CA2032253A1 - 5-lipoxygenase activating protein - Google Patents

5-lipoxygenase activating protein

Info

Publication number
CA2032253A1
CA2032253A1 CA 2032253 CA2032253A CA2032253A1 CA 2032253 A1 CA2032253 A1 CA 2032253A1 CA 2032253 CA2032253 CA 2032253 CA 2032253 A CA2032253 A CA 2032253A CA 2032253 A1 CA2032253 A1 CA 2032253A1
Authority
CA
Canada
Prior art keywords
activating protein
lipoxygenase activating
flap
lipoxygenase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2032253
Other languages
French (fr)
Other versions
CA2032253C (en
Inventor
John W. Gillard
Jillian F. Evans
Jacques-Yves Gauthier
Rejean Fortin
Yvan Guindon
Douglas K. Miller
Richard A.F. Dixon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Canada Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2032253A1 publication Critical patent/CA2032253A1/en
Application granted granted Critical
Publication of CA2032253C publication Critical patent/CA2032253C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.
CA 2032253 1989-12-15 1990-12-14 5-lipoxygenase activating protein Expired - Fee Related CA2032253C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US451,268 1982-12-20
US45126889A 1989-12-15 1989-12-15

Publications (2)

Publication Number Publication Date
CA2032253A1 true CA2032253A1 (en) 1991-06-16
CA2032253C CA2032253C (en) 2000-11-28

Family

ID=23791519

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2032253 Expired - Fee Related CA2032253C (en) 1989-12-15 1990-12-14 5-lipoxygenase activating protein

Country Status (1)

Country Link
CA (1) CA2032253C (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052942A3 (en) * 1998-04-15 2000-02-03 Genset Sa Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8697730B2 (en) 2007-10-26 2014-04-15 Panmira Pharmaceuticals, Llc 5-lipoxygenase activating protein (FLAP) inhibitor
US8772495B2 (en) 2008-05-23 2014-07-08 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein inhibitor
US8841295B2 (en) 2005-11-04 2014-09-23 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052942A3 (en) * 1998-04-15 2000-02-03 Genset Sa Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma
US6531279B1 (en) 1998-04-15 2003-03-11 Genset S.A. Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma
US7494777B2 (en) 1998-04-15 2009-02-24 Serono Genetics Institute S.A. Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma
US7838241B2 (en) 1998-04-15 2010-11-23 Serono Genetics Institute S.A. Genotyping methods using genomic sequence of the 5-lipoxygenase-activating protein (FLAP) and polymorphic markers thereof
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8841295B2 (en) 2005-11-04 2014-09-23 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8697730B2 (en) 2007-10-26 2014-04-15 Panmira Pharmaceuticals, Llc 5-lipoxygenase activating protein (FLAP) inhibitor
US8772495B2 (en) 2008-05-23 2014-07-08 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein inhibitor

Also Published As

Publication number Publication date
CA2032253C (en) 2000-11-28

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