CA2012470A1 - Method for silicon reduction with dimercaptosuccinic acid (dmsa) - Google Patents

Method for silicon reduction with dimercaptosuccinic acid (dmsa)

Info

Publication number
CA2012470A1
CA2012470A1 CA2012470A CA2012470A CA2012470A1 CA 2012470 A1 CA2012470 A1 CA 2012470A1 CA 2012470 A CA2012470 A CA 2012470A CA 2012470 A CA2012470 A CA 2012470A CA 2012470 A1 CA2012470 A1 CA 2012470A1
Authority
CA
Canada
Prior art keywords
dmsa
silicon
dimercaptosuccinic acid
silicon reduction
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2012470A
Other languages
French (fr)
Other versions
CA2012470C (en
Inventor
Harvey Craig Gonick
Farhad Khalil-Manesh
Elmar Willibald Johannes Weiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/325,297 external-priority patent/US4962127A/en
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Priority to CA002012470A priority Critical patent/CA2012470C/en
Publication of CA2012470A1 publication Critical patent/CA2012470A1/en
Application granted granted Critical
Publication of CA2012470C publication Critical patent/CA2012470C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method for silicon reduction with Dimercaptosuccinic Acid (DMSA) is described. DMSA is administered to reduce levels of silicon in blood and tissue thereby reducing blood pressure, improving kidney function, preventing or retarding the progression of chronic renal failure, treating the accumulation of silicon in advanced kidney disease, and/or preventing the onset or improving the current status of dementia and Alzheimer's Disease.
CA002012470A 1989-03-17 1990-03-19 Method for silicon reduction with dimercaptosuccinic acid (dmsa) Expired - Fee Related CA2012470C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002012470A CA2012470C (en) 1989-03-17 1990-03-19 Method for silicon reduction with dimercaptosuccinic acid (dmsa)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/325,297 US4962127A (en) 1989-03-17 1989-03-17 Method for silicon reduction with dimercaptosuccinic acid (DMSA)
CA002012470A CA2012470C (en) 1989-03-17 1990-03-19 Method for silicon reduction with dimercaptosuccinic acid (dmsa)

Publications (2)

Publication Number Publication Date
CA2012470A1 true CA2012470A1 (en) 1991-09-19
CA2012470C CA2012470C (en) 1995-11-07

Family

ID=25674019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002012470A Expired - Fee Related CA2012470C (en) 1989-03-17 1990-03-19 Method for silicon reduction with dimercaptosuccinic acid (dmsa)

Country Status (1)

Country Link
CA (1) CA2012470C (en)

Also Published As

Publication number Publication date
CA2012470C (en) 1995-11-07

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20010319