CA1341061C - Felt-like implant - Google Patents
Felt-like implantInfo
- Publication number
- CA1341061C CA1341061C CA000588522A CA588522A CA1341061C CA 1341061 C CA1341061 C CA 1341061C CA 000588522 A CA000588522 A CA 000588522A CA 588522 A CA588522 A CA 588522A CA 1341061 C CA1341061 C CA 1341061C
- Authority
- CA
- Canada
- Prior art keywords
- felt
- fibres
- melting point
- implant
- resorbable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
Abstract
A felt-like implant of resorbable material is produced by heating a blend of 1 to 20 mm long filaments or fibres of at least two different resorbable materials having different melting points, to a temperature between the melting point of the resorbable material, with the lowest melting point and the melting point of the resorbable material with the highest melting point, followed by shaping or moulding to a felt-like body.
Description
1 3~1 06 1 The invention relates to a felt-like implant made from re~sorbable material.
Such implants are e.g. known from US patent 37 39 773 and comprise flat or velour-like products, which are a.g. used in multilayer or sponge-like struciture form for the treatment of burns or other skin injuries, as well as for other uses. As a result of their porosity they are able to absorb tissue :Fluid and are gradually permeated by the tissue which, after complete resorption of the implant, takes over its supporting or holding function.
However, due' to their limited thickness and flap or cloi~h-like characteristics, these textile-like flat si:ructu:res can only be used to a limited extent.
German. patent 35 19 197 discloses pad-like implants, whose outer sleeve comprises a knitted hose of resorbable filaments or fibres and which are filled with threads, filaments, flocks or scraps of a resorbable material. These tubular pads or com~~resses, which are particularly suitable fo:r treating hernias, have a compressibi:Lity of at least 50$ and are also used for the treatment of Finally, e.g. US patent 4 186 448 discloses foam-like implants made from a uniform, resorbable polyglycoli~ ester. Such sponge-like or foam-like implants suffer from the disadvantage that they still contain impurities as a result of the components necessary for foaming and these impurities are incompatible with the tissue. In la addition, such foam-like implants have a uniform resorption time.
The problem of the present invention is to propose an implant, which can be made in any geometrical shape, which can be cut and sewn in and which i:~ obta:inable in any random consistency from soft to hard, whilst still being sufficiently porous to enable 'the tissue to grow in, whilst preferably achieving a different resorbability.
In accordance with the present invention, there is provided a felt-like implant of resorbable material which is produced by heating a blend of 1 t:o 20 mm long filaments or fibres of at least two different resorbable materials having different mE~lting points, to a temperature between the melting point of the resorbable material, with the lowest melting point and the melting point of the resorbable material with the highest melting point, followed by shaping or moulding to a felt-like body.
It has surprisingly been found that a felt-like implani~ comprising a mixture of relatively short filamf~nts or fibres of at least two ~ 341 06 1 _2_ different resorbable materials with different melting points and which after heating to a temperature between the melting points of these different resorbable materials can be deformed, can be used for numerous purposes, in which the hitherto conventional, flat textile-structures or pad-like implant compresses are not adequate.
For example, felt-llk~e implants can be used in plug form Ln medullary nailing as medullary space plugs, in order to prevent a further penetration of the synthetic resin cement fixing the steel nails into the further tubular bone region.
The Inventive felt-like implants are also suitable as a replace-ment for the dura mater of the brain, i.e. as a meningeal substitute, which serves as a protective capsule for the brain and periosteum of the cranial inner ~;urface. Hitherto only prepared lyophilic dura, which is unsuitable! due to infections, particularly of a virus nature, has been used for i:his purpose.
Another use o1' the inventive felt-like implants is the under-lining of bone defects andl as an intermediate layer for vascular sutures;
so as to prevent an incision of the suture material, as well as when suturing other dif~Ficultly suturable tissue regions, e.g. in the case of a partial hepatectomy.
Resorbable polymers with good physiological compatibility are known per se. Typical r~~present:atives are poly-p-dioxanones, which are commercially available under the name PDS and which chemically are aliphatic polyesters of poly-p-dioxanone, which can be extruded to monofilaments and melt at 85 to 95oC. They are described in "Ethicon OP Forum", no.108, 1981 and in J. Pediatr. Ophthalmol., 13, pp.360-364, 1976.
Polyglactins belong 1to another group of resorbable materials and are a copolymer of glycolide and lactides and which can also be extruded to filaments. They are comnercial.l~~ available under the trademark Vicryl and are described in deta.it e.g. in "Ethicon OP Forum", no.96, 1978 and in J. Pediatr. Ophthalmol., 13, p. 360, 1976. This group also includes lactide - glycolide block copolymers. As a function of the degree of polymerization these polyglactins have a melting point of approximately 180 to 200°C.
As a function of the nature of the resorbable material and also the degree of po:Lymerization, variations occur in the resorbability. For example, in the case of higher melting polyglactina, it is in a range of 60 to 80 days, whereas for the lower melting poly-p-dioxanones is approximatE~ly 200 days. Through corresponding mixing of the mono-filaments of fibres forming the felt-like imp7_ants, it is possible to control the resorption timE~ of the complete felt-like implant, i.e.
the speed with which the implant can be decomposed.
Part_LCUlar preference is given to a mixture of fibres of poly-p--dioxanone and those of polyglactin in a ratio of 5:1 to 1:15 and particularly in a ratio of 1:3.
The :Fibre length of the fibre blend for felt-like implants is 1 to 20 mm and preferably 5 to 12 mm, the diameter o:E the filaments or fibres being 40 to 200 dtex.
Preferably, the fibre blend is heated at a temperature of 100 to 110°C and then shaped to the implant-like farm.
Due to the fact that the fibre blend is heated within the different melting points of the resorbable materials and then shaped, there is a strengthening of the fibres of the higher melting resorbable material through melting bonding of the filaments or fibres of the resorbable material with the lower melting point, so that a porous, although relatively compact: felt-like structure is obtained.
The relatively short. fi:Laments or fibres can easily be moulded on heating :in a corresponding mould to give a felt-like body, either in the form of a disk or a plug.
EXAMPLE
Monofilaments of poly-(lactide-co-glycolide), namely polyglactin 'a10, as obtainable under the trade mark VICRYL and those from poly-p-dioxanone, as D
~ 341 06 1 - 3a -available under the name PDS, in a mixing ratio of 3:1, are reduced in size by grinding or chopping to a length of 5 to 12 mm. After thorough mixing they are heated to 100°C and moulded or pressed into the desired form.
As a result of the different melting points of the two materials, there is a bonding of the fibres from the higher meltin<~ material and a felt-like structure corresponding t:o the implant form is obtained.
As a result of the polyglactin, such a felt plug retains i.ts strength for at least 4 to 5 weeks and, even after t:he resorption of this material, retains an ade<luate dimensional stability for a further 2 to 3 weeks due tc> the poly-p-dioxanone.
Such implants are e.g. known from US patent 37 39 773 and comprise flat or velour-like products, which are a.g. used in multilayer or sponge-like struciture form for the treatment of burns or other skin injuries, as well as for other uses. As a result of their porosity they are able to absorb tissue :Fluid and are gradually permeated by the tissue which, after complete resorption of the implant, takes over its supporting or holding function.
However, due' to their limited thickness and flap or cloi~h-like characteristics, these textile-like flat si:ructu:res can only be used to a limited extent.
German. patent 35 19 197 discloses pad-like implants, whose outer sleeve comprises a knitted hose of resorbable filaments or fibres and which are filled with threads, filaments, flocks or scraps of a resorbable material. These tubular pads or com~~resses, which are particularly suitable fo:r treating hernias, have a compressibi:Lity of at least 50$ and are also used for the treatment of Finally, e.g. US patent 4 186 448 discloses foam-like implants made from a uniform, resorbable polyglycoli~ ester. Such sponge-like or foam-like implants suffer from the disadvantage that they still contain impurities as a result of the components necessary for foaming and these impurities are incompatible with the tissue. In la addition, such foam-like implants have a uniform resorption time.
The problem of the present invention is to propose an implant, which can be made in any geometrical shape, which can be cut and sewn in and which i:~ obta:inable in any random consistency from soft to hard, whilst still being sufficiently porous to enable 'the tissue to grow in, whilst preferably achieving a different resorbability.
In accordance with the present invention, there is provided a felt-like implant of resorbable material which is produced by heating a blend of 1 t:o 20 mm long filaments or fibres of at least two different resorbable materials having different mE~lting points, to a temperature between the melting point of the resorbable material, with the lowest melting point and the melting point of the resorbable material with the highest melting point, followed by shaping or moulding to a felt-like body.
It has surprisingly been found that a felt-like implani~ comprising a mixture of relatively short filamf~nts or fibres of at least two ~ 341 06 1 _2_ different resorbable materials with different melting points and which after heating to a temperature between the melting points of these different resorbable materials can be deformed, can be used for numerous purposes, in which the hitherto conventional, flat textile-structures or pad-like implant compresses are not adequate.
For example, felt-llk~e implants can be used in plug form Ln medullary nailing as medullary space plugs, in order to prevent a further penetration of the synthetic resin cement fixing the steel nails into the further tubular bone region.
The Inventive felt-like implants are also suitable as a replace-ment for the dura mater of the brain, i.e. as a meningeal substitute, which serves as a protective capsule for the brain and periosteum of the cranial inner ~;urface. Hitherto only prepared lyophilic dura, which is unsuitable! due to infections, particularly of a virus nature, has been used for i:his purpose.
Another use o1' the inventive felt-like implants is the under-lining of bone defects andl as an intermediate layer for vascular sutures;
so as to prevent an incision of the suture material, as well as when suturing other dif~Ficultly suturable tissue regions, e.g. in the case of a partial hepatectomy.
Resorbable polymers with good physiological compatibility are known per se. Typical r~~present:atives are poly-p-dioxanones, which are commercially available under the name PDS and which chemically are aliphatic polyesters of poly-p-dioxanone, which can be extruded to monofilaments and melt at 85 to 95oC. They are described in "Ethicon OP Forum", no.108, 1981 and in J. Pediatr. Ophthalmol., 13, pp.360-364, 1976.
Polyglactins belong 1to another group of resorbable materials and are a copolymer of glycolide and lactides and which can also be extruded to filaments. They are comnercial.l~~ available under the trademark Vicryl and are described in deta.it e.g. in "Ethicon OP Forum", no.96, 1978 and in J. Pediatr. Ophthalmol., 13, p. 360, 1976. This group also includes lactide - glycolide block copolymers. As a function of the degree of polymerization these polyglactins have a melting point of approximately 180 to 200°C.
As a function of the nature of the resorbable material and also the degree of po:Lymerization, variations occur in the resorbability. For example, in the case of higher melting polyglactina, it is in a range of 60 to 80 days, whereas for the lower melting poly-p-dioxanones is approximatE~ly 200 days. Through corresponding mixing of the mono-filaments of fibres forming the felt-like imp7_ants, it is possible to control the resorption timE~ of the complete felt-like implant, i.e.
the speed with which the implant can be decomposed.
Part_LCUlar preference is given to a mixture of fibres of poly-p--dioxanone and those of polyglactin in a ratio of 5:1 to 1:15 and particularly in a ratio of 1:3.
The :Fibre length of the fibre blend for felt-like implants is 1 to 20 mm and preferably 5 to 12 mm, the diameter o:E the filaments or fibres being 40 to 200 dtex.
Preferably, the fibre blend is heated at a temperature of 100 to 110°C and then shaped to the implant-like farm.
Due to the fact that the fibre blend is heated within the different melting points of the resorbable materials and then shaped, there is a strengthening of the fibres of the higher melting resorbable material through melting bonding of the filaments or fibres of the resorbable material with the lower melting point, so that a porous, although relatively compact: felt-like structure is obtained.
The relatively short. fi:Laments or fibres can easily be moulded on heating :in a corresponding mould to give a felt-like body, either in the form of a disk or a plug.
EXAMPLE
Monofilaments of poly-(lactide-co-glycolide), namely polyglactin 'a10, as obtainable under the trade mark VICRYL and those from poly-p-dioxanone, as D
~ 341 06 1 - 3a -available under the name PDS, in a mixing ratio of 3:1, are reduced in size by grinding or chopping to a length of 5 to 12 mm. After thorough mixing they are heated to 100°C and moulded or pressed into the desired form.
As a result of the different melting points of the two materials, there is a bonding of the fibres from the higher meltin<~ material and a felt-like structure corresponding t:o the implant form is obtained.
As a result of the polyglactin, such a felt plug retains i.ts strength for at least 4 to 5 weeks and, even after t:he resorption of this material, retains an ade<luate dimensional stability for a further 2 to 3 weeks due tc> the poly-p-dioxanone.
Claims (7)
1. A felt-like implant of resorbable material produced by heating a blend of 1 to 20 mm long filaments or fibres of at least two different resorbable materials having different melting points, to a temperature between the melting point of the resorbable material having the lowest melting point and the melting point of the resorbable material having the highest melting point, followed by shaping or moulding to a felt-like body.
2. Implant according to claim 1, wherein the resorbable materials have different resorption time.
3. Implant according to claim 1, wherein the fibre blend comprises fibres of poly-p-dioxanone and polyglactin in a ratio of 5:1 to 1:15.
4. Implant according to claim 3, wherein the ratio of the fibres of poly-p-dioxanone and polyglactin is approximately 1:3.
5. Implant according to claim 1, wherein the filaments or fibres have a length of about 5 to about 12 mm.
6. Implant according to claim 5, wherein the filaments or fibres have a diameter of about 40 to about 200 dtex.
7. Implant according to claim 3, wherein the fibre blend is heated at a temperature of 100 to 110°C
and then shaped to the implant-like form.
and then shaped to the implant-like form.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3801426A DE3801426A1 (en) | 1988-01-20 | 1988-01-20 | FELTY IMPLANT |
| DEP3801426.2 | 1988-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1341061C true CA1341061C (en) | 2000-07-25 |
Family
ID=6345558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000588522A Expired - Lifetime CA1341061C (en) | 1988-01-20 | 1989-01-18 | Felt-like implant |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0325195B1 (en) |
| JP (1) | JP2659424B2 (en) |
| AU (1) | AU2867689A (en) |
| BR (1) | BR8900239A (en) |
| CA (1) | CA1341061C (en) |
| DE (1) | DE3801426A1 (en) |
| IN (1) | IN172002B (en) |
| MX (1) | MX169819B (en) |
| ZA (1) | ZA89446B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171148A (en) * | 1989-06-30 | 1992-12-15 | Ethicon, Inc. | Dental inserts for treatment of periodontal disease |
| DE4030998C2 (en) * | 1989-10-04 | 1995-11-23 | Ernst Peter Prof Dr M Strecker | Percutaneous vascular filter |
| DE4004475A1 (en) * | 1990-02-14 | 1991-08-22 | Man Technologie Gmbh | Bone implants with fibre mesh on base body |
| CA2108605A1 (en) * | 1992-10-21 | 1994-04-22 | Nagabhushanam Totakura | Bioabsorbable foam pledget |
| CA2114290C (en) * | 1993-01-27 | 2006-01-10 | Nagabushanam Totakura | Post-surgical anti-adhesion device |
| US5542594A (en) * | 1993-10-06 | 1996-08-06 | United States Surgical Corporation | Surgical stapling apparatus with biocompatible surgical fabric |
| US5393594A (en) * | 1993-10-06 | 1995-02-28 | United States Surgical Corporation | Absorbable non-woven fabric |
| US5626611A (en) * | 1994-02-10 | 1997-05-06 | United States Surgical Corporation | Composite bioabsorbable materials and surgical articles made therefrom |
| US6500777B1 (en) | 1996-06-28 | 2002-12-31 | Ethicon, Inc. | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| US6162537A (en) | 1996-11-12 | 2000-12-19 | Solutia Inc. | Implantable fibers and medical articles |
| JP3559885B2 (en) * | 1997-10-22 | 2004-09-02 | グンゼ株式会社 | Artificial dura |
| DE19906172C1 (en) * | 1999-02-08 | 2000-07-13 | Ethicon Gmbh | Resorbable implant used for inducing tissue formation, especially in bone regeneration, has specific density and porosity properties |
| DE19912360A1 (en) * | 1999-03-19 | 2000-09-21 | Aesculap Ag & Co Kg | Strand-shaped implant made of resorbable polymer material, process for its production and use in surgery |
| DE19912648A1 (en) | 1999-03-20 | 2000-09-21 | Aesculap Ag & Co Kg | Flat implant, method for its production and use in surgery |
| US6325810B1 (en) | 1999-06-30 | 2001-12-04 | Ethicon, Inc. | Foam buttress for stapling apparatus |
| DE19959088A1 (en) * | 1999-12-08 | 2001-06-13 | Inst Textil & Faserforschung | Medical device, process for its manufacture and use |
| US6273897B1 (en) | 2000-02-29 | 2001-08-14 | Ethicon, Inc. | Surgical bettress and surgical stapling apparatus |
| DE10046119A1 (en) * | 2000-09-15 | 2002-03-28 | Inst Textil & Faserforschung | Medical bioresorbable implant, method of manufacture and use |
| US20030059460A1 (en) * | 2001-09-27 | 2003-03-27 | Yasuhiko Tabata | Hybrid material for regeneration of living body tissue |
| US20100331963A1 (en) * | 2009-06-30 | 2010-12-30 | Jackie Donners | Method of Making Suture-Less Hollow Scaffolds |
| US10123862B2 (en) | 2013-03-14 | 2018-11-13 | Ethicon, Inc. | Randomly uniform three dimensional tissue scaffold of absorbable and non-absorbable materials |
| US9352071B2 (en) | 2013-03-14 | 2016-05-31 | Ethicon, Inc. | Method of forming an implantable device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937223A (en) * | 1974-04-19 | 1976-02-10 | American Cyanamid Company | Compacted surgical hemostatic felt |
| CA1123984A (en) * | 1977-11-16 | 1982-05-18 | Yuzi Okuzumi | Block copolymers of lactide and glycolide and surgical prosthesis therefrom |
| US4559945A (en) * | 1984-09-21 | 1985-12-24 | Ethicon, Inc. | Absorbable crystalline alkylene malonate copolyesters and surgical devices therefrom |
| BR8505784A (en) * | 1984-11-19 | 1986-08-12 | Johnson & Johnson | MIXTURE, STRENGTH AND ORIENTED SURGICAL FILAMENT, ABSORBIBLE COMPOSITION AND SURGICAL DEVICE |
| GB2181438B (en) * | 1985-10-07 | 1989-10-11 | South African Inventions | Biocompatible material |
-
1988
- 1988-01-20 DE DE3801426A patent/DE3801426A1/en active Granted
-
1989
- 1989-01-16 IN IN41/CAL/89A patent/IN172002B/en unknown
- 1989-01-17 EP EP89100693A patent/EP0325195B1/en not_active Expired - Lifetime
- 1989-01-18 CA CA000588522A patent/CA1341061C/en not_active Expired - Lifetime
- 1989-01-19 BR BR898900239A patent/BR8900239A/en not_active IP Right Cessation
- 1989-01-19 ZA ZA89446A patent/ZA89446B/en unknown
- 1989-01-20 MX MX014624A patent/MX169819B/en unknown
- 1989-01-20 JP JP1010042A patent/JP2659424B2/en not_active Expired - Lifetime
- 1989-01-20 AU AU28676/89A patent/AU2867689A/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US8778673B2 (en) | 2004-12-17 | 2014-07-15 | Lifescan, Inc. | Seeding cells on porous supports |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0325195A3 (en) | 1991-01-02 |
| JPH025961A (en) | 1990-01-10 |
| EP0325195A2 (en) | 1989-07-26 |
| JP2659424B2 (en) | 1997-09-30 |
| AU2867689A (en) | 1989-07-20 |
| EP0325195B1 (en) | 1993-08-04 |
| MX169819B (en) | 1993-07-27 |
| ZA89446B (en) | 1990-09-26 |
| DE3801426C2 (en) | 1989-12-28 |
| BR8900239A (en) | 1989-09-12 |
| IN172002B (en) | 1993-03-13 |
| DE3801426A1 (en) | 1989-08-03 |
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