CA1264500A - Derives de substitution en n d'amido-amino-acides - Google Patents

Derives de substitution en n d'amido-amino-acides

Info

Publication number
CA1264500A
CA1264500A CA000398031A CA398031A CA1264500A CA 1264500 A CA1264500 A CA 1264500A CA 000398031 A CA000398031 A CA 000398031A CA 398031 A CA398031 A CA 398031A CA 1264500 A CA1264500 A CA 1264500A
Authority
CA
Canada
Prior art keywords
hydroxy
pharmaceutically acceptable
lower alkyl
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000398031A
Other languages
English (en)
Other versions
CA1264500C (fr
Inventor
Jerry W. Skiles
Raymond D. Youssefyeh
John T. Suh
Howard Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Priority to CA000398031A priority Critical patent/CA1264500A/fr
Priority to US06/472,551 priority patent/US4686295A/en
Application granted granted Critical
Publication of CA1264500C publication Critical patent/CA1264500C/fr
Publication of CA1264500A publication Critical patent/CA1264500A/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000398031A 1981-03-30 1982-03-10 Derives de substitution en n d'amido-amino-acides Expired - Lifetime CA1264500A (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA000398031A CA1264500A (fr) 1981-03-30 1982-03-10 Derives de substitution en n d'amido-amino-acides
US06/472,551 US4686295A (en) 1982-03-10 1983-03-07 N-carboxy anhydride intermediates

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24905381A 1981-03-30 1981-03-30
US249,053 1981-03-30
CA000398031A CA1264500A (fr) 1981-03-30 1982-03-10 Derives de substitution en n d'amido-amino-acides

Publications (2)

Publication Number Publication Date
CA1264500C CA1264500C (fr) 1990-01-16
CA1264500A true CA1264500A (fr) 1990-01-16

Family

ID=86548567

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000398031A Expired - Lifetime CA1264500A (fr) 1981-03-30 1982-03-10 Derives de substitution en n d'amido-amino-acides

Country Status (1)

Country Link
CA (1) CA1264500A (fr)

Also Published As

Publication number Publication date
CA1264500C (fr) 1990-01-16

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19980120