CA2088273A1 - Processes for formulating a solid oral dosage form of loperamide compounds - Google Patents

Processes for formulating a solid oral dosage form of loperamide compounds

Info

Publication number
CA2088273A1
CA2088273A1 CA2088273A CA2088273A CA2088273A1 CA 2088273 A1 CA2088273 A1 CA 2088273A1 CA 2088273 A CA2088273 A CA 2088273A CA 2088273 A CA2088273 A CA 2088273A CA 2088273 A1 CA2088273 A1 CA 2088273A1
Authority
CA
Canada
Prior art keywords
dosage form
solid oral
oral dosage
loperamide
formulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2088273A
Other languages
French (fr)
Other versions
CA2088273C (en
Inventor
Daniel Louis Barone
Francis Bernard Chapura
Shawn Alan Denny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2088273A1 publication Critical patent/CA2088273A1/en
Application granted granted Critical
Publication of CA2088273C publication Critical patent/CA2088273C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Process for manufacturing a solid oral dosage form of a loperamide compound (preferably the hydrochloride salt of loper-amide) by dissolving a loperamide compound in a short chain alcohol (preferably ethanol) prior to combining with a pharmaceut-ically acceptable carrier(s). The present invention also relates to the solid oral dosage forms (preferably compressed unit dosage form) prepared by this process.
CA002088273A 1990-08-09 1991-07-29 Processes for formulating a solid oral dosage form of loperamide compounds Expired - Fee Related CA2088273C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56501090A 1990-08-09 1990-08-09
US565,010 1990-08-09

Publications (2)

Publication Number Publication Date
CA2088273A1 true CA2088273A1 (en) 1992-02-10
CA2088273C CA2088273C (en) 1996-05-14

Family

ID=24256836

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088273A Expired - Fee Related CA2088273C (en) 1990-08-09 1991-07-29 Processes for formulating a solid oral dosage form of loperamide compounds

Country Status (9)

Country Link
EP (1) EP0542879A1 (en)
JP (1) JPH06500104A (en)
AU (1) AU661972B2 (en)
CA (1) CA2088273C (en)
FI (1) FI930536A7 (en)
IE (1) IE912815A1 (en)
NZ (1) NZ239308A (en)
PT (1) PT98612A (en)
WO (1) WO1992002223A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117834A1 (en) * 2004-05-27 2005-12-15 Janssen Pharmaceutica N.V. Solid dispersions of a basic drug compound and a polymer containing acidic groups
US10508373B2 (en) 2016-05-13 2019-12-17 Nike, Inc. Embroidered article

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332236C (en) * 1985-10-11 1994-10-04 Lourens Wals –,-–-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, n-oxides
DE3906779A1 (en) * 1989-03-03 1990-09-06 Hoechst Ag Compositions against animal parasites (parasites of animals)
GB8908361D0 (en) * 1989-04-13 1989-06-01 Beecham Group Plc Composition
NZ233403A (en) * 1989-04-28 1992-09-25 Mcneil Ppc Inc Simulated capsule-like medicament

Also Published As

Publication number Publication date
EP0542879A1 (en) 1993-05-26
IE912815A1 (en) 1992-02-12
FI930536L (en) 1993-02-08
PT98612A (en) 1992-06-30
NZ239308A (en) 1994-04-27
FI930536A0 (en) 1993-02-08
WO1992002223A1 (en) 1992-02-20
AU661972B2 (en) 1995-08-17
AU8440091A (en) 1992-03-02
CA2088273C (en) 1996-05-14
FI930536A7 (en) 1993-02-08
JPH06500104A (en) 1994-01-06

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed