport, lock fashion, of the containers and is monitored in the autoclave cavity 16, the intermediate transfer chamber 19, the autoclave cavity 18 and the post-transfer chamber 22.
As described above, the sterilization value or Fo value for each container is computed based on data actually measured and progression of the sterilization process, or advance of the containers through the autoclave 10, is controlled in accordance with comparisons between actual sterilization values achieved and predetermined base values fcr sterilization values which are predetermined.
By means of the computer 34, via the interface 32, the valves for controlling pressurization and depressurization, hydraulic or pneumatic cylinders for opening and closing closures, and the transport means, are controlled.
It is an advantage of the invention that an autoclave in accordance with the invention can receive fresh objects and can exhaust treated objects on a substantially continuous albeit stepwise fashion. It is further an advantage that less energy is required to maintain the pressure in the autoclave cavity as, 212751~
first, only a relatively small chamber is depressurized and pressurized in respect of each loading and unloading operation.
It is an important advantage that the autoclave can be operated on a continuous basis as opposed to batch operation.
It is further an advantage that objects to be sterilized are advanced and are ultimately unloaded from the autoclave only in response to appropriate results obtained from automated monitoring of the sterilization value to ensure adequate or appropriate sterilization of the products.
Claims (28)
1. A method of operating an autoclave for sequentially heating separate objects under pressure and cooling said objects, the method including providing an autoclave having, lock fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate respectively the pre-transfer chamber and the post-transfer chamber with and to isolate respectively the pre-transfer chamber and the post-transfer chamber from an operative cavity of the autoclave, and means for selectively pressurizing and depressurizing the respective pre-transfer chamber and post-transfer chamber;
loading an object to be treated into the autoclave by, sequentially, isolating the pre-transfer chamber from the autoclave cavity, depressurizing the pre-transfer chamber, introducing the object into the pre-transfer chamber, isolating the pre-transfer chamber from atmosphere, pressurizing the pre-transfer chamber, communicating the pre-transfer chamber with the autoclave cavity and transferring the object from the pre-transfer chamber into the autoclave cavity; and unloading another object which has been treated from the autoclave by, sequentially, isolating the post-transfer chamber from atmosphere, pressurizing the post-transfer chamber, communicating the post-transfer chamber with the autoclave cavity, transferring said other object into the post-transfer chamber, isolating the post-transfer chamber from the autoclave cavity, depressurizing the post-transfer chamber and removing said other object from the post-transfer chamber.
loading an object to be treated into the autoclave by, sequentially, isolating the pre-transfer chamber from the autoclave cavity, depressurizing the pre-transfer chamber, introducing the object into the pre-transfer chamber, isolating the pre-transfer chamber from atmosphere, pressurizing the pre-transfer chamber, communicating the pre-transfer chamber with the autoclave cavity and transferring the object from the pre-transfer chamber into the autoclave cavity; and unloading another object which has been treated from the autoclave by, sequentially, isolating the post-transfer chamber from atmosphere, pressurizing the post-transfer chamber, communicating the post-transfer chamber with the autoclave cavity, transferring said other object into the post-transfer chamber, isolating the post-transfer chamber from the autoclave cavity, depressurizing the post-transfer chamber and removing said other object from the post-transfer chamber.
2. A method as claimed in Claim 1 in which isolating the respective pre-transfer chamber and post-transfer chamber from the autoclave cavity is by closing pressure tight closures between the respective pre-transfer chamber and post-transfer chamber and the autoclave cavity, in which communicating the respective pre-transfer chamber and post-transfer chamber with the autoclave cavity is by opening said pressure tight closures, and in which transferring the respective objects is via openings left open by opening of said pressure tight closures.
3. A method as claimed in Claim 1 in which pressurizing each respective chamber is by intercommunicating it via a restrictive passage with the autoclave cavity.
4. A method as claimed in Claim 1 in which loading and unloading are synchronized to take place simultaneously.
5. A method as claimed in Claim 1 in which the autoclave is a composite autoclave which includes a first vessel and a second vessel, the pre-transfer chamber being associated with the first vessel and the post-transfer chamber being associated with the second vessel, the method including progressively moving objects from the pre-transfer chamber through the first vessel, heating said objects in the first vessel, intermittently transferring said objects to the second vessel, cooling said objects in the second vessel and progressively moving said objects through the second vessel toward the post-transfer chamber.
6. A method as claimed in Claim 5, in which intermittently transferring said objects from the first vessel to the second vessel is via an intermediate transfer chamber, the method including isolating the intermediate transfer chamber from the second vessel, communicating the intermediate transfer chamber with the first vessel, transferring a respective object from the first vessel to the intermediate transfer chamber, isolating the intermediate transfer chamber from the first vessel, communicating the intermediate transfer chamber with the second vessel and transferring said respective object from the intermediate transfer chamber to the second vessel.
7. A method as claimed in Claim 6 which includes operating the second vessel at a pressure different to the pressure of the first vessel.
8. A method as claimed in Claim 7 which includes, after isolating the intermediate transfer chamber from the first vessel, and before communicating the intermediate transfer chamber with the second vessel, equalizing pressures between the second vessel and the intermediate chamber.
9. A method as claimed in Claim 8 in which equalizing pressures is effected by exposing the intermediate transfer chamber to the second vessel via a restricted passage.
10. A method as claimed in Claim 1, in which introducing said object into the pre-transfer chamber is via a pre-heating chamber, the method including the steps of introducing a respective object into the pre-heating chamber, pre-heating said respective object in the pre-heating chamber, and in which depressurizing the pre-transfer chamber includes isolating the pre-heating chamber from atmosphere, exposing the pre-transfer chamber to the pre-heating chamber, and relieving the pre-transfer chamber into the pre-heating chamber.
11. A method as claimed in Claim 1 which includes measuring, at predetermined time intervals, a temperature in the autoclave cavity, comparing the measured temperature with a predetermined base temperature, and adjusting energy input into the autoclave cavity appropriately in response to the difference between the measured temperature and the predetermined base temperature.
12. A method as claimed in Claim 1 which includes establishing repeatedly, at predetermined time intervals, a temperature of a respective object, computing a sterilization value Fo for said object in accordance with the formula Fo= in which .DELTA.T is a convenient time interval;
ti is the average temperature of a product in the i-th time interval;
tref is a reference temperature;
n is determined such that the sterilization value F0 is bigger than a pre-defined set-point value, comparing the computed value for F0 with a predetermined base value for F0, and unloading said respective object only when the calculated value for F0 of said respective object is at least equal to the base value for F0.
ti is the average temperature of a product in the i-th time interval;
tref is a reference temperature;
n is determined such that the sterilization value F0 is bigger than a pre-defined set-point value, comparing the computed value for F0 with a predetermined base value for F0, and unloading said respective object only when the calculated value for F0 of said respective object is at least equal to the base value for F0.
13. A method as claimed in Claim 12 which includes measuring the average steam temperature, in the or each chamber or cavity in which the respective objects are heated, repeatedly at predetermined time intervals, and computing the value of ti in accordance with the formula ti = in which ti is the average temperature of a product in the i-th time interval;
.DELTA.T is a convenient time interval;
tsteami is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
ti-1 is the average temperature of a product in the i-1 interval.
.DELTA.T is a convenient time interval;
tsteami is the average steam temperature as measured in the i-th time interval;
C is an experimentally determined parameter;
ti-1 is the average temperature of a product in the i-1 interval.
14. A method as claimed in Claim 12 which includes recording the F0 value of each object and identifying each object with said F0 value.
15. A method as claimed in Claim 12 which includes advancing the objects through the autoclave under control of a computer in accordance with predetermined criteria in respect of positions of respective objects in the autoclave and the values of Fo of the respective objects.
16. A method as claimed in Claim 1 in which each object is in the form of a product contained in a container forming part of the autoclave.
17. An autoclave for heating, under pressure, separate objects, the autoclave including, lock-fashion, a pre-transfer chamber and a post-transfer chamber, means selectively to communicate each of the pre-transfer chamber and post-transfer chamber with and to isolate each of the pre-transfer chamber and post-transfer chamber from atmosphere and from an operative cavity of the autoclave, pressurizing means for selectively pressurizing and depressurizing means for selectively depressurizing the respective pre-transfer chamber and post-transfer chamber, loading means suitable for loading the objects into the pre-transfer chamber, unloading means suitable for unloading the objects from the post-transfer chamber, and transport means suitable for transporting the objects from the pre-transfer chamber through the autoclave cavity to the post-transfer chamber.
18. An autoclave as claimed in Claim 17 which is a composite autoclave and which includes a first vessel and a second vessel, the operative cavity being defined as sub-cavities in said first vessel and said second vessel, the pre-transfer chamber being associated with the first vessel, and the post-transfer chamber being associated with the second vessel, the autoclave including an intermediate transfer chamber arranged to operate lock-fashion intermediate the first vessel and the second vessel, and means selectively respectively to communicate the intermediate transfer chamber with each of the first vessel and the second vessel and to isolate the intermediate transfer chamber from each of the first vessel and the second vessel.
19. An autoclave as claimed in Claim 18 in which the second vessel is adapted selectively to be operated at a pressure different to the pressure of the first vessel, the autoclave having pressure equalizing means selectively operable between the intermediate transfer chamber and the second vessel.
20. An autoclave as claimed in Claim 18 which includes a plurality of containers suitable to contain the objects, the transport means being adapted for progressively, intermittently in stepped manner, transporting the containers from the pre-transfer chamber through the first vessel, and thence via the intermediate transfer chamber to the second vessel and through the second vessel to the post-transfer chamber.
21. An autoclave as claimed in Claim 20 in which the transport means is arranged to effect transport along the first vessel upwardly and to effect transport along the second vessel downwardly, the intermediate transfer chamber being arranged intermediate the first vessel and the second vessel at a high level.
22. An autoclave as claimed in Claim 17 in which the pressurizing means includes pressurizing passages between the autoclave cavity and respectively the pre-transfer chamber and post-transfer chamber and valve means selectively to open and close said pressurizing passages.
23. An autoclave as claimed in Claim 17 in which the means selectively to communicate each of the pre-transfer chamber and the post-transfer chamber with and to isolate each of the pre-transfer chamber and the post-transfer chamber from the operative cavity of the autoclave is in the form of openable closures, which are pressure-tight when closed, intermediate the autoclave cavity and respectively the pre-transfer chamber and the post-transfer chamber.
24. An autoclave as claimed in Claim 17 which includes a pre-heating chamber upstream of the pre-transfer chamber, isolating means arranged selectively to isolate the pre-heating chamber from atmosphere, and lock means arranged selectively to communicate the pre-heating chamber and the pre-transfer chamber and to isolate the pre-heating chamber from the pre-transfer chamber.
25. An autoclave as claimed in Claim 17 which includes temperature measuring means arranged to measure temperature repeatedly, at predetermined time intervals, in the autoclave, computing means for computing sterilization values F0 for objects being sterilized in accordance with the formula F0 = in which .DELTA.T is a convenient time interval;
ti is the average temperature of a product in the i-th time interval;
tref is a reference temperature;
n is determined such that the sterilization value F0 is bigger than a pre-defined set-point value, and comparing means for comparing the computed value for F0 with a predetermined base value for F0, the unloading means being adapted in response to the result of comparing the computed and base values for F0, to unload the object only when the computed value for F0 is at least equal to the base value for F0.
ti is the average temperature of a product in the i-th time interval;
tref is a reference temperature;
n is determined such that the sterilization value F0 is bigger than a pre-defined set-point value, and comparing means for comparing the computed value for F0 with a predetermined base value for F0, the unloading means being adapted in response to the result of comparing the computed and base values for F0, to unload the object only when the computed value for F0 is at least equal to the base value for F0.
26. An autoclave as claimed in Claim 25 in which the computing means is adapted to compute a value for ti in accordance with the formula ti =
27. An autoclave as claimed in Claim 25 which includes computerized control means adapted to actuate the transport means to advance the objects through the autoclave in accordance with predetermined criteria in respect of positions of respective objects in the autoclave and the values of Fo of the respective objects.
28. An autoclave as claimed in Claim 17 which includes a plurality of containers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002127514A CA2127514A1 (en) | 1994-07-06 | 1994-07-06 | Autoclave |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002127514A CA2127514A1 (en) | 1994-07-06 | 1994-07-06 | Autoclave |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2127514A1 true CA2127514A1 (en) | 1996-01-07 |
Family
ID=4153964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002127514A Abandoned CA2127514A1 (en) | 1994-07-06 | 1994-07-06 | Autoclave |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2127514A1 (en) |
-
1994
- 1994-07-06 CA CA002127514A patent/CA2127514A1/en not_active Abandoned
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| JPH0230717Y2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |