CA2099569A1 - New a83543 compounds and process for production thereof - Google Patents

New a83543 compounds and process for production thereof

Info

Publication number
CA2099569A1
CA2099569A1 CA002099569A CA2099569A CA2099569A1 CA 2099569 A1 CA2099569 A1 CA 2099569A1 CA 002099569 A CA002099569 A CA 002099569A CA 2099569 A CA2099569 A CA 2099569A CA 2099569 A1 CA2099569 A1 CA 2099569A1
Authority
CA
Canada
Prior art keywords
new
components
nrrl
compounds
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002099569A
Other languages
French (fr)
Other versions
CA2099569C (en
Inventor
Jon S. Mynderse
James W. Martin
Jan R. Turner
Lawrence Creemer
Herbert A. Kirst
Mary C. Broughton
Mary L. B. Huber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/790,287 external-priority patent/US5202242A/en
Application filed by Individual filed Critical Individual
Publication of CA2099569A1 publication Critical patent/CA2099569A1/en
Application granted granted Critical
Publication of CA2099569C publication Critical patent/CA2099569C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

New A83543 components and salts thereof, and N-demethyl derivatives are useful for the control of insects and mites.
Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18719, NRRL 18720, NRRL
18723 are provided. Insecticidal and ectoparasiticidal compositions containing new A83~43 components are also provided.
Pseudoaglycones of Aare useful for the preparation of A83543 components.
CA002099569A 1991-11-08 1992-11-09 New a83543 compounds and process for production thereof Expired - Lifetime CA2099569C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US79028291A 1991-11-08 1991-11-08
US79061691A 1991-11-08 1991-11-08
US07/790,287 US5202242A (en) 1991-11-08 1991-11-08 A83543 compounds and processes for production thereof
US07/790,282 1991-11-08
US07/790,287 1991-11-08
US07/790,616 1991-11-08
PCT/US1992/009684 WO1993009126A1 (en) 1991-11-08 1992-11-09 New a83543 compounds and process for production thereof

Publications (2)

Publication Number Publication Date
CA2099569A1 true CA2099569A1 (en) 1993-05-09
CA2099569C CA2099569C (en) 2004-05-11

Family

ID=27419873

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002099569A Expired - Lifetime CA2099569C (en) 1991-11-08 1992-11-09 New a83543 compounds and process for production thereof

Country Status (12)

Country Link
EP (1) EP0573628B1 (en)
JP (1) JP3797386B2 (en)
CN (1) CN1073483A (en)
AU (1) AU666900B2 (en)
BR (1) BR9205458A (en)
CA (1) CA2099569C (en)
DE (1) DE69228239T2 (en)
ES (1) ES2126605T3 (en)
GR (1) GR3029614T3 (en)
MX (1) MX9206433A (en)
RU (1) RU2165704C2 (en)
WO (1) WO1993009126A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA09249A (en) * 1988-12-19 1992-06-30 Lilly Co Eli Compounds of macrolides.
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
ATE150758T1 (en) * 1993-03-12 1997-04-15 Dowelanco NEW A83543 COMPOUNDS AND METHODS FOR PRODUCING THEM
AU711185B2 (en) * 1995-06-14 1999-10-07 Dow Agrosciences Llc Synthetic modification to spinosyn compounds
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
DE19823397B4 (en) * 1998-05-26 2011-07-28 Bayer CropScience AG, 40789 Use of spinosyns for use as soil insecticides
DE19823396A1 (en) * 1998-05-26 1999-12-02 Bayer Ag Synergistic insecticidal mixtures
ID29130A (en) * 1998-07-02 2001-08-02 Lilly Co Eli FLEX CONTROL FORMULATION IN HUMAN
AU6606400A (en) * 1999-08-12 2001-03-13 Eli Lilly And Company Topical treatment for insect pests in companion animals
IL148601A0 (en) * 1999-09-13 2002-09-12 Dow Agrosciences Llc Pesticidal macrolides
US6585990B1 (en) 2001-03-05 2003-07-01 Dow Agrosciences, Llc Compositions and devices using a spinosyn compound for control of insects
IL157974A0 (en) 2001-03-21 2004-03-28 Dow Agrosciences Llc Pesticidal macrolides
ES2723779T3 (en) 2001-09-17 2019-09-02 Elanco Us Inc Formulation for the control of lice and ticks in cattle
AU2003217591B2 (en) 2002-02-19 2009-02-26 Corteva Agriscience Llc Novel spinosyn-producing polyketide synthases
EP2019589B1 (en) * 2006-05-25 2014-06-04 Dow AgroSciences LLC Spinosyn fumigants
JP5315818B2 (en) * 2007-07-12 2013-10-16 住友化学株式会社 Pest control composition
CN101560477B (en) * 2008-04-16 2012-04-25 上海医药工业研究院 Culture medium for fermenting pleocidin producing bacteria
EP2343975B8 (en) 2008-09-22 2012-10-24 Entarco SA Spinosyn antifouling compositions, methods of use thereof and articles protected from attachment of biofouling organisms
US8268975B2 (en) 2009-04-03 2012-09-18 Dow Agrosciences Llc Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions
US8697661B2 (en) 2009-06-24 2014-04-15 Christine Kritikou Use of spinosyns and spinosyn compositions against herpesviridae viral infections
WO2011143291A1 (en) * 2010-05-11 2011-11-17 Dow Agrosciences Llc Spnk strains
EP2654757A1 (en) 2010-12-22 2013-10-30 Entarco SA The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
ES2553079T3 (en) 2011-05-03 2015-12-04 Dow Agrosciences Llc Improved production of spinosyns with proteins that bind to oxygen
US9404107B2 (en) 2011-05-03 2016-08-02 Dow Agrosciences Llc Integration of genes into the chromosome of Saccharopolyspora spinosa
US8741603B2 (en) * 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
US9631195B2 (en) 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
JP2014111571A (en) * 2012-10-29 2014-06-19 Sumitomo Chemical Co Ltd Agrochemical granule
AU2019309520B2 (en) 2018-07-27 2025-04-03 Aperta Biosciences, Llc Spinosyn formulations for treatment of demodex-induced ocular and facial conditions
CN110734467B (en) * 2019-09-10 2021-08-27 北大方正集团有限公司 Method for extracting and purifying spinosad from fermentation liquor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA09249A (en) * 1988-12-19 1992-06-30 Lilly Co Eli Compounds of macrolides.

Also Published As

Publication number Publication date
GR3029614T3 (en) 1999-06-30
CN1073483A (en) 1993-06-23
JP3797386B2 (en) 2006-07-19
EP0573628A1 (en) 1993-12-15
DE69228239D1 (en) 1999-03-04
EP0573628B1 (en) 1999-01-20
BR9205458A (en) 1994-05-31
CA2099569C (en) 2004-05-11
ES2126605T3 (en) 1999-04-01
MX9206433A (en) 1993-05-01
JPH06506477A (en) 1994-07-21
DE69228239T2 (en) 1999-05-27
RU2165704C2 (en) 2001-04-27
AU3131893A (en) 1993-06-07
AU666900B2 (en) 1996-02-29
WO1993009126A1 (en) 1993-05-13

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