CA1339281C - Nebulizer device - Google Patents
Nebulizer deviceInfo
- Publication number
- CA1339281C CA1339281C CA000612251A CA612251A CA1339281C CA 1339281 C CA1339281 C CA 1339281C CA 000612251 A CA000612251 A CA 000612251A CA 612251 A CA612251 A CA 612251A CA 1339281 C CA1339281 C CA 1339281C
- Authority
- CA
- Canada
- Prior art keywords
- crystal
- nebulizer
- projection
- voltage
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B05B5/0255—Discharge apparatus, e.g. electrostatic spray guns spraying and depositing by electrostatic forces only
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B05B5/053—Arrangements for supplying power, e.g. charging power
- B05B5/0531—Power generators
Abstract
The present invention constituents a portable nebulizer capable of producing a finely divided aerosol having uniformly sized droplets. The nebulizer includes a source of fluid such as a capillary tube coupled to a fluid reservoir to which a high voltage is applied in order to generate the aerosol by electrical atomization. The nebulizer further includes a piezoelectric crystal and a mechanism for deforming the crystal so as to generate the required voltage. By using electrical atomization to generate the aerosol and by piezoelectrically generating the voltage required for atomization, a nebulizer is provided which may be of small size so as to be suitable for hand held operations yet is capable of producing measured amounts of finely divided aerosols which are substantially monodispersed.
Description
NEBULIZER DEVICE
Background of the Invention The present invention relates to devices for atomizing liquids and more particularly to devices for producing finely divided aerosols having uniformly sized droplets.
Finely divided aerosols have generally been produced by nebulizers employing compressed air to atomize fluids.
These devices operate by allowing compressed air to escape from a small orifice at the end of a tube at high velocity.
The low pressure created in the exit region as a result of the bernoulli effect causes the fluid to be atomized to be drawn out of a second tube as a thin filament which is broken up into droplets of various small sizes as it is accelerated in the airstream. This spray is then directed around an impaction surface on which the large droplets are preferentially deposited and whereby some uniformity is provided with respect to droplet size. However, most nebulizers operating with compressed air having difficulty producing aerosols having particle sizes approaching one micron and cannot ordinarily generate aerosols which are sufficiently uniform in size so as to be ~monodispersed".
Finely divided aerosols are highly useful in many applications and particularly in administering medications which are pneumonically delivered to the patient by inhalation. Most "inhalators" used in dispensing medications are compressed air nebulizers of sufficiently small size to be suitable for hand-held use. However, in view of the characteristic limitations of such nebulizers and the further limitations inherent in the small size of most inhalators, users of these devices have had great difficulty in providing aerosols having uniform particle size and in the related problem of providing consistent measured amounts of medication.
Background of the Invention The present invention relates to devices for atomizing liquids and more particularly to devices for producing finely divided aerosols having uniformly sized droplets.
Finely divided aerosols have generally been produced by nebulizers employing compressed air to atomize fluids.
These devices operate by allowing compressed air to escape from a small orifice at the end of a tube at high velocity.
The low pressure created in the exit region as a result of the bernoulli effect causes the fluid to be atomized to be drawn out of a second tube as a thin filament which is broken up into droplets of various small sizes as it is accelerated in the airstream. This spray is then directed around an impaction surface on which the large droplets are preferentially deposited and whereby some uniformity is provided with respect to droplet size. However, most nebulizers operating with compressed air having difficulty producing aerosols having particle sizes approaching one micron and cannot ordinarily generate aerosols which are sufficiently uniform in size so as to be ~monodispersed".
Finely divided aerosols are highly useful in many applications and particularly in administering medications which are pneumonically delivered to the patient by inhalation. Most "inhalators" used in dispensing medications are compressed air nebulizers of sufficiently small size to be suitable for hand-held use. However, in view of the characteristic limitations of such nebulizers and the further limitations inherent in the small size of most inhalators, users of these devices have had great difficulty in providing aerosols having uniform particle size and in the related problem of providing consistent measured amounts of medication.
It is therefore an object of the present invention to provide a portable nebulizer capable of generating finely divided aerosols which are substantially monodispersed.
It is another object of the present invention to provide a nebulizer which may be small enough for hand-held use and yet provides aerosols of substantially uniform particle size while being capable of supplying medication in consistently measured dosages.
It is a further object of the present invention to provide a nebulizer which may be powered by the hand gripping pressure of a user of the device and which is sufficiently economical to construct so as to be disposable.
Summary of the Invention The present invention comprises a portable hand-held nebulizer capable of generating aerosols characterized by uniformly-sized droplets of very small dimensions by electrical atomization. A piezoelectric crystal is constructed and arranged for being mechanically deformed in accordance with pressure applied to a trigger mechanism. The crystal is adapted for generating high voltages in response to such deformations. The crystal is electrically coupled to a capillary tube and a grid element which is spaced apart from the tip of the tube. The capillary tube is connected to a reservoir of fluid to be atomized so as to allow the fluid to be supplied up to the tip of the tube. The preferred embodiment of the present invention also includes a control circuit which regulates the output of this piezoelectric crystal in order to cut off the output below and above prescribed voltage limits.
In operation, the deformation of the piezoelectric crystal produces a high voltage which is transmitted to and applied across the capillary tube and grid element. The electric field existing between the tip of the tube and the grid encourages the discharge of fluid from the tube. This fluld ls broken lnto a very large number of slmllarly slzed droplets by the effects of the electric charges carrled by the fluld and a "fan spray" aerosol ls thereby formed. Thls process of electrlcal atomlzatlon furnlshes an aerosol conslstlng of large numbers of very flne partlcles havlng a hlgh degree of unlformlty. Such aerosols are hlghly useful ln pneumonlcally admlnlsterlng medlcatlons and ln many other appllcatlons.
In summary, the lnventlon provldes a nebullzer whlch ls adapted for produclng flnely dlvlded aerosols havlng unlformly slzed droplets yet whlch ls manually powered by hand grlpplng pressure, sald nebullzer comprlslng: a plezoelectrlc crystal; means for manually deformlng sald crystal so as to generate a hlgh voltage; a pro~ectlon constructed and arranged for belng supplled wlth a flow of liquld to be atomlzed; means for applylng voltage generated by sald crystal to sald pro~ectlon; and means for regulatlng the value of the voltage as applled to sald pro~ectlon as well as for automatlcally controlllng the duratlon of sald appllcatlon of sald voltage ln order to provlde a predetermlned dose of sald llquld.
The lnventlon wlll now be descrlbed ln greater detall wlth reference to the accompanylng drawlngs whereln llke reference characters refer to llke elements.
Brlef Descrlptlon of the Drawlnq The drawlng ls a dlagrammatlc vlew lllustratlng the overall system of the present lnventlon.
Descrlptlon of the Preferred Embodlment Referrlng now to the drawlng, the present lnventlon i 1339281 comprlses a nebullzer devlce 5 lncludlng a plezoelectrlc ceramlc crystal 10 of a conventlonal type such as a lead tltanate-zlrconate crystal. An lmpact element 20 ls posltloned for engaglng the surface 12 of the crystal 10 so that force F
exerted on the element 20 can bend and deform the crystal 10.
The electrlcal contacts 24 and 26 are attached to opposlte faces on the longltudlnal ends of the crystal 10 for plcklng up electrlcal potentlals generated across the crystal 10 by the deformatlon prevlously referred to. The conductlve leads 28 and 30 transmlt the voltage from the contacts 24 and 26 to the control clrcult 32.
The impact element 20 is connected by a mechanical linkage to a trigger mechanism 18 which may be conveniently depressed by hand gripping pressure exerted by a user of the device 5. The force applied by the user to the trigger mechanism 18 is multiplied by the mechanical linkage and brought to bear on the crystal 10 by the impact element 20.
The linkage suitably comprises a rigid lever arm with its fulcrum at 16 positioned more closely to element 20 than to trigger 18 (i.e., with arm 17 being substantially shorter than arm 19). Alternatively, the mechanical linkage may comprise a rack and pinion system with the impact element 20 being driven by a cam from the pinion. Such means for multiplying force are readily understood by those skilled in the art.
The control circuit 32 is operative for regulating the voltage generated by the piezoelectric crystal 10 so that the electrical potential applied between the capillary tube and neutralization grid 42 over the electrically conductive leads 46 and 48 is maintained within the range of 6-10 Kv. In particular, the voltage is preferably not applied between the tube 40 and grid 42 when it is less than about 6 Kv since this may detrimentally affect the uniformity of the aerosol. The control circuit 32 also provides a capacitive or storing function for storing and releasing electrical charge in a well known manner so that the voltage supplied to tube 40 and grid 42 may be sustained beyond the actual period of depression of the trigger mechanism 18. The leads 46 and 48 transmit the electrical potential from the control circuit 32 to the tube 40 and grid 42, respectively, with the positive potential being applied to the tube 40 ~ (and/or the fluid within the tube 40).
The reservoir 50 contains a fluid (and more particularly a liquid) capable of being dispersed by electrical atomization techniques, such as water or ethyl alcohol, and is hydraulically connected to the capillary tube 40 so that the fluid from the reservoir 50 can flow up to the tip 44 of the tube 40. The inside diameter of the capillary tube 40 is preferably in the range of 100-500 microns with its outside dimensions being as thin as possible consistent with maint~ining sufficient strength and rigidity. The capillary tube 40 preferably comprises a stainless steel tube such as a No. 25 hypodermic needle although the tube 40 may be constructed of glass or of a plastic such as tetrafluoroethylene. The fluid level in reservoir 50 should be high enough to allow the fluid to reach the tip of tube 40 by fluid flow or capillary action. Neutralization grid 42 is spaced apart by approximately 1.5 cm from the tip 44 of the capillary tube 40.
In operation, the user slowly presses the trigger mechanism 18 which results in the crystal 10 being progressively deformed as more and more force is applied to the crystal 10 by impact element 20. The piezoelectric crystal 10 generates a voltage which may ordinarily range upward to 20 Kv and may be sustained in the range of 6-10 Kv for a period of several seconds. The exact levels of voltage generated are a function of the force applied to the trigger, and the characteristics of the mechanical linkage 16, impact element 20, and the piezoelectric crystal 10 itself. These components may be adjusted to assist in achieving the desired raw voltage output to the control circuit 32.
As previously described, the control circuit desirably regulates the output of the crystal 10 so as to limit it within the range of 6-10 Kv and "lengthen" the period of time during which voltage is provided. The voltage provided by the control circuit 32 is applied between the capillary tube 40 and neutralization grid 42. The resultant electric field existing between the pointed projection formed by the tip 44 of the tube 40 and grid 42 causes the generation of a fan spray aerosol composed of substantially monodispersed droplets capable of exhibiting higher order 133~281 Tyndall spectra. Droplets with sizes in the range of 0.2 to 5 microns can be readily produced with droplet concentration levels approaching 108 particles per cubic centimeter.
The ability of the device S to produce a satisfactory aerosol can, however, be dependent on the type of fluid which is desired to be dispersed. Fluids having either very low (e.g. benzene) or high (e.g. inorganic acids, salts) conductivities are difficult to disperse by electrical atomization. Furthermore, other characteristics of fluids such as their dielectric constants, dipole moments and surface tensions may affect their ability to be electrically atomized. Consequently, when medications which are dissolved in solution are desired to be dispersed, appropriate vehicles should be chosen for solvating such medications for allowing efficient atomization.
The nature of the aerosol produced by the device 5 is a complex function of the applied voltage, the size and structure of the capillary tube 40, the spacing between the tube 40 and the grid 42, the hydrostatic pressure of liquid at the tip 44 of the tube 40, and the characteristics of the liquid as previously discussed. These factors may be adjusted either individually or in combination to achieve the aerosol particle size and volume desired. In particular, the control circuit 32 is suitably used to insure that voltage applied between the tube and grid is of consistent level and duration for aerosol generation, thereby resulting in measured dosages of medical products atomized by the device 5.
While a preferred embodiment of the present invention has been shown and described, it will be apparent to those skilled in the art that many changes and modifications may be made without departing from the invention in its broader aspects. For example, more than one capillary tube may be employed in the same nebulizer device so as to increase the volume of the aerosol produced as compared with a single tube 13~Z81 nebulizer device. By way of further example, the capillary tube may, under suitable conditions, be replaced by another type of pointed projection such as a short needle constructed and arranged so as to allow the liquid to be atomized as otherwise supplied to its tip. The appended claims are therefore intended to cover such changes and modifications as fall within the true spirit and scope of the invention.
It is another object of the present invention to provide a nebulizer which may be small enough for hand-held use and yet provides aerosols of substantially uniform particle size while being capable of supplying medication in consistently measured dosages.
It is a further object of the present invention to provide a nebulizer which may be powered by the hand gripping pressure of a user of the device and which is sufficiently economical to construct so as to be disposable.
Summary of the Invention The present invention comprises a portable hand-held nebulizer capable of generating aerosols characterized by uniformly-sized droplets of very small dimensions by electrical atomization. A piezoelectric crystal is constructed and arranged for being mechanically deformed in accordance with pressure applied to a trigger mechanism. The crystal is adapted for generating high voltages in response to such deformations. The crystal is electrically coupled to a capillary tube and a grid element which is spaced apart from the tip of the tube. The capillary tube is connected to a reservoir of fluid to be atomized so as to allow the fluid to be supplied up to the tip of the tube. The preferred embodiment of the present invention also includes a control circuit which regulates the output of this piezoelectric crystal in order to cut off the output below and above prescribed voltage limits.
In operation, the deformation of the piezoelectric crystal produces a high voltage which is transmitted to and applied across the capillary tube and grid element. The electric field existing between the tip of the tube and the grid encourages the discharge of fluid from the tube. This fluld ls broken lnto a very large number of slmllarly slzed droplets by the effects of the electric charges carrled by the fluld and a "fan spray" aerosol ls thereby formed. Thls process of electrlcal atomlzatlon furnlshes an aerosol conslstlng of large numbers of very flne partlcles havlng a hlgh degree of unlformlty. Such aerosols are hlghly useful ln pneumonlcally admlnlsterlng medlcatlons and ln many other appllcatlons.
In summary, the lnventlon provldes a nebullzer whlch ls adapted for produclng flnely dlvlded aerosols havlng unlformly slzed droplets yet whlch ls manually powered by hand grlpplng pressure, sald nebullzer comprlslng: a plezoelectrlc crystal; means for manually deformlng sald crystal so as to generate a hlgh voltage; a pro~ectlon constructed and arranged for belng supplled wlth a flow of liquld to be atomlzed; means for applylng voltage generated by sald crystal to sald pro~ectlon; and means for regulatlng the value of the voltage as applled to sald pro~ectlon as well as for automatlcally controlllng the duratlon of sald appllcatlon of sald voltage ln order to provlde a predetermlned dose of sald llquld.
The lnventlon wlll now be descrlbed ln greater detall wlth reference to the accompanylng drawlngs whereln llke reference characters refer to llke elements.
Brlef Descrlptlon of the Drawlnq The drawlng ls a dlagrammatlc vlew lllustratlng the overall system of the present lnventlon.
Descrlptlon of the Preferred Embodlment Referrlng now to the drawlng, the present lnventlon i 1339281 comprlses a nebullzer devlce 5 lncludlng a plezoelectrlc ceramlc crystal 10 of a conventlonal type such as a lead tltanate-zlrconate crystal. An lmpact element 20 ls posltloned for engaglng the surface 12 of the crystal 10 so that force F
exerted on the element 20 can bend and deform the crystal 10.
The electrlcal contacts 24 and 26 are attached to opposlte faces on the longltudlnal ends of the crystal 10 for plcklng up electrlcal potentlals generated across the crystal 10 by the deformatlon prevlously referred to. The conductlve leads 28 and 30 transmlt the voltage from the contacts 24 and 26 to the control clrcult 32.
The impact element 20 is connected by a mechanical linkage to a trigger mechanism 18 which may be conveniently depressed by hand gripping pressure exerted by a user of the device 5. The force applied by the user to the trigger mechanism 18 is multiplied by the mechanical linkage and brought to bear on the crystal 10 by the impact element 20.
The linkage suitably comprises a rigid lever arm with its fulcrum at 16 positioned more closely to element 20 than to trigger 18 (i.e., with arm 17 being substantially shorter than arm 19). Alternatively, the mechanical linkage may comprise a rack and pinion system with the impact element 20 being driven by a cam from the pinion. Such means for multiplying force are readily understood by those skilled in the art.
The control circuit 32 is operative for regulating the voltage generated by the piezoelectric crystal 10 so that the electrical potential applied between the capillary tube and neutralization grid 42 over the electrically conductive leads 46 and 48 is maintained within the range of 6-10 Kv. In particular, the voltage is preferably not applied between the tube 40 and grid 42 when it is less than about 6 Kv since this may detrimentally affect the uniformity of the aerosol. The control circuit 32 also provides a capacitive or storing function for storing and releasing electrical charge in a well known manner so that the voltage supplied to tube 40 and grid 42 may be sustained beyond the actual period of depression of the trigger mechanism 18. The leads 46 and 48 transmit the electrical potential from the control circuit 32 to the tube 40 and grid 42, respectively, with the positive potential being applied to the tube 40 ~ (and/or the fluid within the tube 40).
The reservoir 50 contains a fluid (and more particularly a liquid) capable of being dispersed by electrical atomization techniques, such as water or ethyl alcohol, and is hydraulically connected to the capillary tube 40 so that the fluid from the reservoir 50 can flow up to the tip 44 of the tube 40. The inside diameter of the capillary tube 40 is preferably in the range of 100-500 microns with its outside dimensions being as thin as possible consistent with maint~ining sufficient strength and rigidity. The capillary tube 40 preferably comprises a stainless steel tube such as a No. 25 hypodermic needle although the tube 40 may be constructed of glass or of a plastic such as tetrafluoroethylene. The fluid level in reservoir 50 should be high enough to allow the fluid to reach the tip of tube 40 by fluid flow or capillary action. Neutralization grid 42 is spaced apart by approximately 1.5 cm from the tip 44 of the capillary tube 40.
In operation, the user slowly presses the trigger mechanism 18 which results in the crystal 10 being progressively deformed as more and more force is applied to the crystal 10 by impact element 20. The piezoelectric crystal 10 generates a voltage which may ordinarily range upward to 20 Kv and may be sustained in the range of 6-10 Kv for a period of several seconds. The exact levels of voltage generated are a function of the force applied to the trigger, and the characteristics of the mechanical linkage 16, impact element 20, and the piezoelectric crystal 10 itself. These components may be adjusted to assist in achieving the desired raw voltage output to the control circuit 32.
As previously described, the control circuit desirably regulates the output of the crystal 10 so as to limit it within the range of 6-10 Kv and "lengthen" the period of time during which voltage is provided. The voltage provided by the control circuit 32 is applied between the capillary tube 40 and neutralization grid 42. The resultant electric field existing between the pointed projection formed by the tip 44 of the tube 40 and grid 42 causes the generation of a fan spray aerosol composed of substantially monodispersed droplets capable of exhibiting higher order 133~281 Tyndall spectra. Droplets with sizes in the range of 0.2 to 5 microns can be readily produced with droplet concentration levels approaching 108 particles per cubic centimeter.
The ability of the device S to produce a satisfactory aerosol can, however, be dependent on the type of fluid which is desired to be dispersed. Fluids having either very low (e.g. benzene) or high (e.g. inorganic acids, salts) conductivities are difficult to disperse by electrical atomization. Furthermore, other characteristics of fluids such as their dielectric constants, dipole moments and surface tensions may affect their ability to be electrically atomized. Consequently, when medications which are dissolved in solution are desired to be dispersed, appropriate vehicles should be chosen for solvating such medications for allowing efficient atomization.
The nature of the aerosol produced by the device 5 is a complex function of the applied voltage, the size and structure of the capillary tube 40, the spacing between the tube 40 and the grid 42, the hydrostatic pressure of liquid at the tip 44 of the tube 40, and the characteristics of the liquid as previously discussed. These factors may be adjusted either individually or in combination to achieve the aerosol particle size and volume desired. In particular, the control circuit 32 is suitably used to insure that voltage applied between the tube and grid is of consistent level and duration for aerosol generation, thereby resulting in measured dosages of medical products atomized by the device 5.
While a preferred embodiment of the present invention has been shown and described, it will be apparent to those skilled in the art that many changes and modifications may be made without departing from the invention in its broader aspects. For example, more than one capillary tube may be employed in the same nebulizer device so as to increase the volume of the aerosol produced as compared with a single tube 13~Z81 nebulizer device. By way of further example, the capillary tube may, under suitable conditions, be replaced by another type of pointed projection such as a short needle constructed and arranged so as to allow the liquid to be atomized as otherwise supplied to its tip. The appended claims are therefore intended to cover such changes and modifications as fall within the true spirit and scope of the invention.
Claims (5)
1. A nebulizer which is adapted for producing finely divided aerosols having uniformly sized droplets yet which is manually powered by hand gripping pressure, said nebulizer comprising: a piezoelectric crystal; means for manually deforming said crystal so as to generate a high voltage; a projection constructed and arranged for being supplied with a flow of liquid to be atomized; means for applying voltage generated by said crystal to said projection; and means for regulating the value of the voltage as applied to said projection as well as for automatically controlling the duration of said application of said voltage in order to provide a predetermined dose of said liquid.
2. The nebulizer of claim 1, wherein said projection includes: a capillary tube coupled to a fluid reservoir operative for supplying the liquid to be atomized to the tube.
3. The nebulizer of claim 1, wherein means for manually deforming said crystal includes: a lever arm attached to a trigger mechanism.
4. The nebulizer of claim 1, wherein said means for applying voltage to said crystal includes: a pair of electrical conductors coupled to opposing faces of said crystal, one of which is connected to said projection and the other of which is connected to a grid means spaced apart from said projection, said projection being substantially pointed.
5. The nebulizer of claim 1, wherein the means for regulating the value of the voltage as applied to said projection ensures that voltage generated by said crystal when less than approximately 6Kv is not applied to said projection.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US248,558 | 1988-09-23 | ||
| US07/248,558 US5115971A (en) | 1988-09-23 | 1988-09-23 | Nebulizer device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1339281C true CA1339281C (en) | 1997-08-12 |
Family
ID=22939651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000612251A Expired - Fee Related CA1339281C (en) | 1988-09-23 | 1989-09-21 | Nebulizer device |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5115971A (en) |
| EP (1) | EP0435921B1 (en) |
| JP (1) | JPH04500926A (en) |
| AU (1) | AU635902B2 (en) |
| CA (1) | CA1339281C (en) |
| DE (1) | DE68912133T2 (en) |
| NZ (1) | NZ230752A (en) |
| PT (1) | PT91786B (en) |
| WO (1) | WO1990003224A1 (en) |
| ZA (1) | ZA897238B (en) |
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| US11260416B2 (en) | 2012-05-15 | 2022-03-01 | Eyenovia, Inc. | Ejector devices, methods, drivers, and circuits therefor |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5511726A (en) * | 1988-09-23 | 1996-04-30 | Battelle Memorial Institute | Nebulizer device |
| US5144962A (en) * | 1989-12-01 | 1992-09-08 | Philip Morris Incorporated | Flavor-delivery article |
| ES2154259T3 (en) * | 1990-11-12 | 2001-04-01 | Procter & Gamble | SPRAY DEVICE. |
| EP0501725B1 (en) * | 1991-03-01 | 2001-06-13 | The Procter & Gamble Company | Spraying of liquids |
| GB9115279D0 (en) * | 1991-07-15 | 1991-08-28 | Unilever Plc | Hair and scalp treatment system |
| GB9115278D0 (en) * | 1991-07-15 | 1991-08-28 | Unilever Plc | Liquid spraying apparatus and method |
| GB9115276D0 (en) * | 1991-07-15 | 1991-08-28 | Unilever Plc | Skin treatment system |
| GB9115275D0 (en) * | 1991-07-15 | 1991-08-28 | Unilever Plc | Colour cosmetic spray system |
| GB9115277D0 (en) * | 1991-07-15 | 1991-08-28 | Unilever Plc | Spraying system |
| WO1994006568A1 (en) * | 1992-09-22 | 1994-03-31 | Battelle Memorial Institute | Nebulizer device |
| GB9225098D0 (en) * | 1992-12-01 | 1993-01-20 | Coffee Ronald A | Charged droplet spray mixer |
| US6105571A (en) | 1992-12-22 | 2000-08-22 | Electrosols, Ltd. | Dispensing device |
| US6880554B1 (en) | 1992-12-22 | 2005-04-19 | Battelle Memorial Institute | Dispensing device |
| GB9226717D0 (en) * | 1992-12-22 | 1993-02-17 | Coffee Ronald A | Induction-operated electro-hydrodynamic spray device with means of modifying droplet trajectories |
| GB9303335D0 (en) * | 1993-02-19 | 1993-04-07 | Bespak Plc | Inhalation apparatus |
| US5400975A (en) * | 1993-11-04 | 1995-03-28 | S. C. Johnson & Son, Inc. | Actuators for electrostatically charged aerosol spray systems |
| DE4408032A1 (en) * | 1994-03-10 | 1995-09-14 | Bruker Franzen Analytik Gmbh | Process for the ionization of dissolved atoms or molecules from liquids by electrical spraying |
| GB9406171D0 (en) * | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| US6729334B1 (en) | 1994-06-17 | 2004-05-04 | Trudell Medical Limited | Nebulizing catheter system and methods of use and manufacture |
| US5642730A (en) * | 1994-06-17 | 1997-07-01 | Trudell Medical Limited | Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister |
| IL114154A0 (en) * | 1994-06-17 | 1995-10-31 | Trudell Medical Ltd | Nebulizing catheter system and methods of use and manufacture |
| US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US5873523A (en) * | 1996-02-29 | 1999-02-23 | Yale University | Electrospray employing corona-assisted cone-jet mode |
| US7193124B2 (en) | 1997-07-22 | 2007-03-20 | Battelle Memorial Institute | Method for forming material |
| US6252129B1 (en) | 1996-07-23 | 2001-06-26 | Electrosols, Ltd. | Dispensing device and method for forming material |
| AU741439B2 (en) | 1996-12-30 | 2001-11-29 | Battelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
| US5948483A (en) * | 1997-03-25 | 1999-09-07 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for producing thin film and nanoparticle deposits |
| GB2327895B (en) | 1997-08-08 | 2001-08-08 | Electrosols Ltd | A dispensing device |
| SE512386C2 (en) * | 1998-07-30 | 2000-03-06 | Microdrug Ag | Method and apparatus for classifying electrostatically charged powdery material |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| AU4439101A (en) * | 2000-04-03 | 2001-10-15 | Electrosols Ltd | Devices and formulations |
| WO2001083101A1 (en) * | 2000-04-18 | 2001-11-08 | Kang, Seog, Joo | Apparatus for manufacturing ultra-fine particles using electrospray device and method thereof |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| AU3664102A (en) * | 2000-12-01 | 2002-06-11 | Battelle Memorial Institute | Method for stabilizing biomolecules in liquid formulations |
| US6546927B2 (en) * | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
| JP4667678B2 (en) * | 2001-09-20 | 2011-04-13 | 中央精機株式会社 | Arc welding quality evaluation system |
| US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
| CA2472644C (en) | 2002-01-07 | 2013-11-05 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
| ES2603067T3 (en) | 2002-01-15 | 2017-02-23 | Novartis Ag | Methods and systems for operating an aerosol generator |
| RU2190482C1 (en) * | 2002-02-07 | 2002-10-10 | Брежнев Вячеслав Николаевич | Method of production of aerosol |
| EP1509259B1 (en) | 2002-05-20 | 2016-04-20 | Novartis AG | Apparatus for providing aerosol for medical treatment and methods |
| US20040055595A1 (en) * | 2002-09-19 | 2004-03-25 | Noymer Peter D. | Aerosol drug delivery system employing formulation pre-heating |
| MXPA05007154A (en) * | 2002-12-30 | 2005-09-21 | Nektar Therapeutics | Prefilming atomizer. |
| US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
| EP1680173B1 (en) * | 2003-10-31 | 2011-01-12 | Trudell Medical International | System for manipulating a catheter for delivering a substance to a body cavity |
| US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
| EP1685775B1 (en) * | 2005-01-28 | 2009-10-28 | Panasonic Electric Works Co., Ltd. | Hair dryer with electrostatic atomizing device |
| JP5064383B2 (en) | 2005-05-25 | 2012-10-31 | エアロジェン，インコーポレイテッド | Vibration system and method |
| EP2113178A1 (en) | 2008-04-30 | 2009-11-04 | Philip Morris Products S.A. | An electrically heated smoking system having a liquid storage portion |
| US20100071687A1 (en) * | 2008-09-25 | 2010-03-25 | Micro Base Technology Corporation | Nebulization Apparatus |
| EP2319334A1 (en) | 2009-10-27 | 2011-05-11 | Philip Morris Products S.A. | A smoking system having a liquid storage portion |
| JP5342464B2 (en) * | 2010-01-20 | 2013-11-13 | パナソニック株式会社 | Electric appliance |
| US9282772B2 (en) | 2012-01-31 | 2016-03-15 | Altria Client Services Llc | Electronic vaping device |
| WO2013126777A2 (en) | 2012-02-22 | 2013-08-29 | Altria Client Services Inc. | Electronic smoking article and improved heater element |
| EP2817051B1 (en) | 2012-02-22 | 2017-07-26 | Altria Client Services LLC | Electronic smoking article |
| CN103611206A (en) * | 2013-11-20 | 2014-03-05 | 龙云泽 | Airflow-guide-type directional in-situ electrostatic spraying device |
| US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
| US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
| US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
| US10357060B2 (en) | 2016-03-11 | 2019-07-23 | Altria Client Services Llc | E-vaping device cartridge holder |
| US10368581B2 (en) | 2016-03-11 | 2019-08-06 | Altria Client Services Llc | Multiple dispersion generator e-vaping device |
| RU167914U1 (en) * | 2016-06-16 | 2017-01-12 | Александр Сергеевич Гульпа | AEROFITOTHERAPY DEVICE |
| CN112806341B (en) * | 2021-02-25 | 2023-05-09 | 吉林大学 | Orchard targeting spraying control system and method based on laminar layer |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US705691A (en) * | 1900-02-20 | 1902-07-29 | William James Morton | Method of dispersing fluids. |
| NL255983A (en) * | 1959-12-14 | |||
| DE1224075B (en) * | 1963-09-25 | 1966-09-01 | Heinrich Maltner G M B H | Hand-operated piezoelectric ignition device |
| US3558903A (en) * | 1966-06-25 | 1971-01-26 | Rion Co | Mechanically activated piezoelectric voltage source |
| US3579245A (en) * | 1967-12-07 | 1971-05-18 | Teletype Corp | Method of transferring liquid |
| US3802625A (en) * | 1973-01-08 | 1974-04-09 | Us Army | Device for electrostatic charging or discharging |
| FR2243740B1 (en) * | 1973-09-14 | 1978-10-27 | Voith Gmbh | |
| US3997817A (en) * | 1975-05-21 | 1976-12-14 | Philip Edward Secker | Device for neutralizing the charge on statically-charged surfaces |
| IE45426B1 (en) * | 1976-07-15 | 1982-08-25 | Ici Ltd | Atomisation of liquids |
| US4106697A (en) * | 1976-08-30 | 1978-08-15 | Ppg Industries, Inc. | Spraying device with gas shroud and electrostatic charging means having a porous electrode |
| US4113809A (en) * | 1977-04-04 | 1978-09-12 | Champion Spark Plug Company | Hand held ultrasonic nebulizer |
| DE7917568U1 (en) * | 1979-06-19 | 1979-09-20 | Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart | INHALATION DEVICE |
| US4341347A (en) * | 1980-05-05 | 1982-07-27 | S. C. Johnson & Son, Inc. | Electrostatic spraying of liquids |
| GB2126431B (en) * | 1982-08-25 | 1986-12-03 | Ici Plc | Pump and pump components |
| GB2128900B (en) * | 1982-10-29 | 1985-11-20 | Theoktiste Christofidis | Ionising spray |
| DE3475598D1 (en) * | 1983-03-25 | 1989-01-19 | Ici Plc | Spraying apparatus |
| US4545525A (en) * | 1983-07-11 | 1985-10-08 | Micropure, Incorporated | Producing liquid droplets bearing electrical charges |
| US4630169A (en) * | 1984-09-04 | 1986-12-16 | Exxon Research And Engineering Company | Charge injection device |
| US4702418A (en) * | 1985-09-09 | 1987-10-27 | Piezo Electric Products, Inc. | Aerosol dispenser |
| GB8528032D0 (en) * | 1985-11-13 | 1985-12-18 | Ici Plc | Ocular treatment |
| GB8604328D0 (en) * | 1986-02-21 | 1986-03-26 | Ici Plc | Producing spray of droplets of liquid |
| GB8614566D0 (en) * | 1986-06-16 | 1986-07-23 | Ici Plc | Spraying |
| US4776515A (en) * | 1986-08-08 | 1988-10-11 | Froughieh Michalchik | Electrodynamic aerosol generator |
| US4749125A (en) * | 1987-01-16 | 1988-06-07 | Terronics Development Corp. | Nozzle method and apparatus |
-
1988
- 1988-09-23 US US07/248,558 patent/US5115971A/en not_active Expired - Fee Related
-
1989
- 1989-09-20 JP JP1510173A patent/JPH04500926A/en active Pending
- 1989-09-20 EP EP89910739A patent/EP0435921B1/en not_active Expired - Lifetime
- 1989-09-20 WO PCT/US1989/004102 patent/WO1990003224A1/en active IP Right Grant
- 1989-09-20 AU AU43025/89A patent/AU635902B2/en not_active Ceased
- 1989-09-20 DE DE89910739T patent/DE68912133T2/en not_active Expired - Fee Related
- 1989-09-21 CA CA000612251A patent/CA1339281C/en not_active Expired - Fee Related
- 1989-09-22 PT PT91786A patent/PT91786B/en not_active IP Right Cessation
- 1989-09-22 ZA ZA897238A patent/ZA897238B/en unknown
- 1989-09-22 NZ NZ230752A patent/NZ230752A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11110000B2 (en) | 2012-04-10 | 2021-09-07 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume ophthalmic administration |
| US11260416B2 (en) | 2012-05-15 | 2022-03-01 | Eyenovia, Inc. | Ejector devices, methods, drivers, and circuits therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04500926A (en) | 1992-02-20 |
| DE68912133T2 (en) | 1994-04-28 |
| NZ230752A (en) | 1992-04-28 |
| EP0435921A1 (en) | 1991-07-10 |
| US5115971A (en) | 1992-05-26 |
| PT91786A (en) | 1990-03-30 |
| WO1990003224A1 (en) | 1990-04-05 |
| EP0435921B1 (en) | 1994-01-05 |
| PT91786B (en) | 1995-07-18 |
| AU4302589A (en) | 1990-04-18 |
| AU635902B2 (en) | 1993-04-08 |
| DE68912133D1 (en) | 1994-02-17 |
| ZA897238B (en) | 1990-06-27 |
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| MKLA | Lapsed |