CA1149631A - Apparatus and method for interrogation of biological materials - Google Patents
Apparatus and method for interrogation of biological materialsInfo
- Publication number
- CA1149631A CA1149631A CA000369853A CA369853A CA1149631A CA 1149631 A CA1149631 A CA 1149631A CA 000369853 A CA000369853 A CA 000369853A CA 369853 A CA369853 A CA 369853A CA 1149631 A CA1149631 A CA 1149631A
- Authority
- CA
- Canada
- Prior art keywords
- light
- wavelength
- source
- nanometers
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000012620 biological material Substances 0.000 title claims abstract description 20
- 210000000481 breast Anatomy 0.000 claims abstract description 31
- 230000005855 radiation Effects 0.000 claims abstract description 18
- 238000010521 absorption reaction Methods 0.000 claims abstract description 17
- 230000005540 biological transmission Effects 0.000 claims abstract description 16
- 238000003325 tomography Methods 0.000 claims abstract description 3
- 230000012010 growth Effects 0.000 claims abstract 3
- 238000001514 detection method Methods 0.000 claims description 21
- 229910052710 silicon Inorganic materials 0.000 claims description 10
- 239000010703 silicon Substances 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 230000003902 lesion Effects 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 8
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 8
- 229910052721 tungsten Inorganic materials 0.000 claims description 7
- 239000010937 tungsten Substances 0.000 claims description 7
- 229910052732 germanium Inorganic materials 0.000 claims description 6
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 239000010409 thin film Substances 0.000 claims description 5
- 238000003384 imaging method Methods 0.000 claims description 4
- VSQYNPJPULBZKU-UHFFFAOYSA-N mercury xenon Chemical compound [Xe].[Hg] VSQYNPJPULBZKU-UHFFFAOYSA-N 0.000 claims description 4
- 229910052724 xenon Inorganic materials 0.000 claims description 4
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 239000004973 liquid crystal related substance Substances 0.000 claims description 2
- 230000005670 electromagnetic radiation Effects 0.000 claims 17
- 230000002159 abnormal effect Effects 0.000 claims 4
- 239000000463 material Substances 0.000 claims 3
- 230000036210 malignancy Effects 0.000 claims 2
- 229940056932 lead sulfide Drugs 0.000 claims 1
- 229910052981 lead sulfide Inorganic materials 0.000 claims 1
- 230000031700 light absorption Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 8
- 230000005865 ionizing radiation Effects 0.000 abstract description 3
- 238000000701 chemical imaging Methods 0.000 abstract description 2
- 230000006870 function Effects 0.000 abstract description 2
- 230000002503 metabolic effect Effects 0.000 abstract description 2
- 230000003211 malignant effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 39
- 210000003128 head Anatomy 0.000 description 8
- 108091008695 photoreceptors Proteins 0.000 description 8
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000010453 quartz Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000001931 thermography Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009607 mammography Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
- A61B5/015—By temperature mapping of body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
- A61B5/4312—Breast evaluation or disorder diagnosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11863980A | 1980-02-04 | 1980-02-04 | |
| US118,639 | 1980-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1149631A true CA1149631A (en) | 1983-07-12 |
Family
ID=22379852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000369853A Expired CA1149631A (en) | 1980-02-04 | 1981-02-02 | Apparatus and method for interrogation of biological materials |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS56119232A (it) |
| AU (1) | AU547510B2 (it) |
| BE (1) | BE887366A (it) |
| CA (1) | CA1149631A (it) |
| DE (1) | DE3103609A1 (it) |
| FR (1) | FR2481454B1 (it) |
| GB (1) | GB2068537B (it) |
| IT (1) | IT1135280B (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733739A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | System and method for diagnosis of disease by infrared analysis of human tissues and cells |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4467812A (en) * | 1982-07-19 | 1984-08-28 | Spectrascan, Inc. | Transillumination apparatus |
| US4651743A (en) * | 1982-07-19 | 1987-03-24 | Spectrascan, Inc. | Diaphanoscopy method |
| CA1204605A (en) * | 1982-07-19 | 1986-05-20 | Milton Stoller | Diaphanoscopy method and apparatus |
| US4616657A (en) * | 1982-07-19 | 1986-10-14 | The First National Bank Of Boston | Diaphanoscopy apparatus |
| US4600011A (en) * | 1982-11-03 | 1986-07-15 | The University Court Of The University Of Aberdeen | Tele-diaphanography apparatus |
| FR2542092B1 (fr) * | 1983-03-03 | 1986-02-28 | Inst Francais Du Petrole | Procede et dispositif pour determiner la composition d'un melange alcool-essence, adaptes au reglage automatique de moteurs alimentes en melanges combustibles de teneur en alcool variable |
| GB2136120B (en) * | 1983-03-10 | 1986-10-08 | Shionogi & Co | Photoelectric brain scanner and its use |
| JPS6072542A (ja) * | 1983-09-28 | 1985-04-24 | 株式会社島津製作所 | 光線ｃｔ装置 |
| US4570638A (en) * | 1983-10-14 | 1986-02-18 | Somanetics Corporation | Method and apparatus for spectral transmissibility examination and analysis |
| US5139025A (en) * | 1983-10-14 | 1992-08-18 | Somanetics Corporation | Method and apparatus for in vivo optical spectroscopic examination |
| US5140989A (en) * | 1983-10-14 | 1992-08-25 | Somanetics Corporation | Examination instrument for optical-response diagnostic apparatus |
| FR2561515A1 (fr) * | 1984-03-21 | 1985-09-27 | Amar Roger | Dispositif automatise destine a l'application de rayons laser infrarouges sur des tissus adipeux aux fins d'esthetique corporelle |
| US4774961A (en) * | 1985-11-07 | 1988-10-04 | M/A Com, Inc. | Multiple antennae breast screening system |
| DE3831216A1 (de) * | 1988-09-14 | 1990-03-22 | S & T Marketing Ag | Verfahren und vorrichtung zum testen eines blutgefaesses od. dgl. |
| US5353799A (en) | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
| CN1012557B (zh) * | 1990-03-17 | 1991-05-08 | 北京海淀龙兴医疗设备科技开发公司 | 软组织检测成象方法及其装置 |
| GB9109686D0 (en) * | 1991-05-03 | 1991-06-26 | Nat Res Dev | Teat inspection |
| IL107396A (en) * | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
| US5820558A (en) * | 1994-12-02 | 1998-10-13 | Non-Invasive Technology, Inc. | Optical techniques for examination of biological tissue |
| US6058324A (en) * | 1993-06-17 | 2000-05-02 | Non-Invasive Technology, Inc. | Examination and imaging of biological tissue |
| US6542772B1 (en) | 1994-12-02 | 2003-04-01 | Non-Invasive Technology, Inc. | Examination and imaging of biological tissue |
| JP2001521772A (ja) * | 1997-10-30 | 2001-11-13 | ハイパーメッド・イメジング・インコーポレーテッド | マルチスペクトル／ハイパースペクトルの医療用計器 |
| WO2000010451A1 (en) * | 1998-08-19 | 2000-03-02 | Cedars-Sinai Medical Center | System and method for spectral topography of mammalian matter using white light illumination |
| FR2791135B1 (fr) * | 1999-03-16 | 2001-04-20 | Gemplus Card Int | Procede de test visuel d'opacite de paves grattables et dispositif de mise en oeuvre |
| EP2332460B1 (en) | 2005-05-13 | 2013-06-05 | Olympus Medical Systems Corp. | Biological observation apparatus |
| JP4951256B2 (ja) | 2006-03-16 | 2012-06-13 | オリンパスメディカルシステムズ株式会社 | 生体観測装置 |
| KR20080104307A (ko) * | 2006-03-17 | 2008-12-02 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 혼탁한 매체를 이미징하기 위한 디바이스 |
| KR20240131466A (ko) * | 2018-01-23 | 2024-08-30 | 벡톤 디킨슨 앤드 컴퍼니 | 광 검출을 동적 차폐하기 위한 시스템 및 이를 사용하는 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3327117A (en) * | 1963-08-12 | 1967-06-20 | Ibm | Cancer cell detector using two wavelengths for comparison |
| US3628525A (en) * | 1969-06-19 | 1971-12-21 | American Optical Corp | Blood oxygenation and pulse rate monitoring apparatus |
| US3706877A (en) * | 1970-04-09 | 1972-12-19 | Clifford Instr Inc | Densitometer having an analog computer for calculating a fraction of the total area under a curve |
| US3674008A (en) * | 1970-07-13 | 1972-07-04 | Battelle Development Corp | Quantitative pulsed transilluminator and method of operation |
| US3769963A (en) * | 1972-03-31 | 1973-11-06 | L Goldman | Instrument for performing laser micro-surgery and diagnostic transillumination of living human tissue |
| US4017192A (en) * | 1975-02-06 | 1977-04-12 | Neotec Corporation | Optical analysis of biomedical specimens |
| DE2523886C3 (de) * | 1975-05-30 | 1978-10-19 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Röntgendiagnostikanlage mit mindestens einer in Impulsen betriebenen Röntgenröhre und einer Kinokamera, sowie mit einer Steuereinheit, die den Betrieb der Röntgenröhre und der Kinokamera mit der Netzspannung synchronisiert |
| GB1559810A (en) * | 1975-11-05 | 1980-01-30 | Nat Res Dev | Device for measuring light received from an illuminated material |
| US4077399A (en) * | 1976-08-03 | 1978-03-07 | New Research And Development Laboratories, Inc. | Cranial transillumination device |
| DE2640248C3 (de) * | 1976-09-07 | 1980-11-20 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Röntgenuntersuchungsgerät |
| SE7613587L (sv) * | 1976-12-03 | 1978-06-04 | Andersson Torsten | Metod for diagnostiserande av sjukliga forendringar i kvinnobrost |
| PL109682B1 (en) * | 1977-08-11 | 1980-06-30 | Zaklady Naprawcze Sprzetu Medycznego | Encephalovolumeter |
| DE2903625A1 (de) * | 1978-02-03 | 1979-08-09 | Rush Presbyterian St Luke | Vorrichtung zur automatischen blutanalyse |
| US4212306A (en) * | 1978-05-18 | 1980-07-15 | Khalid Mahmud | Breast examination device and method |
| FI58719C (fi) * | 1979-06-01 | 1981-04-10 | Instrumentarium Oy | Diagnostiseringsanordning foer broestkancer |
-
1981
- 1981-01-21 GB GB8101760A patent/GB2068537B/en not_active Expired
- 1981-01-30 FR FR8101865A patent/FR2481454B1/fr not_active Expired
- 1981-01-30 AU AU66754/81A patent/AU547510B2/en not_active Ceased
- 1981-02-02 CA CA000369853A patent/CA1149631A/en not_active Expired
- 1981-02-03 BE BE0/203683A patent/BE887366A/fr not_active IP Right Cessation
- 1981-02-03 DE DE19813103609 patent/DE3103609A1/de not_active Withdrawn
- 1981-02-03 IT IT19488/81A patent/IT1135280B/it active
- 1981-02-04 JP JP1557281A patent/JPS56119232A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733739A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | System and method for diagnosis of disease by infrared analysis of human tissues and cells |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6675481A (en) | 1981-08-13 |
| DE3103609A1 (de) | 1981-12-03 |
| IT8119488A0 (it) | 1981-02-03 |
| AU547510B2 (en) | 1985-10-24 |
| GB2068537A (en) | 1981-08-12 |
| FR2481454A1 (fr) | 1981-10-30 |
| GB2068537B (en) | 1984-11-14 |
| BE887366A (fr) | 1981-06-01 |
| JPS56119232A (en) | 1981-09-18 |
| FR2481454B1 (fr) | 1985-06-14 |
| IT1135280B (it) | 1986-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |