CA2062941A1 - Procede pour lyophiliser les cellules, matieres et plaquettes de type cellules dans un melange de polymeres amphipatiques biocompatibles - Google Patents
Procede pour lyophiliser les cellules, matieres et plaquettes de type cellules dans un melange de polymeres amphipatiques biocompatiblesInfo
- Publication number
- CA2062941A1 CA2062941A1 CA002062941A CA2062941A CA2062941A1 CA 2062941 A1 CA2062941 A1 CA 2062941A1 CA 002062941 A CA002062941 A CA 002062941A CA 2062941 A CA2062941 A CA 2062941A CA 2062941 A1 CA2062941 A1 CA 2062941A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- medium according
- medium
- molecular weight
- red blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000012637 allosteric effector Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
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- 235000010323 ascorbic acid Nutrition 0.000 description 1
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- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 108010002255 deoxyhemoglobin Proteins 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
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- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000034737 hemoglobinopathy Diseases 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
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- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 description 1
- 230000004108 pentose phosphate pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
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- 229920001983 poloxamer Polymers 0.000 description 1
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- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- WPPDXAHGCGPUPK-UHFFFAOYSA-N red 2 Chemical compound C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=2C=3C4=CC=C5C6=CC=C7C8=C(C=9C=CC=CC=9)C9=CC=CC=C9C(C=9C=CC=CC=9)=C8C8=CC=C(C6=C87)C(C=35)=CC=2)C4=C1C1=CC=CC=C1 WPPDXAHGCGPUPK-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- PXLIDIMHPNPGMH-UHFFFAOYSA-N sodium chromate Chemical compound [Na+].[Na+].[O-][Cr]([O-])(=O)=O PXLIDIMHPNPGMH-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52895590A | 1990-05-25 | 1990-05-25 | |
US528,955 | 1990-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2062941A1 true CA2062941A1 (fr) | 1991-11-26 |
Family
ID=24107917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002062941A Abandoned CA2062941A1 (fr) | 1990-05-25 | 1991-05-24 | Procede pour lyophiliser les cellules, matieres et plaquettes de type cellules dans un melange de polymeres amphipatiques biocompatibles |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0484519A4 (fr) |
JP (1) | JPH05501419A (fr) |
AU (1) | AU8064691A (fr) |
CA (1) | CA2062941A1 (fr) |
IL (1) | IL98269A0 (fr) |
WO (1) | WO1991018504A1 (fr) |
ZA (1) | ZA913995B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL90188A0 (en) * | 1988-05-18 | 1989-12-15 | Cryopharm Corp | Process and medium for the lyophilization of erythrocytes |
US5045446A (en) * | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
US5213814A (en) * | 1989-04-10 | 1993-05-25 | Cryopharm Corporation | Lyophilized and reconstituted blood platelet compositions |
AU650045B2 (en) * | 1990-09-12 | 1994-06-09 | Lifecell Corporation | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
US8067149B2 (en) | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
US6060233A (en) * | 1996-06-14 | 2000-05-09 | Biostore New Zealand, Ltd | Methods for the lyophilization of platelets, platelet membranes or erythrocytes |
US6037116A (en) * | 1996-06-14 | 2000-03-14 | Biostore New Zealand, Ltd. | Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials |
WO1997047192A1 (fr) * | 1996-06-14 | 1997-12-18 | Biostore New Zealand Limited | Compositions et procedes de conservation de tissus vivants |
US6361933B1 (en) | 1996-06-14 | 2002-03-26 | Biostore New Zealand Limited | Solutions for the preservation of tissues |
US6114107A (en) * | 1996-06-14 | 2000-09-05 | Biostore New Zealand Limited | Composition comprising raffinose, TMAO, sodium citrate and methods for the preservation of living tissues |
US5827640A (en) * | 1996-06-14 | 1998-10-27 | Biostore New Zealand Limited | Methods for the preservation of cells and tissues using trimethylamine oxide or betaine with raffinose or trehalose |
US5879875A (en) * | 1996-06-14 | 1999-03-09 | Biostore New Zealand | Compositions and methods for the preservation of living tissues |
US6040132A (en) * | 1996-06-14 | 2000-03-21 | Biostore New Zealand, Ltd. | Methods for the lyophilization of living biological materials |
US5962213A (en) * | 1996-06-14 | 1999-10-05 | Biostore New Zealand Limited | Compositions and methods for the preservation of living tissues |
US6743575B2 (en) | 1996-06-14 | 2004-06-01 | Biostore New Zealand Ltd. | Compositions and methods for the preservation of living tissues |
ATE316757T1 (de) | 1998-05-26 | 2006-02-15 | Lifecell Corp | Cryokonservierung menschlicher roter blutzellen |
US6933326B1 (en) | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
US7112576B1 (en) | 1999-12-10 | 2006-09-26 | Regents Of The University Of Minnesota | Compositions and methods for cryopreservation of peripheral blood lymphocytes |
JP2002226368A (ja) * | 2001-02-02 | 2002-08-14 | Fuji Chem Ind Co Ltd | 赤血球の酸化的損傷抑制剤 |
GB0230152D0 (en) * | 2002-12-24 | 2003-02-05 | Sinvent As | Product |
EP1929289B1 (fr) | 2005-09-26 | 2018-02-21 | Lifecell Corporation | Composition de plaquettes dessechees |
KR101410065B1 (ko) * | 2011-12-09 | 2014-06-27 | 테고사이언스 (주) | 세포의 유용물질을 상온에서 안정하게 보존하는 방법 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3303662A (en) * | 1963-03-01 | 1967-02-14 | Union Carbide Corp | Process for cell preservation |
BE643051A (fr) * | 1963-05-31 | 1964-05-15 | ||
US3915794A (en) * | 1973-02-09 | 1975-10-28 | Rit Rech Ind Therapeut | Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them |
DE2310964A1 (de) * | 1973-03-02 | 1974-09-05 | Schering Ag | Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation |
US4963362A (en) * | 1987-08-07 | 1990-10-16 | Regents Of The University Of Minnesota | Freeze-dried liposome mixture containing cyclosporin |
US5213814A (en) * | 1989-04-10 | 1993-05-25 | Cryopharm Corporation | Lyophilized and reconstituted blood platelet compositions |
US5045446A (en) * | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
IL90188A0 (en) * | 1988-05-18 | 1989-12-15 | Cryopharm Corp | Process and medium for the lyophilization of erythrocytes |
US5178884A (en) * | 1988-05-18 | 1993-01-12 | Cryopharm Corporation | Lyophilized and reconstituted red blood cell compositions |
US4874690A (en) * | 1988-08-26 | 1989-10-17 | Cryopharm Corporation | Lyophilization of red blood cells |
WO1991016060A1 (fr) * | 1990-04-16 | 1991-10-31 | Cryopharm Corporation | Procede pour rendre inactifs des contaminants sanguins viraux et bacteriens |
AU1415992A (en) * | 1991-02-15 | 1992-09-15 | Cryopharm Corporation | Method of lyophilization and reconstitution of mixtures of nucleated non-mammalian cells and blood matter |
-
1991
- 1991-05-24 WO PCT/US1991/003544 patent/WO1991018504A1/fr not_active Application Discontinuation
- 1991-05-24 CA CA002062941A patent/CA2062941A1/fr not_active Abandoned
- 1991-05-24 EP EP19910912119 patent/EP0484519A4/en not_active Withdrawn
- 1991-05-24 AU AU80646/91A patent/AU8064691A/en not_active Abandoned
- 1991-05-24 JP JP3511192A patent/JPH05501419A/ja active Pending
- 1991-05-26 IL IL98269A patent/IL98269A0/xx unknown
- 1991-05-27 ZA ZA913995A patent/ZA913995B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0484519A1 (fr) | 1992-05-13 |
ZA913995B (en) | 1992-03-25 |
AU8064691A (en) | 1991-12-31 |
JPH05501419A (ja) | 1993-03-18 |
WO1991018504A1 (fr) | 1991-12-12 |
IL98269A0 (en) | 1992-06-21 |
EP0484519A4 (en) | 1993-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |