CA2083286A1 - Recombinant fibrinogenases, preparation and use thereof - Google Patents

Recombinant fibrinogenases, preparation and use thereof

Info

Publication number
CA2083286A1
CA2083286A1 CA002083286A CA2083286A CA2083286A1 CA 2083286 A1 CA2083286 A1 CA 2083286A1 CA 002083286 A CA002083286 A CA 002083286A CA 2083286 A CA2083286 A CA 2083286A CA 2083286 A1 CA2083286 A1 CA 2083286A1
Authority
CA
Canada
Prior art keywords
fibrinogenases
recombinant
preparation
glycosylated
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002083286A
Other languages
French (fr)
Other versions
CA2083286C (en
Inventor
Alfred Bach
Heinz Hillen
Siegfried Bialojan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2083286A1 publication Critical patent/CA2083286A1/en
Application granted granted Critical
Publication of CA2083286C publication Critical patent/CA2083286C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Glycosylated, partially glycosylated and non-glycosylated polypeptides which have the amino-acid sequences indicated in the sequence listing and in which up to 10 amino-acid residues can be replaced by residues of other natural amino acids are described. The peptides are suitable for controlling diseases.
CA002083286A 1990-07-26 1991-07-19 Recombinant fibrinogenases, preparation and use thereof Expired - Lifetime CA2083286C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4023699.4 1990-07-26
DE4023699A DE4023699A1 (en) 1990-07-26 1990-07-26 NEW PROTEINS, THEIR PRODUCTION AND USE
PCT/EP1991/001361 WO1992001794A2 (en) 1990-07-26 1991-07-19 Ancrod-like proteins, their preparation and their use

Publications (2)

Publication Number Publication Date
CA2083286A1 true CA2083286A1 (en) 1992-01-27
CA2083286C CA2083286C (en) 2001-11-27

Family

ID=6411021

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002083286A Expired - Lifetime CA2083286C (en) 1990-07-26 1991-07-19 Recombinant fibrinogenases, preparation and use thereof

Country Status (8)

Country Link
EP (1) EP0540560B1 (en)
JP (1) JPH05508771A (en)
AT (1) ATE130872T1 (en)
CA (1) CA2083286C (en)
DE (2) DE4023699A1 (en)
DK (1) DK0540560T3 (en)
ES (1) ES2080326T3 (en)
WO (1) WO1992001794A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3841736A1 (en) * 1988-12-10 1990-07-05 Basf Ag ANCROD PROTEINS, THEIR PREPARATION AND USE
KR0127776B1 (en) * 1994-10-11 1997-12-29 허영섭 CDNA sequences of novel proteases and proteins derived therefrom
US5955306A (en) * 1996-09-17 1999-09-21 Millenium Pharmaceuticals, Inc. Genes encoding proteins that interact with the tub protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610879A (en) * 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
US4585653A (en) * 1984-02-27 1986-04-29 Robert L. Letcher Neuraminidase treated ancrod
DE3841736A1 (en) * 1988-12-10 1990-07-05 Basf Ag ANCROD PROTEINS, THEIR PREPARATION AND USE
CA2015127A1 (en) * 1989-04-26 1990-10-26 John G. Gray, Jr. Novel dna sequences which encode ancrod-like polypeptides and compositions comprising the expression products thereof

Also Published As

Publication number Publication date
WO1992001794A3 (en) 1992-03-05
ES2080326T3 (en) 1996-02-01
DE59106997D1 (en) 1996-01-11
WO1992001794A2 (en) 1992-02-06
DE4023699A1 (en) 1992-01-30
CA2083286C (en) 2001-11-27
EP0540560A1 (en) 1993-05-12
EP0540560B1 (en) 1995-11-29
JPH05508771A (en) 1993-12-09
ATE130872T1 (en) 1995-12-15
DK0540560T3 (en) 1995-12-27

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry