CA1152523A - Preparation of carbamates from aromatic amines and organic carbonates - Google Patents

Abstract

ABSTRACT OF THE DISCLOSURE
This invention is directed to a process for preparing a carbamate from an organic carbamate and an aromatic amine in the presence of catalytic quantities of a Lewis acid catalyst. The Lewis acid catalyst is soluble in the reaction mixture at the reaction conditions employed and is at least one member of the group consisting of a zinc or divalent tin halide, a zinc or divalent tin salt of a monovalent organic compound which has a pKa value of at least 2.8, and a zinc or divalent tin salt of trifluoroacetic acid.

28,594-F

Description

~s~z~

PREPARATION OF CARBAMATES
FROM AROMATIC AMINES AND ORGANIC CARBONAT~S

Lewis acids have been disclosed in U.S.
3,763,217 as being suitable catalysts for reacting an organic carbonate with an aromatic amine to prepare carbamates.
It has been unexpectedly discovered that certain zinc and divalent tin salts provide the desired carbamates in higher yields and/or selectivity than the particular Lewis acids disclosed by Brill in U.S.
3,763, 217.

The present invention pertains to a process for preparing a carbamate from an organic carbonate and an aromatic amine in the presence of a catalytic quantity of a Lewis acid characterized by employing as the Lewis acid catalyst, a catalyst which is soluble in the reaction mixture at the reaction conditions employed and which is at least one member selected from the group consisting of a zinc or divalent tin halide, a zinc or divalent tin salt of a monovalent organic com-pound having a pKa value of at least 2.8, preferably from 4 to 10, and a zinc or divalent tin salt of tri-fluoroacetic acid.

~~ 28,594-F

5;~3 Suitable organic carbonates which can be employed in the process of the present invention include the alkyl, aryl or alkyl aryl esters of carbonic acid.
The ester group can be an alkyl group having up to 12 carbon atoms, preferably a lower alkyl group containing up to 6 carbon atoms or the ester group can be an aryl group containing up to 10 carbon atoms.

Particularly suitable organic carbonates are the cyclic and acyclic organic carbonates such as, ~or example, ethylene carbonate, propylene carbonate, styrene carbonate, dimethyl carbonate, diethyl carbonate, dipropyl carbonate, dibutyl carbonate, dihexyl carbonate, methyl ethyl carbonate, methyl butyl carbonate, diphenyl carbonate, methyl phenyl carbonate, and mixtures thereof.

Any aromatic amine having a conjuga-te pKa value of from 3.5 to 5.5 is suitable for use herein ` with those amines having a conjugate pKa value of from 4 to 5.4 being preferred.

Suitable such aromatic amines include those represented by the formulas R~NH2 ~ (NH2)2 R
HZN~A~}NH2 28,594-F -2-~ IL5~5Z~

R~ ~x H

wherein each R iS independently hydrogen or a hydro-carbyl or hydrocarbyloxy group containing up to 8carbon atoms, preferably up to 4 carbon atoms, A is a divaleni hydrocarbon group having from 1 to 10 carbon atoms, preferably from 1 to 6 carbon atoms, n has a value of zero or 1 and x has an average value of from 1.1 to 10, preferably from 2 to 4.

Particularly suitable amines include, for example, aniline, o-, m- or p-toluidine, 2,4-xylidine, 3,4-xylidine, 2,5-xylidine, 4-ethylaniline, 3-propyl-aniline, 1,3-diaminobenzene, 2,4-diaminotoluene,

2,~-diaminotoluene, 4,4'-diamino-diphenyl methane, 2,4,4'-triamino-diphenyl ether, 2,6-diamino naphthalene, 4,4'-bis-methylene diphenylamine, o-, m- or p-anisidine, and mixtures thereof.

Suitable catalysts which can be employed herein include zinc or divalent tin salts of monovalent organic compounds having a pKa value above 2.8, preferably from 4 to 10, and are soluble in the reaction mixture at the reaction conditions.

Suitable such catalysts include, for example, zinc acetate, zinc propionate, zinc octoate, zinc naphthenate, zinc benzoate, zinc pivalate, zinc stearate, zinc itaconate, zinc p-chlorobenzoate, zinc methoxide, zinc phenolate, zinc acetylacetonate, zinc chloride, stannous chloride, stannous octoate, zinc tallate, zinc 28,594-F -3-neodecanoate, zinc acrylate, zinc formate, zinc chloro-acetate, zinc thiodipropionic acid, stannous laurate, and mixtures thereof.

When the organic carbonate is a cyclic organic carbonate such as, for example, ethylene carbonate, or an acyclic carbonate such as, for example, dimethyl carbonate, a zinc or divalent tin salt of trifluoroacetic acid can be employed, even though trifluoroacetic acid has a pKa value below 2.8.

The reaction is generally conducted at a temperature of from 80C to 300C, preferably from 120C to 250C and most preferably from 130C to 200C
for a time sufficient to complete the reaction depending upon the particular catalyst, reactants and temperature employed. Usually around 150C, the time is from one hour to six hours, preferably from two hours to four hours. The reaction generally should be conducted under conditions at which none of the reactants or desired product undergo decomposition.

The quantity of catalyst employed usually depends upon the activity of the particular catalyst.
Usually from 0.001 mole to 0.2 mole, preferably from 0.005 mole to 0.05 mole, of catalyst per mole of reactant present in a stoichiometric quantity is suitable.

The reactants can be employed on an equimolar basis or one may be present in an excess of the other up to a 20, preferably from a one to a five moles excess of the other. It is preferred that the organic carbonate reactant be employed in excess of the aromatic amine.

28,594-F -4-ZS;~3 Uses for the desired carbamate reaction product is suitably discussed by Rosenthal et al in U.S. 3,919,279, U.S. 3,919,280 and U.S. 3,962,302.

The following examples are illustrative of the present invention but are not to be construed as to limiting the scope thereof in any manner.

Catalysts employed in the Examples and Comparative Runs are designated as shown below. For salts of monovalent organic compounds, the pKa value listed is the pKa value of the organic compound from which it was derived, e.g., for zinc acetate, the pKa is for acetic acid.

CatalystDesiqnation pKa Zinc chloride A
15 Stannous chloride B
Antimony trichloride C
Aluminum trichloride D
Ferric chloride E
Zinc acetate F 4.84 20 Zinc acetate dihydrate G 4.84 Zinc oxyacetate H 4.84 Zinc naphthenate I 5.00 Zinc octoate ~ 4.85 Stannous octoate K 4.85 25 Zinc propionate L 4.88 Zinc salicylate M 3.00 Zinc pivalate N 5.02 Zinc benzoate O 4.17 Zinc acrylate P 4.25 30 Zinc parachlorobenzoate Q 4.03 28,594-F -5-' .

~2~23 CatalystDesi~natlon pKa Zinc phenolate R 10.00 Zinc formate S 3.77 Zinc chloroacetate T 2.85 5 Zinc acetylacetonate U 9.00 Zinc oxalate V 1.23 Stannous oxalate W 1.23 Zinc trifluoroacetate X 0.
Uranium trioxide Y
10 Uranium dioxide Z
, .
Zinc oxyacetate (H) is prepared by drying zinc acetate dihydrate in a heated vacuum oven. Zinc naphthenate (I) is a zinc salt of a naphthenic acid containing 8 weight percent zinc. Naphthenic acid is a term used in petroleum chemistry to denote the monocarboxylic acids derived from certain saturated hydrocarbons, specifically 5- and 6-carbon cycloparafins and their alkyl derivatives.
Specific acids identified in naphthenic acid are cyclohexyl propionic acid (pKa = 4.91), cyclohexyl butyric acid (pKa = 4.95) and cyclopentane carboxylic acid (pKa =
4.99). Estimated pKa for naphthenic acid is 5. Zinc octoate (J) is a zinc salt of 2-ethylhexanoic acid containing 18 weight percent zinc.

In the following examples and comparative runs, 5 grams (53.7 mmols) of aniline and 25 grams (277.5 mmols) of dimethyl carbonate were mixed with the amount of catalyst shown in Table I and poured into a stainless steel cylindrical container, 1 5/8" (41.3 mm) 30 internal diameter, and 2 1/4" (57.2 mm) internal depth with a wall thickness of 3/16" (4.8 mm). A stainless steel lid screwed over the reactor with a polytetrafluoro-ethylene O-ring being used as a seal. Mounted on the 28,594-F -6-~52S2~

lid using stainless steel pipe fittings and parts were a pressure gauge, a pressure relief valve, and a needle valve.

After charging the mixture to the reactor, the lid was sealed by tightening down on the polytetra-fluoroethylene O-ring and the reactor was immersed in a hot fluidized sand bath thermostaticaily corl~Loiied 140C in the center of the bath. The reactor was heated from between 10 to 15 minutes, then shaken to mix the contents. Then heating was continued for the desired time. After cooling the contents were analyzed for yields of carbamate and by-products.

The quantity of catalysts, reaction conditions and results are given in the following Table I. In Table I, the pressure listed under Reaction Conditions is gauge pressure. Under the headings of Reaction Products, MPC stands for methyl phenyl carbamate, NMA
stands for N-methyl aniline, and DPV stands for diphenyl urea. The Mole % Conversion of Aniline to MPC is calculated by dividing the mmols of MPC produced by the mmols of aniline employed (57.3 mmols) and multiplying by 100.

28,594-F -7-5~3 rl n ~ --I ~ ~ ~ N (~
h rl V (~ ~1 ~ u) (~ Ln tt~ O
o ~ o ,l ~ ~ ~ Ln r- ~ ~`
O ~ O

t` ~O
o ~ In .
O O \ ~1 ~ O O ~ O
~ ~ \ ~3 \ ~ \ \ \ \
~ ~ O o ~ ~1 ,~ ~ d' U~ ~
O O O O O O O O
i~
O .
I ,1 ~ ~ ~ O ~ ~
O ~ ~ ~ \ N ~1 ' LO
~ ~ \ \ \ dl \ \ ~ \
. I ~ ~ ~ o ~1 0 0 0 0 0 0 0 I
t~
. . ~ ~ O
~1 ~ ~3 O ~1 ~ ~ t` ~ 1`
H I O ~ \ \ \ d~ d1 ~ ~ \
a, ~3 ~31 ~ ~ ~0 d~ N ~1 0 ~1 Il) ~) ml ~
~ ~ ~_ E~ ._ :~ N ~ t` O ~D --U~ O ~ O ~D O CO O ~1 0 ~1 0 r~ O t` O O
O U~ ~ O ~ N ~ I -N ~1 0~10 r~ 1~1 ~I r-l O ~1 0 ~ N
-- _ _ _ __ _ _ _, O O ~ O O O O O O O O
d~ O
O --1 ~ o ~1 ~1 ~1 ~1 ~1 ~1 ~I N
~: ~1 O
~n S~
~;~ N N N N N N N N
rl O
E-l ~q I
\ ~ ~n ~ In u~ -N N N
0~ ~1 N \ N N N N
~1 0 \ d' \ \ \ \ ~ u) t~ 9 0 ~1 ~ \ \ \ \ \ \ \

~, ho , 'I N ~S ~') d' !o ~ ~`
X ~
~ O

28, 594-F -8 g O ~ O rl ~ ~ ~~ ~ ~ ~ N ~I
NCO CO 00 0 ) O

~1 ~ O
O ~ O ~ O ~ ~ O O
~> ~3 \
~ P ~r` o01 NCDLO ~
~ \ ~ O ~ !Q J
U~ ~
~ O O O O OO O O

~9~1 ~1 (`I ~ (r ~I N
~1 ~1 P~ O ~ ~t` ~1 ~ O Lr~ ~1 ~ ~ \ \ \ \ \ o\
O \ ~
~) O O O OO O O O
U~
In , . . .
. o ~~o aD d O ~U~
~ ~ \ ~
In u~ o ~ ~ co O ~ ~ O
v - - - - - - - -t` ~ co l` ~ o ~`
u~ o ~o ~ o ~ o ~ o cn o o o ,1 o cn ul ~~ ~ ~ o ~
)~ ,~ o~1 o~1 o ~ ~ o ~ 1 o _ _ _ _ _ _ _ _ _ O O ~ I o o o o o o o o V ~ d' ~ ~ ~ ~ ~ ~
O rl ~ O ~ ~1 ~1 ~1 ~1 ~1 ~1 ~1 ~ ~ E~
~ v ~n ~ S~
rl O
E~m u~ In \ InU~ Ln Ll~ U~
. . . .
~q ~ ~ ~ ~ ~ ~ \ \
:~ o \ \ \ \ \ cn o ou~ cn ~ ~ cn ~ ~~1 o o ,~ o o o o V ~ \ ~ z ~ o . co cn o ,1 ~ ~ ~ ~
Q ,~
o -28, 594-F -9-;25;~3 ~-,, q, aD ~ "' N d' d' ~ O
O ~ O rl ~ t` Co Ln O
N
O ~ O
~) I ~ ~ ~
O O O ~D
U~ ~
O O O O O O
~0 00 5~ ~ 1` . .
~i ~ N \ \
O \ (~ ~7 ) N
J,J N O O O O
a~
~; . Ln I
O O ~ ~ O
U ~: N
\
\ ~ ~ OD O ~1 g N N ~ O O
. _ O ~ ~ ~ ~
o ~1 o ~ o ~ o o o o O lR ~ ul CO ~
~1 ~ ~~) N~1 ~ N ~1 ~1 ~1 ~1 n P~ _ _ _ _ _ _ m~ ~
~O oP. O O O O O
O ~~ ~_)O O O d~ d~
0-~1 ~1) o N N N ~1 ~1 ~ ~ `~
~; O
C~ tR
o h ~3 ~ N N N N N
rl O
E~ ~
u~ In U~
Ln Ul ~1N
O \ ~ d' Il') ~1 0 ~ ~ ~1 \
~o ~ ~ d~
\
O O O O O
u~ E~ X :~ N
a P;
S~
~ o ~ t~ 0 m c~
~ ~, X
~ C~

28, 594-F -10-Equimolar amounts of aniline and ethylene carbonate were mixed together. Then lo gram quantities (5.14 g, 0.0552 mole aniline; 4.86 g, 0.0552 mole ethy lene carbonate) of this mixture were weighed into each of a series of 4 dram (15 cc) glass vials. Various catalysts, one per vial, were then weighed into the vials and mixed. Tile ~'idiS wer~ then plac~, unsealed, in a metal block of a "Temp Blok" module heater with thermostatic control to hold any desired temperature and the mixture heated for the desired time. Small aliquots could be removed periodically and analyzed for the degree of carbamate formation, if any.

The various catalysts and ~uantity of catalyst, reaction conditions and results are given in Table II.

28,594-F -11-~2l5~3 o ~
~Q ~ Z ~ ~ ~ r~ ~ 0 c~
O ~ O-rl ~ l N dl d~ N ~ N
O
O ~
U

~ O~d~ ~d'co~1 u~ ~:C O ~ ~ N Lt~
0 OD N ~I t~ Lt~ ~C) ~I N t` N ~:D
~, m~ \ \ \ \ \ \ 1~ \ \ \ \ \ \ \
\ o ~1 ~D c~ ~1 ~r) \ CO L~ ~ N ~ ~1 ~
O ~ ~1 ~1 ~ ~ O t` O ol:~ ~ ~ O dt N ~1 ~1 ~1 ~i N -1 ~1 0 ~i 0 ~i ~l1 ~1 ~) ~1 ~1 ~ ~ o ~
~1 ~ ~ 1` ~ . . . . . . . .
C~ O l~ ~ ~ r) N N d~ N ~ N
IT~ ~ -1 ~1 0 ~I N N ~1 ~I N ~1 ~1 ~1 ~I N
t~ O U) U') L~ C~ N N ~) ~ ~1 U~ ~1 ~1 ~1 ~1 ~ t`') ~I Nd~ d~ N N ~:P N ~ O O
m . O O 0 0 0 0 ~ 0 ~D 0 0 0 o 0 ~ ~ ~ ~ ~ ~ o ~ ~ o o o o ~ O ~ o E~ ~ V ~1 ~1 ~1 ~1 ~1 ~1 ~1 O o .~ o~
O ~ ~ d1 0 N O O N `D ~ ~ ~ d~ ~ O `I) V ~,~ O ~ ~ 1` ~ ~ 1~ ~ ~ ~ ~ d' ~ ~ ~
E~ m ~ ~ 0 ~R ~ ~ U~ . ~I L~ ~ Lr, u~ 0 ~ r~
~o ~IO........... O
~1 ~ \ O \ ~1 0 0 N ~1 ~1 0 \ ~1 0 0 0 \ ~D \ \ \ \ \ \ \ L~ \ \ \
\ ~1 ~1 0 N ~I d~ N N N N O N ~I N
`
V O O O O O O O O O O O O O O

~ ~ O ~I N t`~ ~ u~) ~ ~` a) O .-1 N ~ ~ N N N N N N N 1~ V N
l:il O
V

28, 594-F -12-~;25;Z3 These examples were prepared in the same manner as those for Examples 1-18 except that different amines and a different carbonate were employed. The reactants, reaction conditions and results are given in the following Table III. The amines and their designations and the carbonates and their designations are listed beiow.

Amines Designation 10 2,6-Diaminotoluene AA
2,4-Diaminotoluene BB
p-Toluidene CC
o-Anisidine DD
m-Anisidene EE
15 p-Anisidene FF
Aniline GG

Carbonates Dimethyl carbonate HH
Diethyl carbonate II

28,594-F -13-~2~23 O O
rl U~ ~ o o~
o ~ ~ ~ ~ ~ c~
O ~ -~1 h U ~

O O O ~ CO
td '~, \ ~ ~ ~ \ \
~\ I` \ \ \ ~ ~ \
s~ ~ ~ ~o ~ o In ~ ~D
~r~ . . . . . . .
U ¦ N
. _ N
U~ oo U~o L~o U~o U~ o U~ o ~`1 o ~ 4 ~ ~ ~ N t`l ~ O ~
S~ ; N~ ~N ~1~ r~N ~1 (~ l 0 ~o P~ --~ _ _ _ _ _ _ _ O O
.,1.~ ~ o o o o o o o o ~'U~ ~ ~o ~9 ~ ~ o ~
O r~ ~ O~1 ^ ~1 ~ ~1 ~1 ~1 ~ ~1 E~u~
~D
o rq u a~ ~ ,~
~ ~~1 -- ~ ~ ~ ~ d ' N d' ~1 0 E~ ~ Ln U~ o o o U~
H \ U~ U~ Il) ' ' 1 H ~
H ~ ~1 t` \ \ \ ~ 1~ ~1 \
O~ U) 1~1 U) N
O ~\ ~ \ \ \
~ N ~ H H

1` 0 0 0~`1 N ~ Lll \ ~I ~ ~ U~
O O\ \ \ \ U~ LO t~) U`~
~ ~~ N ~ ~ d ~ t1 ~ Q \ ~ m\

\ In ~n u~
. . . .
~o \ \ \ \ \
~1 ~'S) ~ ~D ~ N
~ \
o \ \ ~a ~I
~ ~ o ~ ~ ~ ~ In ~D
X

28, 594-F -14-~ -15-Zinc acetate (F) was also found to be suitable for catalyzing the reaction between dimethyl carbonate and methylene dianiline, o-phenylenediamine, m-phenylene-diamine, p-phenylenediamine, and an 80/20 mixutre of 2,4-/2,6-diamino toluene.

Zinc naphthenate (I) was also found to be suit~uiè ful catal-y~zin~ ~.e l-eaction between dimethyl carbonate and 2,6-diamino toluene and an 80/20 mixture of 2,4-/2,6-diamino toluene.

Zinc octoate (J) was found to not catalyze the reaction between dimethyl carbonate and 2,4,6--tribromoaniline.

28,594-F -15-

Claims (3)

1. A process for preparing a carbamate from an organic carbonate and an aromatic amine in the presence of catalytic quantity of a Lewis acid catalyst characterized by employing as the Lewis acid catalyst a catalyst which is soluble in the reaction mixture at the reaction conditions employed and which is at least one member selected from the group consisting of a zinc or divalent tin halide, a zinc or divalent tin salt of a monovalent organic compound which has a pKa value of at least 2.8, and a zinc or divalent tin salt of tri-fluoroacetic acid.

2. The process of Claim 1 characterized in that the compound has a pKa of from 4 to 10.

3. The process of Claim 1 characterized in that the catalyst is selected from zinc naphthenate, zinc acetate, zinc propionate, zinc octoate or mixtures thereof.

28,594-F -16-