CA1266661C - Acylmercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl l-prolines - Google Patents
Acylmercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl l-prolinesInfo
- Publication number
- CA1266661C CA1266661C CA452213A CA452213A CA1266661C CA 1266661 C CA1266661 C CA 1266661C CA 452213 A CA452213 A CA 452213A CA 452213 A CA452213 A CA 452213A CA 1266661 C CA1266661 C CA 1266661C
- Authority
- CA
- Canada
- Prior art keywords
- prolines
- sulfonyl
- aryl
- mercaptoalkanoyl
- acylmercaptoalkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
HA285 ABSTRACT ACYLMERCAPTOALKANOYL AND MERCAPTOALKANOYL DERIVATIVES OF ARYL AND ARALKYL SULFINYL OR SULFONYL L- PROLINES This invention provides new acyl mercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl prolines of the formula wherein n is one or two and the other substituents are as defined herein. These new compounds possess angiotensin converting enzyme inhibition activity and thus are useful as anti-hypertensive agents.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000615516A CA1271966A (en) | 1983-04-25 | 1984-04-17 | Aryl and aralkyl sulfonyl l-prolines |
CA452213A CA1266661C (en) | 1983-04-25 | 1984-04-17 | Acylmercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl l-prolines |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48847783A | 1983-04-25 | 1983-04-25 | |
US488,477 | 1983-04-25 | ||
CA452213A CA1266661C (en) | 1983-04-25 | 1984-04-17 | Acylmercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl l-prolines |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000615516A Division CA1271966A (en) | 1983-04-25 | 1984-04-17 | Aryl and aralkyl sulfonyl l-prolines |
Publications (2)
Publication Number | Publication Date |
---|---|
CA1266661A CA1266661A (en) | 1990-03-13 |
CA1266661C true CA1266661C (en) | 1990-03-13 |
Family
ID=34117156
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA452213A Expired CA1266661C (en) | 1983-04-25 | 1984-04-17 | Acylmercaptoalkanoyl and mercaptoalkanoyl derivatives of aryl and aralkyl sulfinyl or sulfonyl l-prolines |
CA000615516A Expired - Lifetime CA1271966A (en) | 1983-04-25 | 1984-04-17 | Aryl and aralkyl sulfonyl l-prolines |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000615516A Expired - Lifetime CA1271966A (en) | 1983-04-25 | 1984-04-17 | Aryl and aralkyl sulfonyl l-prolines |
Country Status (1)
Country | Link |
---|---|
CA (2) | CA1266661C (en) |
-
1984
- 1984-04-17 CA CA452213A patent/CA1266661C/en not_active Expired
- 1984-04-17 CA CA000615516A patent/CA1271966A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA1271966C (en) | 1990-07-24 |
CA1266661A (en) | 1990-03-13 |
CA1271966A (en) | 1990-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKLA | Lapsed | ||
MKLA | Lapsed |
Effective date: 19980313 |