CA1217778A - Herbicidal substituted 2-[1-(oxyamino)- alkylidene]-5-(2-ethylthiopropyl)-1,3-diones - Google Patents
Herbicidal substituted 2-[1-(oxyamino)- alkylidene]-5-(2-ethylthiopropyl)-1,3-dionesInfo
- Publication number
- CA1217778A CA1217778A CA000438123A CA438123A CA1217778A CA 1217778 A CA1217778 A CA 1217778A CA 000438123 A CA000438123 A CA 000438123A CA 438123 A CA438123 A CA 438123A CA 1217778 A CA1217778 A CA 1217778A
- Authority
- CA
- Canada
- Prior art keywords
- compound
- hydrogen
- formula defined
- compounds
- ethylthiopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002363 herbicidal effect Effects 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 35
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- -1 2-ethylthiopropyl Chemical group 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 150000001768 cations Chemical class 0.000 claims description 5
- 230000012010 growth Effects 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 235000010823 Digitaria sanguinalis Nutrition 0.000 claims description 3
- 235000015225 Panicum colonum Nutrition 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims description 2
- 235000007320 Avena fatua Nutrition 0.000 claims description 2
- 244000075850 Avena orientalis Species 0.000 claims description 2
- 235000001602 Digitaria X umfolozi Nutrition 0.000 claims description 2
- 235000017898 Digitaria ciliaris Nutrition 0.000 claims description 2
- 235000005476 Digitaria cruciata Nutrition 0.000 claims description 2
- 235000006830 Digitaria didactyla Nutrition 0.000 claims description 2
- 235000005804 Digitaria eriantha ssp. eriantha Nutrition 0.000 claims description 2
- 235000014716 Eleusine indica Nutrition 0.000 claims description 2
- 235000005373 Uvularia sessilifolia Nutrition 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 244000236458 Panicum colonum Species 0.000 claims 2
- 244000025670 Eleusine indica Species 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 abstract description 13
- 238000006243 chemical reaction Methods 0.000 description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 17
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000002585 base Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000002689 soil Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- VOYADQIFGGIKAT-UHFFFAOYSA-N 1,3-dibutyl-4-hydroxy-2,6-dioxopyrimidine-5-carboximidamide Chemical compound CCCCn1c(O)c(C(N)=N)c(=O)n(CCCC)c1=O VOYADQIFGGIKAT-UHFFFAOYSA-N 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 150000002440 hydroxy compounds Chemical class 0.000 description 4
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 4
- 230000008635 plant growth Effects 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 240000006122 Chenopodium album Species 0.000 description 3
- 235000009344 Chenopodium album Nutrition 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000008064 anhydrides Chemical class 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 150000004820 halides Chemical class 0.000 description 3
- 150000008282 halocarbons Chemical class 0.000 description 3
- 150000002431 hydrogen Chemical group 0.000 description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000000979 retarding effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 2
- WZHZGZNRMBGZCR-AATRIKPKSA-N (e)-6-ethylsulfanylhept-3-en-2-one Chemical compound CCSC(C)C\C=C\C(C)=O WZHZGZNRMBGZCR-AATRIKPKSA-N 0.000 description 2
- CNIMVLCIILGGIX-UHFFFAOYSA-N 2-butanoyl-5-(2-ethylsulfanylpropyl)cyclohexane-1,3-dione Chemical compound CCCC(=O)C1C(=O)CC(CC(C)SCC)CC1=O CNIMVLCIILGGIX-UHFFFAOYSA-N 0.000 description 2
- NPWQOUZEZHPCDV-UHFFFAOYSA-N 3-methylpentanethial Chemical compound CCC(C)CC=S NPWQOUZEZHPCDV-UHFFFAOYSA-N 0.000 description 2
- LOCUWOGARRGULQ-UHFFFAOYSA-N 5-(2-ethylsulfanylpropyl)cyclohexane-1,3-dione Chemical compound CCSC(C)CC1CC(=O)CC(=O)C1 LOCUWOGARRGULQ-UHFFFAOYSA-N 0.000 description 2
- 235000013479 Amaranthus retroflexus Nutrition 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 2
- 244000152970 Digitaria sanguinalis Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 244000058871 Echinochloa crus-galli Species 0.000 description 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 2
- 231100000674 Phytotoxicity Toxicity 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- HJSLFCCWAKVHIW-UHFFFAOYSA-N cyclohexane-1,3-dione Chemical class O=C1CCCC(=O)C1 HJSLFCCWAKVHIW-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000004009 herbicide Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000885 phytotoxic effect Effects 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 229940086542 triethylamine Drugs 0.000 description 2
- KAANTNXREIRLCT-UHFFFAOYSA-N 1-(triphenyl-$l^{5}-phosphanylidene)propan-2-one Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC(=O)C)C1=CC=CC=C1 KAANTNXREIRLCT-UHFFFAOYSA-N 0.000 description 1
- LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- ZPVAJYRYXTXTBU-UHFFFAOYSA-N 2-[n-(3-chloroprop-2-enoxy)-c-propylcarbonimidoyl]-5-(2-ethylsulfanylpropyl)cyclohexane-1,3-dione Chemical compound ClC=CCON=C(CCC)C1C(=O)CC(CC(C)SCC)CC1=O ZPVAJYRYXTXTBU-UHFFFAOYSA-N 0.000 description 1
- 125000001216 2-naphthoyl group Chemical group C1=C(C=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- FXYSLMWUJOJBBA-UHFFFAOYSA-N 3-hydroxycyclohex-2-en-1-one Chemical class OC1=CC(=O)CCC1 FXYSLMWUJOJBBA-UHFFFAOYSA-N 0.000 description 1
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 description 1
- 244000237956 Amaranthus retroflexus Species 0.000 description 1
- 235000004135 Amaranthus viridis Nutrition 0.000 description 1
- 244000078782 Brassica arvensis Species 0.000 description 1
- 235000008427 Brassica arvensis Nutrition 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 244000056139 Brassica cretica Species 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 1
- 235000005484 Chenopodium berlandieri Nutrition 0.000 description 1
- 235000009332 Chenopodium rubrum Nutrition 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 235000011999 Panicum crusgalli Nutrition 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000288 alkali metal carbonate Chemical class 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical group ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
- MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 description 1
- MLUCVPSAIODCQM-UHFFFAOYSA-N crotonaldehyde Natural products CC=CC=O MLUCVPSAIODCQM-UHFFFAOYSA-N 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 125000000262 haloalkenyl group Chemical group 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- GZDAGPDHXQKVHK-UHFFFAOYSA-N o-(3-chloroprop-2-enyl)hydroxylamine;hydrochloride Chemical compound Cl.NOCC=CCl GZDAGPDHXQKVHK-UHFFFAOYSA-N 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
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- 150000002923 oximes Chemical class 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229910052903 pyrophyllite Inorganic materials 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
Substituted 2-[1-(oxyamino)-alkylidene]-5-(2-ethylthio-propyl)cyclo-hexane-1,3-diones have herbicidal activity against grassy weeds.
Substituted 2-[1-(oxyamino)-alkylidene]-5-(2-ethylthio-propyl)cyclo-hexane-1,3-diones have herbicidal activity against grassy weeds.
Description
ii~l'77 o ~
HERBICIDAL SUBSTITUTED 2-[1-(OXYAMINO)-ALKYLIDENE]-5-(2 -ETHYLTHIOPROPYL)-CYCLOHEXANE-1,3-DIONES
BACKGROUND OF THE INVENTION
United States Patent No. 4,011,256 discloses herbicidal cyclohexane-1,3-diones.
SUMMARY OF THE INVENTION
-This invention relates to novel herbicidal compounds, compositions and methods of use thereof. It has been found that novel haloalkenyl and haloaryl-substituted 2-[1-(oxyamino)-alkyl-idene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-diones are particu-larly useful as grassy herbicides in both pre- and post-emergent applications. Moreover, these compounds have excellent soil stability.
DESCRIPTION OF THE INVENTION
The compounds of the invention have the structural formula (I):
R~ ~NO-R
¦ (I) o ~oR5
HERBICIDAL SUBSTITUTED 2-[1-(OXYAMINO)-ALKYLIDENE]-5-(2 -ETHYLTHIOPROPYL)-CYCLOHEXANE-1,3-DIONES
BACKGROUND OF THE INVENTION
United States Patent No. 4,011,256 discloses herbicidal cyclohexane-1,3-diones.
SUMMARY OF THE INVENTION
-This invention relates to novel herbicidal compounds, compositions and methods of use thereof. It has been found that novel haloalkenyl and haloaryl-substituted 2-[1-(oxyamino)-alkyl-idene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-diones are particu-larly useful as grassy herbicides in both pre- and post-emergent applications. Moreover, these compounds have excellent soil stability.
DESCRIPTION OF THE INVENTION
The compounds of the invention have the structural formula (I):
R~ ~NO-R
¦ (I) o ~oR5
2/ \ 3 R R
wherein R is propyl;
Rl is trans 3-chloroallyl or 4-chlorobenzyl;
77~78 One of R2 or R3 is hydrogen and the other is 2-ethyl-thiopropyl;
R4 is hydrogen;
R5 is hydrogen, a cation, or o _CR6 wherein R6 is alkyl of 1 to 6 carbon atoms or aryl of 6 to 10 caxbon atoms.
In terms of desirable phytotoxic properties most preferably Rl is trans 3-chloroallyl. The salts (i.e. R5 is a ~ation) are of interest to improve solubility and ease of formu-lation. The esters (R5 is -C(O)R6) are of interest because they hydrolyze in the field to the parent R5 is hydrogen compound.
Representative R5 groups are hydrogen, NH4+, Na , K , Ca , acetyl, propionyl, butyryl, isobutyryl, isovaleryl, 3,3-dimethylbutyryl, benzoyl, l-naphthoyl, 2-naphthoyl. Preferably R5 is hydrogen.
The compounds of my invention may be prepared according to the following scheme:
~2i~77~
O \\ ~ OCR
R2 ~ + RCX R ~ + HX (1) (II) (IIa) (III) R O
\C~
III AlC13 ~ OH (2) ~ ~4 (IIIa) \ ~
IIIa + H2~0Rl HCl > ~ HCl (IV) (Ia) The appropriate intermediates of the formula (IV) may be made accordin~ to the following reaction sequence:
~r ~777~3 NOH + R Cl > ~ oRl + HCl (4) (V) (Va) (VI) VI 1. Hydrazine ~ H2NORl HCl (5) 2. HCl (IV) Compounds of the formula (I) wherein R5 is other than hydrogen may be prepared according to conventional procedures by treating the hydroxy compound (Ia) with an appropriate basic salt to yield compounds wherein R is Na , NH4 , Ca , etc. Similarly, the hydroxy compound (Ia) may be acylated by treatment with an appropriate acid halide to yield compounds wherein R5 is o _CR6 Reaction (1) above may be performed at ambient temperature employing substantially equimolar amounts of the dione (II) and acid halide (IIa). Preferably the acid chloride (X=Cl) is used. The reaction may be conducted in an organic solvent, such as, halogenated hydrocarbons, ethers or glycols. It is preferred that a base be present, such as an organic amine or alkali metal carbonate salt, in order to quench the hydrogen halide which is evolved. Preferred organic amines are pyridine and trial-kylamines such as triethylamine. Pressure conditions are critical and atmospheric pressure may be conveniently employed.
"
~21777~
Reaction (2) may be performed in an inert organic solvent, such as, halogenated hydrocarbons or ethers. At least two moles of aluminum chloride per mole of ester (III) is used.
Upon work-up, the crude product must be quenched with a proton-donor, preferably a mineral acid such as hydrochloric acid, to produce the trione (IIIa).
Reaction (3) is a conventional oxime forming condensa-tion~ Since the hydrochloride salt (IV) is employed, it is first neutralized with a base, preferably an alkali metal alkoxide, before combining with the trione (IIIa) or the free base from reaction 5 can be used directly. The reaction may be performed in an inert organic solvent, preferably lower alcohols.
Reaction (4) is a conventional alkylation and may be performed in inert organic solvents such as dimethylsulfoxide, acetonitrile, ethers, glycol ethers or hydrocarbons. The reaction is performed in presence of a base, such as potassium carbonate at ambient temperature.
Reaction (5) may be performed at elevated temperatures preferably 30-100C. The phthalimide (VI) is preferably heated at atmospheric pressure with slight molar excess of hydrazine in an inert organic solvent, such as a lower alcohol, to reflux temperature. The crude mixture is then cooled and optionally quenched with a mineral acid, preferably hydrochloric acid, yielding the product salt (IV) or the free base can be used directly in reaction 3.
As an alternative to reactions (1) and (2) above the trione (IIIa) may be formed in one step by treating the dione (II) with the acid halide (IIa) in a halogenated hydrocarbon solvent, ~lZ1777~3 preferably carbon tetrachloride, in the presence of trifluoromethyl sulfonic acid. Typically, the reaction is performed at elevated temperature (30-150C) and is complete within 90 hours but yields a mixture of products. Since the combined reaction time of reactions (1) and (2) is about 24 hours, and results in a purer product, the two-step sequence of reactions (1) and (2) is pre-ferred to the one-step alternative.
The starting materials of Formula II can be prepared by known procedures or obvious modification thereof (e.g. substi-tution of appropriate starting material). The compounds of FormulaII can be conveniently prepared by the following process schematically represented by the following overall reaction equations C=CHC-CH3 + H2C(COR )2 ~ W
(A) (B) (1) R2 ~ (IIa) IIa base ~ OH (3) ~ R3 (C) (IIb) wherein R4 is alkyl of 1 through 3 carbon atoms and R2 and R3 are as defined hereinabove.
These reactions are conventional type reactions and G \ ,i lZl'7778 can be conducted in the usual manner. The first reaction step is typically conducted by contacting compound A with a compound B and a base (e.g. alkali metal alkoxides) under reactive conditions preferably in an inert solvent (e.g. alkanol, e.g. ethanol).
Typically, the reaction is conducted at about from 60 to 110C
using about from 0.5 to 1.5 moles, preferably 0.9 to 1.1 moles, of compound A and of the base per mole of compound B.
In the second step the ester moiety of compound IIa is base hydrolyzed to the carboxylic acid, for example, by contac-ting metallic sodium in alkanol (e.g. ethanol) or alkali metalhydrogen at temperatures in the range of about from 60 to 110C.
By combining the reactants Steps 1 and 2 can be conducted together.
In the third step, compound C can be decarboxylated via treatment with a strong inorganic acid (e.g. hydrochloric acid, sulfuric acid). This step is typically conducted at temperatures in the range of 25 to 110C and can be conveniently conducted in situ after completion of the base hydrolyzation, Step 2.
The compounds of Formula IIIa can also be prepared by reacting the compounds of Formula II with the corresponding anhydride in the presence of an organic base, preferably in an excess of anhydride or inert organic solvent. Typically, this reaction is conducted at temperatures in the range of about from 50 to 110C using about from 5 to 0.5 moles of anhydride per mole of compound II.
The respective products of the above reactions can be isolated and purified by conventional techniques such as chromatography, distillation, crystallization, etc., when appropriate.
1~7778 Definitions The terms "oxyaminoalkylidene" and "oxyiminoalkyl"
refer to the radical having the formula -ON = R-wherein R is alkyl. For example, the terms "1-allyloxyaminobutyli-dene" and "l-allyloxyiminobutyl" refer to the radical having the formula CH2=CH--CH20N= I (CH2 ) 2CH3 Also as is well recognized in the case of the compounds of formula I where R5 is hydrogen, the compounds are generally referred to as cyclohexane-1,3-diones rather than
wherein R is propyl;
Rl is trans 3-chloroallyl or 4-chlorobenzyl;
77~78 One of R2 or R3 is hydrogen and the other is 2-ethyl-thiopropyl;
R4 is hydrogen;
R5 is hydrogen, a cation, or o _CR6 wherein R6 is alkyl of 1 to 6 carbon atoms or aryl of 6 to 10 caxbon atoms.
In terms of desirable phytotoxic properties most preferably Rl is trans 3-chloroallyl. The salts (i.e. R5 is a ~ation) are of interest to improve solubility and ease of formu-lation. The esters (R5 is -C(O)R6) are of interest because they hydrolyze in the field to the parent R5 is hydrogen compound.
Representative R5 groups are hydrogen, NH4+, Na , K , Ca , acetyl, propionyl, butyryl, isobutyryl, isovaleryl, 3,3-dimethylbutyryl, benzoyl, l-naphthoyl, 2-naphthoyl. Preferably R5 is hydrogen.
The compounds of my invention may be prepared according to the following scheme:
~2i~77~
O \\ ~ OCR
R2 ~ + RCX R ~ + HX (1) (II) (IIa) (III) R O
\C~
III AlC13 ~ OH (2) ~ ~4 (IIIa) \ ~
IIIa + H2~0Rl HCl > ~ HCl (IV) (Ia) The appropriate intermediates of the formula (IV) may be made accordin~ to the following reaction sequence:
~r ~777~3 NOH + R Cl > ~ oRl + HCl (4) (V) (Va) (VI) VI 1. Hydrazine ~ H2NORl HCl (5) 2. HCl (IV) Compounds of the formula (I) wherein R5 is other than hydrogen may be prepared according to conventional procedures by treating the hydroxy compound (Ia) with an appropriate basic salt to yield compounds wherein R is Na , NH4 , Ca , etc. Similarly, the hydroxy compound (Ia) may be acylated by treatment with an appropriate acid halide to yield compounds wherein R5 is o _CR6 Reaction (1) above may be performed at ambient temperature employing substantially equimolar amounts of the dione (II) and acid halide (IIa). Preferably the acid chloride (X=Cl) is used. The reaction may be conducted in an organic solvent, such as, halogenated hydrocarbons, ethers or glycols. It is preferred that a base be present, such as an organic amine or alkali metal carbonate salt, in order to quench the hydrogen halide which is evolved. Preferred organic amines are pyridine and trial-kylamines such as triethylamine. Pressure conditions are critical and atmospheric pressure may be conveniently employed.
"
~21777~
Reaction (2) may be performed in an inert organic solvent, such as, halogenated hydrocarbons or ethers. At least two moles of aluminum chloride per mole of ester (III) is used.
Upon work-up, the crude product must be quenched with a proton-donor, preferably a mineral acid such as hydrochloric acid, to produce the trione (IIIa).
Reaction (3) is a conventional oxime forming condensa-tion~ Since the hydrochloride salt (IV) is employed, it is first neutralized with a base, preferably an alkali metal alkoxide, before combining with the trione (IIIa) or the free base from reaction 5 can be used directly. The reaction may be performed in an inert organic solvent, preferably lower alcohols.
Reaction (4) is a conventional alkylation and may be performed in inert organic solvents such as dimethylsulfoxide, acetonitrile, ethers, glycol ethers or hydrocarbons. The reaction is performed in presence of a base, such as potassium carbonate at ambient temperature.
Reaction (5) may be performed at elevated temperatures preferably 30-100C. The phthalimide (VI) is preferably heated at atmospheric pressure with slight molar excess of hydrazine in an inert organic solvent, such as a lower alcohol, to reflux temperature. The crude mixture is then cooled and optionally quenched with a mineral acid, preferably hydrochloric acid, yielding the product salt (IV) or the free base can be used directly in reaction 3.
As an alternative to reactions (1) and (2) above the trione (IIIa) may be formed in one step by treating the dione (II) with the acid halide (IIa) in a halogenated hydrocarbon solvent, ~lZ1777~3 preferably carbon tetrachloride, in the presence of trifluoromethyl sulfonic acid. Typically, the reaction is performed at elevated temperature (30-150C) and is complete within 90 hours but yields a mixture of products. Since the combined reaction time of reactions (1) and (2) is about 24 hours, and results in a purer product, the two-step sequence of reactions (1) and (2) is pre-ferred to the one-step alternative.
The starting materials of Formula II can be prepared by known procedures or obvious modification thereof (e.g. substi-tution of appropriate starting material). The compounds of FormulaII can be conveniently prepared by the following process schematically represented by the following overall reaction equations C=CHC-CH3 + H2C(COR )2 ~ W
(A) (B) (1) R2 ~ (IIa) IIa base ~ OH (3) ~ R3 (C) (IIb) wherein R4 is alkyl of 1 through 3 carbon atoms and R2 and R3 are as defined hereinabove.
These reactions are conventional type reactions and G \ ,i lZl'7778 can be conducted in the usual manner. The first reaction step is typically conducted by contacting compound A with a compound B and a base (e.g. alkali metal alkoxides) under reactive conditions preferably in an inert solvent (e.g. alkanol, e.g. ethanol).
Typically, the reaction is conducted at about from 60 to 110C
using about from 0.5 to 1.5 moles, preferably 0.9 to 1.1 moles, of compound A and of the base per mole of compound B.
In the second step the ester moiety of compound IIa is base hydrolyzed to the carboxylic acid, for example, by contac-ting metallic sodium in alkanol (e.g. ethanol) or alkali metalhydrogen at temperatures in the range of about from 60 to 110C.
By combining the reactants Steps 1 and 2 can be conducted together.
In the third step, compound C can be decarboxylated via treatment with a strong inorganic acid (e.g. hydrochloric acid, sulfuric acid). This step is typically conducted at temperatures in the range of 25 to 110C and can be conveniently conducted in situ after completion of the base hydrolyzation, Step 2.
The compounds of Formula IIIa can also be prepared by reacting the compounds of Formula II with the corresponding anhydride in the presence of an organic base, preferably in an excess of anhydride or inert organic solvent. Typically, this reaction is conducted at temperatures in the range of about from 50 to 110C using about from 5 to 0.5 moles of anhydride per mole of compound II.
The respective products of the above reactions can be isolated and purified by conventional techniques such as chromatography, distillation, crystallization, etc., when appropriate.
1~7778 Definitions The terms "oxyaminoalkylidene" and "oxyiminoalkyl"
refer to the radical having the formula -ON = R-wherein R is alkyl. For example, the terms "1-allyloxyaminobutyli-dene" and "l-allyloxyiminobutyl" refer to the radical having the formula CH2=CH--CH20N= I (CH2 ) 2CH3 Also as is well recognized in the case of the compounds of formula I where R5 is hydrogen, the compounds are generally referred to as cyclohexane-1,3-diones rather than
3-hydroxycyclohex-2-en-1-ones.
Trans-2-[1-(3-chloroallyloxyimino)butyl]-5-(2-ethylthiopropyl)cyclohexane-1,3-dione (a) 86.6 g of crotonaldehyde was added dropwise to a mixture containing 64.0 g of ethanethiol and 2 ml of triethyl-amine in 500 ml of acetonitrile at room temperature (about 20-25C).
The resulting mixture was stirred overnight (about 15 hours) at room temperature and then rotary evaporated to remove acetonitrile~
The residue was dissolved in 300 ml of ~thyl ether, washed twice with water, dried over magnesium sulfate and then concentrated by evaporation affording a yellow liquid concentrate of beta-ethylthio-butyraldehyde.
777~
g (b) A mixture containing 15.9 g of beta-ethylthio-butyraldehyde and 38.2 g of triphenylphosphoranylidene-2-propanone in 300 ml of methylene chloride was refluxed overnight and then evaporated affording a thick residue. The residue was mixed with hexane and filtered. The filtrate was evaporated under vacuum and the residue then distilled under vacuum affording 6-ethylthio-3-hepten-2-one.
(c) 2.53 g of metallic sodium were added to 100 ml of ethanol at room temperature. To this was then added 17.6 g of diethyl malonate, with stirring, and then 17.2 g of 6-ethylthio-3-hepten-2-one was added. The resulting mixture was then refluxed for four hours and then an aqueous sodium hydroxide solution, containing 9.5 g of sodium hydroxide in 75 ml of water, was added and the mixture refluxed for another two hours. The mixture was cooled to 50C and then acidified by the addition of concentrated hydrochloric acid. The mixture was then warm until decarboxylation was complete and then evaporated to a liquid residue. The residue was mixed with ethyl ether, washed with water, and evaporated to a brown liquid. The liquid was base, acid extracted affording 5-(2-ethylthiopropyl) cyclohexane-1,3-dione.
(d) 0.2 g of metallic sodium was dissolved in 1 ml of methanol and then added to 3.2 g of 5-(2-ethylthiopropyl) cyclohexane-1,3-dione. 20 ml of butyric anhydride was added and the mixture then refluxed for three hours. The mixture was then evaporated and the residue mixed with methylene chloride and then extracted with aqueous 5 wt.~ sodium hydroxide. The base extract was washed with methylene ehloride, then acidified with concentrated hydrochloric acid and then extracted into methylene chloride.
12i7778 This was then evaporated affording 2-butyryl-5-(2-ethylthiopropyl) cyclohexane-1,3-dione.
(e) 0.38 g of sodium methoxide, 10 ml of methanol, and 1.0 g of 3-chloroallyloxyamine hydrochloride (H2NOCH2CH=CHCl) were admixed together and then stirred for 10 minutes at room temperature. 2 g of 2-butyryl-5-(2-ethylthiopropyl)cyclohexane-1, 3-dione was added and the resulting mixture stirred for about two days at room temperature. The mixture was then concentrated by evaporation and the concentrate mixed with 60 ml of diethyl ether and 40 ml of water. The ether layer was extracted with 40 ml of aqueous 2 wt. % sodium hydroxide solution, washed with 20 ml of water, dried over anhydrous magnesium sulfate and evaporated affording a minor amount of the title compound as the trans isomer.
The 2% sodium hydroxide solution extract was acidified to about pH 1 with aqueous 6N hydrochloric acid and then extracted with 100 ml of methylene chloride. The organic layer was washed with 40 ml of water, dried over magnesium sulfate and then evaporated affording the trans isomer of the title compound as the residue (Compound No. 1 of Table A hereinbelow). The major portion of the title compound was recovered from the sodium hydroxide extract.
This example illustrates the preparation of the acyloxy compounds of the invention.
To a reaction mixture containing 3~0 g (0.01) mol of 2-[1-(3'-chloroallyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-dione and 0.87 gm (0.011 mol) of pyridine in 20 ml -121777~
of methylene chloride stirred at 0C is added 0.89 gm (0.011 mol) of acetyl chloride. The mixture is then stirred at room temperature for 2 hours. The mixture is then worked up by washing with water, drying with anhydrous magnesium sulfate, and filtered. lhe filtrate is evaporated under vacuum affording 3-acetyloxy-2-[1~3'-chloro-allyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohex-2-en one.
Similarly, by following the same procedure, the corresponding 3-acetyloxy derivative of each of the products listed in Table A hereinbelow are respectively prepared.
This example illustrates the preparation of the salts of the present invention.
To 3.0 gm (0.01 mol) of 2-[1-(3'-chloroallyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-dione in 10 ml of acetone is added 0.4 gm (0.01 mol) of sodium hydroxide dissolved in 2 ml of water. The solvents are evaporated under vacuum affording the 3-hydroxy sodium salt of 2-[1-(3'-chloroallyl-oxyamino)-butylidene]-3-hydroxy-5-(2-ethylthiopropyl)-cyclohex-2-en-l-one.
Similarly, by following the same procedure, the sodium salts of each of the products listed in Table A hereinbelow are respectively prepared.
UTILITY
The compounds of the present invention are, in general, herbicidal in both pre- and post-emergent applications. For pre-emergent control of undesirable vegetation, the herbicidal compounds :` ' ~Z31~77~
-12~
will be applied in herbicidally effective amounts to the locus or growth medium of the vegetation, e.g., soil infested with seeds and/or seedlings of such vegetation. Such application will inhibit the growth of or kill the seeds, germinating seeds and seedlings.
For post-emergent applications, the herbicidal compounds will be applied directly to the foliage and other plant parts. Generally, the herbicidal compounds of the invention are especially effective against grassy weeds and by proper dosage regulation can be safely applied for the control or prevention of grasses in broad leaf crops. The compounds of the invention exhibit excellent soil stability. This is particularly advantageous for pre-emergence application.
The compounds, when applied to growing plants above the ground in such an amount that the compounds will not kill beneficial plants, also show efficient plant growth regulating or retarding effects and may be advantageously employed, for example, to prevent or retard the growth of lateral buds in plants and to promote the thinning out of superfluous fruits in various fruit trees.
The compounds can be applied in any of a variety of compositions. In general, the compounds can be extended with a carrier material of the kind used and commonly referred to in the art such as inert solids, water and organic liquids.
The compounds will be included in such compositions in sufficient amount so that they can exert an herbicidal or growth-regulating effect. Usually from about 0.5 to 95% by weight of the compounds are included in such formulations.
1~177 7~
Solid composltions can be made with inert powders.
The compositions thus can be homogeneous powders that can be used as such, diluted with inert solids to form dusts, or suspended in a suitable liquid medium for spray application. The powders usually comprise the active ingredient admixed with minor amounts of conditioning agent. Natural clays, either absorptive, such as attapulgite, or relatively non-absorptive, such as china clays, diatomaceous earth, synthetic fine silica, calcium silicate and other inert solid carriers of the kind conventionally employed in powdered herbicidal compositions can be used. The active ingredient usually makes up from 0.5-90~ of these powder compositions. The solids ordinarily should be very finely divided. For conversion of the powders to dusts, talc, pyrophyllite, and the like, are customarily used.
Liquid compositions including the active compounds described above can be prepared by admixing the compound with a suitable liquid diluent medium. Typical of the liquid media commonly employed ar~ methanol, benzene, toluene, and the like.
The active ingredient usually makes up about 0.5 to 50% of these liquid compositions. Some of these compositions are designated to be used as such, ancl others to be extended with large quantities of water.
Compositions in the form of wettable powders or liquids can also include one or more surface-active agents, such as wetting, dispersing or emulsifying agents. The surface-active agents cause th~ compositions of wettable powders or licluids to disperse or emulsify easily in water to give aqueous sprays.
~Z1~778 The surface-active agents employed can be of the anionic, cationic or nonionic type. They include, for example, sodium long-chain carboxylates, alkyl aryl sulfonates, sodium lauryl sulfate, polyethylene oxides, lignin sulfonates and other surface-active agents.
When used as a pre-emergent treatment, it is desirable to include a fertilizer, an insecticide, a fungicide or another herbicide.
The amount of active compound or composition admini-stered will vary with the particular plant part or plant growth medium which is to be contacted, the general location of application -- i.e,, sheltered areas such as greenhouses, as compared to ex-posed areas such as fields -- as well as the desired type of control. Generally for both pre- and post-emergent herbicidal control, the compounds of the invention are applied at rates of 0.2 to 60 kg/ha, and the preferred rate is in the range 0.5 to 40 kg/ha.
For plant growth regulating or retarding activity, it is essential to apply the compounds at a concentration not so high as to kill the plants. Therefore, the application rates for plant growth regulat-ing or retarding activity will generally be lower than the rate used ~or killing the plants. Generally, such rates vary from 0.1 to 5 kg/ha, and preferably from 0.1 to 3 kg/ha.
Herbicidal tests on representative compounds of the invention were made using the following methods.
Pre-Emergent Herbicidal Test An acetone solution of the test compound was prepared by mixing 500 mg of the compound, 158 mg of a nonionic surfactant and 20 ml of acetone. Twenty ml of this solution was added to 1~
:~Z~77'7~
80 ml of water to give the test solution.
Seeds of the test vegetation were planted in a pot of soil and the test solution was sprayed uniformly onto the soil surface at a dose of 27.5 micrograms/cm2. The pot was watered and placed in a greenhouse. The pot was watered intermittently and observed for seedling emergence, health of emerging seedlings, etc., for a 3-week period. At the end of this period, the herbi-cidal effectiveness of the compound was rated based on the physio-logical observations. A 0-to-100 scale was used~ 0 representing no phytotoxicity, 100 representing complete kill. The results of these tests appear in Table I.
In follow-up tests, the procedure above was repeated using diluted test solution which was sprayed onto the soil surface at various dosages. The results of these tests appear in Table II.
Post-Emergent ~erbicidal Test .
The test compound was formulated in the same manner as described above for the pre-emergent test. This formulation was uniformly sprayed on 2 similar pots of 24-day-old plants (approximately 15 to 25 plants per pot) at a dose of 27.5 micro-grams/cm2. After the plants had dried, they were placed in a greenhouse and then watered intermittently at their bases, as needed. The plants were observed periodically for phytotoxic effects and physiological and morphological responses to the treatment. After 3 weeks, the herbicidal effectiveness of the compound was rated based on these observations. A 0-to-100 scale was used, 0 representing no phytotoxicity and 100 representing complete kill. The results of these tests appear in Table I.
~Z~77i~3 In follow-up tests, the procedure above was repeated using diluted test solution which was sprayed onto the soil surface at various dosages. The results of these tests appear in Table II.
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TABLE I - HERBICIDAL AC_IVIT
Pre/Post % Control (27.5 gamma/cm2~
No. L M P _ W O
1 0/~0 0/20 0/0 100/100100/10~100/100 L = Lambsquarter (Chenopodium album M = Mustard (Brassica arvensis) P = Pigweed (Amaranthus retroflexus) C = Crabgrass (Digitaria sanguinalis) W = Watergrass (Echinochloa crusgalli) O = Wild Oats (Avenua fatua) ,~
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Obviously many modifications and variations of the invention, described hereinabove and below in the claims, can be made without departing from the essence and scope thereof.
Trans-2-[1-(3-chloroallyloxyimino)butyl]-5-(2-ethylthiopropyl)cyclohexane-1,3-dione (a) 86.6 g of crotonaldehyde was added dropwise to a mixture containing 64.0 g of ethanethiol and 2 ml of triethyl-amine in 500 ml of acetonitrile at room temperature (about 20-25C).
The resulting mixture was stirred overnight (about 15 hours) at room temperature and then rotary evaporated to remove acetonitrile~
The residue was dissolved in 300 ml of ~thyl ether, washed twice with water, dried over magnesium sulfate and then concentrated by evaporation affording a yellow liquid concentrate of beta-ethylthio-butyraldehyde.
777~
g (b) A mixture containing 15.9 g of beta-ethylthio-butyraldehyde and 38.2 g of triphenylphosphoranylidene-2-propanone in 300 ml of methylene chloride was refluxed overnight and then evaporated affording a thick residue. The residue was mixed with hexane and filtered. The filtrate was evaporated under vacuum and the residue then distilled under vacuum affording 6-ethylthio-3-hepten-2-one.
(c) 2.53 g of metallic sodium were added to 100 ml of ethanol at room temperature. To this was then added 17.6 g of diethyl malonate, with stirring, and then 17.2 g of 6-ethylthio-3-hepten-2-one was added. The resulting mixture was then refluxed for four hours and then an aqueous sodium hydroxide solution, containing 9.5 g of sodium hydroxide in 75 ml of water, was added and the mixture refluxed for another two hours. The mixture was cooled to 50C and then acidified by the addition of concentrated hydrochloric acid. The mixture was then warm until decarboxylation was complete and then evaporated to a liquid residue. The residue was mixed with ethyl ether, washed with water, and evaporated to a brown liquid. The liquid was base, acid extracted affording 5-(2-ethylthiopropyl) cyclohexane-1,3-dione.
(d) 0.2 g of metallic sodium was dissolved in 1 ml of methanol and then added to 3.2 g of 5-(2-ethylthiopropyl) cyclohexane-1,3-dione. 20 ml of butyric anhydride was added and the mixture then refluxed for three hours. The mixture was then evaporated and the residue mixed with methylene chloride and then extracted with aqueous 5 wt.~ sodium hydroxide. The base extract was washed with methylene ehloride, then acidified with concentrated hydrochloric acid and then extracted into methylene chloride.
12i7778 This was then evaporated affording 2-butyryl-5-(2-ethylthiopropyl) cyclohexane-1,3-dione.
(e) 0.38 g of sodium methoxide, 10 ml of methanol, and 1.0 g of 3-chloroallyloxyamine hydrochloride (H2NOCH2CH=CHCl) were admixed together and then stirred for 10 minutes at room temperature. 2 g of 2-butyryl-5-(2-ethylthiopropyl)cyclohexane-1, 3-dione was added and the resulting mixture stirred for about two days at room temperature. The mixture was then concentrated by evaporation and the concentrate mixed with 60 ml of diethyl ether and 40 ml of water. The ether layer was extracted with 40 ml of aqueous 2 wt. % sodium hydroxide solution, washed with 20 ml of water, dried over anhydrous magnesium sulfate and evaporated affording a minor amount of the title compound as the trans isomer.
The 2% sodium hydroxide solution extract was acidified to about pH 1 with aqueous 6N hydrochloric acid and then extracted with 100 ml of methylene chloride. The organic layer was washed with 40 ml of water, dried over magnesium sulfate and then evaporated affording the trans isomer of the title compound as the residue (Compound No. 1 of Table A hereinbelow). The major portion of the title compound was recovered from the sodium hydroxide extract.
This example illustrates the preparation of the acyloxy compounds of the invention.
To a reaction mixture containing 3~0 g (0.01) mol of 2-[1-(3'-chloroallyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-dione and 0.87 gm (0.011 mol) of pyridine in 20 ml -121777~
of methylene chloride stirred at 0C is added 0.89 gm (0.011 mol) of acetyl chloride. The mixture is then stirred at room temperature for 2 hours. The mixture is then worked up by washing with water, drying with anhydrous magnesium sulfate, and filtered. lhe filtrate is evaporated under vacuum affording 3-acetyloxy-2-[1~3'-chloro-allyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohex-2-en one.
Similarly, by following the same procedure, the corresponding 3-acetyloxy derivative of each of the products listed in Table A hereinbelow are respectively prepared.
This example illustrates the preparation of the salts of the present invention.
To 3.0 gm (0.01 mol) of 2-[1-(3'-chloroallyloxyamino)-butylidene]-5-(2-ethylthiopropyl)-cyclohexane-1,3-dione in 10 ml of acetone is added 0.4 gm (0.01 mol) of sodium hydroxide dissolved in 2 ml of water. The solvents are evaporated under vacuum affording the 3-hydroxy sodium salt of 2-[1-(3'-chloroallyl-oxyamino)-butylidene]-3-hydroxy-5-(2-ethylthiopropyl)-cyclohex-2-en-l-one.
Similarly, by following the same procedure, the sodium salts of each of the products listed in Table A hereinbelow are respectively prepared.
UTILITY
The compounds of the present invention are, in general, herbicidal in both pre- and post-emergent applications. For pre-emergent control of undesirable vegetation, the herbicidal compounds :` ' ~Z31~77~
-12~
will be applied in herbicidally effective amounts to the locus or growth medium of the vegetation, e.g., soil infested with seeds and/or seedlings of such vegetation. Such application will inhibit the growth of or kill the seeds, germinating seeds and seedlings.
For post-emergent applications, the herbicidal compounds will be applied directly to the foliage and other plant parts. Generally, the herbicidal compounds of the invention are especially effective against grassy weeds and by proper dosage regulation can be safely applied for the control or prevention of grasses in broad leaf crops. The compounds of the invention exhibit excellent soil stability. This is particularly advantageous for pre-emergence application.
The compounds, when applied to growing plants above the ground in such an amount that the compounds will not kill beneficial plants, also show efficient plant growth regulating or retarding effects and may be advantageously employed, for example, to prevent or retard the growth of lateral buds in plants and to promote the thinning out of superfluous fruits in various fruit trees.
The compounds can be applied in any of a variety of compositions. In general, the compounds can be extended with a carrier material of the kind used and commonly referred to in the art such as inert solids, water and organic liquids.
The compounds will be included in such compositions in sufficient amount so that they can exert an herbicidal or growth-regulating effect. Usually from about 0.5 to 95% by weight of the compounds are included in such formulations.
1~177 7~
Solid composltions can be made with inert powders.
The compositions thus can be homogeneous powders that can be used as such, diluted with inert solids to form dusts, or suspended in a suitable liquid medium for spray application. The powders usually comprise the active ingredient admixed with minor amounts of conditioning agent. Natural clays, either absorptive, such as attapulgite, or relatively non-absorptive, such as china clays, diatomaceous earth, synthetic fine silica, calcium silicate and other inert solid carriers of the kind conventionally employed in powdered herbicidal compositions can be used. The active ingredient usually makes up from 0.5-90~ of these powder compositions. The solids ordinarily should be very finely divided. For conversion of the powders to dusts, talc, pyrophyllite, and the like, are customarily used.
Liquid compositions including the active compounds described above can be prepared by admixing the compound with a suitable liquid diluent medium. Typical of the liquid media commonly employed ar~ methanol, benzene, toluene, and the like.
The active ingredient usually makes up about 0.5 to 50% of these liquid compositions. Some of these compositions are designated to be used as such, ancl others to be extended with large quantities of water.
Compositions in the form of wettable powders or liquids can also include one or more surface-active agents, such as wetting, dispersing or emulsifying agents. The surface-active agents cause th~ compositions of wettable powders or licluids to disperse or emulsify easily in water to give aqueous sprays.
~Z1~778 The surface-active agents employed can be of the anionic, cationic or nonionic type. They include, for example, sodium long-chain carboxylates, alkyl aryl sulfonates, sodium lauryl sulfate, polyethylene oxides, lignin sulfonates and other surface-active agents.
When used as a pre-emergent treatment, it is desirable to include a fertilizer, an insecticide, a fungicide or another herbicide.
The amount of active compound or composition admini-stered will vary with the particular plant part or plant growth medium which is to be contacted, the general location of application -- i.e,, sheltered areas such as greenhouses, as compared to ex-posed areas such as fields -- as well as the desired type of control. Generally for both pre- and post-emergent herbicidal control, the compounds of the invention are applied at rates of 0.2 to 60 kg/ha, and the preferred rate is in the range 0.5 to 40 kg/ha.
For plant growth regulating or retarding activity, it is essential to apply the compounds at a concentration not so high as to kill the plants. Therefore, the application rates for plant growth regulat-ing or retarding activity will generally be lower than the rate used ~or killing the plants. Generally, such rates vary from 0.1 to 5 kg/ha, and preferably from 0.1 to 3 kg/ha.
Herbicidal tests on representative compounds of the invention were made using the following methods.
Pre-Emergent Herbicidal Test An acetone solution of the test compound was prepared by mixing 500 mg of the compound, 158 mg of a nonionic surfactant and 20 ml of acetone. Twenty ml of this solution was added to 1~
:~Z~77'7~
80 ml of water to give the test solution.
Seeds of the test vegetation were planted in a pot of soil and the test solution was sprayed uniformly onto the soil surface at a dose of 27.5 micrograms/cm2. The pot was watered and placed in a greenhouse. The pot was watered intermittently and observed for seedling emergence, health of emerging seedlings, etc., for a 3-week period. At the end of this period, the herbi-cidal effectiveness of the compound was rated based on the physio-logical observations. A 0-to-100 scale was used~ 0 representing no phytotoxicity, 100 representing complete kill. The results of these tests appear in Table I.
In follow-up tests, the procedure above was repeated using diluted test solution which was sprayed onto the soil surface at various dosages. The results of these tests appear in Table II.
Post-Emergent ~erbicidal Test .
The test compound was formulated in the same manner as described above for the pre-emergent test. This formulation was uniformly sprayed on 2 similar pots of 24-day-old plants (approximately 15 to 25 plants per pot) at a dose of 27.5 micro-grams/cm2. After the plants had dried, they were placed in a greenhouse and then watered intermittently at their bases, as needed. The plants were observed periodically for phytotoxic effects and physiological and morphological responses to the treatment. After 3 weeks, the herbicidal effectiveness of the compound was rated based on these observations. A 0-to-100 scale was used, 0 representing no phytotoxicity and 100 representing complete kill. The results of these tests appear in Table I.
~Z~77i~3 In follow-up tests, the procedure above was repeated using diluted test solution which was sprayed onto the soil surface at various dosages. The results of these tests appear in Table II.
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TABLE I - HERBICIDAL AC_IVIT
Pre/Post % Control (27.5 gamma/cm2~
No. L M P _ W O
1 0/~0 0/20 0/0 100/100100/10~100/100 L = Lambsquarter (Chenopodium album M = Mustard (Brassica arvensis) P = Pigweed (Amaranthus retroflexus) C = Crabgrass (Digitaria sanguinalis) W = Watergrass (Echinochloa crusgalli) O = Wild Oats (Avenua fatua) ,~
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Obviously many modifications and variations of the invention, described hereinabove and below in the claims, can be made without departing from the essence and scope thereof.
Claims (11)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A compound of the formula wherein R is propyl;
R1 is trans 3-chloroallyl or 4-chlorobenzyl;
One of R2 or R3 is hydrogen, and the other is 2-ethylthiopropyl;
R4 is hydrogen;
R5 is hydrogen, a cation, or wherein R6 is alkyl of 1 to 6 carbon atoms, phenyl or naphthyl.
R1 is trans 3-chloroallyl or 4-chlorobenzyl;
One of R2 or R3 is hydrogen, and the other is 2-ethylthiopropyl;
R4 is hydrogen;
R5 is hydrogen, a cation, or wherein R6 is alkyl of 1 to 6 carbon atoms, phenyl or naphthyl.
2. The compound of Claim 1 wherein R5 is hydrogen.
3. The compound of Claim 1 wherein R5 is a cation.
4. The compound of Claim 1 wherein R1 is trans 3-chloro-allyl.
5. The compound according to Claim 4 wherein R5 is hydrogen.
6. The compound according to Claim 4 wherein R5 is a cation.
7. A method of killing vegetation which comprises applying to said vegetation or its growth environment a herbici-dally effective amount of a compound of the formula defined in Claim 1, or of a composition including as active ingredient a compound of the formula defined in claim 1 together with an agri-culturally acceptable carrier.
8. A method of killing crabgrass, watergrass or wild oats which comprises applying thereto or its growth environment a herbicidally effective amount of a compound of the formula defined in Claim 1, or of a composition including as active ingredient a compound of the formula defined in Claim 1 together with an agri-culturally acceptable carrier.
9. A method of killing watergrass which comprises apply-ing thereto or its growth environment a herbicidally effective amount of a compound of the formula defined in Claim 1, or of a composition including as active ingredient a compound of the formula defined in Claim 1 together with an agriculturally accept-able carrier.
10. A herbicidal composition which comprises an agricul-turally acceptable carrier and, as active ingredient, a compound of the formula defined in Claim 1.
11. A composition according to Claim 10 wherein in the compound of the formula defined in Claim 1, R1 is trans 3-chloro-allyl, and R5 is hydrogen or a cation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000438123A CA1217778A (en) | 1983-09-30 | 1983-09-30 | Herbicidal substituted 2-[1-(oxyamino)- alkylidene]-5-(2-ethylthiopropyl)-1,3-diones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000438123A CA1217778A (en) | 1983-09-30 | 1983-09-30 | Herbicidal substituted 2-[1-(oxyamino)- alkylidene]-5-(2-ethylthiopropyl)-1,3-diones |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1217778A true CA1217778A (en) | 1987-02-10 |
Family
ID=4126198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA000438123A Expired CA1217778A (en) | 1983-09-30 | 1983-09-30 | Herbicidal substituted 2-[1-(oxyamino)- alkylidene]-5-(2-ethylthiopropyl)-1,3-diones |
Country Status (1)
Country | Link |
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CA (1) | CA1217778A (en) |
-
1983
- 1983-09-30 CA CA000438123A patent/CA1217778A/en not_active Expired
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