CA1189412A - Apparatus for injection - Google Patents
Apparatus for injectionInfo
- Publication number
- CA1189412A CA1189412A CA000413077A CA413077A CA1189412A CA 1189412 A CA1189412 A CA 1189412A CA 000413077 A CA000413077 A CA 000413077A CA 413077 A CA413077 A CA 413077A CA 1189412 A CA1189412 A CA 1189412A
- Authority
- CA
- Canada
- Prior art keywords
- upper chamber
- suction cup
- cannula
- tube
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
AN APPARATUS FOR INJECTION
ABSTRACT OF THE DISCLOSURE
An apparatus for injection especially for hypodermic injection by diabetics chiefly for self-treatment and in medical practices and clinics for the hyposensibilization treatment and heparinization in connection with the preparation for operations.
The apparatus comprises cm upper chamber with negative pressure which is accumulated during the manufacturing process ; it comprises further a covering lid with a central funnel for the insertion of a syringe. Said funnel is airtightly fastened to said covering lid and a cannula shaft continues spa-tially said funnel, the lower end of which has its tip extending into a suction cup, which is airtightly sealed against said upper chamber with stored under-pressure. From inside of the rim of said suction cup through a pipe socket inside of said upper chamber next to said cannula shaft expands a valve pin with a wax seal on its upper end. If the suction cup is posi-tioned on the skin, this effects by its one elasticity a lifting of said valve pin. If the wax is broken, the air enters from the suction cup to the upper chamber and the skin will be sucked into the cannula tip.
ABSTRACT OF THE DISCLOSURE
An apparatus for injection especially for hypodermic injection by diabetics chiefly for self-treatment and in medical practices and clinics for the hyposensibilization treatment and heparinization in connection with the preparation for operations.
The apparatus comprises cm upper chamber with negative pressure which is accumulated during the manufacturing process ; it comprises further a covering lid with a central funnel for the insertion of a syringe. Said funnel is airtightly fastened to said covering lid and a cannula shaft continues spa-tially said funnel, the lower end of which has its tip extending into a suction cup, which is airtightly sealed against said upper chamber with stored under-pressure. From inside of the rim of said suction cup through a pipe socket inside of said upper chamber next to said cannula shaft expands a valve pin with a wax seal on its upper end. If the suction cup is posi-tioned on the skin, this effects by its one elasticity a lifting of said valve pin. If the wax is broken, the air enters from the suction cup to the upper chamber and the skin will be sucked into the cannula tip.
Description
BACKCrROUMD OF rM~ INV~Nr~ION
r~he present invention rela-tes -to medical technology, More pa~ticularly ,this invention is concerned wi-th an in à ection apparatus for hypoder-mic injections wherein a plurality of different liquid medicaments can be used,especially for the self-injection of insulin by diabetics, Devices, which drive injection cannulas in-to -the body by sucking first the skin against the cannula tip are known. from prior ar-t, With -the --suction injection bones,vessels and nerves are not touched and the medicine inflow into the tissue is facilitated and pain avoided.
The known devices of this type however have ; the disadvant~ges that -they are relatively bulky and are difficult to be operated by the patient himself~ Small suction injectors using an ex-changeable syringe have the difficulty to locate exactly the point on patients' skin where the punc-ture is to be made and the charging of the syringe wi-th the medicine is frequently a cumbersome ope-; ration.
Furthermore, the prior ar-t suction injectors do not ensure a relati~ely quick release of the cannula tip from the human skin which is rather in-convenient and may be painfull for a patient, ~lither-to existing suc-tion injectors have generally been usecl on animals ~it-tle regard was made -to ste-rilityO ~esicles tha-t, the devices were too largeD
Great e:E:Eort and space were neec;ed to produce -the vacuum. ~he production of vacuum which is to be s-to-red in a handle, as desc~ibed in the Offenlegungs-schrift 25 51 993(Munich 15th July 1976),was cumber-some and took up a great deal of space(~ig.1 oE the above mentioned Offenleglmgsschrift). In ~ig 5 base supports for the suction cup toward the skin was sho~n which were expensive and a subjec-t -to mal functioning also in further developed devices.
~heir blocking mechanism was expensive and cumber-some~
~ here are injection apparatuses for insuline on the market which works by overpressure without a cannula, but -they are in reality useless. ~he pres-surized stream of medicine destroys tissue to a con-siderable extend and leads, when used daily7almost regularly to serious skin irritations. ~he painful--ness of this method exceeds that caused by use of modern cannulas. Besides that, the nozzles become clogged by the protein solution and have to be care-fully cleansed~ ~he recently introcluced insuline pumps for the continuous dosing of old insuline pro-mise to be for many years to come a solution of the problem for only a limited group of patients and even then only for limited periods~ me pumps~
which are carried on the body , require a proble-matical connection with the blood stream or with .
-the lower skin tissue, for example -to the abdomi-nal cavity, thus presenting a po-ten-tial source of i.nfection.
'' ' SUMMARY OF THE INVENTION
___ It is therefore an object of -the inven-tion -to overcome -the disadvan-tages of -the pri.or art suetion :injec-tors, Another object of the invention is to provide an improved suetion injeetor which can be easily manipu-lated by one hand only and may be easily released from -the human skin after the injection.
Still another object of the invention is to pro~
vide a suction injector in which -the eannulas ean be easily exchanged.
A further object of -the invention is to perform the injection with the assistance of negative pres-sure accumulated in the suetion eup so that the skin to be treated will be lifted by this negative pres-sure towards the eannula tipJ The application of the negative pressure permits one to avoid pressure of the suetion eup to bones,nerves and blood vessels sinee vacuum produced over the skin forces the skin into the cannula on the syringe, Disposable suction cups with industrially re-produeed vaeuum in a speeial eontainer are used .
In this invention disposable injeetors do not requi-re a special vacuum generator and are improved here by making the cannula or better the cannula shaft a firm and irremovable ~.art of this injeetP~ ~ If the cannula is firmely incorporated the neeessity of the difficult insertion of the cannula is thus eli-mina-ted,and the cannula can be held better,which re~
duces the danger of injury through the ca~mula before and after use, A boring past -the funnel for -the re-ception of a syringe cone -to inner portion of the disposable injection appara-tus can be used -to the reventilation after the injection, if it is sealed by a membrane before use.
~hese and other objects of the invention are attained by a suction injector, par-ticularly for use with hypodermic injections, comprising an upper chamber with negative pressure which is accumulated during the manufacturing process; a covering lid with a central funnel for the insertion of a eon-tainer with means for applying measured doses of a liquid; a eannula shaft, airtightly fastened to said covering lid and spatially continuing said - . funnel, the lower end of which has its tip exten-ding into a suetion cup immediately touching to said upper chamber having a wall part together with it; and valve means for preventing the trans-fer of negative pressure in said upper ehamber to said suction cup, until said suction cup is in pres-sure eontaet with the skinO
A inner cylindrical portion with a shiftable suppor-ting tube surrounding the cannula shaft may : be formed with a relati~ely thin radial extension wherein flexible projeetions from said supporting tube may be adapted to penetra-te through said ra-dial extension to break said seal when said sup-porting tube is li~ted towards said cannula~
The valve mechanism between the ou-ter and upper chamber, ac-ting as a large vacuum reservoir, and the inner portion consists only as an o-ther e~ample,of two la-teral openings of the vacuum re-servoir and the supporting tube which can be pu-shed together to meet each other~ Produc-tion would be rather expensive, and the sealing would require the use of wax or a special coordination of the elas-ticity between the parts which touch.
In another example, if the cannula is air-tigh-tly and firmly inserted during the manufac-turing process into a hard covering lid, in such a way that it extends through the entire upper chamber and fur-ther air-tightly through the cham-ber's base plate into the suction cup, the inner portion can be dispensed wi-th, at leas-t for the lower part3 In order to save medicine and to in-sure exact dosing, a cylindrical depression, star-ting on the top, can be provided to bring -the sy-ringe closer to the cannula tip. For -the valve mechanism, a pipe socket can be used, which is closed ba a valve pin with a suitable surfaceD
Airtightness is guaranteed by a covering between the pipe socket and She valve pin on the upper ~' . ' end of this pipe socket. ~his covering can, for example be made of wax, which is applied when the lid is attached by -the use of hea-t or by diathermy or by ultrasonics If the wax seal is brokenJ by th~ lifting of the ~alve pin, i-ts ring shaped rim rail leaves the pipe socket and the valve pin no lon.ger offerts friction resis-tance while the skin is being lifted by suction~
.. ~he injector may be provided with a guiding device including a cylindrical chamber having an outer wall defining said suction cup and a gui-ding bar formed with a guiding groove for suppor-ting the syringe, ~ A ring-formed membrane serving as a covering .~ lid for the upper chamber or an opening ln a hard ~ covering lid closed by a membrane may be used to check the necessary underpressure inside of -the upper chamber.
A tube which extends from the covering lid to ~ 20 the base plate open to the suction cup and sealed ; against the upper chamber may allow to check,if ; the valve mechanism which prevents the equiliza-. tion of the pressure is activated~p,e, by means of the closing of the upper end of said tube by a cannula with bag~
~he novel features which are considered as charac-teris-tic for the invention are set forth in par-ticular in -the appended claims. Thé in~ention itself9 however, both as to i-ts constructi.on and its method of operation, together wi-th additional objects and advantages thereof, will be best un-derstood from the following description of spe-cific embodiments when read in connection with the accompany drawing~
. ~
_ g _ BRIEF DESCRIPIION OF ~HE DRI~WING
Fig,l shows in a cross- sec-tional side view an embodiment of the invention where the cannula shaft i3 incorporated and fixed before use~
Fig,2 shows a cross-sectional side view of the embodime-nt of Figo1 during use with an au-xiliary means for the guiding the cannula and the syringe. Directly below can be seen a par-tial view ,shown from above.
Fig,3 is a cross-sec-tional side view of an embodiment of the invention with a valve pin next - to the cannula.
Figo4 shows in a cross-sectional side view an embodiment similar to the one mentioned in ` Figure 3 during use.
Fig.5 shows in a cross-~sectional side view an embodiment of a suc-tion injector with a shiftab-le supporting tube with arms serving as valve means before use.
Fig~6 is a top plan view of the device of the Figs, 5 and 7, Fig.7 shows in a view partially in cross-sec-tion ~the device of Fig~5 during usé, Fig,8 is a view,partially in a cross-sectio-nal side view of a au~iliary apparatus for guidin~
the cannula into a suction injector, ~ igo 9 is a de-tail in a cross-sectional side view whlch relates to an embodimen-t of the invention having means for blocking -the negative pressure~
Fig,10 is a detail in a cross-sectional side view of a still fur-ther embodiment for blocking the negative pressure, Fig,11. shows a cross-sectional side view of a device as in ~ig~5 schematically simplified and at a ratio 2:1, which gives details of reventilations and coupling means.
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' D~TAIIJED D~S(~RIPTION OF THE PRE~ERRED EM:13ODIMENTS
:;
- ~ig~1 shows the device ,as it looks, after `~ i-t has been removed from packaging be~ore use.
It consists of an upper and outer chamber(11) ; with a central conical opening(79), which conti-nues downwards into the firmly held cannula shaft An inner portion(76) ,which expands downwards in-to the suction cup(4), surrounds the greater part of the cannula shaft. A supporting tube(75) slides into the inner portion~76) and extends beyond the ` 10 rim of the suction cup(4), A lateral cross-groove ~ (95) of the suppor-ting tube(75) lies under a ~a-,'~! , teral boring(94) of the inner portion, An adhesive : .
mass seals the space between said lateral boring and the wall of the inner portion. lrhe membrane (83)is drawn in inside of the inner portion by vacuum in a ring-shaped manner and is covered by ; a strip of a membrane(96) which is adhesive on its lower side, in such a manner,that this strip - of the membrane covers and ~eals a hole in the membrane (83) and the central conical opening(79) serving as a funnel. ~he membrane(96)continues in -to the free end(98).
Fig~2 shows a device as in Figure 1 on which a syringe-holding groove (81) with the clip ends (99)and the headpiece, which is partially open7 is s o positioned,that an injection syringe,ready ; - 12 ~
for useD comes -to res-t between the clip end(99) with its cone over the conical opening(79). ~he supporting tube was lifted by pressure against -the sk~n, which is indicated by a dotted line~
so that the slanting slit of the supporting tube comes in-to posi-tion over -the hole of the inner portion, A equalization of pressure between the suction cup and the outer chamber ,which origi-naIly had underpressure, is thus brought about, causing the skin to be raised? so that it is sucked tightly onto the rim of the suction cup and penetrates the point of the cannula shaf-t, ~he membrane(96)is pulled by its end(98) so far -to the left,that.the central conical opening is : e~posed, ~or the continuation of use,the syringe cone lies firmly within the clip ends~until the central conical openingD ~he injection is brought about in the standar manner by pressure on the syringe piston,which is not shown. An additional pull on the end(98) of the membrane(96) frees the hole (97)of the membrane(83),so that exterior air ;, can flow through the inner portion(11)into the suction cup area. ~he skin thus drops back and releases itselfs from the point of the cannula an from the rim of the suction cup. ~he membra-ne strip(96) in a simplified variation ,does not . - 13 -e~tend over the central conical opening. In -this ca-se, the syringe is already connected tightly to -the device by means of the syringe cone insi~le the cen--tral conical opening, before the device ls placed on -the skin. A precondi-tion for -this is a certain amount of frictio~ force between the syringe piStOll and cy-linder9 which prevents a movemen-t of the piston and the influence of suction from the suction cup in the time before penetration of the cannula tip into the skin A support piece between the syringe piston and syringe cylinder jwhich is removed immediately before the emptying of the syringe 9 can also serve this pur-pose. ~he device can also be connected with the co-nical pipe of a medicine dosing device~ as shown particularly clearly in ~ig .12 of the United States Patent No 4139008( ~ebruary 13, l979)or in ~igs.
4 to 10 of the above described device. Directly below a partial view can be seen in a de~ail of ~ig.2 9 shown from above.
~ig.3 shows in a cross-sectisnal side view an example, in which a cannula(28) is firmly and air-tightly welded into the upper chamber for vacuum ~-~ storage, which has a greater capacity than the the suction cup(4), is sealed off :Erom this suction cup~ which lies beneath it , by a base plate(9), which is penetrated solely by the tip of the can~
nula shaft, when this is sealed wi-thin the base pla-~ 14 --te. ~here is a pipe socket(lO) eccen-trically posi-tioned in l;he base pla-te, which extends into -the upper chamber and is closed by a valve pin(20).
The ~alve pin is posi-tioned wi-th i-ts ring shaped ~iim rail(12) at the uQper end o~ the pipe socke-t, in such a manner -that the rim rail is sealed to -the wall of the pipe socke-t by a layer of wax(13).
A second rim rail(1~)of the valve pin is perfora-ted along its length to permit the entr~v of air and positioned close to the lower end of the pipe socket, ~he valve pin ends at the height of the suction cup rim~ Between -the covering lid and the base plate, there is a thin -tube(15), which opens into the suction cup, and the upper end of which is sealed before use by a sealing plaster(16), when syringes are utilized, ~he tube,which goes through and is sealed against the upper chamber, serves, ; when supply bottles are used for dosing injectors, .~
as a means of checking the effect of underpressure - 20 on the skin. A thin portion of the covering lid or an opening in this lid, which is closed by a membrane(83), permits by means of an indentation the determination, as -to whether underpressure is or is not present, When the device is placed on the skin, that skin which moves in over the rim of -the suction cup pushes up the valve pin,so that its upper rim rail leaves the pipe socket, permitting air -to move from -the suction cup into -the upper ~8~æ
chamber, The skin is thus lif-ted in-to the can-nula , and -the injection is completed, as descri-bed above, Fig,4 shows a variation of -the example of ~ig,3 , in which the upper end of the pipe socke-t (10) is sealed by a rubber stopper(17). ~he valve pin has a cannula (18)7 which is below also open to the side, ~he valve pin(20) is preven-ted from turning by being flattened on one side across from a corresponding rail in the pipe socket and has on its lower end a centrally positioned ring(19).In the stage which is shown, the pressure on the ring by the skin- indicated by the dot-ted line-,which has been drawn up by the effec-ts of vacuum from ~; the upper chamber, has alread~ caused the valve ;~ pin to be raised. ~he cannula ol the valve pinhad penetrated the thin center of the rupper stop-per and had brought about an equalization of pressure'between the upper chamber and the suc tion cup in a short way as described above, Fig,5 illustrates a modification of the suc-tion cup shown in ~igs 1 and 2. According this em--,,.i bodiment,the upper chamber(11) is provided with a central conical opening(79)adapted to receive the projec-ting portion of the cannula (not illustrated herein). At the lower portion -thereof the inner portion(76) of the suction cup(4) is formed with a substantially cylindrical downwardly projec-ting strip-like rim(24) and a relhtively thin portion ' (78), ~he .supporting -tube(75) which is adapted -to slide inwardly upwardly of the -tube(76) is provi-ded with a ring-shaped bottom por-tion(22)~ This bo-t-tom portion has -three sector-like arms(77)(also shown in Fig.7 and Fig~6) equally spaced from one another in a circumferential direction whi&h are loca-ted at the periphery of the bottom portion(22) and extend upwardly from the surface thereofO ~he arms(77) have slightly outwardly curved ends(78) which may easily penetrate the -thinned portion or extension(84) of the tube(76) and break the seal bet-ween the upper and outer chamber(25)and the inner chamber(26), ~he thinned portion(84)may be repla-ced by strips which merge into the wall of the suc-tion cup. In eva uated position the upper and outer chamber(25) is closed with membrane(83).
Fig,6 shows a plan view of the supporting tu-be(75) having arms(77)wherein an outer dotted line illustrates the outer ends of the arms(77) in their upward position, me supporting tube with arms may ~- be made of polivinylchloride whereas the remaining parts of the device may be formed of polystyrene, In practice the cannula which is adjusted to a filled syringe may be inserted into the opening (79) in a manner as shown in Fig 7, When -the device is removed from a s-terile con-tainer and -the supporting -tube (75)is place over the skin to be treated the ends of the arms(77) of -`17 -the bottom portion(22) penetra-te the -thinned por--tion(84) due to the movement o:E the tube(75) upward wi-thin -the inner por-tion(76). Due to resul-ti~g ope-nings in the portion(84) the inner chamber(26) will communicate with the outer chamber(25) accumulating nega-tive pressure towards the cannula and the li-quid medicine will be discharged from the tip of the cannula by pressing the spraying piston in a conven-tional mode.
Figo7 illustrates an axial section of the suc-tion cup immediately before or after the injection.
The position of the human skin is illustrated by a dotted line, Fig,8 shows an auxiliary device for guiding the cannula(28) sho~,~m in Figs 5-10~ The device in-cludes a cylindrical body(80) which is openend from the bottom and provided wlth a guiding bar inclu-ding a straight portion(81) and a sloped portion (82), both formed with a guiding channel for sup-porting of the preliminarily filled cannula. The cannula(28) slides in the sloped portion(82) un-til it tips into -the straight portion(81)along which it slides further in-to the central conical opening(79)~ The suction injector may be placed into the cylindrical body(80) of the auxiliary device which may be positioned over the surface of the side selected lor injection and the injec-tion then may be performed as described above.
Addi-tionally , the auxiliary device may be provided wi-th an elas-tic angle(87) which per-forates into -the ring-shaped membrane(83) so that ambient air may flow into -the suc-tion cup~
Ihe skin is thus pulled back out of the cannula and the injector may be lifted and removed from -the auxiliary device whïch may be used repeatedly.
~ig,9 shows a cross-sectional side view of the lower part of a device, as in ~igs,5 and 7,in which the cannula has been lef-t outO
~he valve mechanism between the outer chamber and the suction cup has been modified in -the following manner. Ihe upper9vacuum storing chamber has an opening(78)-to the suction cup, l'his opening is closed by the rim of a ha-t sha-ped -membrane(2~,which is sealed around the opening by an adhesive mass. Ihe ha-t shaped -~ 20 projection of the membrane ex-tends beyond the supporting tube(75)9which itself extends beyond the rim of the suction cup with its lo-wer end, If the suppor~ing tube is lifted by pressure against -the skin, the rim of the ; hat snaped membrane is pulled away from the i opening and exchange of pressure between the - 19 ~
z upper and outer chamber and the suction cup takes place~
In ~igo10 ,there is only a.n adhesive membrane over the valve opening(7~ his membrane has a pull cord(21) welded into it,the kno-tted end of which is attached in. a sli-t in the upper end of -the supporting tube. If the supporting tube is rai-sed, tension on the pull cord causes the removal of the membrane from the valve opening, ~ig,11 shows a cross-sectional side view enlarged in a ra-tio 2:1 , a device as in ~igure 1.
In addition , a boring(3)to the inner portion has been pu-t into the central opening. No air can es-cape from this boring9 as long as -the syringe cone is sealed to the device~ If this syringe cone is liftes after injection ,the reventilation occurs~
An additional channel(6) is usefull,when a medi-cine dosing device is used. ~or such usage, a re-ventllation boring (8) in the outer chamber can be of use as part of an automatic injector,when a role of adhesive tape(7),which seals the boring, is pul].ed back after the injection, so that air can enter through the reventilation boring, A
cannula with an air-tightly sealed rubber sac~(27) is placed in ~ig~11 into the channe1(6) Ihe sack was pushed by the syringe cone somewhat to the side, but i-t indicates by collapsing the influ-ence of vacuum in the inner portion. Polystyrene with with little gas permeabili-ty is, for example, sui-ta-ble as a material :Eor -the produc-tion oE the devices :Eor suc-tion injection wi-th stored underpressure.
It will be understood that each of the elements described above, or -two or more toge-ther, may also find a useful'application in other types of suction injectors differing from the types described above, Whil'e the invention has been illustrated and described as embodied in a-suction injector,it is not intended to be limi-ted to the details shown,since various modifications and structural changes may be made without departing in any way from the spirit of the present invention.
Wi-thout further analysis, the foregoing will so ~t fully reveal the gis-t of the present invention that ` others can, by applying current knowledge, readily adapt it for various applications without omitting features that,from the standpoint of prior art7fair-ly constitute essential characteristics of the ge-neric or spe'cific aspects of this invention.
-~ What is claimed as new and desired to be pro-tected by ~etters Patent is set forth in the ap-pended claims.
r~he present invention rela-tes -to medical technology, More pa~ticularly ,this invention is concerned wi-th an in à ection apparatus for hypoder-mic injections wherein a plurality of different liquid medicaments can be used,especially for the self-injection of insulin by diabetics, Devices, which drive injection cannulas in-to -the body by sucking first the skin against the cannula tip are known. from prior ar-t, With -the --suction injection bones,vessels and nerves are not touched and the medicine inflow into the tissue is facilitated and pain avoided.
The known devices of this type however have ; the disadvant~ges that -they are relatively bulky and are difficult to be operated by the patient himself~ Small suction injectors using an ex-changeable syringe have the difficulty to locate exactly the point on patients' skin where the punc-ture is to be made and the charging of the syringe wi-th the medicine is frequently a cumbersome ope-; ration.
Furthermore, the prior ar-t suction injectors do not ensure a relati~ely quick release of the cannula tip from the human skin which is rather in-convenient and may be painfull for a patient, ~lither-to existing suc-tion injectors have generally been usecl on animals ~it-tle regard was made -to ste-rilityO ~esicles tha-t, the devices were too largeD
Great e:E:Eort and space were neec;ed to produce -the vacuum. ~he production of vacuum which is to be s-to-red in a handle, as desc~ibed in the Offenlegungs-schrift 25 51 993(Munich 15th July 1976),was cumber-some and took up a great deal of space(~ig.1 oE the above mentioned Offenleglmgsschrift). In ~ig 5 base supports for the suction cup toward the skin was sho~n which were expensive and a subjec-t -to mal functioning also in further developed devices.
~heir blocking mechanism was expensive and cumber-some~
~ here are injection apparatuses for insuline on the market which works by overpressure without a cannula, but -they are in reality useless. ~he pres-surized stream of medicine destroys tissue to a con-siderable extend and leads, when used daily7almost regularly to serious skin irritations. ~he painful--ness of this method exceeds that caused by use of modern cannulas. Besides that, the nozzles become clogged by the protein solution and have to be care-fully cleansed~ ~he recently introcluced insuline pumps for the continuous dosing of old insuline pro-mise to be for many years to come a solution of the problem for only a limited group of patients and even then only for limited periods~ me pumps~
which are carried on the body , require a proble-matical connection with the blood stream or with .
-the lower skin tissue, for example -to the abdomi-nal cavity, thus presenting a po-ten-tial source of i.nfection.
'' ' SUMMARY OF THE INVENTION
___ It is therefore an object of -the inven-tion -to overcome -the disadvan-tages of -the pri.or art suetion :injec-tors, Another object of the invention is to provide an improved suetion injeetor which can be easily manipu-lated by one hand only and may be easily released from -the human skin after the injection.
Still another object of the invention is to pro~
vide a suction injector in which -the eannulas ean be easily exchanged.
A further object of -the invention is to perform the injection with the assistance of negative pres-sure accumulated in the suetion eup so that the skin to be treated will be lifted by this negative pres-sure towards the eannula tipJ The application of the negative pressure permits one to avoid pressure of the suetion eup to bones,nerves and blood vessels sinee vacuum produced over the skin forces the skin into the cannula on the syringe, Disposable suction cups with industrially re-produeed vaeuum in a speeial eontainer are used .
In this invention disposable injeetors do not requi-re a special vacuum generator and are improved here by making the cannula or better the cannula shaft a firm and irremovable ~.art of this injeetP~ ~ If the cannula is firmely incorporated the neeessity of the difficult insertion of the cannula is thus eli-mina-ted,and the cannula can be held better,which re~
duces the danger of injury through the ca~mula before and after use, A boring past -the funnel for -the re-ception of a syringe cone -to inner portion of the disposable injection appara-tus can be used -to the reventilation after the injection, if it is sealed by a membrane before use.
~hese and other objects of the invention are attained by a suction injector, par-ticularly for use with hypodermic injections, comprising an upper chamber with negative pressure which is accumulated during the manufacturing process; a covering lid with a central funnel for the insertion of a eon-tainer with means for applying measured doses of a liquid; a eannula shaft, airtightly fastened to said covering lid and spatially continuing said - . funnel, the lower end of which has its tip exten-ding into a suetion cup immediately touching to said upper chamber having a wall part together with it; and valve means for preventing the trans-fer of negative pressure in said upper ehamber to said suction cup, until said suction cup is in pres-sure eontaet with the skinO
A inner cylindrical portion with a shiftable suppor-ting tube surrounding the cannula shaft may : be formed with a relati~ely thin radial extension wherein flexible projeetions from said supporting tube may be adapted to penetra-te through said ra-dial extension to break said seal when said sup-porting tube is li~ted towards said cannula~
The valve mechanism between the ou-ter and upper chamber, ac-ting as a large vacuum reservoir, and the inner portion consists only as an o-ther e~ample,of two la-teral openings of the vacuum re-servoir and the supporting tube which can be pu-shed together to meet each other~ Produc-tion would be rather expensive, and the sealing would require the use of wax or a special coordination of the elas-ticity between the parts which touch.
In another example, if the cannula is air-tigh-tly and firmly inserted during the manufac-turing process into a hard covering lid, in such a way that it extends through the entire upper chamber and fur-ther air-tightly through the cham-ber's base plate into the suction cup, the inner portion can be dispensed wi-th, at leas-t for the lower part3 In order to save medicine and to in-sure exact dosing, a cylindrical depression, star-ting on the top, can be provided to bring -the sy-ringe closer to the cannula tip. For -the valve mechanism, a pipe socket can be used, which is closed ba a valve pin with a suitable surfaceD
Airtightness is guaranteed by a covering between the pipe socket and She valve pin on the upper ~' . ' end of this pipe socket. ~his covering can, for example be made of wax, which is applied when the lid is attached by -the use of hea-t or by diathermy or by ultrasonics If the wax seal is brokenJ by th~ lifting of the ~alve pin, i-ts ring shaped rim rail leaves the pipe socket and the valve pin no lon.ger offerts friction resis-tance while the skin is being lifted by suction~
.. ~he injector may be provided with a guiding device including a cylindrical chamber having an outer wall defining said suction cup and a gui-ding bar formed with a guiding groove for suppor-ting the syringe, ~ A ring-formed membrane serving as a covering .~ lid for the upper chamber or an opening ln a hard ~ covering lid closed by a membrane may be used to check the necessary underpressure inside of -the upper chamber.
A tube which extends from the covering lid to ~ 20 the base plate open to the suction cup and sealed ; against the upper chamber may allow to check,if ; the valve mechanism which prevents the equiliza-. tion of the pressure is activated~p,e, by means of the closing of the upper end of said tube by a cannula with bag~
~he novel features which are considered as charac-teris-tic for the invention are set forth in par-ticular in -the appended claims. Thé in~ention itself9 however, both as to i-ts constructi.on and its method of operation, together wi-th additional objects and advantages thereof, will be best un-derstood from the following description of spe-cific embodiments when read in connection with the accompany drawing~
. ~
_ g _ BRIEF DESCRIPIION OF ~HE DRI~WING
Fig,l shows in a cross- sec-tional side view an embodiment of the invention where the cannula shaft i3 incorporated and fixed before use~
Fig,2 shows a cross-sectional side view of the embodime-nt of Figo1 during use with an au-xiliary means for the guiding the cannula and the syringe. Directly below can be seen a par-tial view ,shown from above.
Fig,3 is a cross-sec-tional side view of an embodiment of the invention with a valve pin next - to the cannula.
Figo4 shows in a cross-sectional side view an embodiment similar to the one mentioned in ` Figure 3 during use.
Fig.5 shows in a cross-~sectional side view an embodiment of a suc-tion injector with a shiftab-le supporting tube with arms serving as valve means before use.
Fig~6 is a top plan view of the device of the Figs, 5 and 7, Fig.7 shows in a view partially in cross-sec-tion ~the device of Fig~5 during usé, Fig,8 is a view,partially in a cross-sectio-nal side view of a au~iliary apparatus for guidin~
the cannula into a suction injector, ~ igo 9 is a de-tail in a cross-sectional side view whlch relates to an embodimen-t of the invention having means for blocking -the negative pressure~
Fig,10 is a detail in a cross-sectional side view of a still fur-ther embodiment for blocking the negative pressure, Fig,11. shows a cross-sectional side view of a device as in ~ig~5 schematically simplified and at a ratio 2:1, which gives details of reventilations and coupling means.
., ..~
~..~, .,r~
,:
,, .
.~
-'' - 11 -~`
~' .
' D~TAIIJED D~S(~RIPTION OF THE PRE~ERRED EM:13ODIMENTS
:;
- ~ig~1 shows the device ,as it looks, after `~ i-t has been removed from packaging be~ore use.
It consists of an upper and outer chamber(11) ; with a central conical opening(79), which conti-nues downwards into the firmly held cannula shaft An inner portion(76) ,which expands downwards in-to the suction cup(4), surrounds the greater part of the cannula shaft. A supporting tube(75) slides into the inner portion~76) and extends beyond the ` 10 rim of the suction cup(4), A lateral cross-groove ~ (95) of the suppor-ting tube(75) lies under a ~a-,'~! , teral boring(94) of the inner portion, An adhesive : .
mass seals the space between said lateral boring and the wall of the inner portion. lrhe membrane (83)is drawn in inside of the inner portion by vacuum in a ring-shaped manner and is covered by ; a strip of a membrane(96) which is adhesive on its lower side, in such a manner,that this strip - of the membrane covers and ~eals a hole in the membrane (83) and the central conical opening(79) serving as a funnel. ~he membrane(96)continues in -to the free end(98).
Fig~2 shows a device as in Figure 1 on which a syringe-holding groove (81) with the clip ends (99)and the headpiece, which is partially open7 is s o positioned,that an injection syringe,ready ; - 12 ~
for useD comes -to res-t between the clip end(99) with its cone over the conical opening(79). ~he supporting tube was lifted by pressure against -the sk~n, which is indicated by a dotted line~
so that the slanting slit of the supporting tube comes in-to posi-tion over -the hole of the inner portion, A equalization of pressure between the suction cup and the outer chamber ,which origi-naIly had underpressure, is thus brought about, causing the skin to be raised? so that it is sucked tightly onto the rim of the suction cup and penetrates the point of the cannula shaf-t, ~he membrane(96)is pulled by its end(98) so far -to the left,that.the central conical opening is : e~posed, ~or the continuation of use,the syringe cone lies firmly within the clip ends~until the central conical openingD ~he injection is brought about in the standar manner by pressure on the syringe piston,which is not shown. An additional pull on the end(98) of the membrane(96) frees the hole (97)of the membrane(83),so that exterior air ;, can flow through the inner portion(11)into the suction cup area. ~he skin thus drops back and releases itselfs from the point of the cannula an from the rim of the suction cup. ~he membra-ne strip(96) in a simplified variation ,does not . - 13 -e~tend over the central conical opening. In -this ca-se, the syringe is already connected tightly to -the device by means of the syringe cone insi~le the cen--tral conical opening, before the device ls placed on -the skin. A precondi-tion for -this is a certain amount of frictio~ force between the syringe piStOll and cy-linder9 which prevents a movemen-t of the piston and the influence of suction from the suction cup in the time before penetration of the cannula tip into the skin A support piece between the syringe piston and syringe cylinder jwhich is removed immediately before the emptying of the syringe 9 can also serve this pur-pose. ~he device can also be connected with the co-nical pipe of a medicine dosing device~ as shown particularly clearly in ~ig .12 of the United States Patent No 4139008( ~ebruary 13, l979)or in ~igs.
4 to 10 of the above described device. Directly below a partial view can be seen in a de~ail of ~ig.2 9 shown from above.
~ig.3 shows in a cross-sectisnal side view an example, in which a cannula(28) is firmly and air-tightly welded into the upper chamber for vacuum ~-~ storage, which has a greater capacity than the the suction cup(4), is sealed off :Erom this suction cup~ which lies beneath it , by a base plate(9), which is penetrated solely by the tip of the can~
nula shaft, when this is sealed wi-thin the base pla-~ 14 --te. ~here is a pipe socket(lO) eccen-trically posi-tioned in l;he base pla-te, which extends into -the upper chamber and is closed by a valve pin(20).
The ~alve pin is posi-tioned wi-th i-ts ring shaped ~iim rail(12) at the uQper end o~ the pipe socke-t, in such a manner -that the rim rail is sealed to -the wall of the pipe socke-t by a layer of wax(13).
A second rim rail(1~)of the valve pin is perfora-ted along its length to permit the entr~v of air and positioned close to the lower end of the pipe socket, ~he valve pin ends at the height of the suction cup rim~ Between -the covering lid and the base plate, there is a thin -tube(15), which opens into the suction cup, and the upper end of which is sealed before use by a sealing plaster(16), when syringes are utilized, ~he tube,which goes through and is sealed against the upper chamber, serves, ; when supply bottles are used for dosing injectors, .~
as a means of checking the effect of underpressure - 20 on the skin. A thin portion of the covering lid or an opening in this lid, which is closed by a membrane(83), permits by means of an indentation the determination, as -to whether underpressure is or is not present, When the device is placed on the skin, that skin which moves in over the rim of -the suction cup pushes up the valve pin,so that its upper rim rail leaves the pipe socket, permitting air -to move from -the suction cup into -the upper ~8~æ
chamber, The skin is thus lif-ted in-to the can-nula , and -the injection is completed, as descri-bed above, Fig,4 shows a variation of -the example of ~ig,3 , in which the upper end of the pipe socke-t (10) is sealed by a rubber stopper(17). ~he valve pin has a cannula (18)7 which is below also open to the side, ~he valve pin(20) is preven-ted from turning by being flattened on one side across from a corresponding rail in the pipe socket and has on its lower end a centrally positioned ring(19).In the stage which is shown, the pressure on the ring by the skin- indicated by the dot-ted line-,which has been drawn up by the effec-ts of vacuum from ~; the upper chamber, has alread~ caused the valve ;~ pin to be raised. ~he cannula ol the valve pinhad penetrated the thin center of the rupper stop-per and had brought about an equalization of pressure'between the upper chamber and the suc tion cup in a short way as described above, Fig,5 illustrates a modification of the suc-tion cup shown in ~igs 1 and 2. According this em--,,.i bodiment,the upper chamber(11) is provided with a central conical opening(79)adapted to receive the projec-ting portion of the cannula (not illustrated herein). At the lower portion -thereof the inner portion(76) of the suction cup(4) is formed with a substantially cylindrical downwardly projec-ting strip-like rim(24) and a relhtively thin portion ' (78), ~he .supporting -tube(75) which is adapted -to slide inwardly upwardly of the -tube(76) is provi-ded with a ring-shaped bottom por-tion(22)~ This bo-t-tom portion has -three sector-like arms(77)(also shown in Fig.7 and Fig~6) equally spaced from one another in a circumferential direction whi&h are loca-ted at the periphery of the bottom portion(22) and extend upwardly from the surface thereofO ~he arms(77) have slightly outwardly curved ends(78) which may easily penetrate the -thinned portion or extension(84) of the tube(76) and break the seal bet-ween the upper and outer chamber(25)and the inner chamber(26), ~he thinned portion(84)may be repla-ced by strips which merge into the wall of the suc-tion cup. In eva uated position the upper and outer chamber(25) is closed with membrane(83).
Fig,6 shows a plan view of the supporting tu-be(75) having arms(77)wherein an outer dotted line illustrates the outer ends of the arms(77) in their upward position, me supporting tube with arms may ~- be made of polivinylchloride whereas the remaining parts of the device may be formed of polystyrene, In practice the cannula which is adjusted to a filled syringe may be inserted into the opening (79) in a manner as shown in Fig 7, When -the device is removed from a s-terile con-tainer and -the supporting -tube (75)is place over the skin to be treated the ends of the arms(77) of -`17 -the bottom portion(22) penetra-te the -thinned por--tion(84) due to the movement o:E the tube(75) upward wi-thin -the inner por-tion(76). Due to resul-ti~g ope-nings in the portion(84) the inner chamber(26) will communicate with the outer chamber(25) accumulating nega-tive pressure towards the cannula and the li-quid medicine will be discharged from the tip of the cannula by pressing the spraying piston in a conven-tional mode.
Figo7 illustrates an axial section of the suc-tion cup immediately before or after the injection.
The position of the human skin is illustrated by a dotted line, Fig,8 shows an auxiliary device for guiding the cannula(28) sho~,~m in Figs 5-10~ The device in-cludes a cylindrical body(80) which is openend from the bottom and provided wlth a guiding bar inclu-ding a straight portion(81) and a sloped portion (82), both formed with a guiding channel for sup-porting of the preliminarily filled cannula. The cannula(28) slides in the sloped portion(82) un-til it tips into -the straight portion(81)along which it slides further in-to the central conical opening(79)~ The suction injector may be placed into the cylindrical body(80) of the auxiliary device which may be positioned over the surface of the side selected lor injection and the injec-tion then may be performed as described above.
Addi-tionally , the auxiliary device may be provided wi-th an elas-tic angle(87) which per-forates into -the ring-shaped membrane(83) so that ambient air may flow into -the suc-tion cup~
Ihe skin is thus pulled back out of the cannula and the injector may be lifted and removed from -the auxiliary device whïch may be used repeatedly.
~ig,9 shows a cross-sectional side view of the lower part of a device, as in ~igs,5 and 7,in which the cannula has been lef-t outO
~he valve mechanism between the outer chamber and the suction cup has been modified in -the following manner. Ihe upper9vacuum storing chamber has an opening(78)-to the suction cup, l'his opening is closed by the rim of a ha-t sha-ped -membrane(2~,which is sealed around the opening by an adhesive mass. Ihe ha-t shaped -~ 20 projection of the membrane ex-tends beyond the supporting tube(75)9which itself extends beyond the rim of the suction cup with its lo-wer end, If the suppor~ing tube is lifted by pressure against -the skin, the rim of the ; hat snaped membrane is pulled away from the i opening and exchange of pressure between the - 19 ~
z upper and outer chamber and the suction cup takes place~
In ~igo10 ,there is only a.n adhesive membrane over the valve opening(7~ his membrane has a pull cord(21) welded into it,the kno-tted end of which is attached in. a sli-t in the upper end of -the supporting tube. If the supporting tube is rai-sed, tension on the pull cord causes the removal of the membrane from the valve opening, ~ig,11 shows a cross-sectional side view enlarged in a ra-tio 2:1 , a device as in ~igure 1.
In addition , a boring(3)to the inner portion has been pu-t into the central opening. No air can es-cape from this boring9 as long as -the syringe cone is sealed to the device~ If this syringe cone is liftes after injection ,the reventilation occurs~
An additional channel(6) is usefull,when a medi-cine dosing device is used. ~or such usage, a re-ventllation boring (8) in the outer chamber can be of use as part of an automatic injector,when a role of adhesive tape(7),which seals the boring, is pul].ed back after the injection, so that air can enter through the reventilation boring, A
cannula with an air-tightly sealed rubber sac~(27) is placed in ~ig~11 into the channe1(6) Ihe sack was pushed by the syringe cone somewhat to the side, but i-t indicates by collapsing the influ-ence of vacuum in the inner portion. Polystyrene with with little gas permeabili-ty is, for example, sui-ta-ble as a material :Eor -the produc-tion oE the devices :Eor suc-tion injection wi-th stored underpressure.
It will be understood that each of the elements described above, or -two or more toge-ther, may also find a useful'application in other types of suction injectors differing from the types described above, Whil'e the invention has been illustrated and described as embodied in a-suction injector,it is not intended to be limi-ted to the details shown,since various modifications and structural changes may be made without departing in any way from the spirit of the present invention.
Wi-thout further analysis, the foregoing will so ~t fully reveal the gis-t of the present invention that ` others can, by applying current knowledge, readily adapt it for various applications without omitting features that,from the standpoint of prior art7fair-ly constitute essential characteristics of the ge-neric or spe'cific aspects of this invention.
-~ What is claimed as new and desired to be pro-tected by ~etters Patent is set forth in the ap-pended claims.
Claims (18)
I CLAIM:
1. An apparatus for injection, particularly for use with hypodermic injections, comprising an upper chamber in which reduced air pressure is maintained before use as long as possible accor-ding to the leakage properties of the material of said chamber; a covering lid with a central funnel for the insertion of a container with means for ap-plying measured doses of a liquid; a cannula shaft, airtightly fastened to said covering lid and spa-tially continuing said funnel, the lower end of which has its tip extending into a suction cup, immediately touching to said upper chamber and having a base plate together with it; and valve means for preventing the communication of the redu-ced air pressure in said upper chamber to said suc-tion cup, until said suction cup is in pressure contact with the skin.
2. The apparatus of claim 1, wherein a membra-nous portion of said covering lid is provided for checking the influence of negative pressure inside of said upper chamber.
3. The apparatus of claim 1, wherein said can-nula shaft is firmly incorporated into said cove-ring lid.
4. The apparatus of claim 1 ,wherein said upper chamber with stored negative pressure is defined bet-ween an outer portion and an inner portion.
5. The apparatus of claim 4, wherein said upper chamber surrounds said smaller inner portion, in which a supporting tube, shiftable within said inner portion, surrounds said cannula shaft in such manner that the shifting of the supporting tube activates said valve means.
6. The apparatus of claim 5, wherein said val-ve means consists of openings in the wall of said in-ner portion, corresponding to openings in said suppor-ting tube, which openings are brought together through the raising of said supporting tube by the pressure of the skin.
7. The apparatus of claim 5, wherein said sup-porting tube includes a tube and a bottom portion with flexible projections being formed on said bot-tom portion.
8. The apparatus of claim 7, wherein said base plate is formed with a relatively thin radial exten-sion, said flexible projections being adapted to pe-netrate said radial extension to break a seal when said supporting tube is lifted toward said cannula.
9. The apparatus of claim 5, wherein said val-ve means are an opening between said upper chamber and said suction cup closed by a membrane connected to said supporting tube, which is withdrawn by the shifting upwards of said supporting tube.
10. The apparatus of claim 9, wherein said val-ve means are an opening, which is closed by a mem-brane containing a cord, which is fastened to the upper end of said supporting tube, and which causes the removal of said membrane from said opening.
11. The apparatus of claim 1, wherein a cannula is air-tightly fastened to said covering lid,which extends through said upper chamber and penetrates its base plate, to which it is sealed, and conti-nues into said suction cup.
12. The apparatus of claim 1 ,wherein said val-ve means are a pipe socket, which is air-tightly fastened onto the wall of said base plate between said upper chamber and said suction cup, which is near said cannula shaft and is closed by a valve pin.
13. The apparatus of claim 12, wherein said valve pin has two ring shaped rim rails, both of which are inserted into said pipe socket before the use of said apparatus.
14. The apparatus of claim 12, wherein a thin layer of adhesive mass seals the space between said valve pin and said pipe socket.
15. The apparatus of claim 1, wherein a tube is provided, which extends from said covering lid to said base plate open to said suction cup and is sealed against said upper chamber, for checking the opening of said valve means or for reventila-tion.
16. The apparatus of claim 1, which includes a device for guiding said cannula for the injection.
17. The apparatus of claim 16, wherein said gui-ding device includes a cylindrical member having an outer wall defining said suction cup and a guiding bar formed with a guiding groove for supporting said cannula before insertion into said apparatus.
18. The apparatus of claim 1, wherein a poin-ted tool is fixed to said apparatus by a flexible connection means, which can be used to perforate a a membranous seal for reventilation.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU87573/82A AU8757382A (en) | 1982-08-25 | 1982-08-25 | Suction injection syringe |
| CA000413077A CA1189412A (en) | 1982-08-25 | 1982-09-07 | Apparatus for injection |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU87573/82A AU8757382A (en) | 1982-08-25 | 1982-08-25 | Suction injection syringe |
| CA000413077A CA1189412A (en) | 1982-08-25 | 1982-09-07 | Apparatus for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1189412A true CA1189412A (en) | 1985-06-25 |
Family
ID=32509137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000413077A Expired CA1189412A (en) | 1982-08-25 | 1982-09-07 | Apparatus for injection |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU8757382A (en) |
| CA (1) | CA1189412A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596293A (en) * | 2009-09-30 | 2012-07-18 | 泰尔茂株式会社 | Injection aid and medication syringe device |
| CN102834132A (en) * | 2010-03-31 | 2012-12-19 | 泰尔茂株式会社 | Prefilled syringe and method for assembling prefilled syringe |
| EP3380174A4 (en) * | 2015-11-28 | 2019-04-24 | Biopreme Medical Technologies, Inc. | Negative pressure injection device |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5960609B2 (en) | 2010-02-01 | 2016-08-02 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | Low dose pre-filled drug delivery device |
-
1982
- 1982-08-25 AU AU87573/82A patent/AU8757382A/en not_active Abandoned
- 1982-09-07 CA CA000413077A patent/CA1189412A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596293A (en) * | 2009-09-30 | 2012-07-18 | 泰尔茂株式会社 | Injection aid and medication syringe device |
| EP2484396B1 (en) * | 2009-09-30 | 2023-01-25 | Terumo Kabushiki Kaisha | Injection aid and medication syringe device |
| CN102834132A (en) * | 2010-03-31 | 2012-12-19 | 泰尔茂株式会社 | Prefilled syringe and method for assembling prefilled syringe |
| EP3380174A4 (en) * | 2015-11-28 | 2019-04-24 | Biopreme Medical Technologies, Inc. | Negative pressure injection device |
| US10695509B2 (en) | 2015-11-28 | 2020-06-30 | Biopreme Medical Technologies Inc. | Negative pressure injection device |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8757382A (en) | 1984-03-01 |
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| MKEC | Expiry (correction) | ||
| MKEX | Expiry |