CA2042113A1 - Spiro-isoquinoleinepyrrolidine et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase - Google Patents

Spiro-isoquinoleinepyrrolidine et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase

Info

Publication number
CA2042113A1
CA2042113A1 CA002042113A CA2042113A CA2042113A1 CA 2042113 A1 CA2042113 A1 CA 2042113A1 CA 002042113 A CA002042113 A CA 002042113A CA 2042113 A CA2042113 A CA 2042113A CA 2042113 A1 CA2042113 A1 CA 2042113A1
Authority
CA
Canada
Prior art keywords
carbon atoms
aryl
pyrrolidines
isoquinoline
spiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002042113A
Other languages
English (en)
Other versions
CA2042113C (fr
Inventor
Michael S. Malamas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth
American Home Products Corporation
Michael S. Malamas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth, American Home Products Corporation, Michael S. Malamas filed Critical Wyeth
Publication of CA2042113A1 publication Critical patent/CA2042113A1/fr
Application granted granted Critical
Publication of CA2042113C publication Critical patent/CA2042113C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002042113A 1990-05-21 1991-05-08 Spiro-isoquinoleinepyrrolidine et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase Expired - Fee Related CA2042113C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US526,356 1990-05-21
US07/526,356 US5037831A (en) 1990-05-21 1990-05-21 Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
CA2042113A1 true CA2042113A1 (fr) 1991-11-22
CA2042113C CA2042113C (fr) 2001-08-28

Family

ID=24097007

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002042113A Expired - Fee Related CA2042113C (fr) 1990-05-21 1991-05-08 Spiro-isoquinoleinepyrrolidine et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase

Country Status (11)

Country Link
US (1) US5037831A (fr)
EP (1) EP0458551B1 (fr)
JP (1) JP3244283B2 (fr)
AT (1) ATE160780T1 (fr)
CA (1) CA2042113C (fr)
DE (1) DE69128302T2 (fr)
DK (1) DK0458551T3 (fr)
ES (1) ES2110977T3 (fr)
GR (1) GR3026186T3 (fr)
HK (1) HK1004067A1 (fr)
SG (1) SG47773A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5189167A (en) * 1991-11-25 1993-02-23 American Home Products Corporation Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
WO1993011126A1 (fr) * 1991-11-25 1993-06-10 American Home Products Corporation 1'-amino-2[(benzothiazolyle)methyl]spiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones et leurs analogues utiles comme inhibiteurs de reductase d'aldose
US5189168A (en) * 1991-11-25 1993-02-23 American Home Products Corporation 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5189044A (en) * 1992-03-20 1993-02-23 American Home Products Corporation Isoquinoline-1,3-dione acetyl carbamates useful as aldose reductase inhibitors
SG120054A1 (en) * 1997-04-15 2006-03-28 Csir Appetite suppressant steroidal glycosides
GB2355657B (en) * 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
HUP0302555A3 (en) 2000-11-30 2005-06-28 Pfizer Prod Inc Pharmaceutical compositions containing gaba agonists and aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
ATE518544T1 (de) 2007-03-12 2011-08-15 Zadec Aps Rotbusch-extrakt gegen diabetes
EP2848252A3 (fr) 2007-03-23 2015-06-17 The Board of Regents of the University of Texas System Inhibiteurs d'aldose-réductase pour le traitement de l'uvéite
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
CN103547261A (zh) 2010-12-23 2014-01-29 德克萨斯大学系统董事会 用于治疗copd的方法
CN107286092B (zh) * 2017-05-24 2020-02-21 浙江大学 甲氧基苯甲酰胺和重氮酸酯经碳-氢官能化制备异喹啉二酮的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
WO1986002647A1 (fr) * 1984-10-30 1986-05-09 Pfizer Inc. Utilisation de spiro-heteroazolones dans le traitement des complications dues au diabete
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
EP0264586B1 (fr) * 1986-08-28 1991-04-03 Sanwa Kagaku Kenkyusho Co., Ltd. Dérivés de l'hydantoine pour le traîtement de complications du diabète
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
EP0458551A1 (fr) 1991-11-27
CA2042113C (fr) 2001-08-28
EP0458551B1 (fr) 1997-12-03
DE69128302D1 (de) 1998-01-15
ES2110977T3 (es) 1998-03-01
HK1004067A1 (en) 1998-11-13
ATE160780T1 (de) 1997-12-15
DK0458551T3 (da) 1998-08-10
JP3244283B2 (ja) 2002-01-07
SG47773A1 (en) 1998-04-17
US5037831A (en) 1991-08-06
DE69128302T2 (de) 1998-03-26
GR3026186T3 (en) 1998-05-29
JPH04226984A (ja) 1992-08-17

Similar Documents

Publication Publication Date Title
CA2042113A1 (fr) Spiro-isoquinoleinepyrrolidine et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase
TW369535B (en) A pyrazolopyridine compound and the process for preparing thereof
AU572252B2 (en) 5-methyl-4,5 dihydro-3(2h) pyridazinone derivatives
NO922512D0 (no) Tetrahydropyrrolo(1,2-a)pyrazin-4-spiro-3'-pyrrolidinderivater, fremgangsmaate for fremstilling derav, samt farmasoeytiske preparater inneholdende slike
AU1507888A (en) New bicyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same
CA2042112A1 (fr) N'-alkylspiro-isoquinoleinepyrrolidinetetrones et leurs analogues, utiles comme agents inhibiteurs de l'aldose-reductase
KR930702346A (ko) 알도스 리덕타제 억제제로서 유용한 1'-아미노스피로[이소퀴놀린-4(1h),3'-피롤리딘]-1,2',3,5'(2h)-테트론 및 이의 동족체
CA2377147A1 (fr) Nouveaux alcaloides d'indolocarbazole issus d'un actinomycete marin
HK108997A (en) 1'-amino-2-(benzothiazolyl)methyl¾spiro isoquinoline-4(1H),3'-pyrrolidine¾-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed