CA2019622A1 - Substituted arylamines and heteroarylamines, their preparation process and pharmaceutical composition containing them - Google Patents

Substituted arylamines and heteroarylamines, their preparation process and pharmaceutical composition containing them

Info

Publication number
CA2019622A1
CA2019622A1 CA002019622A CA2019622A CA2019622A1 CA 2019622 A1 CA2019622 A1 CA 2019622A1 CA 002019622 A CA002019622 A CA 002019622A CA 2019622 A CA2019622 A CA 2019622A CA 2019622 A1 CA2019622 A1 CA 2019622A1
Authority
CA
Canada
Prior art keywords
heteroarylamines
composition containing
preparation process
optionally substituted
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002019622A
Other languages
French (fr)
Other versions
CA2019622C (en
Inventor
Jean-Marc Kamenka
Alain Privat
Robert Rubin Chicheportiche
Jean Costentin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Jean-Marc Kamenka
Alain Privat
Robert Rubin Chicheportiche
Jean Costentin
Centre National De La Recherche Scientifique (C.N.R.S.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jean-Marc Kamenka, Alain Privat, Robert Rubin Chicheportiche, Jean Costentin, Centre National De La Recherche Scientifique (C.N.R.S.) filed Critical Jean-Marc Kamenka
Publication of CA2019622A1 publication Critical patent/CA2019622A1/en
Application granted granted Critical
Publication of CA2019622C publication Critical patent/CA2019622C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

The invention relates to substituted arylamines and heteroarylamines, their preparation process and the pharma-ceutical composition containing them. Said substituted amine is in accordance with the formula:
in which R1 and R2 are optionally substituted alkyl radicals or form with N an optionally substituted piperazine or piperidine cycle, R3 and R4 represent a hydrogen atom or an organic radical, Y represents CR6 or N and R5 is an optionally substituted benzothiophenyl, benzofuranyl or naphthyl radical.
These amines can be used in pharmaceutical compositions for the treatment of nervous depression or for stimulating vigilance.
CA002019622A 1989-06-29 1990-06-22 Substituted arylamines and heteroarylamines, their preparation process and pharmaceutical composition containing them Expired - Fee Related CA2019622C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8908704A FR2649105B1 (en) 1989-06-29 1989-06-29 ARYLAMINES AND SUBSTITUTED HETEROARYLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR8908704 1989-06-29

Publications (2)

Publication Number Publication Date
CA2019622A1 true CA2019622A1 (en) 1990-12-29
CA2019622C CA2019622C (en) 2002-01-08

Family

ID=9383267

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002019622A Expired - Fee Related CA2019622C (en) 1989-06-29 1990-06-22 Substituted arylamines and heteroarylamines, their preparation process and pharmaceutical composition containing them

Country Status (7)

Country Link
EP (1) EP0406111B1 (en)
JP (1) JP3047112B2 (en)
AT (1) ATE143960T1 (en)
CA (1) CA2019622C (en)
DE (1) DE69028808T2 (en)
ES (1) ES2095242T3 (en)
FR (1) FR2649105B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763951B1 (en) * 1997-06-03 2000-12-01 Sod Conseils Rech Applic NOVEL PHENCYCLIDINES DERIVATIVES, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU8024998A (en) 1997-06-03 1998-12-21 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel phencyclidine derivatives, preparation methods and pharmaceutical compositions containing same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317953A3 (en) * 1987-11-24 1990-12-05 G.D. Searle & Co. N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury

Also Published As

Publication number Publication date
JP3047112B2 (en) 2000-05-29
FR2649105B1 (en) 1994-04-29
CA2019622C (en) 2002-01-08
DE69028808D1 (en) 1996-11-14
FR2649105A1 (en) 1991-01-04
DE69028808T2 (en) 1997-04-30
JPH0344356A (en) 1991-02-26
EP0406111A1 (en) 1991-01-02
EP0406111B1 (en) 1996-10-09
ES2095242T3 (en) 1997-02-16
ATE143960T1 (en) 1996-10-15

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