CA2064231A1 - Combinaisons et methodes pour le traitement ou la prevention des maladies dues a des thromboses - Google Patents

Combinaisons et methodes pour le traitement ou la prevention des maladies dues a des thromboses

Info

Publication number
CA2064231A1
CA2064231A1 CA 2064231 CA2064231A CA2064231A1 CA 2064231 A1 CA2064231 A1 CA 2064231A1 CA 2064231 CA2064231 CA 2064231 CA 2064231 A CA2064231 A CA 2064231A CA 2064231 A1 CA2064231 A1 CA 2064231A1
Authority
CA
Canada
Prior art keywords
leu
amino acid
tyrosine
peptide
alanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2064231
Other languages
English (en)
Inventor
John M. Maraganore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2064231A1 publication Critical patent/CA2064231A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA 2064231 1989-07-20 1990-07-20 Combinaisons et methodes pour le traitement ou la prevention des maladies dues a des thromboses Abandoned CA2064231A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38336089A 1989-07-20 1989-07-20
US383,360 1989-07-20

Publications (1)

Publication Number Publication Date
CA2064231A1 true CA2064231A1 (fr) 1991-01-21

Family

ID=23512759

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2064231 Abandoned CA2064231A1 (fr) 1989-07-20 1990-07-20 Combinaisons et methodes pour le traitement ou la prevention des maladies dues a des thromboses

Country Status (4)

Country Link
EP (1) EP0482069A1 (fr)
AU (1) AU6054090A (fr)
CA (1) CA2064231A1 (fr)
WO (1) WO1991001142A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4005591A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
DE19607239A1 (de) * 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230742A (en) * 1986-10-09 1991-03-26 Smithkline Beckman Corp Thrombolytic composition comprising a plasminogen activator (tpa, uk or sk) and a thromboxane receptor antagonist; kits thereof; and process for preparation thereof
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz

Also Published As

Publication number Publication date
EP0482069A1 (fr) 1992-04-29
WO1991001142A1 (fr) 1991-02-07
AU6054090A (en) 1991-02-22

Similar Documents

Publication Publication Date Title
US5759542A (en) Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5256559A (en) Methods and compositions for inhibiting platelet aggregation
AU652125B2 (en) Novel inhibitors of thrombin
US5240913A (en) Inhibitors of thrombin
EP0365468B1 (fr) Combinaison pharmaceutiquement active de l'activateur du plasminogène et de l'hirudine
EP0333356A2 (fr) Peptides de hirudine
AU623882B2 (en) Methods and compositions for inhibiting platelet aggregation
US5182260A (en) Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
WO1990003391A1 (fr) Peptides d'hirudine
CA2064231A1 (fr) Combinaisons et methodes pour le traitement ou la prevention des maladies dues a des thromboses
US5951981A (en) Thrombolytic agents with antithrombotic activity
EP0483261A1 (fr) Derives de peptides d'hirudine
US5234686A (en) Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment
EP0732102A2 (fr) Composition pour le traitement de l'infarctus du myocarde aigu contenant de l'hirudine et de l'acide acétylsalicylique
WO1992018139A1 (fr) Molecules chimeriques ayant une activite d'activation de plasminogene et affinite pour les plaques atherosclerotiques
Verstraete Thrombolysis: an approach still on the move
Markwardt Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Erfurt, Federal Republic of Germany
BG61670B2 (bg) Инхибитори на тромбина

Legal Events

Date Code Title Description
FZDE Dead