CA2063297C - Biosensor and measuring apparatus using the same - Google Patents
Biosensor and measuring apparatus using the sameInfo
- Publication number
- CA2063297C CA2063297C CA 2063297 CA2063297A CA2063297C CA 2063297 C CA2063297 C CA 2063297C CA 2063297 CA2063297 CA 2063297 CA 2063297 A CA2063297 A CA 2063297A CA 2063297 C CA2063297 C CA 2063297C
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- Canada
- Prior art keywords
- biosensor
- base
- connector
- electrodes
- alignment control
- Prior art date
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Abstract
The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.
The biosensor of the subject invention as provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.
By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
The biosensor of the subject invention as provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.
By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
Description
TITLE OF TF3E IIViTENTT~pN
BICJSE1~ISO~t ~1D MEASURIiVG APPARATUS USTIVG '.~Fi~ SAI~lE
BAC~GRpLTND 9F TF3E I1VVENTION
In the context that in recent years varinua biooenet~re utilizing singular catalytic action of enzymes have been developed and are undergoing clinical trial ~.~~lications, demand ex~.sts for biosen~c~rs capable of ma~Cing rap~.d and highly accurate measurementsa Taking glucose sensors as an excample, today 1Q when there is a marked increase ~.n the number ai persons afflicted with diabetes; the measurement and management oil blood sugar requ3,re ~xtr~xnely complicated steg~s if blood were to be centrifuged to make measurements of the plasma as done traditionally arid there is a demand for a sensor capable of making measurements from whole blood.
~t~ a simple type, there is one, eim~.lar to the test paper used in testing urine, of using a stick-shaped support and pla.cin.~ t;~ereon a medium containing an ea~:zyme reacting only to.a sugar (glucose) arid a dye which changes at the time of enzyme reaction or due to the products of enzyme reaction. The method is to drip brood Zc~ on this medium and. to measure changes ~.x~ the dye after a given period of time, either with the naked eye or optically, but there is much. hindrance from colored substa.nees in the blood and the accuracy is low.
On one hand, there are pxvposals for devices which, includ~.r~g the electrodes, can be thrown away after each measurement, but while mak~.n~ measurement operations extremely sample, Pram the standpoint of electrode te~,ials, such e.s platinum, a.nd their stz ut~ture, they cannot avoid becama.n~ very expensive devices. Also, while sputtering method ar vapor deposition method can be ~.sed for manufacturing the platinum electrodes, they wild.
be very expensive to manufacture.
As a throw-away method including the electroder~, a biosenaor was proposed in the laid peen Patent Application S~iO 61-29351. This biosensor, as shown in Fig. ~, hs.s an electrpde system 3p (30'), 31.
(31') and 32 (32') formed from such material as carbon by a method such as screen printing upon an insulating base 37, and after forming an insulating ~.ayer 33, the electrode system is covered by a multi-apertured medium 35 holding an oxidoreductase and an electron receptor, and the whale a,s unitized with a support 34 and a cover 36.
When a sample fluid is dripped onto the multi-~.0 apertured medium the o~cidoreductase and the e~.eatron receptor held by the mu~.ta.-apertured medium are dissolved by the sample flail, enzyme reaction proceeds between the substrates in the sample fluid and the electron receptor is reduced. ~fGer the reaction .is completed, Che reduced ~.5 el.eatron receptor is electroohema.ca~.ly oxidized and the substrate concentration within the sample fluid is' obtained from the value of o~c~.d3.zat~it~x~ Current at .hat time.
In the above noted measurement., a given voltage ~c~ fe provided to tkie sensor~;s elevtxode system, the current flowing between the eleet,rodes is measured, and the substrate concentration in the sample fluid is calculated on the basis of this signal.
In prior art structure such as that given 25 above, wasteful measuring wc~x~k vcaurred suc~a as inserting ~J
the throw-away sensors backwards and even making measurements with sensors :inserGGd backwards. Hence, there ~.s desire for a simple sensor and easily manipulated biaseneor device Gtr simply, rapidly and S ha.ghly accurately measuring specific components within a biological specimen such as bland, 8Ul~lARY OF THE Z~rTVEI~7TTiQl~
The subject invention farms a biosensor by providing, a projection or a depression on one part of a base material having at least a working electrode s.nd a counter electrode in the hr~usang itself, which supports this biasensor during insertion, extraction and ~.n.
between, a mating portion consisting of a groove, a depression or a projection is provided to mate with the 15 said projection or depression only when the sensor is inserted ira the prescribed direction, to form a biosenst~r meas~ering apparatus further having an acGivat~.nc~ switch in the mating portion.
Thus, by pravid~.ng a projection or a 20 depression, iG is possible to prevent the error of inserting the sensor backwards into the device, and have ' the activating switch of the device operate only when 3.nsertian id made in the prescribed direction.
w - e~ o ~~~e J'~) sRSE~ ~ESCRZ~~zort of ~~ ~~w~raGs Fig. ~ a,s an e~pladed Slant view of a bic~sensor in one embodiment of 'the subject inventa.on.
Fig. ~ i.s an external slant view of a biosensor in one embodiment of the subject invention.
Fig. 3 is a simulated erc~ss-section view of the mating portion of the biosensor and the biosensor measuring epparatus itself in cane embodiment. of the subject invention.
Fig. 4 is an external, slant view of a bic~ser~sor ~.n another embodiment oaf the sulaject invention.
~'~.J. ~ is a simulated crt~ss-gect~.c~n visor of the mating portion of the biosensor and the b~.c~sensor measuring apparatus itself in another embodxment~ of the 15 subject invention: .
Fig. 6 is an outside slant view of the ~~.osenaor in another emk~odiment of the subject invention.
Fig. 7 is a simulated cross-section view of the mating portion of the b~.osensor and the biosensor 2Q measuring apparatus itself in another embodiment of the subject invention.
''~~ ~~ ~~ ~ ~ ~ ~' Fig. 8 is a block diagram of the Control system of the biosensor measuring apparatus o~ an embodiment of the sLrbject invention.
Fig. 9 is an exploded slant view of a prior art 3~iosensor.
DETAIyEb D~SG'RIPTIt7N OF TF~E INVENTION
The r~ubjeCt invention is related to a biasensor and biosensor measuring apparatus capable o~ rapidly and easily determining with high accuracy a specific component within varzous b~.ological epe~imens, The subject invention is a biosensar charaoterized by tree provision of a protrusion ox a depression in a portion. of the sensor for the purpose o~
preventing backward insertion.
AL~P, tl'3~ ~Llb~A~"t 1TIV~.'11t.3.4112 i~ a bibFl411~30X' measuring apparatus characterized by having, in the main 3~ody free~.y supporting a sensor provided with a protrusion or a depression for preventing backward insertion, mating means Consisting of a ~rvove ox a depression or a protrusion mating with the aaie~
protrusion or depression onzy when the eaid sensor is inserted in the specified direction.
i~~~~~'~~~
Furthermore, the subject invention is a biosansor measuring apparatus characterized by provision of a swiech which turns on the driving power source by the insertion of the sensor into the connector, which is the insertion aperture for the sensor.
In the subject inventa.an, the reverse insertion of the sensor is prevented by a simple structure and an attar in the direction of its insertion a.s recognized without activating the apparatus.
The details of the subject invention will be given in the fo~.lowing together with its embodiments.
~'ig. ~. is an exploded s~,ant view of the biosensor and Fig. 2, i;~ its external slant view. Atop the base 1 are an saunter electrode ~ and a working electrode 5, lead 3 and lead 2 con-netted to same and an insulating layer 6.
Also, while not shewr~ i~a the figures, a reaction ~.ayer is farmed to saver the ctaunter electrode and the working electrode containing an enzyme and mediator (electron rec~:ptar) . ~A cover 9 is affixed above the base ~. over a spacer 7. 8 is the sampls~ supply hole, and frarn here the fluid to be tasted (specimen) a.s introduced above the counter electrode and the working electrode by means of the capil~.ary effect. With the ir~traductic~n of the fluid to be tested, the air within is expelled through air hole 2~ 10. ~.1 is an inverse i,nsex~tion prevent~.n~ protrusion to prevent backw,~rd insertion, and by this protru~~.or~ at is C~~x.9~e~~
possible to prevent the backward insertion into the biosensor apparatus itself, as related below.
Also, Fig. 3 shawl a state where the sensor 29 is inserted into the canxaector 13 of the apparatus itself (not sha~,Nn) from the direction shown by the arrow, and the epee atus itself can freely support the sensor. In the figure, 1~ is the switch deposed in the mating portion and is ganged tc~ the driving power supply.
Fig. 8 is a block diagram c~f the control system of the subject invexxtion's biosensc~r apparatus. The measurement steps using this apparatus are a~ follows.
First, when sensor 29 is properly inserted into the connector of the main body, r~w~.tch 12 activates the driving power supply, the insertion of the sea~eor ~9 is detected by the detector G~.rcui,t ~.4 and thrauc~la the CriU
~.5 components such a.s the current-voltage conversion amplifier 16, the A/p converter 1~ and the temperature sensor is are turned on.
Next, when the fluid to be tested is introdLlaed 20 into the sensor this is detected anal the measurement is commenced. Atter reactit~n takes plaee far a given time, a valtagre zs applied between the working electrode and the counter electrode via the reactic~xt voltage sett~,nc~
circuit 2~.
g ~rhe signal obtained by the measurement ig converted into concentration [in the ~aample7 key the signal processor composed of the GPU 15, etc., and is displayed on the BCD display 27.
~hhe driving power supply of the measuring apparatus is composed of the battery 25, etc., and power is supplied via the voltage regulator circuit 23, checking the voltage by ~:he battery checker 2~. .Also, 28 is a buzzer indicating the progress of the measuring operation, i~ is a signal genera.tox~ circua.t gener~.ting a pulse which is the operatxnr~ clock of tha apparatus, and 22 is a circuit which resets the CPU when, for instance, the measurement is halted while in progress. 20 is ~~
memory teach as an EFPROM) for storing the compensating values, etc., fox each ~.pparatus.
~Cn the above, the interior wall 0~ the connector is stepped and if the sensor i.g inserted backwards the protrusion for preventing reverse insertion touches the stepped poxtic~n and the ~cnsor will not go in 2o to the apecaEied position so that mis-ins~rtion is visually noticeable. Also, ~.r~ this case, the sensor will not press on the operating switch 12 either so Ghat the apparatus will not operate.
What is meant bx exxoneoug d~.rectian. of 25 inse~rt~.on ~.s when Front and back is reversed, or when an ~~~~~~~fl insertion xe attempted via the sample supply hole which is in the opposite direot~.on from the lead porti.an. Tn either ease) by providing a protrusion or a. depression in a pardon aF the base, the apparatus van be made to operate only when the insertion is made gram the specified direction.
Moreover, ether embc~d~.ments are shown in Figs.
4 a.nd. 5 and figs . 6 and 7 .
Fag, 4 showy an examp~.e where a depression 3~
is provided at a corner nes.r the sensor base's leads.
Fig. 5 shows the state where the sensor hd.s been inserted in a connector having a mating portion to mate w~.th this depression.
Fig. 6 shows the case where a depression 39 ie provided near the middle of the lead portion of the base.
~'ig. 7 shows the sts,te where the sensor has been inserted into a connector having a mating portion to iaate with this depresgian.
As shown ire the ,above embodiments, by providing the biosensor with a protrusion or a depression and by providing a mating portion in the main body of the biosensor apparatus to mate with tha.s protrusion or depression, it is poss3b~.e to prevent s, baclcwa.~Cd ~.naertian. Moreover, by providing the maGang portion ~~E ~~Jl~
with a switch to turn on the; driving power supply, it is possible to aperate the sv~itch only when the sensor ie inserted in the proper direction.
While in the above embodiments the backward ~.nsertion preuention protrusa.ons were l~p~ated at the aide of the serxsor, the same effect can be obtaznerl by placing this pratrusion can the upper or lower surfa.oe of the sensor. Alex, the location o~ the depression to be provided on th.e sensor is not limited to those t~hawr~ in the said embodiments,
BICJSE1~ISO~t ~1D MEASURIiVG APPARATUS USTIVG '.~Fi~ SAI~lE
BAC~GRpLTND 9F TF3E I1VVENTION
In the context that in recent years varinua biooenet~re utilizing singular catalytic action of enzymes have been developed and are undergoing clinical trial ~.~~lications, demand ex~.sts for biosen~c~rs capable of ma~Cing rap~.d and highly accurate measurementsa Taking glucose sensors as an excample, today 1Q when there is a marked increase ~.n the number ai persons afflicted with diabetes; the measurement and management oil blood sugar requ3,re ~xtr~xnely complicated steg~s if blood were to be centrifuged to make measurements of the plasma as done traditionally arid there is a demand for a sensor capable of making measurements from whole blood.
~t~ a simple type, there is one, eim~.lar to the test paper used in testing urine, of using a stick-shaped support and pla.cin.~ t;~ereon a medium containing an ea~:zyme reacting only to.a sugar (glucose) arid a dye which changes at the time of enzyme reaction or due to the products of enzyme reaction. The method is to drip brood Zc~ on this medium and. to measure changes ~.x~ the dye after a given period of time, either with the naked eye or optically, but there is much. hindrance from colored substa.nees in the blood and the accuracy is low.
On one hand, there are pxvposals for devices which, includ~.r~g the electrodes, can be thrown away after each measurement, but while mak~.n~ measurement operations extremely sample, Pram the standpoint of electrode te~,ials, such e.s platinum, a.nd their stz ut~ture, they cannot avoid becama.n~ very expensive devices. Also, while sputtering method ar vapor deposition method can be ~.sed for manufacturing the platinum electrodes, they wild.
be very expensive to manufacture.
As a throw-away method including the electroder~, a biosenaor was proposed in the laid peen Patent Application S~iO 61-29351. This biosensor, as shown in Fig. ~, hs.s an electrpde system 3p (30'), 31.
(31') and 32 (32') formed from such material as carbon by a method such as screen printing upon an insulating base 37, and after forming an insulating ~.ayer 33, the electrode system is covered by a multi-apertured medium 35 holding an oxidoreductase and an electron receptor, and the whale a,s unitized with a support 34 and a cover 36.
When a sample fluid is dripped onto the multi-~.0 apertured medium the o~cidoreductase and the e~.eatron receptor held by the mu~.ta.-apertured medium are dissolved by the sample flail, enzyme reaction proceeds between the substrates in the sample fluid and the electron receptor is reduced. ~fGer the reaction .is completed, Che reduced ~.5 el.eatron receptor is electroohema.ca~.ly oxidized and the substrate concentration within the sample fluid is' obtained from the value of o~c~.d3.zat~it~x~ Current at .hat time.
In the above noted measurement., a given voltage ~c~ fe provided to tkie sensor~;s elevtxode system, the current flowing between the eleet,rodes is measured, and the substrate concentration in the sample fluid is calculated on the basis of this signal.
In prior art structure such as that given 25 above, wasteful measuring wc~x~k vcaurred suc~a as inserting ~J
the throw-away sensors backwards and even making measurements with sensors :inserGGd backwards. Hence, there ~.s desire for a simple sensor and easily manipulated biaseneor device Gtr simply, rapidly and S ha.ghly accurately measuring specific components within a biological specimen such as bland, 8Ul~lARY OF THE Z~rTVEI~7TTiQl~
The subject invention farms a biosensor by providing, a projection or a depression on one part of a base material having at least a working electrode s.nd a counter electrode in the hr~usang itself, which supports this biasensor during insertion, extraction and ~.n.
between, a mating portion consisting of a groove, a depression or a projection is provided to mate with the 15 said projection or depression only when the sensor is inserted ira the prescribed direction, to form a biosenst~r meas~ering apparatus further having an acGivat~.nc~ switch in the mating portion.
Thus, by pravid~.ng a projection or a 20 depression, iG is possible to prevent the error of inserting the sensor backwards into the device, and have ' the activating switch of the device operate only when 3.nsertian id made in the prescribed direction.
w - e~ o ~~~e J'~) sRSE~ ~ESCRZ~~zort of ~~ ~~w~raGs Fig. ~ a,s an e~pladed Slant view of a bic~sensor in one embodiment of 'the subject inventa.on.
Fig. ~ i.s an external slant view of a biosensor in one embodiment of the subject invention.
Fig. 3 is a simulated erc~ss-section view of the mating portion of the biosensor and the biosensor measuring epparatus itself in cane embodiment. of the subject invention.
Fig. 4 is an external, slant view of a bic~ser~sor ~.n another embodiment oaf the sulaject invention.
~'~.J. ~ is a simulated crt~ss-gect~.c~n visor of the mating portion of the biosensor and the b~.c~sensor measuring apparatus itself in another embodxment~ of the 15 subject invention: .
Fig. 6 is an outside slant view of the ~~.osenaor in another emk~odiment of the subject invention.
Fig. 7 is a simulated cross-section view of the mating portion of the b~.osensor and the biosensor 2Q measuring apparatus itself in another embodiment of the subject invention.
''~~ ~~ ~~ ~ ~ ~ ~' Fig. 8 is a block diagram of the Control system of the biosensor measuring apparatus o~ an embodiment of the sLrbject invention.
Fig. 9 is an exploded slant view of a prior art 3~iosensor.
DETAIyEb D~SG'RIPTIt7N OF TF~E INVENTION
The r~ubjeCt invention is related to a biasensor and biosensor measuring apparatus capable o~ rapidly and easily determining with high accuracy a specific component within varzous b~.ological epe~imens, The subject invention is a biosensar charaoterized by tree provision of a protrusion ox a depression in a portion. of the sensor for the purpose o~
preventing backward insertion.
AL~P, tl'3~ ~Llb~A~"t 1TIV~.'11t.3.4112 i~ a bibFl411~30X' measuring apparatus characterized by having, in the main 3~ody free~.y supporting a sensor provided with a protrusion or a depression for preventing backward insertion, mating means Consisting of a ~rvove ox a depression or a protrusion mating with the aaie~
protrusion or depression onzy when the eaid sensor is inserted in the specified direction.
i~~~~~'~~~
Furthermore, the subject invention is a biosansor measuring apparatus characterized by provision of a swiech which turns on the driving power source by the insertion of the sensor into the connector, which is the insertion aperture for the sensor.
In the subject inventa.an, the reverse insertion of the sensor is prevented by a simple structure and an attar in the direction of its insertion a.s recognized without activating the apparatus.
The details of the subject invention will be given in the fo~.lowing together with its embodiments.
~'ig. ~. is an exploded s~,ant view of the biosensor and Fig. 2, i;~ its external slant view. Atop the base 1 are an saunter electrode ~ and a working electrode 5, lead 3 and lead 2 con-netted to same and an insulating layer 6.
Also, while not shewr~ i~a the figures, a reaction ~.ayer is farmed to saver the ctaunter electrode and the working electrode containing an enzyme and mediator (electron rec~:ptar) . ~A cover 9 is affixed above the base ~. over a spacer 7. 8 is the sampls~ supply hole, and frarn here the fluid to be tasted (specimen) a.s introduced above the counter electrode and the working electrode by means of the capil~.ary effect. With the ir~traductic~n of the fluid to be tested, the air within is expelled through air hole 2~ 10. ~.1 is an inverse i,nsex~tion prevent~.n~ protrusion to prevent backw,~rd insertion, and by this protru~~.or~ at is C~~x.9~e~~
possible to prevent the backward insertion into the biosensor apparatus itself, as related below.
Also, Fig. 3 shawl a state where the sensor 29 is inserted into the canxaector 13 of the apparatus itself (not sha~,Nn) from the direction shown by the arrow, and the epee atus itself can freely support the sensor. In the figure, 1~ is the switch deposed in the mating portion and is ganged tc~ the driving power supply.
Fig. 8 is a block diagram c~f the control system of the subject invexxtion's biosensc~r apparatus. The measurement steps using this apparatus are a~ follows.
First, when sensor 29 is properly inserted into the connector of the main body, r~w~.tch 12 activates the driving power supply, the insertion of the sea~eor ~9 is detected by the detector G~.rcui,t ~.4 and thrauc~la the CriU
~.5 components such a.s the current-voltage conversion amplifier 16, the A/p converter 1~ and the temperature sensor is are turned on.
Next, when the fluid to be tested is introdLlaed 20 into the sensor this is detected anal the measurement is commenced. Atter reactit~n takes plaee far a given time, a valtagre zs applied between the working electrode and the counter electrode via the reactic~xt voltage sett~,nc~
circuit 2~.
g ~rhe signal obtained by the measurement ig converted into concentration [in the ~aample7 key the signal processor composed of the GPU 15, etc., and is displayed on the BCD display 27.
~hhe driving power supply of the measuring apparatus is composed of the battery 25, etc., and power is supplied via the voltage regulator circuit 23, checking the voltage by ~:he battery checker 2~. .Also, 28 is a buzzer indicating the progress of the measuring operation, i~ is a signal genera.tox~ circua.t gener~.ting a pulse which is the operatxnr~ clock of tha apparatus, and 22 is a circuit which resets the CPU when, for instance, the measurement is halted while in progress. 20 is ~~
memory teach as an EFPROM) for storing the compensating values, etc., fox each ~.pparatus.
~Cn the above, the interior wall 0~ the connector is stepped and if the sensor i.g inserted backwards the protrusion for preventing reverse insertion touches the stepped poxtic~n and the ~cnsor will not go in 2o to the apecaEied position so that mis-ins~rtion is visually noticeable. Also, ~.r~ this case, the sensor will not press on the operating switch 12 either so Ghat the apparatus will not operate.
What is meant bx exxoneoug d~.rectian. of 25 inse~rt~.on ~.s when Front and back is reversed, or when an ~~~~~~~fl insertion xe attempted via the sample supply hole which is in the opposite direot~.on from the lead porti.an. Tn either ease) by providing a protrusion or a. depression in a pardon aF the base, the apparatus van be made to operate only when the insertion is made gram the specified direction.
Moreover, ether embc~d~.ments are shown in Figs.
4 a.nd. 5 and figs . 6 and 7 .
Fag, 4 showy an examp~.e where a depression 3~
is provided at a corner nes.r the sensor base's leads.
Fig. 5 shows the state where the sensor hd.s been inserted in a connector having a mating portion to mate w~.th this depression.
Fig. 6 shows the case where a depression 39 ie provided near the middle of the lead portion of the base.
~'ig. 7 shows the sts,te where the sensor has been inserted into a connector having a mating portion to iaate with this depresgian.
As shown ire the ,above embodiments, by providing the biosensor with a protrusion or a depression and by providing a mating portion in the main body of the biosensor apparatus to mate with tha.s protrusion or depression, it is poss3b~.e to prevent s, baclcwa.~Cd ~.naertian. Moreover, by providing the maGang portion ~~E ~~Jl~
with a switch to turn on the; driving power supply, it is possible to aperate the sv~itch only when the sensor ie inserted in the proper direction.
While in the above embodiments the backward ~.nsertion preuention protrusa.ons were l~p~ated at the aide of the serxsor, the same effect can be obtaznerl by placing this pratrusion can the upper or lower surfa.oe of the sensor. Alex, the location o~ the depression to be provided on th.e sensor is not limited to those t~hawr~ in the said embodiments,
Claims (6)
1. A biosensor having a base with a front end, a back end, and two sides, wherein said front end is for insertion into a connector comprising an alignment control protrusion only on one of the sides of the base, wherein the base has at least a working electrode and a counter electrode together with leads connected to each of said electrodes, said alignment control means being separate from said electrodes and said leads.
2. A biosensor measuring apparatus comprising:
a connector freely supporting a biosensor, the biosensor having a base with a front end, a back end, and two sides, wherein said front end is for insertion into a connector, said biosensor having an alignment control means including a protrusion only on one of the sides of the base, the base also having at least a working electrode and a counter electrode together with leads connected to each of said electrodes, said alignment control means being separate from said leads and said electrodes, a driving power supply to supply a voltage to the said biosensor;
signal processing means to process the current from the electrodes of said biosensor;
display means to display the output of said signal processing means; and mechanical switching means to turn on said driving power supply when said biosensor is inserted in a specified direction in a support means.
a connector freely supporting a biosensor, the biosensor having a base with a front end, a back end, and two sides, wherein said front end is for insertion into a connector, said biosensor having an alignment control means including a protrusion only on one of the sides of the base, the base also having at least a working electrode and a counter electrode together with leads connected to each of said electrodes, said alignment control means being separate from said leads and said electrodes, a driving power supply to supply a voltage to the said biosensor;
signal processing means to process the current from the electrodes of said biosensor;
display means to display the output of said signal processing means; and mechanical switching means to turn on said driving power supply when said biosensor is inserted in a specified direction in a support means.
3. A biosensor measuring apparatus as claimed in claim 2, wherein said connector having a wall surface which contacts said protrusion when said biosensor is inserted in the specified direction and contacts a tip portion of said biosensor when inserted in the opposite direction.
4. A biosensor comprising:
a base having a working electrode and a counter electrode disposed on a surface of the base, the base also having respective leads connected to each of the electrodes, the base also having a front end, a back end and two sides wherein the front end is for insertion into a connector, the base also having an alignment control protrusion only on one of the sides thereof for ensuring proper insertion of the biosensor into a receiving apparatus;
a spacer disposed on the surface of the base, the spacer having a slot for defining a specimen supply aperture to provide a specimen with direct access to the electrodes; and a cover disposed so to sandwich the spacer between itself and the base, the cover having a hole which overlays a portion of the slot to allow air to escape when the specimen enters the specimen supply aperture.
a base having a working electrode and a counter electrode disposed on a surface of the base, the base also having respective leads connected to each of the electrodes, the base also having a front end, a back end and two sides wherein the front end is for insertion into a connector, the base also having an alignment control protrusion only on one of the sides thereof for ensuring proper insertion of the biosensor into a receiving apparatus;
a spacer disposed on the surface of the base, the spacer having a slot for defining a specimen supply aperture to provide a specimen with direct access to the electrodes; and a cover disposed so to sandwich the spacer between itself and the base, the cover having a hole which overlays a portion of the slot to allow air to escape when the specimen enters the specimen supply aperture.
5. The biosensor of claim 4 wherein the spacer and the cover have approximately the same dimensions and the base extends beyond the dimensions of the spacer and cover in order to expose the leads disposed thereon.
6. A biosensor measuring apparatus comprising:
a connector having an alignment control protrusion;
a biosensor having an alignment control slot disposed off-center in a front end of a base for mating with the alignment control protrusion of the connector to ensure proper insertion of the biosensor in the connector, the biosensor having at least a working electrode and a counter electrode together with leads connected to each of said electrodes;
a driving power supply to supply a voltage to the biosensor;
signal processing means to process the current from the electrodes of said biosensor;
display means to display the output of said signal processing means; and, mechanical switching means disposed to turn on said driving power supply only when said biosensor is properly inserted into the connector.
a connector having an alignment control protrusion;
a biosensor having an alignment control slot disposed off-center in a front end of a base for mating with the alignment control protrusion of the connector to ensure proper insertion of the biosensor in the connector, the biosensor having at least a working electrode and a counter electrode together with leads connected to each of said electrodes;
a driving power supply to supply a voltage to the biosensor;
signal processing means to process the current from the electrodes of said biosensor;
display means to display the output of said signal processing means; and, mechanical switching means disposed to turn on said driving power supply only when said biosensor is properly inserted into the connector.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2063297 CA2063297C (en) | 1992-03-18 | 1992-03-18 | Biosensor and measuring apparatus using the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2063297 CA2063297C (en) | 1992-03-18 | 1992-03-18 | Biosensor and measuring apparatus using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2063297A1 CA2063297A1 (en) | 1993-09-19 |
CA2063297C true CA2063297C (en) | 1999-11-09 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA 2063297 Expired - Lifetime CA2063297C (en) | 1992-03-18 | 1992-03-18 | Biosensor and measuring apparatus using the same |
Country Status (1)
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CA (1) | CA2063297C (en) |
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1992
- 1992-03-18 CA CA 2063297 patent/CA2063297C/en not_active Expired - Lifetime
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CA2063297A1 (en) | 1993-09-19 |
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