CA2118424A1 - Calibration reagent having a stabilized concentration of dissolved gas - Google Patents
Calibration reagent having a stabilized concentration of dissolved gasInfo
- Publication number
- CA2118424A1 CA2118424A1 CA 2118424 CA2118424A CA2118424A1 CA 2118424 A1 CA2118424 A1 CA 2118424A1 CA 2118424 CA2118424 CA 2118424 CA 2118424 A CA2118424 A CA 2118424A CA 2118424 A1 CA2118424 A1 CA 2118424A1
- Authority
- CA
- Canada
- Prior art keywords
- dissolved
- reagent
- helium
- vehicle
- calibration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 68
- 239000007789 gas Substances 0.000 claims abstract description 63
- 239000001307 helium Substances 0.000 claims abstract description 47
- 229910052734 helium Inorganic materials 0.000 claims abstract description 47
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims abstract description 47
- 239000007788 liquid Substances 0.000 claims description 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- 210000004369 blood Anatomy 0.000 claims description 14
- 239000001301 oxygen Substances 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 11
- 230000035699 permeability Effects 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 239000001569 carbon dioxide Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 229910001414 potassium ion Inorganic materials 0.000 claims description 6
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910001424 calcium ion Inorganic materials 0.000 claims description 3
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000004868 gas analysis Methods 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 description 17
- 239000000243 solution Substances 0.000 description 16
- 238000004458 analytical method Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000012482 calibration solution Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000010943 off-gassing Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000003570 air Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- -1 E 1 COMPOUND Chemical class 0.000 description 1
- 239000007993 MOPS buffer Substances 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- JLQUFIHWVLZVTJ-UHFFFAOYSA-N carbosulfan Chemical compound CCCCN(CCCC)SN(C)C(=O)OC1=CC=CC2=C1OC(C)(C)C2 JLQUFIHWVLZVTJ-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/70—Blood gas control solutios containing dissolved oxygen, bicarbonate and the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87113992A | 1992-04-20 | 1992-04-20 | |
| US07/871,139 | 1992-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2118424A1 true CA2118424A1 (en) | 1993-10-28 |
Family
ID=25356804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2118424 Abandoned CA2118424A1 (en) | 1992-04-20 | 1993-04-16 | Calibration reagent having a stabilized concentration of dissolved gas |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0639277A4 (de) |
| JP (1) | JPH07505953A (de) |
| AU (1) | AU4289093A (de) |
| CA (1) | CA2118424A1 (de) |
| WO (1) | WO1993021533A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136607A (en) * | 1995-11-02 | 2000-10-24 | Bayer Corporation | Multi-analyte reference solutions with stable pO2 in zero headspace containers |
| AT409800B (de) | 1999-09-13 | 2002-11-25 | Hoffmann La Roche | Verfahren und vorrichtung zur verbesserung der lagerfähigkeit tonometrierter flüssigkeiten |
| EP1527338B1 (de) | 2002-07-26 | 2011-08-31 | Instrumentation Laboratory Company | Verfahren zum reduzieren der sauerstoffverlustrate aus wässrigen lösungen |
| WO2004053483A2 (en) | 2002-12-11 | 2004-06-24 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
| JP2008506129A (ja) * | 2004-07-13 | 2008-02-28 | ラジオメーター・メディカル・アー・ペー・エス | 基準気体を収容するコンテナ、基準流体のセット、基準流体を収容するカセット、及び、基準流体を含む装置 |
| GB0721090D0 (en) * | 2007-10-26 | 2007-12-05 | Bedfont Scient Ltd | Container for calibration bag |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681255A (en) * | 1970-09-03 | 1972-08-01 | Gen Electric | Process for the preparation of liquid calibration fluids |
| US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
| US4116336A (en) * | 1975-05-30 | 1978-09-26 | Radiometer A/S | Package containing a reference liquid for blood gas equipment |
| US3973913A (en) * | 1976-01-29 | 1976-08-10 | Louderback Allan Lee | Blood control standard |
| US4289648A (en) * | 1979-03-20 | 1981-09-15 | Ortho Diagnostics, Inc. | Blood gas controls composition, method and apparatus |
| US4786394A (en) * | 1985-08-29 | 1988-11-22 | Diamond Sensor Systems, Inc. | Apparatus for chemical measurement of blood characteristics |
| US4753888A (en) * | 1986-04-09 | 1988-06-28 | Bionostics, Inc. | Multiple control standard for blood analysis |
| US4871439A (en) * | 1987-02-05 | 1989-10-03 | Steven Enzer | Disposable self-calibratable electrode package |
| US4945062A (en) * | 1988-06-15 | 1990-07-31 | Bionostics Incorporated | Control for blood gas/calcium analysis instrumentation |
| US4960708A (en) * | 1988-10-13 | 1990-10-02 | Baxter International Inc. | Pressurized packaged reference liquid for blood gas analysis |
| US5023186A (en) * | 1989-05-31 | 1991-06-11 | Baxter Diagnostics Inc. | Blood gas/electrolytes calibrator and methods of making and using the same |
-
1993
- 1993-04-16 JP JP5518632A patent/JPH07505953A/ja active Pending
- 1993-04-16 EP EP93912284A patent/EP0639277A4/de not_active Withdrawn
- 1993-04-16 CA CA 2118424 patent/CA2118424A1/en not_active Abandoned
- 1993-04-16 AU AU42890/93A patent/AU4289093A/en not_active Abandoned
- 1993-04-16 WO PCT/US1993/003603 patent/WO1993021533A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07505953A (ja) | 1995-06-29 |
| EP0639277A1 (de) | 1995-02-22 |
| AU4289093A (en) | 1993-11-18 |
| WO1993021533A1 (en) | 1993-10-28 |
| EP0639277A4 (de) | 1997-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |