CA2044748A1 - Pyrazolopyrimidinone antianginal agents - Google Patents

Pyrazolopyrimidinone antianginal agents

Info

Publication number
CA2044748A1
CA2044748A1 CA 2044748 CA2044748A CA2044748A1 CA 2044748 A1 CA2044748 A1 CA 2044748A1 CA 2044748 CA2044748 CA 2044748 CA 2044748 A CA2044748 A CA 2044748A CA 2044748 A1 CA2044748 A1 CA 2044748A1
Authority
CA
Canada
Prior art keywords
c1
c3
c6
alkyl
c2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2044748
Other languages
French (fr)
Other versions
CA2044748C (en
Inventor
Andrew S. Bell
David Brown
Nicholas K. Terrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to GB909013750A priority Critical patent/GB9013750D0/en
Priority to GB9013750.6 priority
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2044748A1 publication Critical patent/CA2044748A1/en
Application granted granted Critical
Publication of CA2044748C publication Critical patent/CA2044748C/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10677918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2044748(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05BCONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00Program-control systems
    • G05B2219/30Nc systems
    • G05B2219/36Nc in input of data, input key till input tape
    • G05B2219/36395Load local computer program from host, data transfer ram to rom, BTR

Abstract

Compounds of the formula:

(see fig.I) wherein R1 is H, C1-C3 alkyl, C3-C5 cycloalkyl or C1-C3 perfluoroalkyl; R2 is H, C1-C6 alkyl optionally substituted by CH, C1-C3 alkoxy or C3-C6 cycloalkyl, or C1-C3 perfluoroalkyl; R3 is C1-C3 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C7 cycloalkyl, C1-C6 perfluoroalkyl or (C3-C6 cycloalkyl)C1-C6 alkyl; R4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, morpholino, or 4-N-(R6)-piperazinyl group; R5 is H, C1-C4 alkyl, C1-C3 alkoxy, NR7R8 or CONR7R8R6 is H, C1-C6 alkyl, (C1-C3 alkoxy) C2-C6 alkyl, hydroxy C2-C6 alkyl, (R7R8N)C2-C6 alkyl, (R7R8NCO)C1-C6 alkyl, CONR7R8, CSNR7R8 or C(NH)NR7R8; R7 and R8 are each independently H, C1-C4 alkyl, (C1-C3 alkoxy)C2-C4 alkyl or hydroxy C2-C4 alkyl; and pharmaceutically acceptable salts thereof, are selective cGMP PDE
inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.
CA 2044748 1990-06-20 1991-06-17 Pyrazolopyrimidinone antianginal agents Expired - Lifetime CA2044748C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB909013750A GB9013750D0 (en) 1990-06-20 1990-06-20 Therapeutic agents
GB9013750.6 1990-06-20

Publications (2)

Publication Number Publication Date
CA2044748A1 true CA2044748A1 (en) 1991-12-21
CA2044748C CA2044748C (en) 1998-02-03

Family

ID=10677918

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2044748 Expired - Lifetime CA2044748C (en) 1990-06-20 1991-06-17 Pyrazolopyrimidinone antianginal agents

Country Status (30)

Country Link
EP (1) EP0463756B1 (en)
JP (1) JPH07121945B2 (en)
KR (1) KR940006628B1 (en)
CN (1) CN1028758C (en)
AT (1) AT121403T (en)
AU (1) AU626757B2 (en)
BR (1) BR9102560A (en)
CA (1) CA2044748C (en)
CY (1) CY1971A (en)
CZ (1) CZ279289B6 (en)
DE (3) DE69108991D1 (en)
DK (1) DK0463756T3 (en)
EG (1) EG19651A (en)
ES (1) ES2071919T4 (en)
FI (1) FI95132C (en)
GB (1) GB9013750D0 (en)
HK (1) HK219496A (en)
HU (1) HU218945B (en)
IE (1) IE66040B1 (en)
IL (1) IL98482A (en)
LU (1) LU90360I2 (en)
NL (1) NL990005I2 (en)
NO (2) NO178029C (en)
NZ (1) NZ238586A (en)
PL (1) PL166490B1 (en)
PT (1) PT98011B (en)
RU (2) RU2047617C1 (en)
TW (1) TW222633B (en)
YU (1) YU47962B (en)
ZA (1) ZA9104707B (en)

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