CA2100554C

CA2100554C - Detergent compositions with high activity cellulase and softening clays

Detergent compositions with high activity cellulase and softening clays

Info

Publication number: CA2100554C
Authority: CA; Canada
Prior art keywords: detergent composition; composition according; cellulase; clay; ser
Prior art date: 1991-01-16
Legal status : Expired - Fee Related

Application number

CA 2100554

Other languages

English (en)

French (fr)

Other versions

CA2100554A1 (en

Inventor

Andre C. Convents

Alfred Busch

Andre C. Baeck

Current Assignee

Procter and Gamble Co

Original Assignee

Procter and Gamble Co

Priority date

1991-01-16

Filing date

1992-01-13

Publication date

1998-05-05

1991-01-16 Priority claimed from EP91870006.3A external-priority patent/EP0495344A1/en

1991-11-06 Priority claimed from EP91202880A external-priority patent/EP0495258A1/en

1992-01-13 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co

1992-07-17 Publication of CA2100554A1 publication Critical patent/CA2100554A1/en

1998-05-05 Application granted granted Critical

1998-05-05 Publication of CA2100554C publication Critical patent/CA2100554C/en

2012-01-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

108010059892 Cellulase Proteins 0.000 title claims abstract description 155
239000000203 mixture Substances 0.000 title claims abstract description 147
239000003599 detergent Substances 0.000 title claims abstract description 100
229940106157 cellulase Drugs 0.000 title claims abstract description 92
230000000694 effects Effects 0.000 title abstract description 47
239000004927 clay Substances 0.000 claims abstract description 70
238000000034 method Methods 0.000 claims abstract description 53
239000008394 flocculating agent Substances 0.000 claims abstract description 11
-1 polysiloxane Polymers 0.000 claims description 37
230000002285 radioactive effect Effects 0.000 claims description 21
102000004190 Enzymes Human genes 0.000 claims description 20
108090000790 Enzymes Proteins 0.000 claims description 20
150000001875 compounds Chemical class 0.000 claims description 20
229940088598 enzyme Drugs 0.000 claims description 18
239000004094 surface-active agent Substances 0.000 claims description 18
210000004027 cell Anatomy 0.000 claims description 17
229920001296 polysiloxane Polymers 0.000 claims description 16
239000000243 solution Substances 0.000 claims description 16
108020004414 DNA Proteins 0.000 claims description 15
108091028043 Nucleic acid sequence Proteins 0.000 claims description 15
229920000642 polymer Polymers 0.000 claims description 15
229910000323 aluminium silicate Inorganic materials 0.000 claims description 14
229920005646 polycarboxylate Polymers 0.000 claims description 14
239000012085 test solution Substances 0.000 claims description 13
239000013598 vector Substances 0.000 claims description 12
125000003275 alpha amino acid group Chemical group 0.000 claims description 10
GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 9
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 8
229910000271 hectorite Inorganic materials 0.000 claims description 8
239000002243 precursor Substances 0.000 claims description 8
241001480714 Humicola insolens Species 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 7
108020004511 Recombinant DNA Proteins 0.000 claims description 6
229920002678 cellulose Polymers 0.000 claims description 6
239000001913 cellulose Substances 0.000 claims description 6
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
239000011256 inorganic filler Substances 0.000 claims description 5
229910003475 inorganic filler Inorganic materials 0.000 claims description 5
229910021647 smectite Inorganic materials 0.000 claims description 5
229910021653 sulphate ion Inorganic materials 0.000 claims description 5
150000001860 citric acid derivatives Chemical class 0.000 claims description 4
241000894006 Bacteria Species 0.000 claims description 3
241000588724 Escherichia coli Species 0.000 claims description 3
238000005341 cation exchange Methods 0.000 claims description 3
239000001963 growth medium Substances 0.000 claims description 3
229910052901 montmorillonite Inorganic materials 0.000 claims description 3
210000005253 yeast cell Anatomy 0.000 claims description 3
241000228212 Aspergillus Species 0.000 claims description 2
241000187747 Streptomyces Species 0.000 claims description 2
230000006870 function Effects 0.000 claims description 2
241000233866 Fungi Species 0.000 claims 3
241000235070 Saccharomyces Species 0.000 claims 2
229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
241000228245 Aspergillus niger Species 0.000 claims 1
240000006439 Aspergillus oryzae Species 0.000 claims 1
235000002247 Aspergillus oryzae Nutrition 0.000 claims 1
241000193830 Bacillus <bacterium> Species 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical class [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
241000223221 Fusarium oxysporum Species 0.000 claims 1
241000235648 Pichia Species 0.000 claims 1
239000003513 alkali Substances 0.000 claims 1
150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
239000007788 liquid Substances 0.000 abstract description 26
239000003795 chemical substances by application Substances 0.000 abstract description 23
239000000463 material Substances 0.000 description 32
229920002134 Carboxymethyl cellulose Polymers 0.000 description 31
239000001768 carboxy methyl cellulose Substances 0.000 description 29
235000010948 carboxy methyl cellulose Nutrition 0.000 description 29
239000008112 carboxymethyl-cellulose Substances 0.000 description 29
229940105329 carboxymethylcellulose Drugs 0.000 description 29
239000004744 fabric Substances 0.000 description 25
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 21
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 18
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
239000004615 ingredient Substances 0.000 description 12
238000002360 preparation method Methods 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
238000005342 ion exchange Methods 0.000 description 11
238000012216 screening Methods 0.000 description 11
229910001868 water Inorganic materials 0.000 description 11
239000002245 particle Substances 0.000 description 10
238000012360 testing method Methods 0.000 description 10
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 9
229910021536 Zeolite Inorganic materials 0.000 description 9
125000000217 alkyl group Chemical group 0.000 description 9
229940117927 ethylene oxide Drugs 0.000 description 9
239000000377 silicon dioxide Substances 0.000 description 9
239000010457 zeolite Substances 0.000 description 9
108010084185 Cellulases Proteins 0.000 description 8
102000005575 Cellulases Human genes 0.000 description 8
XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 8
238000005259 measurement Methods 0.000 description 8
108090000623 proteins and genes Proteins 0.000 description 8
108010071097 threonyl-lysyl-proline Proteins 0.000 description 8
238000011282 treatment Methods 0.000 description 8
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
239000007844 bleaching agent Substances 0.000 description 7
235000014113 dietary fatty acids Nutrition 0.000 description 7
239000000194 fatty acid Substances 0.000 description 7
229930195729 fatty acid Natural products 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
159000000000 sodium salts Chemical class 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000008901 benefit Effects 0.000 description 6
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
238000004140 cleaning Methods 0.000 description 6
229920001577 copolymer Polymers 0.000 description 6
230000002209 hydrophobic effect Effects 0.000 description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
239000000047 product Substances 0.000 description 6
235000018102 proteins Nutrition 0.000 description 6
239000000523 sample Substances 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
239000011734 sodium Substances 0.000 description 6
239000000758 substrate Substances 0.000 description 6
244000060011 Cocos nucifera Species 0.000 description 5
235000013162 Cocos nucifera Nutrition 0.000 description 5
229920000742 Cotton Polymers 0.000 description 5
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 5
239000000654 additive Substances 0.000 description 5
125000004432 carbon atom Chemical group C* 0.000 description 5
150000007942 carboxylates Chemical class 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
239000002609 medium Substances 0.000 description 5
244000005700 microbiome Species 0.000 description 5
239000002736 nonionic surfactant Substances 0.000 description 5
108010020755 prolyl-glycyl-glycine Proteins 0.000 description 5
239000002689 soil Substances 0.000 description 5
241000894007 species Species 0.000 description 5
239000000375 suspending agent Substances 0.000 description 5
238000005406 washing Methods 0.000 description 5
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical group [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
BOJYMMBYBNOOGG-DCAQKATOSA-N Lys-Pro-Ala Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O BOJYMMBYBNOOGG-DCAQKATOSA-N 0.000 description 4
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
AHZNUGRZHMZGFL-GUBZILKMSA-N Met-Arg-Ser Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(O)=O)CCCNC(N)=N AHZNUGRZHMZGFL-GUBZILKMSA-N 0.000 description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
239000004721 Polyphenylene oxide Substances 0.000 description 4
XTZNCVSCVHTPAI-UHFFFAOYSA-N Salmeterol xinafoate Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21.C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 XTZNCVSCVHTPAI-UHFFFAOYSA-N 0.000 description 4
239000012190 activator Substances 0.000 description 4
125000000539 amino acid group Chemical group 0.000 description 4
150000001768 cations Chemical class 0.000 description 4
239000002299 complementary DNA Substances 0.000 description 4
230000001276 controlling effect Effects 0.000 description 4
230000008021 deposition Effects 0.000 description 4
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 4
238000009826 distribution Methods 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
239000011159 matrix material Substances 0.000 description 4
239000002773 nucleotide Substances 0.000 description 4
125000003729 nucleotide group Chemical group 0.000 description 4
229920000570 polyether Polymers 0.000 description 4
230000008569 process Effects 0.000 description 4
108010053725 prolylvaline Proteins 0.000 description 4
239000007921 spray Substances 0.000 description 4
238000006467 substitution reaction Methods 0.000 description 4
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
VCSABYLVNWQYQE-UHFFFAOYSA-N Ala-Lys-Lys Natural products NCCCCC(NC(=O)C(N)C)C(=O)NC(CCCCN)C(O)=O VCSABYLVNWQYQE-UHFFFAOYSA-N 0.000 description 3
JGIAYNNXZKKKOW-KKUMJFAQSA-N Asn-His-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC(=O)N)N JGIAYNNXZKKKOW-KKUMJFAQSA-N 0.000 description 3
NZWDWXSWUQCNMG-GARJFASQSA-N Asp-Lys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)N)C(=O)O NZWDWXSWUQCNMG-GARJFASQSA-N 0.000 description 3
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 3
CVOZXIPULQQFNY-ZLUOBGJFSA-N Cys-Ala-Cys Chemical compound C[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CS)C(O)=O CVOZXIPULQQFNY-ZLUOBGJFSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
UFPXDFOYHVEIPI-BYPYZUCNSA-N Gly-Gly-Asp Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CC(O)=O UFPXDFOYHVEIPI-BYPYZUCNSA-N 0.000 description 3
239000004367 Lipase Substances 0.000 description 3
102000004882 Lipase Human genes 0.000 description 3
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YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 description 3
KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 3
BJEYSVHMGIJORT-NHCYSSNCSA-N Phe-Ala-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=CC=C1 BJEYSVHMGIJORT-NHCYSSNCSA-N 0.000 description 3
CSYVXYQDIVCQNU-QWRGUYRKSA-N Phe-Asp-Gly Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O CSYVXYQDIVCQNU-QWRGUYRKSA-N 0.000 description 3
MKGIILKDUGDRRO-FXQIFTODSA-N Pro-Ser-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1 MKGIILKDUGDRRO-FXQIFTODSA-N 0.000 description 3
ZAUHSLVPDLNTRZ-QXEWZRGKSA-N Pro-Val-Asn Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O ZAUHSLVPDLNTRZ-QXEWZRGKSA-N 0.000 description 3
SVWQEIRZHHNBIO-WHFBIAKZSA-N Ser-Gly-Cys Chemical compound [H]N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CS)C(O)=O SVWQEIRZHHNBIO-WHFBIAKZSA-N 0.000 description 3
239000004902 Softening Agent Substances 0.000 description 3
BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
RVMNUBQWPVOUKH-HEIBUPTGSA-N Thr-Ser-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O RVMNUBQWPVOUKH-HEIBUPTGSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
230000002411 adverse Effects 0.000 description 3
108010024078 alanyl-glycyl-serine Proteins 0.000 description 3
150000001408 amides Chemical class 0.000 description 3
150000001412 amines Chemical class 0.000 description 3
239000003945 anionic surfactant Substances 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000011575 calcium Substances 0.000 description 3
229910001424 calcium ion Inorganic materials 0.000 description 3
239000002738 chelating agent Substances 0.000 description 3
108010004073 cysteinylcysteine Proteins 0.000 description 3
108010060199 cysteinylproline Proteins 0.000 description 3
108010069495 cysteinyltyrosine Proteins 0.000 description 3
230000001461 cytolytic effect Effects 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
230000001747 exhibiting effect Effects 0.000 description 3
239000008103 glucose Substances 0.000 description 3
125000001183 hydrocarbyl group Chemical group 0.000 description 3
235000019421 lipase Nutrition 0.000 description 3
238000002156 mixing Methods 0.000 description 3
108010024654 phenylalanyl-prolyl-alanine Proteins 0.000 description 3
239000004033 plastic Substances 0.000 description 3
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150000003138 primary alcohols Chemical class 0.000 description 3
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238000010561 standard procedure Methods 0.000 description 3
239000011550 stock solution Substances 0.000 description 3
239000003760 tallow Substances 0.000 description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
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UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 2
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BUANFPRKJKJSRR-ACZMJKKPSA-N Ala-Ala-Gln Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](C)C(=O)N[C@H](C([O-])=O)CCC(N)=O BUANFPRKJKJSRR-ACZMJKKPSA-N 0.000 description 2
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XSLGWYYNOSUMRM-ZKWXMUAHSA-N Ala-Val-Asn Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O XSLGWYYNOSUMRM-ZKWXMUAHSA-N 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
108010065511 Amylases Proteins 0.000 description 2
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HJDNZFIYILEIKR-OSUNSFLBSA-N Arg-Ile-Thr Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O HJDNZFIYILEIKR-OSUNSFLBSA-N 0.000 description 2
FKQITMVNILRUCQ-IHRRRGAJSA-N Arg-Phe-Asp Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(O)=O FKQITMVNILRUCQ-IHRRRGAJSA-N 0.000 description 2
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