CA2007935A1 - Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these - Google Patents
Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing theseInfo
- Publication number
- CA2007935A1 CA2007935A1 CA2007935A CA2007935A CA2007935A1 CA 2007935 A1 CA2007935 A1 CA 2007935A1 CA 2007935 A CA2007935 A CA 2007935A CA 2007935 A CA2007935 A CA 2007935A CA 2007935 A1 CA2007935 A1 CA 2007935A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- alkyl
- substituted
- nitrogen
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/12—Ketones containing more than one keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
- C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
Abstract
Compounds of the general formula I
(see formula I) where A is ethylene or methylene which can be substituted by methyl, hydroxyl or oxo, L is one of the following (see formula II) R1 and R2 are hydrogen or methyl, R3 is hydrogen, hydroxyl ar C1-C6-alkoxy, R4 ; is hydrogen, C1-C4-alkyl, halogen or methoxy, R5 is hydrogen or methoxy, and R6 is hydrogen, methyl, cyano, a C2-C10 group of the formula (see formula III) where R',R" and R'" are each alkyl of 1 to 9 carbons, the total of carbons in R',R",R'" is 2 to 10, and R' can also be hydrogen, or the following -CHR7-OR8, -CHR7-NR9R10, -COR11, (see formula IV) or -SO2R11 where R7 is hydrogen or C1-C4-alkyl, R8 is hydrogen, C1-C4-alkyl, C1-C20-alkanoyl, or benzoyl which can be substituted, R9 and R10 are hydrogen, C1-C4-alkyl, C1-C6-alkanoyl, or benzoyl which can be substituted, or form, together with the nitrogen to which they are bonded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, R11 is hydrogen, C1-C4-alkyl, or -OR13 or -NR14R15 where R13 is hydrogen, C1-C8-alkyl which can be substituted by 1 or 2 hydroxyls, or aryl or aralkyl each of which can be substituted in the aryl moiety, and where R14 and R15 are hydrogen, or aralkyl or aryl which can be substituted, or R14 and R15 form, together with the nitrogen to which they are banded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, and R12 is C1-C4-alkyl, and the physiologically tolerated salts thexeof, processes far the preparation thereof, and drugs and cosmetics prepared therefrom are described.
(see formula I) where A is ethylene or methylene which can be substituted by methyl, hydroxyl or oxo, L is one of the following (see formula II) R1 and R2 are hydrogen or methyl, R3 is hydrogen, hydroxyl ar C1-C6-alkoxy, R4 ; is hydrogen, C1-C4-alkyl, halogen or methoxy, R5 is hydrogen or methoxy, and R6 is hydrogen, methyl, cyano, a C2-C10 group of the formula (see formula III) where R',R" and R'" are each alkyl of 1 to 9 carbons, the total of carbons in R',R",R'" is 2 to 10, and R' can also be hydrogen, or the following -CHR7-OR8, -CHR7-NR9R10, -COR11, (see formula IV) or -SO2R11 where R7 is hydrogen or C1-C4-alkyl, R8 is hydrogen, C1-C4-alkyl, C1-C20-alkanoyl, or benzoyl which can be substituted, R9 and R10 are hydrogen, C1-C4-alkyl, C1-C6-alkanoyl, or benzoyl which can be substituted, or form, together with the nitrogen to which they are bonded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, R11 is hydrogen, C1-C4-alkyl, or -OR13 or -NR14R15 where R13 is hydrogen, C1-C8-alkyl which can be substituted by 1 or 2 hydroxyls, or aryl or aralkyl each of which can be substituted in the aryl moiety, and where R14 and R15 are hydrogen, or aralkyl or aryl which can be substituted, or R14 and R15 form, together with the nitrogen to which they are banded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, and R12 is C1-C4-alkyl, and the physiologically tolerated salts thexeof, processes far the preparation thereof, and drugs and cosmetics prepared therefrom are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3903992.7 | 1989-02-10 | ||
DE3903992A DE3903992A1 (en) | 1989-02-10 | 1989-02-10 | AROMATIC KETO COMPOUNDS, THEIR PRODUCTION AND MEDICINAL PRODUCTS AND COSMETICS THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2007935A1 true CA2007935A1 (en) | 1990-08-10 |
CA2007935C CA2007935C (en) | 2000-03-07 |
Family
ID=6373813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002007935A Expired - Lifetime CA2007935C (en) | 1989-02-10 | 1990-01-17 | Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0382078B1 (en) |
JP (1) | JP2924972B2 (en) |
KR (1) | KR900012878A (en) |
AT (1) | ATE94864T1 (en) |
CA (1) | CA2007935C (en) |
DE (2) | DE3903992A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194664A (en) * | 1989-02-10 | 1993-03-16 | Basf Aktiengesellschaft | Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these |
DE4033568A1 (en) * | 1990-10-22 | 1992-04-23 | Henkel Kgaa | BICYCLIC COMPOUNDS WITH ANTISEBORRHOIC EFFECT |
FR2753091B1 (en) * | 1996-09-09 | 2001-03-16 | Oreal | USE OF AN RXR-TYPE RETINOID RECEPTOR AGONIST TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE LOSS |
DE102005049225A1 (en) * | 2005-10-14 | 2007-04-19 | P + L Gmbh & Co. Kg | Device for clamping tool to spindle shaft of machine tool, comprises sleeve accommodated in cylindrical outer end of spindle shaft |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62215581A (en) * | 1986-03-18 | 1987-09-22 | Koichi Shiyudo | Flavone carboxylic acid derivative |
FR2601670B1 (en) * | 1986-07-17 | 1988-10-07 | Cird | NOVEL AROMATIC BICYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND IN COSMETICS |
JPH07121890B2 (en) * | 1989-03-15 | 1995-12-25 | 紘一 首藤 | Carboxylic acid derivative |
-
1989
- 1989-02-10 DE DE3903992A patent/DE3903992A1/en not_active Withdrawn
-
1990
- 1990-01-17 CA CA002007935A patent/CA2007935C/en not_active Expired - Lifetime
- 1990-02-01 AT AT90101948T patent/ATE94864T1/en not_active IP Right Cessation
- 1990-02-01 DE DE90101948T patent/DE59002774D1/en not_active Expired - Fee Related
- 1990-02-01 EP EP90101948A patent/EP0382078B1/en not_active Expired - Lifetime
- 1990-02-10 KR KR1019900001623A patent/KR900012878A/en not_active Application Discontinuation
- 1990-02-13 JP JP2029790A patent/JP2924972B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2007935C (en) | 2000-03-07 |
ATE94864T1 (en) | 1993-10-15 |
EP0382078A1 (en) | 1990-08-16 |
KR900012878A (en) | 1990-09-03 |
JPH02235838A (en) | 1990-09-18 |
DE59002774D1 (en) | 1993-10-28 |
DE3903992A1 (en) | 1990-08-16 |
JP2924972B2 (en) | 1999-07-26 |
EP0382078B1 (en) | 1993-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |