CA2125403A1 - Novel tissue plasminogen activator variants - Google Patents

Novel tissue plasminogen activator variants

Info

Publication number
CA2125403A1
CA2125403A1 CA002125403A CA2125403A CA2125403A1 CA 2125403 A1 CA2125403 A1 CA 2125403A1 CA 002125403 A CA002125403 A CA 002125403A CA 2125403 A CA2125403 A CA 2125403A CA 2125403 A1 CA2125403 A1 CA 2125403A1
Authority
CA
Canada
Prior art keywords
tissue plasminogen
plasminogen activator
novel tissue
variants
activator variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002125403A
Other languages
French (fr)
Other versions
CA2125403C (en
Inventor
Herbert L. Heyneker
Gordon A. Vehar
Nicholas F. Paoni
William F. Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Herbert L. Heyneker
Gordon A. Vehar
Nicholas F. Paoni
William F. Bennett
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbert L. Heyneker, Gordon A. Vehar, Nicholas F. Paoni, William F. Bennett, Genentech, Inc. filed Critical Herbert L. Heyneker
Publication of CA2125403A1 publication Critical patent/CA2125403A1/en
Application granted granted Critical
Publication of CA2125403C publication Critical patent/CA2125403C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Biologically active variant tissue plasminogen activators are disclosed. The disclosure focuses on position 276 variants that exhibit enhanced fibrin specificity.
CA002125403A 1991-12-16 1992-12-14 Novel tissue plasminogen activator variants Expired - Lifetime CA2125403C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80853791A 1991-12-16 1991-12-16
US808,537 1991-12-16
PCT/US1992/010677 WO1993012225A1 (en) 1991-12-16 1992-12-14 Novel tissue plasminogen activator variants

Publications (2)

Publication Number Publication Date
CA2125403A1 true CA2125403A1 (en) 1993-06-24
CA2125403C CA2125403C (en) 2002-08-27

Family

ID=25199065

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002125403A Expired - Lifetime CA2125403C (en) 1991-12-16 1992-12-14 Novel tissue plasminogen activator variants

Country Status (6)

Country Link
EP (1) EP0618964A4 (en)
JP (1) JP3112480B2 (en)
AU (1) AU670774B2 (en)
CA (1) CA2125403C (en)
NZ (1) NZ246432A (en)
WO (1) WO1993012225A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034234A (en) * 1994-11-17 2000-03-07 Taiho Pharmaceutical Co., Ltd. Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
US5073494A (en) * 1985-04-22 1991-12-17 Genentech, Inc. Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
FR2581652B1 (en) * 1985-04-22 1989-12-22 Genentech Inc NEW MUTANTS OF TISSUE ACTIVATOR OF HUMAN PLASMINOGEN
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
NO882226L (en) * 1987-05-22 1988-11-23 Zymogenetics Inc FIBRINOLYTIC PROTEINS.
DE3851259T2 (en) * 1987-06-04 1994-12-15 Zymogenetics Inc Mutated t-PA with Kringle replacement.
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
EP0618973B1 (en) * 1991-12-16 1996-11-27 Genentech, Inc. t-PA SUBSTITUTION VARIANTS WITH IMPROVED FIBRIN-SPECIFICITY

Also Published As

Publication number Publication date
JPH07500971A (en) 1995-02-02
EP0618964A1 (en) 1994-10-12
CA2125403C (en) 2002-08-27
AU3275593A (en) 1993-07-19
JP3112480B2 (en) 2000-11-27
EP0618964A4 (en) 1995-12-06
AU670774B2 (en) 1996-08-01
NZ246432A (en) 1996-06-25
WO1993012225A1 (en) 1993-06-24

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20121214