CA2035492A1 - Liquid lavage/ventilation of the pulmonary system - Google Patents

Liquid lavage/ventilation of the pulmonary system

Info

Publication number
CA2035492A1
CA2035492A1 CA002035492A CA2035492A CA2035492A1 CA 2035492 A1 CA2035492 A1 CA 2035492A1 CA 002035492 A CA002035492 A CA 002035492A CA 2035492 A CA2035492 A CA 2035492A CA 2035492 A1 CA2035492 A1 CA 2035492A1
Authority
CA
Canada
Prior art keywords
liquid
ventilation
biologically active
perfluorocarbon
pulmonary system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002035492A
Other languages
French (fr)
Other versions
CA2035492C (en
Inventor
K. Michael Sekins
Thomas H. Shaffer
Marla R. Wolfson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alliance Pharmaceutical Corp
Temple Univ School of Medicine
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/495,817 external-priority patent/US5158536A/en
Application filed by Individual filed Critical Individual
Priority to CA002332618A priority Critical patent/CA2332618A1/en
Publication of CA2035492A1 publication Critical patent/CA2035492A1/en
Application granted granted Critical
Publication of CA2035492C publication Critical patent/CA2035492C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides for the pulmonary administration of biologically active agents via liquid lavage/ventilation.
A liquid medium comprising at least one biologically active agent and a liquid carrier is passed through at least a portion of the patient's pulmonary air passages.
The liquid medium may be a breathable liquid, such as a perfluorocarbon liquid or physiological saline solution. Suitable perfluorocarbon liquids having the requisite physical and thermal properties are characterized by an average molecular weight in the range of from about 350 to about 560. Representative perfluorocarbon liquids are FC-84, FC-72, RM-82, FC-75, RM-101, and perfluorodecalin.
CA002035492A 1990-03-19 1991-02-01 Liquid lavage/ventilation of the pulmonary system Expired - Fee Related CA2035492C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002332618A CA2332618A1 (en) 1990-03-19 1991-02-01 Liquid lavage/ventilation of the pulmonary system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US495,817 1990-03-19
US07/495,817 US5158536A (en) 1989-08-28 1990-03-19 Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002332618A Division CA2332618A1 (en) 1990-03-19 1991-02-01 Liquid lavage/ventilation of the pulmonary system

Publications (2)

Publication Number Publication Date
CA2035492A1 true CA2035492A1 (en) 1991-09-20
CA2035492C CA2035492C (en) 2001-03-27

Family

ID=23970103

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002035492A Expired - Fee Related CA2035492C (en) 1990-03-19 1991-02-01 Liquid lavage/ventilation of the pulmonary system

Country Status (1)

Country Link
CA (1) CA2035492C (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650378A4 (en) * 1992-07-16 1995-07-12 Univ Temple TREATMENT OF PHYSIOLOGICAL CONDITIONS WITH A PERFLUOROCARBON DEGAZE LIQUID.
EP1208851A3 (en) * 1991-11-14 2003-05-07 Alliance Pharmaceutical Corporation A medicament for pulmonary drug delivery
US7726311B2 (en) 2002-11-29 2010-06-01 Universite De Sherbrooke Method and apparatus for conducting total liquid ventilation with control of residual volume and ventilation cycle profile
CN114098699A (en) * 2021-11-05 2022-03-01 中国科学院精密测量科学与技术创新研究院 Experiment bed for magnetic resonance perfusion imaging of small animals
CN115006800A (en) * 2021-03-04 2022-09-06 上海增欣机电科技股份有限公司 A visual expectoration breathing trainer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1208851A3 (en) * 1991-11-14 2003-05-07 Alliance Pharmaceutical Corporation A medicament for pulmonary drug delivery
EP0650378A4 (en) * 1992-07-16 1995-07-12 Univ Temple TREATMENT OF PHYSIOLOGICAL CONDITIONS WITH A PERFLUOROCARBON DEGAZE LIQUID.
US7726311B2 (en) 2002-11-29 2010-06-01 Universite De Sherbrooke Method and apparatus for conducting total liquid ventilation with control of residual volume and ventilation cycle profile
CN115006800A (en) * 2021-03-04 2022-09-06 上海增欣机电科技股份有限公司 A visual expectoration breathing trainer
CN114098699A (en) * 2021-11-05 2022-03-01 中国科学院精密测量科学与技术创新研究院 Experiment bed for magnetic resonance perfusion imaging of small animals

Also Published As

Publication number Publication date
CA2035492C (en) 2001-03-27

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed