CA2067817A1 - Muscarinic receptor antagonists - Google Patents

Muscarinic receptor antagonists

Info

Publication number
CA2067817A1
CA2067817A1 CA2067817A CA2067817A CA2067817A1 CA 2067817 A1 CA2067817 A1 CA 2067817A1 CA 2067817 A CA2067817 A CA 2067817A CA 2067817 A CA2067817 A CA 2067817A CA 2067817 A1 CA2067817 A1 CA 2067817A1
Authority
CA
Canada
Prior art keywords
receptor antagonists
independently
muscarinic receptor
het
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2067817A
Other languages
French (fr)
Other versions
CA2067817C (en
Inventor
David Alker
Peter Edward Cross
Alexander Roderick Mackenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
David Alker
Peter Edward Cross
Alexander Roderick Mackenzie
Pfizer Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David Alker, Peter Edward Cross, Alexander Roderick Mackenzie, Pfizer Limited filed Critical David Alker
Publication of CA2067817A1 publication Critical patent/CA2067817A1/en
Application granted granted Critical
Publication of CA2067817C publication Critical patent/CA2067817C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • E—FIXED CONSTRUCTIONS
    • E21—EARTH DRILLING; MINING
    • E21B—EARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B29/00—Cutting or destroying pipes, packers, plugs, or wire lines, located in boreholes or wells, e.g. cutting of damaged pipes, of windows; Deforming of pipes in boreholes or wells; Reconditioning of well casings while in the ground
    • E21B29/06—Cutting windows, e.g. directional window cutters for whipstock operations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T407/00—Cutters, for shaping
    • Y10T407/19—Rotary cutting tool
    • Y10T407/1906—Rotary cutting tool including holder [i.e., head] having seat for inserted tool
    • Y10T407/1908—Face or end mill
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T408/00—Cutting by use of rotating axially moving tool
    • Y10T408/89—Tool or Tool with support
    • Y10T408/893—Hollow milling Tool

Abstract

2067817 9110647 PCTABS00006 Muscarinic receptor antagonists, particularly useful in the treating of irritable bowel syndrome, of formula (I), and their pharmaceutically acceptable salts, wherein R is -CN or -CONH2; and R1 is a group of formula (a), (b), (c) or Het, where R2 and R3 are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)qOH, halo, trifluoromethyl, -(CH2)qNR4R5, -SO2NH2, or -(CH2)qCONR4R5; R4 and R5 are each independently H or C1-C4 alkyl; q is 0, 1 or 2; r is 1, 2 or 3; X and X1 are each independently O or CH2; m is 1, 2 or 3; n is 1, 2 or 3, with the proviso that when the group -(CH2)m- is attached to the 3-position of the piperidine or pyrrolidine ring, n is 2 or 3; p is 0 or 1; and "Het" is pyridyl, pyrazinyl or thienyl.
CA002067817A 1990-01-06 1990-11-28 Muscarinic receptor antagonists Expired - Fee Related CA2067817C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE9000304.7 1990-01-06
GB9000304.7 1990-01-06
GB909003047A GB9003047D0 (en) 1990-02-10 1990-02-10 Insert type window mill

Publications (2)

Publication Number Publication Date
CA2067817A1 true CA2067817A1 (en) 1991-07-07
CA2067817C CA2067817C (en) 1994-06-28

Family

ID=10670791

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002067817A Expired - Fee Related CA2067817C (en) 1990-01-06 1990-11-28 Muscarinic receptor antagonists

Country Status (5)

Country Link
US (1) US5199513A (en)
EP (1) EP0442675A3 (en)
CA (1) CA2067817C (en)
GB (1) GB9003047D0 (en)
NO (1) NO304444B1 (en)

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US6070665A (en) * 1996-05-02 2000-06-06 Weatherford/Lamb, Inc. Wellbore milling
US5887668A (en) * 1993-09-10 1999-03-30 Weatherford/Lamb, Inc. Wellbore milling-- drilling
US5887655A (en) * 1993-09-10 1999-03-30 Weatherford/Lamb, Inc Wellbore milling and drilling
US5806595A (en) * 1993-09-10 1998-09-15 Weatherford/Lamb, Inc. Wellbore milling system and method
US5836387A (en) * 1993-09-10 1998-11-17 Weatherford/Lamb, Inc. System for securing an item in a tubular channel in a wellbore
US6202752B1 (en) 1993-09-10 2001-03-20 Weatherford/Lamb, Inc. Wellbore milling methods
US5727629A (en) * 1996-01-24 1998-03-17 Weatherford/Lamb, Inc. Wellbore milling guide and method
US6024168A (en) * 1996-01-24 2000-02-15 Weatherford/Lamb, Inc. Wellborne mills & methods
US5787978A (en) * 1995-03-31 1998-08-04 Weatherford/Lamb, Inc. Multi-face whipstock with sacrificial face element
US5826651A (en) * 1993-09-10 1998-10-27 Weatherford/Lamb, Inc. Wellbore single trip milling
US5720349A (en) * 1995-10-12 1998-02-24 Weatherford U.S., Inc. Starting mill and operations
US5445222A (en) * 1994-06-07 1995-08-29 Shell Oil Company Whipstock and staged sidetrack mill
US5803176A (en) * 1996-01-24 1998-09-08 Weatherford/Lamb, Inc. Sidetracking operations
US6056056A (en) * 1995-03-31 2000-05-02 Durst; Douglas G. Whipstock mill
CA2225207C (en) * 1995-07-07 2003-11-25 The Red Baron (Oil Tools Rental) Limited Single trip whipstock assembly
US5636692A (en) * 1995-12-11 1997-06-10 Weatherford Enterra U.S., Inc. Casing window formation
US5862870A (en) * 1995-09-22 1999-01-26 Weatherford/Lamb, Inc. Wellbore section milling
US6170576B1 (en) 1995-09-22 2001-01-09 Weatherford/Lamb, Inc. Mills for wellbore operations
US5908071A (en) * 1995-09-22 1999-06-01 Weatherford/Lamb, Inc. Wellbore mills and inserts
US5984005A (en) * 1995-09-22 1999-11-16 Weatherford/Lamb, Inc. Wellbore milling inserts and mills
US5642787A (en) * 1995-09-22 1997-07-01 Weatherford U.S., Inc. Section milling
US5791417A (en) 1995-09-22 1998-08-11 Weatherford/Lamb, Inc. Tubular window formation
US5709265A (en) 1995-12-11 1998-01-20 Weatherford/Lamb, Inc. Wellbore window formation
US5626189A (en) * 1995-09-22 1997-05-06 Weatherford U.S., Inc. Wellbore milling tools and inserts
US5657820A (en) * 1995-12-14 1997-08-19 Smith International, Inc. Two trip window cutting system
US6155349A (en) * 1996-05-02 2000-12-05 Weatherford/Lamb, Inc. Flexible wellbore mill
US6547006B1 (en) 1996-05-02 2003-04-15 Weatherford/Lamb, Inc. Wellbore liner system
US5771972A (en) * 1996-05-03 1998-06-30 Smith International, Inc., One trip milling system
US6648068B2 (en) 1996-05-03 2003-11-18 Smith International, Inc. One-trip milling system
US5816324A (en) * 1996-05-03 1998-10-06 Smith International, Inc. Whipstock accelerator ramp
US5778980A (en) * 1996-05-29 1998-07-14 Baroid Technology, Inc. Multicut casing window mill and method for forming a casing window
US5762143A (en) * 1996-05-29 1998-06-09 Baroid Technology, Inc. System and method for placement and retrieval of a subsurface diverting tool used in drilling and completing wells
US5735359A (en) * 1996-06-10 1998-04-07 Weatherford/Lamb, Inc. Wellbore cutting tool
AU719919B2 (en) * 1996-07-15 2000-05-18 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
US5833003A (en) * 1996-07-15 1998-11-10 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
US5730221A (en) * 1996-07-15 1998-03-24 Halliburton Energy Services, Inc Methods of completing a subterranean well
AU714721B2 (en) * 1996-07-15 2000-01-06 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
CA2210563C (en) * 1996-07-15 2004-03-02 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
US5813465A (en) * 1996-07-15 1998-09-29 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
US5862862A (en) * 1996-07-15 1999-01-26 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
CA2209958A1 (en) * 1996-07-15 1998-01-15 James M. Barker Apparatus for completing a subterranean well and associated methods of using same
CA2210561C (en) * 1996-07-15 2004-04-06 Halliburton Energy Services, Inc. Apparatus for completing a subterranean well and associated methods of using same
US6032740A (en) * 1998-01-23 2000-03-07 Weatherford/Lamb, Inc. Hook mill systems
US6374918B2 (en) 1999-05-14 2002-04-23 Weatherford/Lamb, Inc. In-tubing wellbore sidetracking operations
US6684953B2 (en) 2001-01-22 2004-02-03 Baker Hughes Incorporated Wireless packer/anchor setting or activation
US20070240876A1 (en) * 2006-04-12 2007-10-18 Lynde Gerald D Non-metallic whipstock
US7958940B2 (en) * 2008-07-02 2011-06-14 Jameson Steve D Method and apparatus to remove composite frac plugs from casings in oil and gas wells
US8499834B2 (en) * 2009-10-01 2013-08-06 Baker Hughes Incorporated Milling tool for establishing openings in wellbore obstructions
US11268339B2 (en) * 2020-06-29 2022-03-08 Halliburton Energy Services, Inc. Guided wash pipe milling

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2014805A (en) * 1933-05-29 1935-09-17 Frank J Hinderliter Apparatus for cutting through the side wall of a pipe
US2103622A (en) * 1936-07-25 1937-12-28 Robert B Kinzbach Side tracking apparatus
US2882015A (en) * 1957-06-10 1959-04-14 J E Hill Directional window cutter for whipstocks
US3051255A (en) * 1960-05-18 1962-08-28 Carroll L Deely Reamer
US3301339A (en) * 1964-06-19 1967-01-31 Exxon Production Research Co Drill bit with wear resistant material on blade
US3908759A (en) * 1974-05-22 1975-09-30 Standard Oil Co Sidetracking tool
US4266621A (en) * 1977-06-22 1981-05-12 Christensen, Inc. Well casing window mill
US4610320A (en) * 1984-09-19 1986-09-09 Directional Enterprises, Inc. Stabilizer blade
US4646857A (en) * 1985-10-24 1987-03-03 Reed Tool Company Means to secure cutting elements on drag type drill bits
US4796709A (en) * 1986-01-06 1989-01-10 Tri-State Oil Tool Industries, Inc. Milling tool for cutting well casing
US4887668A (en) * 1986-01-06 1989-12-19 Tri-State Oil Tool Industries, Inc. Cutting tool for cutting well casing
US4618010A (en) * 1986-02-18 1986-10-21 Team Engineering And Manufacturing, Inc. Hole opener
GB8626294D0 (en) * 1986-11-04 1986-12-03 Ici Plc Fineness gauge
US5012863A (en) * 1988-06-07 1991-05-07 Smith International, Inc. Pipe milling tool blade and method of dressing same
US5010967A (en) * 1989-05-09 1991-04-30 Smith International, Inc. Milling apparatus with replaceable blades

Also Published As

Publication number Publication date
US5199513A (en) 1993-04-06
NO910543D0 (en) 1991-02-11
EP0442675A2 (en) 1991-08-21
EP0442675A3 (en) 1992-09-16
NO910543L (en) 1991-08-12
GB9003047D0 (en) 1990-04-11
CA2067817C (en) 1994-06-28
NO304444B1 (en) 1998-12-14

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Legal Events

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EEER Examination request
MKLA Lapsed