CA2105665A1 - Diphenylthiazole Derivative - Google Patents
Diphenylthiazole DerivativeInfo
- Publication number
- CA2105665A1 CA2105665A1 CA 2105665 CA2105665A CA2105665A1 CA 2105665 A1 CA2105665 A1 CA 2105665A1 CA 2105665 CA2105665 CA 2105665 CA 2105665 A CA2105665 A CA 2105665A CA 2105665 A1 CA2105665 A1 CA 2105665A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- halogenated
- hydrogen atom
- lower alkanesulfonyl
- alkanesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MIECVJDZXBUVSN-UHFFFAOYSA-N 2,4-diphenyl-1,3-thiazole Chemical class C=1SC(C=2C=CC=CC=2)=NC=1C1=CC=CC=C1 MIECVJDZXBUVSN-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004647 alkyl sulfenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000003424 uricosuric effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel diphenylthiazole derivatives having the following general formula (I):
(see fig. I) (I) wherein m and n are independently 1 or 2; R1 and R~
each represent a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylsulfenyl group, a nitro group, an amino group, a methanesulfonyloxy group or a halogen atom; A1 represents a lower alkanesulfonyl group, a halogenated lower alkanesulfonyl group, or a halogenated or haloalkylated benzenesulfonyl group; and A~ represents a hydrogen atom, a lower alkanesulfonyl group, a halogenated lower alkanesulfonyl group, or a lower alkyl group;
and pharmaceutically acceptable salts thereof; are efficacious as drugs having antiinflammatory, analgesic, antiallergic, uricosuric or platelet aggregation inhibiting effects.
(see fig. I) (I) wherein m and n are independently 1 or 2; R1 and R~
each represent a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylsulfenyl group, a nitro group, an amino group, a methanesulfonyloxy group or a halogen atom; A1 represents a lower alkanesulfonyl group, a halogenated lower alkanesulfonyl group, or a halogenated or haloalkylated benzenesulfonyl group; and A~ represents a hydrogen atom, a lower alkanesulfonyl group, a halogenated lower alkanesulfonyl group, or a lower alkyl group;
and pharmaceutically acceptable salts thereof; are efficacious as drugs having antiinflammatory, analgesic, antiallergic, uricosuric or platelet aggregation inhibiting effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2105665 CA2105665C (en) | 1991-03-07 | 1991-03-07 | Diphenylthiazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2105665 CA2105665C (en) | 1991-03-07 | 1991-03-07 | Diphenylthiazole derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2105665A1 true CA2105665A1 (en) | 1992-09-08 |
| CA2105665C CA2105665C (en) | 1997-08-19 |
Family
ID=4152273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2105665 Expired - Fee Related CA2105665C (en) | 1991-03-07 | 1991-03-07 | Diphenylthiazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2105665C (en) |
-
1991
- 1991-03-07 CA CA 2105665 patent/CA2105665C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2105665C (en) | 1997-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |