CA1266304A - Catheter system for controlled removal by radiant energy of biological obstructions - Google Patents

Abstract

AZB/dmc ABSTRACT OF THE DISCLOSURE

A catheter for delivering radiant energy, such as a laser beam, is used in a technique to controllably apply the radiant energy in a patient's body, such as in a blood vessel. The radiant energy is applied in a manner which erodes biological material and may be used to drill through vascular obstructions. The catheter emits the radiant energy from its distal end in a pattern which defines a relatively small working region in which the energy density level is sufficiently high to remove the biological material. The energy distribution is substantially uniform across the beam. Distally beyond the working region, the energy density of the beam decays sharply so that biological material beyond the working region is not removed.
Biological material is removed in very limited layer-like regions and in a manner in which a distally propogated segment of the beam will not have sufficient energy density to puncture the blood vessel wall. The catheter is a of elongate flexible tubular construction having a fiber optic wave guide extending through the lumen of the catheter. The distal end of the optical fiber terminates within the catheter and is secured in alignment with an optical system at the distal end of the catheter.

Description

30~L

AZB/dmc CATHETER SYSTEM FOR CONTROLLED REMOVAL
BY RADIANT ENERGY OF BIQLOGICAL OBSTRUCTIONS

FIELD OF T~E INVENTION

This invention relates to catheters and techniques for delivering and applying radiant energy, such as in the form of a laser beam, to the human body for controlled and selective removal of tissue, plaque and othex biological material.

BACKGROUND OF THE INVENTION

This invention relates to the use and application of radiant energy within the human body for the controlled removal or etching away, for examplel by ablation, of tissue or other biological material, in particular the removal of a vascular lS obstruction. The treatment of vascular obstructions includirlg peripheral as well as coronary vascular obstructions~ has been the subject of much ~
invetigation in recent years. Vascular surgery in .
- . - . ~

,., , ,: :

3~L

AZB/dmc which a diseased vessel is removed and replaced with a graft, or in which the blocked region of the . vessel is bypassed with a graft, has become relatively common. ~evertheless, it is desirable that procedures and techniques be improved to redu e the level of trauma to a patient so as to simplify the procedure and treatment for the patient but without sacrificing effectiveness. While procedures for surgical removal and by-pa~sing of vascular obstructions have become well developed, it clearly is desirable to provide alternatives to such non-conventional surgical procedures~ ;
Among the alternatives which have been developed is the angioplasty procedure in which devices such as the balloon dilatation catheter of the type illustrated in Gruntzig patent no.
: 4,195,637, are used to open a passage through a vascular obstruction. In the balloon dilatation technique a catheter having a special balloon at its distal end is advanced through the patient's blood vessels until the balloon is placed within the : : obstruction~ The balloon then is expanded under ~ : substantial pressure to forcibly enlarge the lumen : within the blood vesse~. When the procedure is : ~ 25 success:eul the lumen of the blood vessel remains ~.
open after the baIloon has been deflated and ` '`, ~ `' ' :. , "

gl;~6~

AZB/dmc removed. The material which caused the obstruction, typically arterial plaque, is compressed radially outwardly. Those patients who can be treated successfully with the dilatation technique are spared the trauma, time and expense of traditional vascular surgery. However, the angioplasty technique cannot be used to treat all vascular obstructions and, indeed, the majority of obstructions cannot be treated in that manner.
When an obstructed vessel is treated surgically by replacement or bypass of the vessel, the diseased portion of the vessel either is removed in its entirety or is permitted to remain, in its obstructed condition, in the patient but with a bypass vessel grafted across the blocked regions.
In the angioplasty technique the plaque which formed ~ the obstruction remains in the artery although in a ; compressed condition. In some instances the plaque and vessel wall may rearrange themselves after some time to begin to o~struct the vessel again.
Although the general desirability of recanalizing an obstructed blood vessel by removal of the vascular obstructions from the vessel has long been recognized, no effective system or treatment technique has yet been discovered or developed for that purpose. The possibility of . .

; .
- , : . .
.. . .
:,~ ""~

. .

....

~2~i3~4 AZB/dmc using laser energy for that purpose also has been recognized for some time. While recent availability of laser sources o~ controllable radiant energy have been found useful for some surgical operations, such as in certain kinds of eye su~gery, no suitable device and technique have been developed by which a beam of radiant energy such as laser energy can be applied to a vascular obstruction to select.ively and controllably remove that obstruction without causing trauma to the vessel, so as to leave the natural vessel in a healthy, unblocked, recanalized and functioning condition.
Proposals and efforts to apply laser energy to remove a vascular obstruction have encoun~ered : 15 numerous difficulties. Prior efforts to deliver a beam of laser energy typically have involved the use of various configurations of catheters having arra~gements of fiber optical conductors to conduct the radiant energy into the patient's vessel in an : effort to direct the beam to the obstruction so as to destroy the obstruction. No devices or techniques have been developed by which it was ~ possible to control effectively the beam. I~ the : : beam i~ not aligned properly in the blood vessel itcan impinge against the lining of the blood vessel ~: thereby damaging the vessel wall and possibly , puncture the wall. Even if the beam is aligned ; ~ .

" ., . ~. .,~,, .
.

: ~: . :.

~2~ Ei3~

A~B/dmc properly in the blood vessel, the lining of the vessel can be damaged or the vessel can be punctured if there is a bend in the vessel just distal of the location of the obstruction.
Also among the significant difficulties encountered in trying to use laser energy to clear vascular obstructions is the tendency of the laser beam to cause biological material to char in the region surrounding the target~ Such charring results, at least in part, from poor control over the manner and amount o energy applied. In the context of a delicate blood vessel, charring can present very serious problems, possibly doing severe damage to the surrounding tissue. Additionally, any biological material which becomes charred and adheres to the distal tip of the optical fiber conductor prevents emission of the beam from the distal tip of the conductor. In that case, the material at the end of the conductor becomes highly heated which, in turn, causes overheating and destruction of the optical fiber.
Other difficulties relate to the manner o positioning and locating the distal end o the catheter so that it is positioned properly with respect to the obstruction. Prior proposals which have included the use of supplemental optical fibers to transmit illuminating light into the blood vessel 1 ~

.
,,.

.; .. . . .
: : - . : , . .
,: , : . :

.:
.. ....
.~

~2~6~3~D~

AZB/dmc in conjunction with other groups of fibers to permit visual observation of the interior of the blood vessel are not practical because they are too large and too stiff for use in coronary arteries. Another difficulty is that there often may be material such as blood in the region between the emission point of the laser beam at the end of the fiber and the obstruction. Such material may obstruct the optical path. The blood may become charred at the distal emitting tip of the fiber which, as described above, can result in overheating and destruction of the op'ical fiber.
All of the foregoing difficulties have been complicated by the dimensional limitations imposed on any catheter which is to be inserted into a blood vess~l, particularly narrow blood vessels such as coronary arteries which can have lumens of the order of 1.5 to 4.5 millimeters diameter.
The present lnvention relates to new catheter systems for delivering radiant energy to a selected site wit~in a blood vessel in a manner which enables the radiant energy to be applied controllably to an obstruction and in a manner which avoids the fore~oing and other difficulties~

:~ I
. .

:, ~ ., . .:

. . .

;3 2s410/7as A~B/dmc SUMMARY OF THE INVENTION

The invention relates to new methods and means for delivering radiant energy from a source to a site within a patient's blood vessel where the energy is to be applied. More particularly, the invention concerns new methads and devices including a new catheter having a fiber optics conductor to deliver radiant energy ~e.g., from a laser) to the site to be treated. The catheter has, at its distal end, a miniature optical system to controllably apply the radiant energy at the site. The optical system and catheter are arranged so that the radiant energy is distributed substantially uniformly in a beam which combines an exponentially decaying energy leveI with a geometrically expanding beam pattern.
The optical system controls the beam to define a working region surrounding the axis of the propagation direction of the energy in which the removal of biological material takes place in a very limited layer-like region txansverse to that àxis, A system for practising the invention includes an elongate, small diameter catheter having a lumen which carries an opticaI fiber. The proximal end of the cat~eter has a connector by which the op~ical ~iber may be connected to receive the radiant energy ~ output from a laser. The distal end of the catheter `: ~

~: :
::

AZB/dmc has an optical housing which incorporates a net negative optical power lens system arranged to emit a beam of radiant energy in an expanding (divergent), unfocused pattern. The energy S distribution is substantially uniform over the cross-section of the expanding beam. The beam has a short segment which extends a short distance from the distal emission aperture o~ the optical system and defines the working region in which the radiant energy is at a high enough level to remove the biological material. Depending on the frequency of the radiant energy and the absorption properties of the biological material, thermal disassociation or ablative photo-decomposition may be employed as the dominant etching or eroding mechanism. Distally beyond the working region the exponentially decaying `~ beam diverges to a lower, safe energy density which will minimize damage to the biological material.
The depth of the working region as measured along the optical axis of the projected beam varies somewhat depending on the index of refraction of a light-propagating medium into which the beam is projected; up to about 1 to 1.5 mm is pre$erred. A
medium having a greater index of refraction will , 25 tend to decrease the divergence of the beam thereby in~reasing the depth of the working region in the ,~ direction of the optical axis. The optical system , , " :; . ~ . ' ': :

~Z~63`C~

AZB/dmc is arranged so that the maximum depth of the working region is relatively short, of th~ order of 1.5 millimeters maximum depth, so that a distally propagated segment of the beam will not have S sufficient energy level to puncture the vessel wall~ The maximum diameter of the working region is not smaller than and may be slightly greater than the catheter diameter to enable the catheter to advance through the hole which the beam wlll form through the obstructing material.
The optical system at the distal end of the catheter includes a housing which contains one or more lenses spaced from each other by radiopaque spacers, The use of radiopaque spacers enables the catheter to be positioned in the blood vessel accu.! ately by f luoroscopy. A special internal holder is provided to receive and securely position the distal end of the optical fiber rigidly with respect to the optical component~ in the housing.
The manner in which the optical fiber is mounted isolates completely the distal end of the optical fiber from the blood vessel. That completely avoids the possibility of biological material contacting the distal tip of the optical fiber which might .. 25 result in formation of a char on the tip with reaulting destruction of the optical fiber.

: . " . " . .

'' , ~............ ~: ;

. : ~ :~- .. :

~Ei~;3~

2B410~709 AZB/dmc The spacers and the housing cooperate to provlde optical precision in a miniature environment. The catheter is arranged so that the distal tip of the optical housing may be advanced into direct contact with ~he vascular obstruction.
This assures that there will be little or no optically obstructing material between the distal tip of the catheter and the vascular obstruction and also assures that the distal tip of the catheter will be positioned properly with respect to the obstruction.
The catheter may be provided with a lumen by which liquid may be flushed into and aspirated from the operative site in the blood vessel to draw away debris which may be developed during the removal procedure.
It is among the objects of the invention to provide a catheter adapted to deliver radiant energy into a blood vessel to enable forming a hole in vascular obstructions, and the effective removal o such obstructions.
Another object of the invention is to provide a catheter of the type described which is arranged to emit the radiant energy from an emission aperture at , 25 ~ the distal end of the catheter in a pattern which minimizes the risk of undue injury to or puncture of the vall of the blood vessel.
' ~

' :
: .

3~

AZB/dmc Another object of the invention i5 to provide a device of the type described in which the distal end of the catheter may be placed and oriented accurately wi~h respect to the targeted obstruction by fluoroscopic means, and without requiring the use of endoscopic visualization systems.
A further object of the invention is to provide a device of the type described in which the pattern of the beam emitted from the distal tip of the catheter is arranged to orm an aperture in an obstruction not substantially greater than the catheter diameter but large enough to permit the catheter to be advanced through the obstruction.
Another object of the invention is to provide a device of the type described in which the distal tip of the optical fiber is completely isolated ~rom biological material.
A further object of the invention is to provide a catheter of the type described having a miniature optical system at the distal end of the catheter.
Anothex object of the invention is to achieve the foregoing and other objects within a catheter of very small diameter.

,, .,' . . ;, 1,, : , .. ,:.
.- ;: , :.

~3~i;3~

AZB/dmc BRIEF DESCRIPTION OF THE DRAWINGS

The foregoing and other objects and advantages of the invention will be appreciated more fully from the following further description thereof, with reference to the accompanying drawings wherein:
.FIG. 1 illustrates generally a catheter according to the invention;
FIG. 2 is a section taken on line 2-2 in Fig. 1 r FIG. 3 is a diagrammatic illustration of the distal tip of the catheter showing the divergent beam pattern emitted from the optical housing;
FIG. 3A schematically illustrates the thermal :: profile of a heat pattern created in an absorbing medi-.lm in response to the combined exponentially dec~ying energy and geometrically expanding beam pattern which is provided by the invention;
FIG. 3B is a graphic representation comparing energy distribution according to the invention with a Gaussian anergy distribution;
: ~ FIG. 4 is an optical-schematic view, greatly ; enlarged, of an optical system of the invention and it9 relation to the distal end of the optical fiber;
FIGo 5 iS an optical-schematic view similar to : ~ 25 that of FIG. 3 illustrating another embodiment of the optical system `: ::
-"

:, : ~ : .: - :

~L2~i63~

AZB/dmc FIGS. 6A and 6B are energy distribution plots illustrating substantially uniform energy distribution in the working portion of the energy beam for the system illustrated in FIG. 4;
FIGS. 7A and 7B are energy distribution plots illustrating substantially uniform energy distribution at the working portion of the energy beam for the optical system illustrated in FIG. 5;
FIG. a is a greatly enlarged sectional side view of the distal end of the catheter including an optical system assembly according to the inventlon;
FIG. 9 illustrates in further detail, the fiber holder and distal tip of the fiber shown in the assembly of FIG. 8;
FIG. 10 illustrates dimensional details of the fiber: optics conductor;
: FIG. 11 is a diagrammatic illustration of the : distal end of the catheter in a partlally stenosed blood vessel FIG. 12 is another diagrammatic illustratlon of the distal end of the catheter in abutment with the stenosis in a fully obstructed blood vessel; and FIG~ 13 is an axial-sectional view of another embodiment of an optical system.
. . .
: ~:
. :
:: :

,, ~: ~ ' ~ '' : '-~i~3~3~

AZB/dmc ~ 14 -DETAILED DESCRIPTION OF THE ILLUSTRATIVE EMBODIMENTS

As is shswn generally in FIGS. 1 and 2, the catheter is formed from an elongate flexible body 10 and, for example, may be extruded from an appropriate pla~tic material such as Teflon ~trade name for polytetrafluoroethylene). The body 1.0 has a lumen 12 for enclosing a fiber optic light : conductor 14. The distal end of ~,he catheter is provided with an optical housing indicated generally at 16 which contains a net-negative optical lens system. The optical system in the housing receives ` radiant energy from the distal tip of the fiber :
optic light conductor 14. The radiant energy is i emitted from the optical system in a controlled - 15 predetermined pattern from an emission aperture 18.
~he proximal end of the catheter includes a molded fitting 20 which is secured to the catheter body 10~ Projecting from the proximal end of the fitting 20 are a pair of flexible tubes 22, 24. The ~ 20 tube 22 is adapted to receive the fiber opti~ light -: conductor 14, which extends through the fitting 20.
The proximal end of the tube 22 is provided with a connector 26 which is connected to the proximal end of the fiber optic ligh conductor 14. Connector 26 ~- 25 is adapted to be mounted with respect to the source of radiant energy, such as a laser (illustrated !

., :
' ~
' ~ :

' : ~ ` ,' ' :

~fi~

AZB/dmc diagramma~ically at 27) so that the proximal end of the light conductor 14 may receive the radiant energy and conduct it along its length to the optical system 16. The other tube 24 communicates through the fitting 20 with he lumen 12 of the catheter body 10 and preferably is provided with a conventional luer connector 28~
The catheter body is provided with a plura}ity of ~luid flow apertures 30 near the distal end. The pathway defined between the luee connector 28, tube 24, main catheter body 10 and apertures 30 provide for communication with the distal region of the patient's blood vessel where the distal end of the catheter is located. It provides a passageway for fluids or gases to flow both to and from the distal region of the patient's blood vessel and also prov~des a means for making pressure measurements.
In accordance with the invention the optical system forms the beam of radiation so that the beam will be unfocused and will expand geometrically for example, at an angle of about 20~ to tha optical beam axis 0-0, in saline solution as it leaves the emission aperture 18. FIG. 3 illustrates diagrammatically at 32 the peripheral rays of the beam whlen the beam is emitted into a saline solution, while FIG. 3A illustrates the response of the ~aterial to the energy pattern of the beam with , :: : , :
, :~ ~'~' . .
:
; ~

..

:: :
,:: .

:
. .
:. .. ~, ~26~3~)4 Azs/dmc respect to propagation distance from the emission aperture 18. From FIG. 3 it will be appreciated that, owing to the geometrical expansion of the beam along the beam axis, the energy density of the emitted beam decreases in a distal direction along the beam axis 0-0, while the cross-sectional area of the beam increases with propagation along the axis.
Thi~ decrease in energy density is in addition to the exponential decay in energy level that i9 due directly to increasing propagation distance.
In accordance with the present invention, the relatively small diameter region adjacent the emission aperture 18, indicated at W in FIG. 3 and FIG. 3A, is considered to be the working region in which the energy density is sufficient to remove obstructing biological material. From FIG. 3 it will be appreciated that the working region W is comparatively short when the radiation beam is emitted int~ a low refraction medium such as clear saline solution (not shown). When the beam 1s emitted into such a medium, the optical system ; causes the beam to diverge at the aforesaid anglè
(e.g~: 20~) which assures that its effective working powe~ density preferably will not extend more than a . 25 millime~ter or two beyond the emission aperture 18.
When the emission aperture is brought close enough to b~ological material (e.g., thrombus, plaque~

_, , .

.

- : , 3~

AZB/dmc blood) 50 that the latter is in the working region W, the beam will operate on (i~e.: remove by thermal, ablative, or other action) the biological material that is in the working region.
From the thermal profile shown in E~IG. 3A, it will be appreciated that the invention combines an exponentially decaying energy profile with a geometrically expanding beam pattern, which assures a larger decrease in energy density along the op~ical axis 0-0 than would be available rom a converging or a collimated beam pattern. The thermal profile in an absorbing medium ls represented in FIG. 3A by isothermal lines 33, 34 and 35, respectively. The shaded region within the first isothermal line 33 is the thermal response lS within the working region W. Within that region the energy density, in Joules per cubic centimeter of spatial volume, preferably should exceed 3000 J/cm3, so that the biological material in the working region wiL1 be removed (as by ablation, erosion, etc.). Between the first and second isothermal lines 33 and 34, the energy density falls off to a range between 3U00 J/cm3 and 272 J/cm3, in which the temperature of the biological material . will be about 100 C. ~Outside the third isothermal ^ 25 line, the temperature of biological material will be ^~ le~s than 50 C. A temperature of 50 C or above :

, :

., : . ,.: .

',1 ' ~''' ' ` ' ' ' `
. ~ ~ . : ..

~L26~i36~

AZB/dmc - 18 ~

will cause irreversible protein denaturizationO
When the temperature is below 50 C, cell trauma typically is insignificant and self reversing.
Within the working region W, the output beam has a substantially uniform energy distribution with respect to displacement rom the beam axis 0-0. By way of example, the beam has more than 50%
irradiance for radial distances of up to about 70 of the l/e2 beam radius, as i8 represented in curve A in FI~. 3B. Examples of such an irradiance profile are illustrated in ~IGS~ 6 and 7. By contrast if the energy distribution of the beam were non-uniform, such as Gaussian, its 50~ irradiance point would be located at 58% of the 1/e2 radius as is represented in Curve B in FIG. 3B.
As has been mentioned above, ~he axial length of the working region W may vary somewhat, depending on the index of refraction of the medium in the working region (e.g.: saline solution) into which it irradiates before being brought tv the biological material. An outer limit for the length W is selected to be at a predetermined value which will reduce the chance of projecting the energy beam in a manner ~rhich might risk serious damage to biological material located beyond the target, i.e.- more ~han about one to two millimeters away, so as to minimize the chance of damaging an artery, or other blood :, :
, ~, ; ,1 ,' , :
.:, ",.....
. ,, ~ -: : : , ::
,~, : . ., , ~ , , : , . .

~Z~ii3~L

AZB/dmc vessel. By way of example, for a 1.0 to 1.5 milllmeter diameter catheter intended to be used in small bore arteries such as coronary arteries, a maximum length for the working region W of the order of 1.5 millime~ers appears desirable.
Further in accordance with the invention, it ; will be understood that in an imaginary plane transverse to the optical axis ~-0 located about 1.5 mm. in front of the emission aperture 18, the energy density o the emitted beam is substantially uniformly distributed throughout an imaginary circle which is diametrically larger than the catheter 10.
The energy density proximal of and within that circle is adequate to remove biological material so as to form a hole through which the catheter can be advanced. For example, pulses from an argon source, delivered at 25 watt/sec., 25% duty cycle, in a beam lmm. in diameter~ through a saline solution, will remove about 0.25mm depth of non-calcific plaque per pulse, across the beam diameterO When the beam perforates or otherwise passes distally beyond the obstruction and the fluid beyond the hole is transparent ~e.g.: saline solution), the density of ~ ~ energy which propagates more than about 1.5 mm.
-; ~ 25 beyond the obstruction will be toQ low to va~orize ~;~ other more distant material, such as the wall o a blood vessel~

~ :
.
,:

.. - ., : . ~ . ,. :. .. , ~ .. .
: . ~ . . . ~ .. . , , :

AZB/dmc FIGS. 11 and 12 illustrate somewhat diagrammatically the manner in which the catheter is applied to vascular obstructions. As shown in FIGo 11 the blood vessel V has a lumen L which is partially obstructed by a stenosis S. The catheter is advanced through the patient's vascular system to bring the distal tip of the optical system 16 directly against the stenosis S. FIG. 12 illustrates an enlarged detail of the dis~al tip o~
the optical system 16 as it is brought to bea~
against a totally-blocking stenosis S within the lumen L of a blood vessel. In accordance with the invention, radiant energy emitted from the emission aperture 18 at the distal tip of the optical system 16 will ablate or otherwise remove the stenotic material S. As the catheter is advanced through the blood vessel V and as the radiant energy is applied, preferably in pulses of suitable peak power, discrete layers of the stenotic material will be removed 50 as to ultimately form a tunnel through the stenotic material S. The recanalized lumen formed by the tunnel is suggested diagrammatically in phantom at h' in FIG~ 12. The recanaIized tunnel ~: L' thus formed is, as mentioned, slightly greater in :~ 25 diameter than the diameter of the catheter 10 to faciLitate advancement of the catheter through the : blood vessel.

,, .

. ~: ,.. : , .. .

3~D~

AZB/dmc ~ The condition illustrated in FIG. ll in which : the stenosis does not block completely the lumen L
of the blood vessel V, may permit some of the radiant energy to pass through the opening in the stenosis so as ~o be directed toward a distal portion of the inner surface of the blood vessel wall. While that would not be likely to occur if the region distal of the catheter tip is filled with relatively opaque, radiant energy absorbing fluid, it i~ contemplated that the system may be used with ~ a saline flushing technique and some of the region : of the lumen distal of the catheter tip might be ~ filled with a more clear saline liquid, allowing : transmission of the radiant energy. Thus, in some circumstances such as where a distal portion of the blood vessel V is curved, as illustrated in FIGo 11 the present invention minimizes the risk that radiant energy which might impinge on a distal portion of the blood vessel wall will not perforate that wall.
FIGS. 4 and 5 illustrate two embodiments of the optical system 16. As shown in FIG. 4 the light-output end 36 of the fiber optics conductor 14 ~: is coupled to a spherical lens 38, a first : :25 plano-concave lens 40 and a second plano-concave lens 42, in succes ion. ~he intercomponent spacings and component thiknesses along the optical axis 0-0 :: :

~2~i63~L

AZB/dmc of the system are indicated on the figure as dl to d6, respectively. Representative design parameters for the optical system of FIG~ 4 are stated in Table I, following:
Table I. Design Parameters for Optical Sys_em Fig. 4 Optical Fiber Component Spacings &
Thicknesses dl 0.3574mm : Numerical Aperture = 0.3 d2 - l.OOmm Exit Viameter = 0.1 mm d3 = l.OOmm S S (Substantially Uniform (Distribution Characteristic d~ - l.OOmm d5 = l.OOmm d6 = l.QOmm : Total Length = 5.3574mm ~ 20 Radius :~ Lens Type Material n~530nm) o~ Curvature 38 Sphere BK-7 1.5200 rl = 0.5 mm 40 Plano-concave BK-7 1.5200 r2 = I~156 mm 42 Plano-concave Corning 7740 1.477 r3 = 0.867 mm Lens Type Thickness " 38 Sphere ~d2 Plano-concave d4 - 42 Plano-concave d . : 6 .
:

. .~
: :
. .
~ .
";'' ',':':';,""~ "~

~ : : ,.. -. : . .
:~ . , : ;;~ . : ~: . .

~Z6~i3~4 AZB/dmc ~he operative portion of the radiation from the system shown in FIG. 4 is loca~ed within the region W extending about 1.5 mm from the concave surface 44 of the exit lens 42, which for purposes of illustration is shown bounded by a transverse plane indicated by line 46. Shown also in FIG. 4 are ray tracings S0 rom the lower hal ~below the optical axis 0-0 as seen in the figure) of the light output end 36 o~ fiber optics conductor 14 to the boundary plane 46, for a wavelength of 530 nm. In order to see the entire ray distribution at the boundary plane one can superimpose a mirror image of the traced rays with respect ~o the optical axis. The aperture stop is fixed at the back surface of the spherical lens 38, for ray-tracing purposes.
The ray-tracing method used in development of FIG. 4 was consistent with the assumption that the optical fiber 14 behaves like a uniform energy distribution source, to find out the ~pproximate

2~ energy distribution at the boundary plane 46. The upper half of the optical fiber tip 36 (0.05mm in extent) was first divided into 200 point sources.
Five rays from each point source (1,000 total) spanning the numerical aperture of 0.3 were traced through the optical system 20 to the boundary plane 46. The distance between the optical axis 0-0 and the outermost dimension (0.75mm from the optical axisJ of the fiber optics conductor-lens system at : :

,~, AZB/dmc - 2~ -the boundary plane was divided into twelve equal compartments to collect the traced rays. The number of rays which landed in each of these twelve compartments, indicative of beam intensi~y, are plotted as histograms in FIGS. 6A and 6B, for the wavelengths 530mm and 330nm, respectively. Assuming that each ray carries the same amount of energy, the histograms in FIGS. 6A and 6B approximate the energy distribution at the boundary plane 46 for the optical system shown in FIG. 4. It can be seen from E'IG. 6 that this system creates an approximately 1.5mm diameter spot of substantially uniform energy distribution in cross-section, e.g., at the boundary plane 46, 1.5 mm from the concave surface 44 of the exit lens 42. FIG. 6A is an energy distribution plot at the boundary plane for light of wavelength equal to 530 nm. The same plot for 330 nm radiant energy is shown in FIG. 6B.
FIG. 5 illustrates another embodiment of the optical system 16, in which the spherical lens 38 is fol}owed by a single bi-concave lens 48. Otherwise ~ the system of FIG. 5 is similar to the system of i FIG. 4. Design parameters for the system in FIG. S
are stated in Table II following:
..

.~
`:~:

~:
,........ , .1 , : . , .

,: :: "~, ~; ., ~.
. .

~2~3~q~

AXB/dmc 6ssas Table II. Design Parameters for Optical System Fig. 5 -Optical Fiber Lens Spacings Thicknesses Numerical Aperture = 0.3 dl = 0.31mm Exit Diameter = 0.1 mm d2 = l.OOmm Substantially Uniform Energy d3 = 3.19mm Distribution Characteristic d4 = l.OOmm Total Length = 5.50 mm Radius of Lens ~e~ Material n (530 nm) Curvature 38 Sphere BK-7 1.5200 rl = 0.5 mm 48 Bi-Concave Corning 7740 1.477 r21 - 1-092 mm r31 = 1.158 mm Lens Type Thickness ~ 38 Sphere d2 ; 48 Bi-Concave d4 Energy distribution in the boundary plane 46, for the embodiment of ~IG~ 5 is shown in FIGS. 7A
and 7B for wavelengths 530 nm and 330 nm, respectively. The de~igns of the systems shown FIGS~ 4 and 5 will work particularly well for thS of light in the range from 330 nm to : 530nm, but are not limited to that range.
, ;.

~3~

AZB/dmc - 2~ -As can be seen from the dimensions in Tables I
and II, the optical syste~ 16 is miniature, The system of FIG~ 4 has a total length of 5.36 mm; that of FIG. S is 5.50 mm long. Each system including the housing ~or the lenses is only 1.5 mm in diameter.
FIGS. 8 to 10 inclusive, show an optical assembly 16 which facilitates assembly of the lens components 38, 40 and 42 with the required spa~ial and positioning precision. A glass tube 51 snugly encloses the optical elements, which are spaced apart in the tube with tubular spacers ~2, 54 and 56. A holder 58 for the fiber optics conductor 14 is fi~ted into one end of the tube 51, followed by the first spacer 52 which holds the spherical lens 28 the required distance from the aperture surface 36 of khe fiber optics light conductor 14. The next spacer 54 establishes the spacing between the spherical lens and the intermediate plano-convex lens 40. The last spacer 5~ establishes the spacing between the intermediate lens and the exit lens 42.
To assure that the distal end o~ the fiber optics conductor 14 is spaced and oriented in a precise position with respect to the optical system ~:25 : 16, its coupling to the optical system 16 includes a high precision holder 58. The fiber optics conductor holder 58 may be made of glass, ceramic or other material capable of being formed to a high ' ,, ., :: .
: ~ , ,......................... ~ .:

: - . , : : , AZB/dmc degree of precision tolerance. The fiber optics light conductor 14 is prepared as shown in FIG. 9, with the distal part of its buffer sheath 61 removed. The holder 58 has a precision formed axial bore made up of two sections including an enlarged diameter proximal segment 60 and a narrow diameter distal segment 63. The bore 60, 63 receives the clad fiber of the light conductor 14. To prepare ; the optical iber for attachment to the holder 58, : 10 the pla~tic buffer sheath 61 which typically surrounds and protects the optical fiber is removed to an extent such that the projecting portion 65 (see FIG. 9~ of the fiber conductor can be extended thxough the distal small diameter bore 63 in the holder. Care is taken when stripping the buPfer sheath 60 so as not to damage the layer of rsflective cladding 67 ~bout the core of the conductive fiber 14. The stripped end of the fiber assembly thus is inserted into the holder so ~hat the stripped protruding portion 65 of the fiber extends into the sma~l diameter bore 63 while the proxi~al portion containing the buffer sheath 61 is contained within the larger diameter portion 60 o~
~:: the axial bore in the holder 58. The end of the optical. fiber which protrudes beyond surface 62 of `. ~ holder 58 may be finished flush with surface 62 of ~ the holder 58. The foregoing arrangement serves to :: :
., , -~, : ~ . . . .. , ... i . . ..
,~

:

~q~663~

AZB/dmc hold the aperture end 36 of the fiber flush with the distal end surface 62 of holder 58, against which the first tubular spacer 52 abuts. This arrangement establishes precisely the spacing between the aperture end 36 of ~he light conductor 14 and the spherical lens 28. The rigidity and precision with which the holder 58 can be made also assures precise alignment and positioning of the fiber along the optical axis of the system. The fiber optics light conductor 14 may be held in the holder 58 with an epoxy cement.
The ~pacers may be made of a thin-wall tubiny (e.g: thin-wall tubing having outer diameter 0.040 inch and wall thickness 0.005 inch) which will not cause vignetting. For optimum radiopacity performance a radiopaque material such as tantalum is pseerred as a spacer material.
The catheter body 10 is fitted over the narrower back end 64 of the holder 58 spaced a short distance from the shoulder 68 between the two parts of the holder. The glass tube 51 is bent over the shoulder 68, às by fusing the end 65 of the glass around the shoulder. A filler 66, which may be made of a plastic, such as Teflon (trademark for polytetrafluoroethylene)~ fills the annular space between the~catheter body lO and confronting end 65 of the glass tube 51. The outer diameter of the ~::: ; :
,~. , ... ..

AZB/dmc 6~9~B

entire assembly, from the catheter body 10 to the glass tube 51, is substantially the same, providing a smooth uniform surface the entire length of the catheter, as is indicated in Figure 1.
The concave surface 44 of the exit lens component 42 is formed after the assembly of the holder 64, lens components 38, 40, 42 and spacers 52, 54, 56 into the glass tube S} has been completed. Pyrex brand glass No~ 7740 is chosen as the material for the exit lens 42 and the glass tube Sl. The exit lens 42 begins as a glass rod 1~5 mm long and 1.0 mm outer diameter with the end which will form the interior after assembly polished flat. When assembled into the glass tube 51, the exit lens 42 is fused to the glass tube, Pyrex brand glass being preferred because it has a lower softening temperature than other suitable optical glass materials. Such other materials can be used for the inner lens components 28 and 30. After using, the concave exit lens surface 44 is formed, and the exit end edge 55 of the glass tube is rounded to mate smoothly with the periphery of the concave surface.
In FIG. 13~ the optical system illustrated comprises a single net-negative lens element 142 at the exit end 55 of the glass tube 51, separated precisely from the nearer transverse surface 62 of the light conductor holder 58 ~y a radiopaque spacer ,- :
. ' :

, : ~

, , , :, ;, , . : . . .

~L26~;3~L

AZB/dmc 154. Preferably the lens expands the light beam 14' exiting from the light conductor 14 to a beam 14"
exiting from the lens at an angle of about 20 to the optical axis o-O~ The beam power parameters are adjusted so that in the working region W between the concave exit surface 144 and the nearby transverse plane 46 the radiant energy has the required density, substantially uniformly distributed to perform tissue removal acccording to the inventionO
The aperture of the lens opening t44, 144) in the present invention is very close to the full outer diameter oE the supporting envelope, namely, the tube 51, so as to provide an expan~ing beam that is just under the housing diameter close-in to the housing 51, for enabling the housing to be a~vanced . into the hole that is being formed~ as well as to maximize the energy that can be delivered through the miniature optical system 16.
From the foregoing it will be appreciated that 2Q the invention provides a catheter adapted to - transmit and deliver radiant energy of a character adapted to etch or erode biological material, such as a vascular obstruction. The invention may be ;~ used with radiant energy in the visible, infra-red, ultra-vîolet and far-ultraviolet (200nm) ranges. The invention embodies an : arrangement for delivering the radiant energy in a ~ .
, .. ... .
. :.
.: , :., . . . . . . . . . .

.. :. ~, ::

:,. : :
. .

i3q~

2B410/7~9 AZB/dmc manner which avoids the risk of perforating the wall of the vessel. It should be understood, however, f that the foregoing description of the invention is intended merely to be illustrative ~hereof and that other modifications and embodiments will be apparent to those skilled in the art without departing from its spirit.
Having thus described the invention what we desire to claim and secure by letters patent is:

" ._ .

: , , , .,, . ; . ~ ;.
,- ~;, . :.

. : .. ..
,. : . ,

Claims (29)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A catheter for recanalizing an obstructed lumen by selectively removing sequential layers of biological obstructing material by radiant energy comprising:
an elongate catheter body containing a flexible optical conductor;
the proximal end of the catheter having means to enable said radiant energy to enter the flexible optical conductor;
the distal end of the catheter having an emission aperture from which a beam of said radiant energy may be emitted, said emission aperture having a cross-sectional dimension which substantially corresponds to that of the distal end of the catheter;
said catheter and emission aperture being constructed and arranged to shape the radiant energy beam emitted from the emission aperture to define an unfocused beam having a working region in which the density of energy is sufficient to cause said removal, and so that the portion of the beam extending distal to the working region has insufficient energy density to cause said removal;
and the cross-sectional dimensions of the beam in the working region being no smaller than about the diameter of the distal end of the catheter thereby to enable the catheter to be passed through a recanalized hole formed by said working region, the axial depth of the working region being not substantially greater than the cross-sectional dimension of the distal end of the catheter.

2. A catheter as defined in Claim 1, wherein said means for shaping the beam further comprises net-negative optical means at the distal end of the catheter.

3. A catheter as defined in Claim 1, wherein said optical means encloses and isolates the exit end of the optical conductor to preclude contact of the exit end of the optical conductor with the biological material.

4. A catheter as defined in Claim 1, wherein said optical means is constructed and arranged so that the beam emitted from the emission aperture will have substantially uniform energy distribution in a plane transverse to the direction of propagation of said energy.

5. A catheter as defined in Claim 3 further comprising:
means for holding said exit end of the optical conductor and said lens means in a prescribed spatial relationship.

6. An optical system as defined in Claim 5 in which the optical means includes an exit lens and in which a concave surface of said exit lens confronts said transverse plane.

7. A catheter as defined in Claim 2 in further combination with a laser source of said radiant energy.

8. An optical system as defined in Claim 5 further comprising:
the optical means including an exit lens means having net negative optical power; and a spherical object lens between said exit end of said optical conductor and the exit lens means.

9. An optical system as defined in Claim 8 in which said exit lens is bi-concave.

10. An optical system as defined in Claim 8 in which said exit lens is plano-concave.

11. An optical system as defined in Claim 5 including a tubular housing for holding said end and said lens means in said spatial relationship.

12. An optical system as defined in Claim 11 including a radiopaque tubular spacer within said housing.

13. An optical system as defined in Claim 11 in which the aperture of said exit lens means is substantially equal to the outer diamter of said tubular housing.

14. An optical system as defined in Claim 8 including a plano-concave lens between said object lens and said exit lens, a first tubular spacer within said housing between said object lens and said plano-concave lens, and a second tubular spacer within said housing between said plano-concave lens and said exit lens.

15. An optical system as defined in Claim 11 in which said exit lens means and said housing are made of glass capable of being fused together.

16. An optical system as defined in Claim 15 in which said glass is a predominantly borosilicate glass.

17. An optical system as defined in Claim 5 in which said holding means includes a part which is radiopaque.

18. An optical system as defined in Claim 6 in which said holding means includes a rigid holder for said exit end of said optical conductor and spacer means for fixing the distance between said holder and said exit lens means.

19. An optical system as defined in Claim 18 including a tubular housing enclosing said exit lens means, said spacer means and a part of said receiver.

20. An optical system as defined in Claim 11 in which said housing is radio-transparent and includes a part which is radiopaque.

21. An optical system as defined in Claim 20 in which said part is a tubular spacer for an optical component of said system.

22. An optical system as defined in Claim 5 including a tubular housing made of a glass that is fusible to said exit lens means, in which the edge of said housing at the periphery of said lens means is rounded to form a smooth boundary with said lens means.

23. A catheter as defined in Claim 1 wherein the catheter body has a lumen extending therethrough from its proximal to its distal portions, the catheter body having aperture means at its distal portion in communication with the lumen and means at the proximal end of the catheter for making a fluid connection to the lumen.

24. A catheter as defined in Claim 23 wherein the optical conductor extends through the lumen.

25. A catheter as defined in Claim 3 further comprising means for holding the exit end of the optical conductor and lens means in prescribed spatial relation, said holding means comprising:
a rigid tubular holder having a proximal end and distal end, the holder having a bore extending therethrough to receive the distal end of the optical conductor, said optical conductor being secured rigidly within the bore of the holder;
the exit end of the optical conductor being flush with the distal end of the holder;
a tubular housing for receiving at least a portion of the holder and the proximal end of the housing and for receiving the lens means at the more distal regions of the housing;
spacer means within the tubular housing and in engagement with the lens means and the distal end of the holder to space precisely the holder and conductor carried thereby with respect to the lens means; and means for securing holder to the tubular housing.

26. A catheter as defined in Claim 25 further comprising:
the holder having a shouldered portion between its ends;
said tubular holder being formed to engage the shoulder to secure the holding means to the tubular holder.

27. A catheter as defined in Claim 26 further comprising:
the proximal end of the holding means being received in the lumen at the distal end of the catheter body, the juncture region between the distal end of the catheter body and the proximal end of the tubular housing being filled to present a smooth and continuous outer surface along said catheter.

28. A catheter as defined in Claim 1 wherein the length of the working region along the axis is no greater than approximately 1.5 millimeters.

29. A catheter for recanalizing an obstructed lumen by selectively removing sequential layers of biological obstructing material by radiant energy comprising:
an elongate catheter body containing a flexible optical conductor;
the proximal end of the catheter having means to enable said radiant energy to enter the flexible optical conductor;
the distal end of the catheter having an emission aperture from which said radiant energy may be emitted, said emission aperture having a cross-sectional dimension which substantially corresponds to that of the distal end of the catheter;
said catheter and emission aperture being constructed and arranged to shape the radiant energy emitted from the emission aperture to define an unfocused pattern having a working region in which the density of energy is sufficient to cause said removal, and so that the portion of the emitted energy extending distal to the working region has insufficient energy density to cause said removal;
and the cross-sectional dimensions of the emitted energy in the working region being no smaller than about the diameter of the distal end of the catheter thereby to enable the catheter to be passed through a recanalized hole formed by said working region, the axial depth of the working region being not substantially greater than the cross-sectional dimension of the distal end of the catheter.