CA2032253A1 - 5-lipoxygenase activating protein - Google Patents
5-lipoxygenase activating proteinInfo
- Publication number
- CA2032253A1 CA2032253A1 CA 2032253 CA2032253A CA2032253A1 CA 2032253 A1 CA2032253 A1 CA 2032253A1 CA 2032253 CA2032253 CA 2032253 CA 2032253 A CA2032253 A CA 2032253A CA 2032253 A1 CA2032253 A1 CA 2032253A1
- Authority
- CA
- Canada
- Prior art keywords
- activating protein
- lipoxygenase activating
- flap
- lipoxygenase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004023 5-Lipoxygenase-Activating Proteins Human genes 0.000 title 1
- 108090000411 5-Lipoxygenase-Activating Proteins Proteins 0.000 title 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 229940114079 arachidonic acid Drugs 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45126889A | 1989-12-15 | 1989-12-15 | |
US451,268 | 1989-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2032253A1 true CA2032253A1 (en) | 1991-06-16 |
CA2032253C CA2032253C (en) | 2000-11-28 |
Family
ID=23791519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2032253 Expired - Fee Related CA2032253C (en) | 1989-12-15 | 1990-12-14 | 5-lipoxygenase activating protein |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2032253C (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999052942A3 (en) * | 1998-04-15 | 2000-02-03 | Genset Sa | Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US8697730B2 (en) | 2007-10-26 | 2014-04-15 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase activating protein (FLAP) inhibitor |
US8772495B2 (en) | 2008-05-23 | 2014-07-08 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
US8841295B2 (en) | 2005-11-04 | 2014-09-23 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
-
1990
- 1990-12-14 CA CA 2032253 patent/CA2032253C/en not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999052942A3 (en) * | 1998-04-15 | 2000-02-03 | Genset Sa | Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma |
US6531279B1 (en) | 1998-04-15 | 2003-03-11 | Genset S.A. | Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma |
US7494777B2 (en) | 1998-04-15 | 2009-02-24 | Serono Genetics Institute S.A. | Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma |
US7838241B2 (en) | 1998-04-15 | 2010-11-23 | Serono Genetics Institute S.A. | Genotyping methods using genomic sequence of the 5-lipoxygenase-activating protein (FLAP) and polymorphic markers thereof |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US8841295B2 (en) | 2005-11-04 | 2014-09-23 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US8697730B2 (en) | 2007-10-26 | 2014-04-15 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase activating protein (FLAP) inhibitor |
US8772495B2 (en) | 2008-05-23 | 2014-07-08 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
Also Published As
Publication number | Publication date |
---|---|
CA2032253C (en) | 2000-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |