CA2011262A1 - Use of mixed micelles - Google Patents

Use of mixed micelles

Info

Publication number
CA2011262A1
CA2011262A1 CA2011262A CA2011262A CA2011262A1 CA 2011262 A1 CA2011262 A1 CA 2011262A1 CA 2011262 A CA2011262 A CA 2011262A CA 2011262 A CA2011262 A CA 2011262A CA 2011262 A1 CA2011262 A1 CA 2011262A1
Authority
CA
Canada
Prior art keywords
mixed micelles
carriers
mixed
active substances
micelles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2011262A
Other languages
French (fr)
Other versions
CA2011262C (en
Inventor
Wayne Hein
Hans Steffen
Andreas Supersaxo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2011262A1 publication Critical patent/CA2011262A1/en
Application granted granted Critical
Publication of CA2011262C publication Critical patent/CA2011262C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Seal Device For Vehicle (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Mixed micelles can be used as carriers for the parenteral administration of pharmaceutically active substances. Mixed micelles carry the active substances directly into the lymphatic system. As an example, it has been found that the use of the mixed micelle systems as carriers for administering immunomodulators and cytostatics, increases the bioavailability of these active compounds.
CA002011262A 1989-03-21 1990-03-20 Use of mixed micelles Expired - Fee Related CA2011262C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH104189 1989-03-21
CH1041/89 1989-03-21
CH103/90 1990-01-12
CH10390 1990-01-12

Publications (2)

Publication Number Publication Date
CA2011262A1 true CA2011262A1 (en) 1990-09-21
CA2011262C CA2011262C (en) 2000-06-20

Family

ID=25683528

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002011262A Expired - Fee Related CA2011262C (en) 1989-03-21 1990-03-20 Use of mixed micelles

Country Status (15)

Country Link
EP (1) EP0388817B1 (en)
JP (1) JP3007111B2 (en)
KR (1) KR900013942A (en)
AT (1) ATE102479T1 (en)
AU (1) AU635248B2 (en)
CA (1) CA2011262C (en)
DE (1) DE59004845D1 (en)
DK (1) DK0388817T3 (en)
ES (1) ES2062140T3 (en)
HU (1) HUT53799A (en)
IE (1) IE64191B1 (en)
IL (1) IL93721A (en)
MC (1) MC2102A1 (en)
NZ (1) NZ232865A (en)
PT (1) PT93522B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6461090A (en) * 1989-10-30 1991-05-02 Abbott Laboratories Injectable formulation for lipophilic drugs
CA2033725C (en) * 1990-01-24 2001-05-29 Folker Pittrof Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
JP2740153B2 (en) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー Mixed micelle

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (en) * 1976-07-12 1989-02-09 Hoffmann La Roche INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS
DE3221579A1 (en) * 1982-06-08 1983-12-22 Eckert, Theodor, Prof. Dr., 4400 Münster Solubilisation of active substances, which are sparingly soluble in water, in aqueous solution using a mixture of cholinephosphoric acid glycerol diester (choline-lecithin) and sodium deoxycholate as solubiliser, and the therapeutic use of the aqueous solutions obtained thereby
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
EP0252004A1 (en) * 1986-06-26 1988-01-07 Ciba-Geigy Ag Pharmaceutical compositions for parenteral application
CA1319886C (en) * 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions

Also Published As

Publication number Publication date
IE64191B1 (en) 1995-07-12
JPH02289511A (en) 1990-11-29
JP3007111B2 (en) 2000-02-07
MC2102A1 (en) 1991-03-11
AU5140490A (en) 1990-09-27
EP0388817B1 (en) 1994-03-09
PT93522A (en) 1990-11-07
DK0388817T3 (en) 1994-05-02
HUT53799A (en) 1990-12-28
DE59004845D1 (en) 1994-04-14
NZ232865A (en) 1992-07-28
CA2011262C (en) 2000-06-20
EP0388817A3 (en) 1991-07-03
ATE102479T1 (en) 1994-03-15
ES2062140T3 (en) 1994-12-16
IE901017L (en) 1990-09-21
KR900013942A (en) 1990-10-22
EP0388817A2 (en) 1990-09-26
PT93522B (en) 1996-03-29
IL93721A0 (en) 1990-12-23
HU901555D0 (en) 1990-06-28
IL93721A (en) 1994-04-12
AU635248B2 (en) 1993-03-18

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed