CA2060507A1 - Compositions anticoagulantes a base de facteur xa - Google Patents
Compositions anticoagulantes a base de facteur xaInfo
- Publication number
- CA2060507A1 CA2060507A1 CA2060507A CA2060507A CA2060507A1 CA 2060507 A1 CA2060507 A1 CA 2060507A1 CA 2060507 A CA2060507 A CA 2060507A CA 2060507 A CA2060507 A CA 2060507A CA 2060507 A1 CA2060507 A1 CA 2060507A1
- Authority
- CA
- Canada
- Prior art keywords
- factor
- inactivated
- vivo
- active
- serine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/367,544 US5120537A (en) | 1989-06-14 | 1989-06-14 | Factor xa based anticoagulant compositions |
US367,544 | 1989-06-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2060507A1 true CA2060507A1 (fr) | 1990-12-15 |
CA2060507C CA2060507C (fr) | 1996-12-10 |
Family
ID=23447608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002060507A Expired - Fee Related CA2060507C (fr) | 1989-06-14 | 1990-06-06 | Compositions anticoagulantes a base de facteur xa |
Country Status (10)
Country | Link |
---|---|
US (1) | US5120537A (fr) |
EP (1) | EP0477274B1 (fr) |
JP (1) | JPH0784392B2 (fr) |
AT (1) | ATE101796T1 (fr) |
AU (1) | AU630477B2 (fr) |
CA (1) | CA2060507C (fr) |
DE (1) | DE69006851T2 (fr) |
DK (1) | DK0477274T3 (fr) |
ES (1) | ES2063365T3 (fr) |
WO (1) | WO1990015619A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS136091A3 (en) * | 1990-05-10 | 1992-04-15 | Zymo Genetics | Agents for determining thrombi and their application |
US5597799A (en) * | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
US20040072757A1 (en) * | 1990-09-04 | 2004-04-15 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
US5278144A (en) * | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
US5861374A (en) * | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
US5788965A (en) * | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US5817788A (en) * | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
US5716795A (en) * | 1991-10-04 | 1998-02-10 | Matschiner; John T. | Thrombomodulin-based coagulometric assay of the protein C system |
WO1993007491A1 (fr) * | 1991-10-04 | 1993-04-15 | Board Of Regents Of The University Of Nebraska | Methode en un temps base sur la thrombomoduline soluble de determination de l'etat de proteines inhibant la coagulation dependante de la vitamine k |
US6039944A (en) * | 1992-02-28 | 2000-03-21 | Zymogenetics, Inc. | Modified Factor VII |
US5266462A (en) * | 1992-06-03 | 1993-11-30 | Baxter Diagnostics Inc. | Measurement of platelet activities |
US5589571A (en) * | 1994-10-28 | 1996-12-31 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
HUP9700603A3 (en) * | 1996-03-20 | 2001-08-28 | Baxter Ag | Pharmaceutical preparation for the treatment of blood coagulation disorders |
IL149398A0 (en) * | 1999-11-02 | 2002-11-10 | Aventis Pharma Gmbh | USE OF RUSSELL'S VIPER VENOM-INDUCED PLASMA FACTOR Xa ACTIVITY TO MONITOR THE ACTIVITY OF FACTOR Xa INHIBITORS |
WO2001051067A1 (fr) * | 2000-01-13 | 2001-07-19 | Baxter International Inc. | Composition anticoagulante a facteurs sanguins inactives multiples |
AU2002359790A1 (en) * | 2001-12-21 | 2003-07-15 | Charlotte Mecklenburg Hospital Authority Doing Business As Carolinas Medical Center | Regulation of nad(p)h oxidase growth and transcription in melanoma cells |
AU2003237870A1 (en) * | 2002-06-07 | 2003-12-22 | The Brigham & Women's Hospital, Inc. | Method and composition for inhibing or slowing blood coagulation |
US7771956B2 (en) * | 2003-06-30 | 2010-08-10 | Brigham & Women's Hospital, Inc. | Method for detecting the presence of a phospholipid |
GB0710321D0 (en) * | 2007-05-30 | 2007-07-11 | Nhs Blood & Transplant | Method |
US9956272B2 (en) | 2007-05-30 | 2018-05-01 | Bio Products Laboratory Limited | Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same |
SG185263A1 (en) * | 2007-09-28 | 2012-11-29 | Portola Pharm Inc | Antidotes for factor xa inhibitors and methods of using the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
EP0430930B1 (fr) * | 1985-03-15 | 1993-09-01 | Btg International Limited | Protéine facteur IX |
US4832849A (en) * | 1988-06-16 | 1989-05-23 | Merrell Dow Pharmaceuticals Inc. | Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii |
-
1989
- 1989-06-14 US US07/367,544 patent/US5120537A/en not_active Expired - Lifetime
-
1990
- 1990-06-06 EP EP90909958A patent/EP0477274B1/fr not_active Expired - Lifetime
- 1990-06-06 DE DE69006851T patent/DE69006851T2/de not_active Expired - Fee Related
- 1990-06-06 ES ES90909958T patent/ES2063365T3/es not_active Expired - Lifetime
- 1990-06-06 CA CA002060507A patent/CA2060507C/fr not_active Expired - Fee Related
- 1990-06-06 JP JP2509853A patent/JPH0784392B2/ja not_active Expired - Fee Related
- 1990-06-06 AT AT90909958T patent/ATE101796T1/de not_active IP Right Cessation
- 1990-06-06 DK DK90909958.2T patent/DK0477274T3/da active
- 1990-06-06 WO PCT/US1990/003208 patent/WO1990015619A1/fr active IP Right Grant
- 1990-06-06 AU AU59226/90A patent/AU630477B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ES2063365T3 (es) | 1995-01-01 |
CA2060507C (fr) | 1996-12-10 |
DE69006851D1 (de) | 1994-03-31 |
JPH0784392B2 (ja) | 1995-09-13 |
ATE101796T1 (de) | 1994-03-15 |
DE69006851T2 (de) | 1994-06-30 |
DK0477274T3 (da) | 1994-03-28 |
WO1990015619A1 (fr) | 1990-12-27 |
US5120537A (en) | 1992-06-09 |
JPH04505765A (ja) | 1992-10-08 |
AU630477B2 (en) | 1992-10-29 |
AU5922690A (en) | 1991-01-08 |
EP0477274A1 (fr) | 1992-04-01 |
EP0477274B1 (fr) | 1994-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |