CA2056129A1 - Process for preparing 1,5-benzothiazepine derivative - Google Patents
Process for preparing 1,5-benzothiazepine derivativeInfo
- Publication number
- CA2056129A1 CA2056129A1 CA2056129A CA2056129A CA2056129A1 CA 2056129 A1 CA2056129 A1 CA 2056129A1 CA 2056129 A CA2056129 A CA 2056129A CA 2056129 A CA2056129 A CA 2056129A CA 2056129 A1 CA2056129 A1 CA 2056129A1
- Authority
- CA
- Canada
- Prior art keywords
- preparing
- methoxyphenyl
- dihydro
- ethyl
- benzothiazepine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 5
- WFDIJRYMOXRFFG-UHFFFAOYSA-N acetic acid anhydride Natural products CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 4
- HSUGRBWQSSZJOP-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate Chemical compound C1=CC(OC)=CC=C1C1C(OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- NZHUXMZTSSZXSB-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one Chemical compound C1=CC(OC)=CC=C1C1C(O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 NZHUXMZTSSZXSB-UHFFFAOYSA-N 0.000 abstract 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Control Of Driving Devices And Active Controlling Of Vehicle (AREA)
- Control Of Vehicle Engines Or Engines For Specific Uses (AREA)
- Combined Controls Of Internal Combustion Engines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing hydrochloride of 3-acetoxy-2, 3-dihydro-5-[ 2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)- 1, 5-benzothiazepin-4(5H)-one which comprises reacting 3-hydroxy-2, 3-dihydro-5-[2-(dimethyl-amino)ethyl]-2-(p-methoxyphenyl)-1, 5-benzothiazepin-4(5H)-one with acetyl chloride in acetic acid or a mixed solvent of acetic acid and acetic anhydride. According to the process, hydrochloride of 3-acetoxy-2, 3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzo-thiazepin-4(5H)-one is readily obtained in one step.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP336010/1990 | 1990-11-29 | ||
JP2326010A JPH04197837A (en) | 1990-11-29 | 1990-11-29 | Event-driven type computer for controlling vehicle |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2056129A1 true CA2056129A1 (en) | 1992-05-30 |
CA2056129C CA2056129C (en) | 1996-10-15 |
Family
ID=18183089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002056129A Expired - Lifetime CA2056129C (en) | 1990-11-29 | 1991-11-28 | Process for preparing 1,5-benzothiazepine derivative |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPH04197837A (en) |
CA (1) | CA2056129C (en) |
-
1990
- 1990-11-29 JP JP2326010A patent/JPH04197837A/en active Pending
-
1991
- 1991-11-28 CA CA002056129A patent/CA2056129C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH04197837A (en) | 1992-07-17 |
CA2056129C (en) | 1996-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |