CA1193167A - Tablet forming cleanser composition and method of preparation - Google Patents

Abstract

ABSTRACT OF THE DISCLOSURE

A cleansing composition is disclosed that is particularly suited for compaction into tablet form, and comprises a phosphate salt, an optionally added silicate salt, such as a metasilicate and at least one perborate salt, wherein at least a portion of the perborate salt component is present as a compacted, gran-ulated mixture with from about 0.01% to about 0.70% by weight of the perborate salt, of a polymeric fluorocarbon. Prefer-ably, the perborate salt includes sodium perborate monohydrate and anhydrous sodium perborate, and polytetrafluoroethylene comprises the polymeric fluorocarbon used to prepare the granules.

When present, the silicate salt is preferably utilized within a particle size ranging from about 1 to about 25 microns.
The silicate aids disintegration and assists in mechanical cleaning, when the composition is prepared in tablet form for use as a denture cleanser.

The use of the perborate granules reduces the difficulty of compacting the composition to form tablets, without impeding the operation and activity of the tablets as effervescent cleansers.

Description

--',?. ~ 3 r~

~ACKGROUND OF TtlE INVENTIOII
e~.

The present invention relates generally to cleansing cnmposi-tions3 and more particularly to cleansing compositions that are prepared in tablet ~orm for useO

Description of the Prior Art:

Cleanser compositions,, and in particular those compositions havinq utility for hard sur~ace cleaning applications, haYe utilized oxidizing agents and bleaching agents in concert to 1~ remove vlsible stains, while at the same time providing the - capability for the removal of scale or plaque buildup on the surfaces~ Thus; a ~fariety of cleansing eompositions are known and have been prepared either with abrasive materials for use - as scourin~ cleansers, or alone for purpose of mild surfacel 20 cleaning applicatlons suoh as passive dispersion in a 1iquid medium such as water" for soaking app~ ications, such as the cleaning of denturesO All of these compositions have employed a variety of sulfa~e salts, such as bisulfates~ monopersulfates, and sulfates as detergents, oxidizers and the like" and have

2~ also utilized alkali metal and alkaline earth rnetal halides as b7eaches~ Such compositions have also included perborate9 carbonate and phosphate salts in varying amounts~ to provide "

r e~fervescence an(l ~ct i v~l ki on .. I~presen tati v~ cl eans i r1g comp;J
si~ions covering these various ~pplications are set ft)rth in U.S. P~tent. No. 3,337~466 ~o Puetzer et al . 7 U.S. Patent No~

3,458,446 to Diaz, U.S. Patent No. 3,558~497 to La~les, U.S~
Patent No~ 3,704~227 to Hill, and commonly assicJned co~endiny Canadian application, Serial Number 399,943, filed March 31, 1982.

In the instance where the cleansing composition5 mentioned ab~ve contain one or more perborate salts~ and the compositions 1~ are prepared into table~s by compression, the compositions have .
presented certain drawbaeks in that they are difficul t to com-press~ and the resul~ing tablets lack mechanical strength.
These problems are ow;ng primar;ly to physical proper~ie~ o~
the perborate salts employed. In p~rticular~ anhydrous sodium 1~ . perborate, which has been utilized in the compositio~s in my copendin~ applicat;ons 9 ;5 commercia~ly a~ailable as a fluffy - powder hav;ng a low specifi weigh~ and density and therefore resistant to co~pact~on and agglomeration. To a lesser extPnt~
this same difficul~y is experienced with another perborate salt additiYe~ sodium perborate monohydrate~ . -Prior attempts to remedy these deficienc;es haYe ~ocused upon the addi ti~n of greater amounts of standard tabletln~ aids such as talc~ sodium benzoate~ and the like~ The addîtîon of greater amounts of these ingredients~ ho~e~er, while remedying the di~f~culties of lnitial process;ng and tablet form2tion9 ca.rry ~ith them certain other-drawbacks~ namely that the fnrmed table-s exhibit retarded aotion in USe7 that renders them 12ss commercially desirable. In particular, the increased amounts of tableting aids tend to prolon~ the disintegration $ime o~
the t~blet, with the result that the activlty of the ~able~
is delayed and ir some instances slightly suppressed~ and the.re-fore less attractiYe to potential consumers.

, . .

-4~ s~

A process is disclosed in U.S. Patent No. 4,115,51Y to Brichard et al., for the manufacture of sodium perbora~e monohydrate, that purportedly results in the preparation of granules of the monohydrate possessing the desired particle si7e, specific weight, abrasion resistance and flowability so~yht for use in connection with the compaction o~ dental cleanser tablets. The ~echnique disclosed by the patent9 however, is complex and cos~y, and requires specialized apparatu~ to conduct a ~luidized bed particle formation in contact with hyd.ogen peroxide. The patentees refer to prior art processes for ~he formation of the monohydrate salt, and indicate that ~hose processes" as well" are complex and ex~
pensive, and frequent1y yield particles that are unsuitable for the present applicationsD

1~ U.S~ Patent No. 3,34O~1~2D to Hotko~ discloses that polyfluoro-carbons may be utilized in the manufacture of tablets~ as ~ 1 ubricants ~ and in amount~ by weight of the tableting composi-~ion~ ranging from about 1~ to about 15% b~y weigh~, to supplant such known lubricants as magnesium stearate, sodium lauryl 20 sulfatep polyethylene glycols and the like. Hotko suggests that the fluoropolymer may be added directly to the tableting mixture, in its capacity and amount as a lubricant, and pur-portedly has a favorable effec~ on the tablet-forming proress~
There is no disclosure in Hotko that the fluoropolymers would serve as agglomeration or compaction aids, to fac;litate the preparation of granulated materials of increased and improved s pec i f i c we i g h t .

A need therefore exists for the preparation and employment of a granulated perborate salt that is easily and efficien~ly compressed in csmbination with th~ remaining ingredients of cleansing compositions, t9 enable the compositions to be fsrmed into cleanser tablets that exhibit mechanical stabili~y without reduced activi t,y~

SUM~lARY OF THE IN`JENTION
__ In accordance with the present invention, a cleansing csmpo-sition is prepared that is particularly suited for ccmpression

5 in.o tablet form. The cleansing composition comprises a phosphate salt in an amount from about 20~; to about 45h by weight, an optional silicate salt in particulate for~, in an amount of up to about 20~ by weight and at least one perborate salt in an amount of at least 50~ by weight; wherein at least a por-~ion of the perbora~e salt is present as a cDmpac~ed, granu-lated mixture with from about 0.01'~ to about 0.70~ by we;ght of the salt, of a polymeric fluorocarbon.

The mixture of the perborate salt and the polymeric fluorocar-bon is prepared by compaction~ such as by slugging or roller 1~ compaction, followed by comminution under agitation to form granules that may, for example" have a particle size capable of passi ng through a 3D mesh screen ,, Preferably, the phosphate salt comprises an alkali metal phos-phate, such as trisodiu~ phosphate, pre-sent in an amount o~ .
from about 25% to abou~ 40% by weight. The silica~e salt com-prises an alkali metal me~asilioate such as sodium metasilicate~
and may be present ~ n ar amount from about lO~o to about 20% by weight. Further3 the silicate sal.t should have a partlcle size on the order of 1 micron to about 25 microns, as this particle size range enables the guantities of the silicate salt utilized herein to be ;ncluded~ ~ithout adverse effect upon the disinte-gration time of a tablet prepared from the present composition.

Th~ perborate salts utilized in the present compos;tion may eomprise alkali metal perborates selected from the group oon-sisting of alkali metal perborate monohydrates and anhydrous

- 6 - ~ '7 alkali metal perborates. ~n particular, the sodium salts are contemplated, and the present compositions may contain from abnut 50,; to about 70~ by weight of the p~rborate salts.
Preferably, the compositions contained from about ~Ok to about ~5~ by weight of the perborate salts3 including at least 20b hy weight of the ~nhydrous alkali metal perborate.

The polymeric fluorocarbon i 5 preferably present in an amount of from about 0.33X to about 0.~6% by weight o~ the perborate salt~ and may include at least one fluoroolefin~ Preferably a 10 the polymeric fluorocarbon comprises polytetrafluoroethylene9 and the perbora~e s~l~ prepared in compacted, granular form~
comprise~ the anhydrous alkali metal perboratea The present cleansing compos~tions may also include other in-gredients such as colorants9 detergents, pH adjustment addi~
15 tives~ perfumes and the like, and are particularly useful when prepared in tablet form for use, for example~ as denture rleansers~

The present invention also relates to a method for preparing the efferYescing cleansing ~omposition, comprising preparing a perborate salt in a compacted9 granular mixture with a poly-meric fluorocarbon9 in which the polymeric fluorocarbon is present in an amount by weight of the perborate salt9 ranging from about O.OlX to about 0.70%, ad~ing ~o the perborate sal~
a quantity of a phosphate salt and a silicate salt, whereby the phosphate salt is present in an amount by weight of the total composition of from about 20X to about 45,~ the silicate salt is present in an amount of up to about 20b by ~Jeight, and the perborate salt is present in an amount of at least ~0~ by weight, all to form a second mixture~ and compacting 3D the second mixture to form a plurality of tablets therefrom.
Preferablyg the silicate salt comprises an alkali metal meta-silic3te having a p~rticle size ranging from about I m;cron _7~

to about 25 mierons, the perbora~e salt comprises a mixture of sodium perborate monohydra~e and anhydrous sodium per borate, and the phosphate salt comprises trisodium phosphate.

Accordingly, it is a principal object o~ the presen~ inven~ion to provide an efferveseing cleanser composition capable of serving as a denture cleanser in tablet formO

It is a further ubject oF ~he present invention to provide a cleanser composi~ion as aforesaid, ~hat is easily molded into tablets that retain their mechanical stability and strength, 10 It is a still further object of the present invention to p~o-vide a cleanser composi~ion as aforesaid, that is promptly activated upon placement in water.

It is a still further object of the present invention to pro-~ vide a method for ~he prepa~ation of the present cleansing compositions~ which is simple and inexpensive.

Other obJects and advantages will become apparent to those skilled in the art ~rom a consideration of the ensuing detailed descrip-tion.

DETAILED DESCRIPTIûN
.

The cleansing compositions of the present invention comprise a phosphate salt in an amount of from about 20% to about 45X
by weightO Preferably9 the phosphate salt may be present in an amount ranging from about 25% to about 40~ by weight, and compri ses alkali metal phosphates and alkaline earth metdl yhosphates, with alkali ~etal phosphates preferred~ More -8~

particularly, the alkali ~etal phosphate may co~prise tri-SQdi um phosphate~

The phosphate componen~ serves as a cleaner9 and in the in-stance where the present cDmpositions are utilized as denture 5 cleansers, attacks and disintegrates the dental plaque that forms on the surface of ~le dentures. This cleaning role i5 in additinn to the function of the phosphates as builders.

The silicate sal~ may be added to the present compositions to serve as a mechanical cleaner, as it is believed that the 10 sil ;cate exerts some mild abr~sive action upon the surface of the dentures, ~hat causes ~he breakup of the dental pl aque and other scale that may have formed thereon during use~ The silicate salt preferably coinpr;ses an alkali metal metasili-. cate, such as sodium me~asilicate. Naturally, the invention 1~ includes other metasilicates within its scope~ and sh~uld not - be limited to the specifio metasilica~e disclosed herein~

The sil;cate salt may be added in an amount of up to about ?0 by weight of the composition~ and preferably in an amount Df from about lOX to about 20% by weightO llhen utilized~ the sil;cage salt is prov;ded ;n particulate form~ with particle sizes that should range between 1 micron and 25 microns in size.
The adherence to this size 1 imitation is important9 as the metasilicates lying outside this particle si~e range9 tend to adversely effect the activity cf thP present compositîonj when it is prepared in tablet formO

More particularly; earlier efforts to utili~e metasilica~e salts with particle sizes lying outside the aforementioned range, resulted in the preparation of tablets that exhibi~ed disintegration delays so excessiYe as to render the ~able~s .

9~ ~. .

co~mercially unusable. In some instances, the metasilica~e appeared to completely block disintegration~ and had to be deleted.

It is therefore one of the ~eatures o~ ~he present inven~ion, that the use o~ a metasilicate component having the par~icle si~e range disclosed herein9 poses no Pbstacle to the disinte-gration of table~s prepared from such a composi~ionO

The presen~ compositions may also contain a~ least one per-borate salt in an amount of at least 50~ by weight. ~he per-borate salt functions in a variety of capaoities within thepresent compositions~ as it provides cleaning action, as well a5 promoting the ac~iYi~y of the co~positions by initiating effervescence as well as inhibiting tarnish and corrosion o~
susceptible substrates immersed in ~olutions of the present composition.

The perborate salts may be selected from alka~i metal perbor-ates and alkaline earth metal perborates9 and more particularly may be sel ected from al kal i metal perborate monohydrate an~
anhydrous alkali me~al perborates. Thus~ the sodium and po-tassium salts of th perbora~e monohydrate and anhydrous per- .
borates may be utili2ed, and preferably~ the perborate salts may comprise sodium perborate monohydrate and anhydrous sodium perborate.

The perborate salts are preferably present in an amount rang~
ing from about ~OX to about 70% by weight of the compositiony and more preferably from about 50~O to about 65/o by weight.
The perborate salts may comprise a mix~ure of the anhydrous perborate and the perborate monohydrate3 in which instance the ~L'~ ;S'L~
- 1 0 ^-anhydrous perborate is present i n an amount of at least 20 by weight~ and preferably ;n an amoun~ from about ~0~ to about 2~ by we~ght.

A further fea~ure of the present compos;tions, comprises ~he preparation of at least a portion o~ the perborate salt in a compacted9 granula~ed mix~ure with from about 0~01~ to about 0.70~ by weight of the salt, of a polymeric fluorocarbon.
The preparation of this compac~ed granular mixture and its employment in the present composi tion is particu-larly note-10 worthy, as it facilitates the compac~ion of the perboratesalt without adversely effecting the properties and ac~ivi~y of tablets prepared from the composition. Perborate salts~
and in particular, anhydrous sod;um perborate, are extremely light, fluffy materials having a low specific weight~ that have been dif~icult to compact when attempts to incorporate this materia.l in denture cleanser tablets, for example, have ~ been made~ Thus, the perborate component has tended to stick to the tablet dies, and tablets prepared with the perborate haYe been extremely frangi bl e and therefore commerci al ly un-20 . des~rable~ Prior art attempts to remedy this defîciency bythe addition of greatcr quantities of cnnventional tableting aidsa have resulted in the preparation-of tab1ets that~ while dimensionally stable and mechanically strong~ exhibit gre~tly diminish2d aotiv;ty when placed in sqlution~ Thus, disinte-25 gration times are undesirably prolonged~ and in some instancesdisintegration does not take place.

As discussed earlier herein, U~S. Patent No. 3,340,152 tn Hotko, describes th2 use of a polymeric f!uorocarbon as a lubricant in tablet formation. Efforts to utilize the poly-meric fluorocarbons disolosed by Hotko within the ranges set ~g~

forth in the patent, proved fruitless, as the resultingt~blets~ while di~ensionally stable~ exhibited little ~r no ac~ivity in solution, L.ikewise, efforts to place even redllced amounts of ~he polymerie fluorocarbons in direct 5 combination with th~ ingredients of cleansers such as those presen~ly disclosed, resulted in the preparation of tablets having similar drawbacks~ Accordingly~ the preparation of the perborate salts in the manner disclosed in the present invention is important to the preparation of composi~ions in tablet form, that possess the property sf dimensional stability and ease of preparation, in combination with reten~ion of desirable solution activityO Thus9 tablets prepared by the present invention disintegrate as guickly~ and in some in-stances more quickly than acceptable denture tablets prepared 1~ in accordance with the prior art.

The mixture .of the perbora~e salts with the polymeric fluoro-~ carhon may include the fluorocarbon in an amount preferably ranging from about 0.33% to abou~ 0.66X by weight of the per-borate salt~ The polymeric fluorocarbon may be selec~ed from a wel1 known group of polymeric and copolymer~c substances made up of carbon and fluorine, which, in addition~ may con-tain hydrogren and/or chlorine. The fluorocarbon may include at least one fluoroolefin9 for examples polytetrafluoroethylene9 copolymers o~ tetraf7uoroe~hylene and hexafluoropropylene; and copolymers of vinylidene fluoride and hexafluoropropylene would be inoluded. The preferred polymeric fluorocarbon comprises polytetrafluoroethylene.

The fluorocarbon polymers may be utilized in the ~orm of powders having particle sizes acceptable foe combinatinn with the per-30 borate salts, and preferably ranging up to about 150 microns insize. The exact particle size may vary~ and an average partiW
cle s;ze of from about 25 to about 75 microns may be used. The 33~

exact particle size of the polymeric fluorocarbon is not c:riti-cal to the practice o-F ~he present invention.

The preparation of the perbora~e salt-polymeric ~luorocarbon mixture into compact granules may be conducted by compaction 5 on a continuous or batch basis, by rneans, ~or ex;~mple7 of a roller compac~or or a tablet slugging machine" to form a plur~
ality o~ pre~orms such as ~lakes or slugs~ Pref~rms ~rould thereafter be subjected to comminu~ion under agitatlon to form the desired particles, and may possess particle sizes 10 rangin~ on the order of 30 mesh or greater.

.

In addition to the inyredients set forth abo~e~ the present compos~tions may contaïn ~ variety of addi~i~nal ingredients selected on the basis of desired end use. Thus~ ~or example~
the compositiorls ~ay include detergent compoundsD such as organic and inorganic detergents, includin~ n~n-iunic deter~
gents such as the various polyoxyethylene ethers of aromatic and aliphatic alc~hols, as well as the polyoxyethyl2ne ethPrs of hydrophobic propylene oxide polymers~ These compounds assist in maintaining a fDaming action~ in the in~ance ~here - .the cleansing compos;tions are placed in aqueous solution~ -Also, the compositlons may contain other adjuvant materials~
that may be inorganic or ~rganîc in structure. Thus~ inorganîc ~ater-soluble alkaline builders such as a~kali and alkaline earth metal carbonates" hydroxides5, and mixtures may be added, Particularly~ sodium carbonate may be present in an amount ~f 30 up to abOut Z~ by weight, as it functions not only as ~ -buïlder, i but enhances e~fervescence and assists ;n stabilizing the pH
of the solutions obtained From the composition.

The present compositions may also contain seguestrants for the purpos e of mai n tai ni ng sol uti on clarity, in the instance where the sompositions are placed in solution. The sequestrants may also assist in the inhibition of corrosion and tarnish of parti cl es soaked i n sol u ti ons containing the present composi-tions. Useful seque~trants include ethy7ene diamine ~etrac-edic acid (EDTAj and i~s correspnnding alkali salts, as well as other polyfunctional organic acids, such as citric acid, maleic acid and their corresponding sal~sO The sequestrants may be present in amoun~s of up to about 3' by weight~

In ~he instance where the composition is to be pr~pared for use as a denture cleanser, other additives such as flavorin~s3 colorants, perfumes and the like may be added in various amounts, as 'mentioned earlier. For example, the flavor;n~s may include varieties of mint, oil of clo~e9 artifir;al vanilla flavoring~ anJ others. These materials may be included and b1ended in various rombinations with~n the scope of the present 2D invention. The choice of the required amounts is likewise within the sk~ll of the art.

In th~ instance where the present cleansing compositions are fsrmulated for use as denture cleansers9 the colorants useful her2in are those known as F.D~&C. and D.&C~ dyes and lakes, 2~ These materials are certified by the Federal Food and Drug Administration as acceptable .or use in food, drug and C05-metic applications, and drug ~nd cosmetic colorings. The ma-ter;als acceptable for the foregoing spectrum of use are prPferably water-soluble, and include indigoid dye, known as F.D.~C. Blue No~ 2, which is the disodium salt of 595'-indigo-tindisulfonic ac;d. S;milarly, the dye known as F 7 D.~C.
Green No. 1, comprises a triphenylmethane dye and is the monosodium salt oF ~ (N-ethyl-p-sulfobenzylamino)diphenYl-methylene~ (r~-ethyl N-p-sul-Foniumbenzyl )-a 2'5-cyclohexadi-enimine3. A full recitation of all F.D~ . and D~&~. and their correspondiny chemical.structures may be found -3n the Kir~-Othmer Encycl~pedia of Chemical Technology, at ~olume pages 8~7-~84.. Dyes and colorants will :Eade at diE~rent rates and m~y be chosen to provide speciEic end points.

. The ~oregoing colorants may be blended with each other in a 10 Yariety of combinations. I~ is particular~y desirabl~ ~hat the colorants be ch~sen so that the composition when initially dissol~ed will present a deep hue.. Thi~ is important in t.he instance where the compnsition serves as ~ denture cleanser7 as the fading phen~menon embodied in denture cleansers can be more 1~ . easily observed by the end user.

The present inventi~n includes a method for the preparation of the compositions~ which comprises preparing at least a p~r~ion of the perborate salk component as a first m~xture3 including the polymeric fluorocarbon, and compacting the f~rst mixture t~ form a plurality of particles thereof~ The remainder o~
the in~redients, including the sili cat~ sal t prepared with a .
.particle size within the aforementioned ranges, are then rom-bined to form a second mixture wh;ch.may be prepared in tablet form, in the instance, ~or example~ where the pre~ent comp~si~
25 tions are to be utilized as denture cleansers~ It is pre~er~
able to prepare the present compositions in tablet ~orm ln such instance, as ;t is easier to achieYe the uriformity of quantity and distribution of the ingredients of the compo~i-tions that is necessary to assure the corresponding uniformity of performance of the cleanser~ Thus3 oleanser tab~ets haYe been found to exhibit uniformity of co~or reaction, disintegra-tion and fade time, in cleaning ability on a tablet-to-tablet basis, ;, , , I

-15~

In accordance with ~he presen~ invention, ~he compositions may be prepared in tablet form without ~he need for increased addition o~ ingredients such as excipients, ~ableting agents and the like. While such ingredients may be added~ the amounts of these ingredien~s may be reduced, due to the favorable effect exerted by the polymeric fluorocarbon present in khe compacte~ granules of the perb~rate salt~ Naturally9 minor additional quantities of ingredients such as the polymeric fluorocarbon, may be made for their stated purposez such as 10 for lubrieation and the like; however such additions and ~heir respective amoun~s are not critical and do no~ form a part of the ~resent invention~

A fuller understanding of the present inven~ion will be gained from a revlew of the following illustrative examples~ Unless specified otherwise, all amounts expressed as percent, are intended to ~e a percent by weight~

EXAMPLES I - IV

A series of oleanser oompositions were prepared having the ingredients set -Forth in Table I 7 below.

r ,~ I~ ,_ Oc~ ,~ ~u~,-- _- o I ~
~_ ~ ~ ~D O ~ ~ ~3 c ~:n u7 -u Q) ~_ r` ~N N ~ N In r~
~_ ~ o ~_ ~, _ I O
c J
O
. o r~
a ~
N O E E
,-- ~ ~
a a s~
~ , ,_ a~ q ~
~ ~ C
i~r N N ~) O r~ O I C U) C~
~DO _ C ~
~J . ~ N 1~ ~ ~_ t, o~ ~

S~
~;

D ~ .L>
&~
O
~ ~ o o t O C
C ~ Q~S_ 3 a~
C L r~

a~ ~ u E ~Cl v~ 3 J~ Q ~ o c v~ ~ ~ ~ ~ O
Lr~ E t~i ~ ~ta ~i O E ~ c o o ~ O ~ C ' C ~L~
_ ~ c ' a~ V ~ t ~ E V ~
~ O ~ ~ JJ L O =l ~ C~~ G ~ C C
0 5 0 ~ O ~ O ~ O I~ 0 * ~

" ~ L 6 ! 71 The compositions w~re prepared as followsO Initially, a quantity of anyhdrDus sodium perborate in the form of a fluffy powder, was combined in a container with a ~uantity of polytetrafluoroe~hylene powder i dentified as Grade F5A
5 by the EoI~ duPont DeNemours & COO~ Inc. The polytetra-fluDroethylene was ad~ed in the amounts based upon the weight of the perborate, 25 indicated with respect to each of the exampl es, above . Bl ending was performed for about 3 minutes3 after which the mix~ure was compressed by passing thrsugh a tablet slug~ing machine h~ving 27/32" dies. The slugs were then passed through an oscill ati ng granul ator havi ng a 16 mesh Screen9 to form the granules of the anhydrous perborate/tetra fluoroethylene mixture.

The remaining ingredients of the composition were added to the perborate9 the phosphate added first~ to form ~he ~econd mixture. In the instance where metasilicate was added, a po~der having a particle sizP ranging from 10 to 25 microns was used~
The result~ng second mixture was stirred and thereby blended for a period of about 3 minutes7 after which the mixture wa~9 formed into tablets by compression in a tablet slugging ma-chine having a tablet die of 27/32l', The tablets were formed to a hardness ranging from about 20 to .about 30 S.C.U. " and were thereafter cured i n a hot ai r o\len for 45 mi nutes at 9 ~ o C .

25 After the preparati on of the tabl ets was complete, representa-tive tablets from each of the four formulations were tested for activity and efficacy, by placement in individual containers having approximately 120 ,~illiliters of water at 45C.

Each of the oompositions tested~ exhibited a disintegration 3~ time of appror.imately 90 seconds; a pH ranginy up to about 11~29 and ~ fade time of approximately 5 minutes~ It ~as determined that each of the compositions could thus be pre~
pared into tablets for use as denture cleansers, with satis~
factory activity and efficacy~

This invention may be embodied in other Form~ or earried out 5 in o~her ways withou~ departin~ from the spirit or essential char~cteristics ~hereof. The present disclosure is therefore to be considered as in all respects illustra~ive and not re-strictive, the scope of the invention being indicated by the appended claims, and all changes which come within the mean 10 ing and range of equivalency are intended to be embnaced therei n.

Claims (37)

WHAT IS CLAIMED IS:

1. An effervescent cleansing composition comprising:
A. a phosphate salt in an amount of from about 20% to about 45% by weight;
B. a silicate salt in an amount of up to about 20% by weight; and C. at least one perborate salt in an amount of at least 50% by weight:
wherein at least a portion of said perborate salt is present in a compacted, granulated mixture with from about 0.01% to about 0.70% by weight of said salt of a polymeric fluorocarbon.

2. The composition of Claim 1 wherein said phosphate salt comprises an alkali metal phosphate.

3. The composition of Claim 2 wherein said phosphate salt comprises trisodium phosphate.

4. The composition of Claims 1, 2 or 3 wherein said phosphate salt is present in an amount of from about 25% to about 40%
by weight.

5. The composition of Claim 1 wherein said silicate salt com-prises an alkali metal metasilicate.

6. The composition of Claim 5 wherein said alkali metal meta-silicate comprises sodium metasilicate.

7. The composition of Claims 5 or 6 wherein said silicate salt is present in an amount of from about 10% to about 20%
by weight.

8. The composition of Claims 5 or 6 wherein said silicate salt has a particle size of from about 1 micron to about 25 microns.

9. The composition of Claim 1 wherein said perborate salt is selected from the group consisting of alkali metal and alkaline earth metal perborates.

10. The composition of Claim 9 wherein said perborate salt comprises an alkali metal perborate.

11. The composition of Claim 10 wherein said alkali metal perborate is selected from the group consisting of alkali metal perborate monohydrates and anhydrous alkali metal per-borates.

12. The composition of Claim 11 wherein said alkali metal perborates comprise sodium perborate.

13. The composition of Claim 9 wherein said perborate salt is present in an amount of from about 50% to about 70%
by weight.

14. The composition of Claim 11 wherein said perborate is present in an amount of from about 50% to about 65% by weight.

15. The composition of Claim 14 wherein said perbor-ate salt includes at least 20% by weight of an anhydrous alkali metal perborate.

16. The composition of Claim 15 wherein said anhydrous per-borate is present in an amount of from about 20% to about 25% by weight.

17. The composition of Claim 15 wherein said anhydrous per-borate comprises anhydrous sodium perborate.

18. The composition of Claim 16 wherein said anhydrous per-borate comprises anhydrous sodium perborate.

19. The composition of Claim 1 wherein said polymeric fluorocarbon includes at least one fluoroolefin.

20. The composition of Claim 19 wherein said polymeric fluorocarbon comprises polytetrafluoroethylene.

21. The composition of Claims 1, 19 or 20 wherein said polymeric fluorocarbon is present in an amount from about 0.33% to about 0.66% by weight.

22. The composition of Claim 13 wherein said polymeric fluorocarbon includes at least one fluoroolefin.

23. The composition of Claim 15 wherein said polymeric fluorocarbon includes at least one fluoroolefin.

24. The composition of Claim 22 wherein said polymeric fluorocarbon comprise polytetrafluoroethylene.

25. The composition of Claim 23 wherein said polymeric fluorocarbon comprises polytetrafluoroethylene.

26. The composition of Claim 13 wherein said polymeric fluorocarbon is present in an amount from about 0.33% to about 0.66% by weight. .

27. The composition of Claim 15 wherein said polymeric fluorocarbon is present in an amount from about 0.33% to about 0.66% by weight.

28. The composition of Claim 22 wherein said polymeric fluorocarbon is present in an amount from about 0.33% to about 0.66% by weight.

29. The composition of Claim 23 wherein said polymeric fluorocarbon is present in an amount from about 0.33% to about 0.66% by weight.

30. The composition of Claim 1 further including at least one material selected from the group consisting of builders, detergents, lubricants, sequestrants, perfumes, flavorings, excipients, disintegrants, and mixtures thereof.

31. The composition of Claim 30 wherein said sequestrant comprises ethylene diamine tetracidic acid and its alkali metal salts, and said builders include sodium carbonate.

32. A tablet useful as a denture cleanser comprising the composition of Claims 1, 5 or 12,

33. A tablet useful as a denture cleanser comprising the composition of Claim 3.

34. A tablet useful as a denture cleanser comprising the composition of Claim 6.

35. A tablet useful as a denture cleanser comprising the composition of Claim 12.

36. A tablet useful as a denture cleanser comprising the composition of Claim 14.

37. A tablet useful as a denture cleanser comprising the composition of Claim 19.