CA1264500C - N-substituted-amido-amino acids - Google Patents

N-substituted-amido-amino acids

Info

Publication number
CA1264500C
CA1264500C CA398031A CA398031A CA1264500C CA 1264500 C CA1264500 C CA 1264500C CA 398031 A CA398031 A CA 398031A CA 398031 A CA398031 A CA 398031A CA 1264500 C CA1264500 C CA 1264500C
Authority
CA
Canada
Prior art keywords
alkyl
carbon atoms
lower alkoxy
amino
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA398031A
Other languages
French (fr)
Other versions
CA1264500A (en
Inventor
Jerry W Skiles
Raymond D Youssefyeh
John T Suh
Howard Jones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000398031A priority Critical patent/CA1264500A/en
Priority to US06/472,551 priority patent/US4686295A/en
Application granted granted Critical
Publication of CA1264500C publication Critical patent/CA1264500C/en
Publication of CA1264500A publication Critical patent/CA1264500A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ABSTRACT OF THE DISCLOSURE Compounds of the formula wherein R and R9 are independently hydroxy, lower alkoxy, lower alkenoxy, di(lower alkyl)amino-lower alkoxy, hydroxy-lower alkoxy, acylamino-lower alkoxy, acyloxy-lower alkoxy, aryloxy, aryloxyl-lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxyamino, or aryl-lower alkylamino, R1, R2, R3, R4, R5, R7, and R8 are independently alkyl, alkenyl or alkynyl containing up to 20 carbon atoms, aryl or aryl-lower alkyl containing up to 12 carbon atoms, heterocyclic or heterocyclic-lower alkyl containing up to 12 carbon atoms, or cycloalkyl or cycloalkyl alkyl containing up to 20 carbon atoms. R6 is heterocyclic or heterocyclic alkyl; R2 and R3 taken together with the carbon and nitrogen to which they are respectively attached and R3 and R5 taken together with the nitrogen and carbon to which they are respectively attached form an N-heterocycle containing from 3 to 5 carbon atoms or 2 to 4 carbon atoms and a sulfur atom, and wherein said alkyl, alkenyl, and alkynyl groups can be substituted with hydroxy, lower alkoxy, thio, lower alkylmercapto, amino, lower alklamino, di(lower alkyl) amino, halogen, and nitro; and salts thereof, especially salts with pharmaceutically acceptable acids and bases. The compounds possess hypertensive and antitensin convert-ing enzyme inhibitory activity.
CA000398031A 1981-03-30 1982-03-10 N-substituted-amido-amino acids Expired - Lifetime CA1264500A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA000398031A CA1264500A (en) 1981-03-30 1982-03-10 N-substituted-amido-amino acids
US06/472,551 US4686295A (en) 1982-03-10 1983-03-07 N-carboxy anhydride intermediates

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24905381A 1981-03-30 1981-03-30
US249,053 1981-03-30
CA000398031A CA1264500A (en) 1981-03-30 1982-03-10 N-substituted-amido-amino acids

Publications (2)

Publication Number Publication Date
CA1264500C true CA1264500C (en) 1990-01-16
CA1264500A CA1264500A (en) 1990-01-16

Family

ID=86548567

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000398031A Expired - Lifetime CA1264500A (en) 1981-03-30 1982-03-10 N-substituted-amido-amino acids

Country Status (1)

Country Link
CA (1) CA1264500A (en)

Also Published As

Publication number Publication date
CA1264500A (en) 1990-01-16

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19980120