CA2007336A1 - Diagnostic test using chimeric antibodies - Google Patents

Diagnostic test using chimeric antibodies

Info

Publication number
CA2007336A1
CA2007336A1 CA2007336A CA2007336A CA2007336A1 CA 2007336 A1 CA2007336 A1 CA 2007336A1 CA 2007336 A CA2007336 A CA 2007336A CA 2007336 A CA2007336 A CA 2007336A CA 2007336 A1 CA2007336 A1 CA 2007336A1
Authority
CA
Canada
Prior art keywords
antibody
binding
solid phase
chimeric antibodies
diagnostic test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2007336A
Other languages
French (fr)
Other versions
CA2007336C (en
Inventor
Brigitte Kaluza
Helmut Lenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2007336A1 publication Critical patent/CA2007336A1/en
Application granted granted Critical
Publication of CA2007336C publication Critical patent/CA2007336C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Chimeric monoclonal antibodies or fragments thereof are used according to the present invention in diagnostic tests for the quantitative immunological determination of substances in the blood or serum of patients. For the diagnostic detection of substances in serum or blood of patients by binding of two monoclonal antibodies R1 and R2 directed against the substance, of which the first antibody R1 is capable of binding to a solid phase or is already bound and the second antibody R2 carries a label, binding of the antibody R1 to the solid phase if desired, separation of the complex formed of R1, substance and R2 which is bound to the solid phase and detection via the labelling of the antibody R2, a chimeric monoclonal antibody or a fragment thereof is used at least for one of the antibodies R1 or R2.
CA002007336A 1989-01-10 1990-01-08 Diagnostic test using chimeric antibodies Expired - Lifetime CA2007336C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3900534.8 1989-01-10
DE3900534A DE3900534A1 (en) 1989-01-10 1989-01-10 DIAGNOSTIC PROOF USING CHIMAIR ANTIBODIES

Publications (2)

Publication Number Publication Date
CA2007336A1 true CA2007336A1 (en) 1990-07-10
CA2007336C CA2007336C (en) 2001-01-02

Family

ID=6371816

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002007336A Expired - Lifetime CA2007336C (en) 1989-01-10 1990-01-08 Diagnostic test using chimeric antibodies

Country Status (9)

Country Link
US (1) US5614367A (en)
EP (1) EP0378175B1 (en)
JP (1) JP2787098B2 (en)
AT (1) ATE123340T1 (en)
AU (1) AU629886B2 (en)
CA (1) CA2007336C (en)
DE (2) DE3900534A1 (en)
DK (1) DK0378175T3 (en)
ZA (1) ZA90136B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6403769B1 (en) 1994-02-01 2002-06-11 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins that include antibody and nonantibody portions

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5579463A (en) * 1990-03-30 1996-11-26 Anritsu Corporation Waveform display apparatus of frequency sweep type for facilitating display of a high definition waveform
DE69132242T2 (en) * 1990-03-30 2001-01-25 Anritsu Corp., Tokio/Tokyo Display device for easy observation of signal profiles at high resolution
DE4033120A1 (en) * 1990-10-18 1992-04-23 Boehringer Mannheim Gmbh Genomic DNA fragment encoding antibody variable region prodn. - by attaching primers to hybridoma DNA then subjecting to polymerase chain reaction, for constructing genes encoding chimeric antibodies
US5617523A (en) * 1990-11-30 1997-04-01 Anritsu Corporation Waveform display apparatus for easily realizing high-definition waveform observation
US6087088A (en) * 1997-01-31 2000-07-11 Bayer Corporation Binding assays using more than one label for determining analyte in the presence of interfering factors
US20030171551A1 (en) * 1997-01-31 2003-09-11 Joseph D. Rosenblatt Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
DE19739218A1 (en) * 1997-09-08 1999-03-11 Boehringer Mannheim Gmbh Purification of substances from a biological sample
ES2185104T3 (en) * 1997-12-11 2003-04-16 Roche Diagnostics Gmbh ELIMINATION OF INTERFERENCES IN DIAGNOSTIC PROCEDURES BY PERMITS OF D-AMINO ACIDS.
DE19828466A1 (en) 1998-06-26 1999-12-30 Roche Diagnostics Gmbh Suppressor peptides derived from antibodies for use in immunoassays
US6492497B1 (en) * 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
US6680209B1 (en) * 1999-12-06 2004-01-20 Biosite, Incorporated Human antibodies as diagnostic reagents
DE19962583A1 (en) * 1999-12-23 2001-06-28 Mueller Hermelink Hans Konrad New antibodies specific for plasma cells, useful for treatment and diagnosis of autoimmune diseases and plasma cell tumors
EP1258729A3 (en) * 2001-05-18 2004-01-02 Takeda Chemical Industries, Ltd. A method of selecting an antibody, a hybridoma, a monoclonal antibody and use thereof
US20040018556A1 (en) * 2002-07-29 2004-01-29 Cantor Thomas L. Reagent and method for determination of a substance using an immunoaggregator
WO2007011698A2 (en) * 2005-07-15 2007-01-25 Siemens Medical Solutions Diagnostics Humanized antibody conjugates and related methods, assays, reagents, and kits
DK2220121T3 (en) * 2007-11-12 2015-12-07 U3 Pharma Gmbh AXL antibodies
CA2759836A1 (en) 2009-05-11 2010-11-18 U3 Pharma Gmbh Humanized axl antibodies
BR112020005390A2 (en) * 2017-09-20 2020-09-29 Mersana Therapeutics, Inc. compositions and methods to predict response to napi2b-directed therapy
CA3109790A1 (en) 2018-08-17 2020-02-20 Mersana Therapeutics, Inc. Napi2b-targeted polymer antibody-drug conjugates and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6147500A (en) * 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS62201598A (en) * 1986-02-28 1987-09-05 Teijin Ltd Mouse-human chimera antibody h chain and chimera dna sequence, plasmid and cell coding same
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL84285A (en) * 1986-10-27 1993-03-15 Int Genetic Engineering Chimeric antibody with specificity to human tumor antigen
IL85035A0 (en) * 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU625613B2 (en) * 1988-01-05 1992-07-16 Novartis Ag Novel chimeric antibodies
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DE3900534A1 (en) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh DIAGNOSTIC PROOF USING CHIMAIR ANTIBODIES
EP0479901A1 (en) * 1990-04-25 1992-04-15 City Of Hope Removal of human anti-murine and heterophilic antibody interference in double antibody eia assays

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6403769B1 (en) 1994-02-01 2002-06-11 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins that include antibody and nonantibody portions

Also Published As

Publication number Publication date
CA2007336C (en) 2001-01-02
DK0378175T3 (en) 1995-10-02
DE59009163D1 (en) 1995-07-06
AU629886B2 (en) 1992-10-15
JPH02231567A (en) 1990-09-13
JP2787098B2 (en) 1998-08-13
DE3900534A1 (en) 1990-07-12
EP0378175B1 (en) 1995-05-31
EP0378175A2 (en) 1990-07-18
AU4768490A (en) 1990-07-19
ZA90136B (en) 1990-10-31
ATE123340T1 (en) 1995-06-15
US5614367A (en) 1997-03-25
EP0378175A3 (en) 1991-04-03

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Legal Events

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EEER Examination request
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