CA2082811A1 - 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent - Google Patents

5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent

Info

Publication number
CA2082811A1
CA2082811A1 CA002082811A CA2082811A CA2082811A1 CA 2082811 A1 CA2082811 A1 CA 2082811A1 CA 002082811 A CA002082811 A CA 002082811A CA 2082811 A CA2082811 A CA 2082811A CA 2082811 A1 CA2082811 A1 CA 2082811A1
Authority
CA
Canada
Prior art keywords
tetrahydrofolate
methylene
modulator
chemotherapeutic agent
ch2fh4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002082811A
Other languages
French (fr)
Other versions
CA2082811C (en
Inventor
Colin P. Spears
Bengt G. Gustavsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2082811A1 publication Critical patent/CA2082811A1/en
Application granted granted Critical
Publication of CA2082811C publication Critical patent/CA2082811C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the compound 5,10-methylene-tetrahydrofolate (CH2FH4), and its solution isomer FH4, therapeutic uses of these compounds, and compositions thereof. CH2FH4 and FH4 strongly modulate the in vivo antitumor effects of 5-Fluorouracil.
CA002082811A 1990-05-11 1991-05-13 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent Expired - Lifetime CA2082811C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52171290A 1990-05-11 1990-05-11
US521,712 1990-05-11
PCT/US1991/003186 WO1991017660A1 (en) 1990-05-11 1991-05-13 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent

Publications (2)

Publication Number Publication Date
CA2082811A1 true CA2082811A1 (en) 1991-11-12
CA2082811C CA2082811C (en) 2004-11-16

Family

ID=24077829

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002082811A Expired - Lifetime CA2082811C (en) 1990-05-11 1991-05-13 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent

Country Status (3)

Country Link
AU (1) AU7953291A (en)
CA (1) CA2082811C (en)
WO (1) WO1991017660A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH684644A5 (en) * 1992-07-13 1994-11-15 Eprova Ag 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compounds.
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
CH693255A5 (en) * 1997-06-13 2003-05-15 Eprova Ag Use of tetrahydrofolates natürlichenstereoisomeren in the form suitable for the preparation of a pharmaceutical composition for influencing the homocysteine ​​level.
SE0303526D0 (en) * 2003-12-22 2003-12-22 Biofol Ab Chemotherapeutic agents
EP2617421A1 (en) * 2012-01-20 2013-07-24 Isofol Medical AB Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer

Also Published As

Publication number Publication date
AU7953291A (en) 1991-12-10
CA2082811C (en) 2004-11-16
WO1991017660A1 (en) 1991-11-28

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry