CA1144533A - Procedure for the preparation of organolithium compounds together with lithium hydride - Google Patents
Procedure for the preparation of organolithium compounds together with lithium hydrideInfo
- Publication number
- CA1144533A CA1144533A CA000404171A CA404171A CA1144533A CA 1144533 A CA1144533 A CA 1144533A CA 000404171 A CA000404171 A CA 000404171A CA 404171 A CA404171 A CA 404171A CA 1144533 A CA1144533 A CA 1144533A
- Authority
- CA
- Canada
- Prior art keywords
- chloride
- lithium
- catalyst
- metal
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 title claims abstract description 86
- 238000000034 method Methods 0.000 title claims description 30
- 238000002360 preparation method Methods 0.000 title claims description 19
- 229910000103 lithium hydride Inorganic materials 0.000 title abstract description 29
- 150000002900 organolithium compounds Chemical class 0.000 title description 25
- 239000003054 catalyst Substances 0.000 claims abstract description 62
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 32
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000011593 sulfur Substances 0.000 claims abstract description 31
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 24
- 239000001301 oxygen Substances 0.000 claims abstract description 24
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 11
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 11
- 150000002894 organic compounds Chemical class 0.000 claims abstract description 9
- 229910052744 lithium Inorganic materials 0.000 claims description 76
- 239000000203 mixture Substances 0.000 claims description 42
- 150000002736 metal compounds Chemical class 0.000 claims description 39
- 229910052751 metal Inorganic materials 0.000 claims description 31
- 239000002184 metal Substances 0.000 claims description 31
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 27
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 23
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 19
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 18
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 18
- 230000000737 periodic effect Effects 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 150000001721 carbon Chemical group 0.000 claims description 14
- 239000010949 copper Substances 0.000 claims description 14
- 229910052763 palladium Inorganic materials 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 12
- 229910052723 transition metal Inorganic materials 0.000 claims description 12
- 150000003624 transition metals Chemical class 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 10
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 10
- 150000001412 amines Chemical class 0.000 claims description 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 10
- 229910052802 copper Inorganic materials 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 150000002170 ethers Chemical class 0.000 claims description 10
- 229910052742 iron Inorganic materials 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 9
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims description 9
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- -1 polycyclic aromatic compound Chemical class 0.000 claims description 9
- 229910052725 zinc Inorganic materials 0.000 claims description 9
- 239000011701 zinc Substances 0.000 claims description 9
- 239000011592 zinc chloride Substances 0.000 claims description 9
- 235000005074 zinc chloride Nutrition 0.000 claims description 9
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 8
- 229910052703 rhodium Inorganic materials 0.000 claims description 8
- 239000010948 rhodium Substances 0.000 claims description 8
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 8
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 7
- 125000001931 aliphatic group Chemical group 0.000 claims description 7
- 235000010290 biphenyl Nutrition 0.000 claims description 7
- 239000004305 biphenyl Substances 0.000 claims description 7
- 150000002739 metals Chemical class 0.000 claims description 7
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 229910021591 Copper(I) chloride Inorganic materials 0.000 claims description 6
- 229910021592 Copper(II) chloride Inorganic materials 0.000 claims description 6
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims description 6
- 229910017052 cobalt Inorganic materials 0.000 claims description 5
- 239000010941 cobalt Substances 0.000 claims description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 5
- GICWIDZXWJGTCI-UHFFFAOYSA-I molybdenum pentachloride Chemical compound Cl[Mo](Cl)(Cl)(Cl)Cl GICWIDZXWJGTCI-UHFFFAOYSA-I 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 4
- 229910021556 Chromium(III) chloride Inorganic materials 0.000 claims description 4
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 claims description 4
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 4
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims description 4
- 229910021604 Rhodium(III) chloride Inorganic materials 0.000 claims description 4
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 4
- 229910052793 cadmium Inorganic materials 0.000 claims description 4
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052804 chromium Inorganic materials 0.000 claims description 4
- 239000011651 chromium Substances 0.000 claims description 4
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 claims description 4
- 235000007831 chromium(III) chloride Nutrition 0.000 claims description 4
- 239000011636 chromium(III) chloride Substances 0.000 claims description 4
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims description 4
- 229960003280 cupric chloride Drugs 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 4
- 229910052750 molybdenum Inorganic materials 0.000 claims description 4
- 239000011733 molybdenum Substances 0.000 claims description 4
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims description 4
- BMGNSKKZFQMGDH-FDGPNNRMSA-L nickel(2+);(z)-4-oxopent-2-en-2-olate Chemical compound [Ni+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O BMGNSKKZFQMGDH-FDGPNNRMSA-L 0.000 claims description 4
- 229910052758 niobium Inorganic materials 0.000 claims description 4
- 239000010955 niobium Substances 0.000 claims description 4
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 4
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims description 4
- CLSUSRZJUQMOHH-UHFFFAOYSA-L platinum dichloride Chemical compound Cl[Pt]Cl CLSUSRZJUQMOHH-UHFFFAOYSA-L 0.000 claims description 4
- SONJTKJMTWTJCT-UHFFFAOYSA-K rhodium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Rh+3] SONJTKJMTWTJCT-UHFFFAOYSA-K 0.000 claims description 4
- 229910052707 ruthenium Inorganic materials 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 claims description 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052721 tungsten Inorganic materials 0.000 claims description 4
- 239000010937 tungsten Substances 0.000 claims description 4
- 229910052720 vanadium Inorganic materials 0.000 claims description 4
- 229910052726 zirconium Inorganic materials 0.000 claims description 4
- 229910021380 Manganese Chloride Inorganic materials 0.000 claims description 3
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 claims description 3
- 125000006267 biphenyl group Chemical group 0.000 claims description 3
- DBGPLCIFYUHWKA-UHFFFAOYSA-H hexachloromolybdenum Chemical compound Cl[Mo](Cl)(Cl)(Cl)(Cl)Cl DBGPLCIFYUHWKA-UHFFFAOYSA-H 0.000 claims description 3
- 229910052741 iridium Inorganic materials 0.000 claims description 3
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 3
- 235000002867 manganese chloride Nutrition 0.000 claims description 3
- 239000011565 manganese chloride Substances 0.000 claims description 3
- 229910052762 osmium Inorganic materials 0.000 claims description 3
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052715 tantalum Inorganic materials 0.000 claims description 3
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical compound Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 claims 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 abstract description 11
- 238000006138 lithiation reaction Methods 0.000 abstract description 11
- 230000003197 catalytic effect Effects 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 125000003367 polycyclic group Chemical group 0.000 abstract description 3
- 230000000707 stereoselective effect Effects 0.000 abstract description 2
- 150000003623 transition metal compounds Chemical class 0.000 abstract description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 72
- 239000000243 solution Substances 0.000 description 26
- 239000000725 suspension Substances 0.000 description 23
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 22
- 239000000706 filtrate Substances 0.000 description 21
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 19
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 15
- 239000005977 Ethylene Substances 0.000 description 15
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 description 15
- 239000004576 sand Substances 0.000 description 15
- 238000003756 stirring Methods 0.000 description 13
- 239000007789 gas Substances 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 239000005051 trimethylchlorosilane Substances 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 150000001993 dienes Chemical class 0.000 description 9
- 229920006395 saturated elastomer Polymers 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- XFAOKAPNQBVYFX-UHFFFAOYSA-N cyclopenta[c]dithiine-3-thione Chemical compound S1SC(=S)C=C2C=CC=C21 XFAOKAPNQBVYFX-UHFFFAOYSA-N 0.000 description 8
- 230000007062 hydrolysis Effects 0.000 description 8
- 238000006460 hydrolysis reaction Methods 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000004821 distillation Methods 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- PGOLTJPQCISRTO-UHFFFAOYSA-N vinyllithium Chemical compound [Li]C=C PGOLTJPQCISRTO-UHFFFAOYSA-N 0.000 description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- VCPPTNDHEILJHD-UHFFFAOYSA-N lithium;prop-1-ene Chemical compound [Li+].[CH2-]C=C VCPPTNDHEILJHD-UHFFFAOYSA-N 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 230000035484 reaction time Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- SRYTYXMHFJHYIZ-UHFFFAOYSA-N 3,7-diphenyl-1$l^{4},2,8-trithiabicyclo[3.3.0]octa-1(5),3,6-triene Chemical compound S1C(C=2C=CC=CC=2)=CC(C=2)=S1SC=2C1=CC=CC=C1 SRYTYXMHFJHYIZ-UHFFFAOYSA-N 0.000 description 4
- BEAHIJLFCSRCOX-UHFFFAOYSA-N C[Si](C)(C)CC([Si](C)(C)C)=CC=C[Si](C)(C)C Chemical class C[Si](C)(C)CC([Si](C)(C)C)=CC=C[Si](C)(C)C BEAHIJLFCSRCOX-UHFFFAOYSA-N 0.000 description 4
- 229910015400 FeC13 Inorganic materials 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 150000004756 silanes Chemical class 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- HYWCXWRMUZYRPH-UHFFFAOYSA-N trimethyl(prop-2-enyl)silane Chemical compound C[Si](C)(C)CC=C HYWCXWRMUZYRPH-UHFFFAOYSA-N 0.000 description 4
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- KWKAKUADMBZCLK-UHFFFAOYSA-N methyl heptene Natural products CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 3
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 3
- QYZLKGVUSQXAMU-UHFFFAOYSA-N penta-1,4-diene Chemical compound C=CCC=C QYZLKGVUSQXAMU-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000006884 silylation reaction Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- IIWSLXWOGWUDPL-UHFFFAOYSA-N trimethyl(prop-1-en-2-yl)silane Chemical compound CC(=C)[Si](C)(C)C IIWSLXWOGWUDPL-UHFFFAOYSA-N 0.000 description 3
- UDYJJCZCPMQSQG-AATRIKPKSA-N trimethyl-[(e)-prop-1-enyl]silane Chemical compound C\C=C\[Si](C)(C)C UDYJJCZCPMQSQG-AATRIKPKSA-N 0.000 description 3
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 3
- XWJBRBSPAODJER-UHFFFAOYSA-N 1,7-octadiene Chemical compound C=CCCCCC=C XWJBRBSPAODJER-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- LQAHWDDDURVRNM-UHFFFAOYSA-N C(C(C1=CC=CC=C1)S1)=C2[S+]1SC=C2C1=CC=CC=C1 Chemical compound C(C(C1=CC=CC=C1)S1)=C2[S+]1SC=C2C1=CC=CC=C1 LQAHWDDDURVRNM-UHFFFAOYSA-N 0.000 description 2
- DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical compound C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- AUKXLNUGPJFWQM-VOTSOKGWSA-N [(e)-but-1-enyl]-trimethylsilane Chemical group CC\C=C\[Si](C)(C)C AUKXLNUGPJFWQM-VOTSOKGWSA-N 0.000 description 2
- ZSVVUYSSPNFVDR-UHFFFAOYSA-N [Li]\C=C\CCC Chemical compound [Li]\C=C\CCC ZSVVUYSSPNFVDR-UHFFFAOYSA-N 0.000 description 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- WYURNTSHIVDZCO-SVYQBANQSA-N deuterated tetrahydrofuran Substances [2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H] WYURNTSHIVDZCO-SVYQBANQSA-N 0.000 description 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 150000004678 hydrides Chemical class 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 150000002642 lithium compounds Chemical class 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 150000002896 organic halogen compounds Chemical class 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 2
- HITROERJXNWVOI-SOFGYWHQSA-N (5e)-octa-1,5-diene Chemical compound CC\C=C\CCC=C HITROERJXNWVOI-SOFGYWHQSA-N 0.000 description 1
- OWXJKYNZGFSVRC-NSCUHMNNSA-N (e)-1-chloroprop-1-ene Chemical compound C\C=C\Cl OWXJKYNZGFSVRC-NSCUHMNNSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- LZENMJMJWQSSNJ-UHFFFAOYSA-N 3H-1,2-dithiole-3-thione Chemical class S=C1C=CSS1 LZENMJMJWQSSNJ-UHFFFAOYSA-N 0.000 description 1
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 description 1
- 238000006418 Brown reaction Methods 0.000 description 1
- UTPMRESHYKQVCF-UHFFFAOYSA-N C1S[S+]2SC=CC2=C1 Chemical class C1S[S+]2SC=CC2=C1 UTPMRESHYKQVCF-UHFFFAOYSA-N 0.000 description 1
- 101150041968 CDC13 gene Proteins 0.000 description 1
- 241000736839 Chara Species 0.000 description 1
- 239000005749 Copper compound Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910013454 LiC4 Inorganic materials 0.000 description 1
- 229910008293 Li—C Inorganic materials 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 229910021120 PdC12 Inorganic materials 0.000 description 1
- 229910002666 PdCl2 Inorganic materials 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- JARYEVBSCNFXFN-AATRIKPKSA-N [(e)-but-2-enyl]-trimethylsilane Chemical compound C\C=C\C[Si](C)(C)C JARYEVBSCNFXFN-AATRIKPKSA-N 0.000 description 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical group [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 description 1
- BZEZSORUWZUMNU-UHFFFAOYSA-N [Li]CCCC[Li] Chemical compound [Li]CCCC[Li] BZEZSORUWZUMNU-UHFFFAOYSA-N 0.000 description 1
- IZVXZTXACRSIFM-UHFFFAOYSA-N [Li]\C=C\CC Chemical compound [Li]\C=C\CC IZVXZTXACRSIFM-UHFFFAOYSA-N 0.000 description 1
- HXGDTGSAIMULJN-UHFFFAOYSA-N acetnaphthylene Natural products C1=CC(C=C2)=C3C2=CC=CC3=C1 HXGDTGSAIMULJN-UHFFFAOYSA-N 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940126543 compound 14 Drugs 0.000 description 1
- 229940127204 compound 29 Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 150000001880 copper compounds Chemical class 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940045803 cuprous chloride Drugs 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- ILNKLXHFYKXPKY-UHFFFAOYSA-N iridium osmium Chemical compound [Os].[Ir] ILNKLXHFYKXPKY-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- YNXURHRFIMQACJ-UHFFFAOYSA-N lithium;methanidylbenzene Chemical class [Li+].[CH2-]C1=CC=CC=C1 YNXURHRFIMQACJ-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910001510 metal chloride Inorganic materials 0.000 description 1
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical compound C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 description 1
- 150000005673 monoalkenes Chemical class 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-OUBTZVSYSA-N oxygen-17 atom Chemical compound [17O] QVGXLLKOCUKJST-OUBTZVSYSA-N 0.000 description 1
- 150000002940 palladium Chemical class 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003284 rhodium compounds Chemical class 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ZZMNTYSYNAPGHP-ZHACJKMWSA-N trimethyl-[(1e)-octa-1,7-dienyl]silane Chemical compound C[Si](C)(C)\C=C\CCCCC=C ZZMNTYSYNAPGHP-ZHACJKMWSA-N 0.000 description 1
- UFUHTHNESOEDRH-BQYQJAHWSA-N trimethyl-[(e)-pent-1-enyl]silane Chemical compound CCC\C=C\[Si](C)(C)C UFUHTHNESOEDRH-BQYQJAHWSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A catalytic system is provided for the lithiation of .alpha. -olefins and .alpha.,.omega.-diolefins with concurrent production of lithium hydride. The catalysts include oxygen and sulfur containing organic compounds and polycyclic aromatics which can be combined with alkali metals and/or transition metal compounds.
High yields of pure and stereospecific lithiated olefins are obtainable.
A catalytic system is provided for the lithiation of .alpha. -olefins and .alpha.,.omega.-diolefins with concurrent production of lithium hydride. The catalysts include oxygen and sulfur containing organic compounds and polycyclic aromatics which can be combined with alkali metals and/or transition metal compounds.
High yields of pure and stereospecific lithiated olefins are obtainable.
Description
1 ¦ FIELD OF THE INVENTION
2 I .
(3 ¦ The present invention relates to a catalyst system for 4 ¦ the preparation of organolithium compounds from lithium and olefins with concurrent production of an equimolar amount of 6 lithium hydride, ,' 10 11 The conventional technical method of producing organo-12 lithium compounds (Kirk-Othmer, "Enc Chem. Techn.", Vol 12, 13 p. 547, 19~7) is based on the reaction of lithium metal with 14 organic halogen compounds, in which organolithium compounds as well as l~thium halides are produced:
17 RX + 2 Li- ~ RLi + LiX (1) 18 X = Cl, Br, I
19 Allyllithium and benzyllithium compounds may among others be produced by the splitting of the corresponding ether derivative 21 or acyloxy derivative with lithium metal (J. A. Katzen-ellenbogen 22 R. S. Lenox, J. Org. Chem., 38, 326, 1973; U Schollko~f in 23 "Methoden der Organischen Chemie", Houben-Weyl, XIII/l, P. 161;
24 J. J. Eisch, A. M. 3acobs, J. Org. Chem 28, 2145, 1963):
ROR' + 2Li > R-Li + R'OLi (2) 26 R = allyl, benzyl 27 R'- phenyl, mesitoyl 29 From the organolithium compounds so produced, numerous I ot r orcanolithiu~, compounds may be obtsined b~ means of .
11~4533 1 1 metal-H exchange:
43 ~ ~-Li + R'H , R-H + R'-Li (3) 5 1 or by means of metal-halogen exchange (D. Seebach. K.-H. Geiss 6 1 in "New Applications of Organometallic Reagents in Organic 7 ¦ Synthesis", p.l, Elsevier, 1976):
8 ¦ R-Li + R'-X~ R'-Li + R-X ~4) 9 ¦ X = Cl, Br, I
.' 101 . ,.
11 1 Only in exceptional cases had it heretofore been possible to 12 ¦ synthesize organolithium compounds directly from lithium metal 13 ¦ and hydrocarbons. Thus, for instance, l-alkines (H. Ogura, 14 ¦ H. Takashi, Synth. Commun., 3 135, 1973), trip~enylmethane or acenaphtylene (B, J. Wakefield, "The Chemistry of Organolithiu 16 Compounds", p. 70, Pergamon Press, 1974) may be lithiated with 17 metallic lithium. According to D, L. Skinner et al (J. Org.
lB Chem.,32, 105, 1967) lithium reacts with 1-alkenes in the 19 absence of a solvent to produce l-alkinyllithium compounds and lithium hydride.:
21 RCH=CH2 + 4 Li ~ RC_C-Li ~ 3 LiH (5) 22 whereby l-lithio-l-alkenes are produced as byproducts of the 23 reaction, at very small yields. In the presence of tetrahydro-24 furan (THF) l-lithio -l-hexene was obtained from lithium and l-hexene at boiling temperatures, at 9% yield.
27 A procedure for the preparation of organolithium compounds 28 from lithium and ethylene in dimethoxymethane or THF in the 29 presence of biphenyl and, if the ca~e, naphLha~ene ~as recently 30 ~1 mzde o~n (V P~autenstrauch of Firmenich 5 A., Geneva, Swiss .
, . Patent 585, 760, May 20, 1974; V. Rautenstrauch, Angew, Chem., 2 ¦ 87, 254, 1975). The yields of organolithium compounds according
(3 ¦ The present invention relates to a catalyst system for 4 ¦ the preparation of organolithium compounds from lithium and olefins with concurrent production of an equimolar amount of 6 lithium hydride, ,' 10 11 The conventional technical method of producing organo-12 lithium compounds (Kirk-Othmer, "Enc Chem. Techn.", Vol 12, 13 p. 547, 19~7) is based on the reaction of lithium metal with 14 organic halogen compounds, in which organolithium compounds as well as l~thium halides are produced:
17 RX + 2 Li- ~ RLi + LiX (1) 18 X = Cl, Br, I
19 Allyllithium and benzyllithium compounds may among others be produced by the splitting of the corresponding ether derivative 21 or acyloxy derivative with lithium metal (J. A. Katzen-ellenbogen 22 R. S. Lenox, J. Org. Chem., 38, 326, 1973; U Schollko~f in 23 "Methoden der Organischen Chemie", Houben-Weyl, XIII/l, P. 161;
24 J. J. Eisch, A. M. 3acobs, J. Org. Chem 28, 2145, 1963):
ROR' + 2Li > R-Li + R'OLi (2) 26 R = allyl, benzyl 27 R'- phenyl, mesitoyl 29 From the organolithium compounds so produced, numerous I ot r orcanolithiu~, compounds may be obtsined b~ means of .
11~4533 1 1 metal-H exchange:
43 ~ ~-Li + R'H , R-H + R'-Li (3) 5 1 or by means of metal-halogen exchange (D. Seebach. K.-H. Geiss 6 1 in "New Applications of Organometallic Reagents in Organic 7 ¦ Synthesis", p.l, Elsevier, 1976):
8 ¦ R-Li + R'-X~ R'-Li + R-X ~4) 9 ¦ X = Cl, Br, I
.' 101 . ,.
11 1 Only in exceptional cases had it heretofore been possible to 12 ¦ synthesize organolithium compounds directly from lithium metal 13 ¦ and hydrocarbons. Thus, for instance, l-alkines (H. Ogura, 14 ¦ H. Takashi, Synth. Commun., 3 135, 1973), trip~enylmethane or acenaphtylene (B, J. Wakefield, "The Chemistry of Organolithiu 16 Compounds", p. 70, Pergamon Press, 1974) may be lithiated with 17 metallic lithium. According to D, L. Skinner et al (J. Org.
lB Chem.,32, 105, 1967) lithium reacts with 1-alkenes in the 19 absence of a solvent to produce l-alkinyllithium compounds and lithium hydride.:
21 RCH=CH2 + 4 Li ~ RC_C-Li ~ 3 LiH (5) 22 whereby l-lithio-l-alkenes are produced as byproducts of the 23 reaction, at very small yields. In the presence of tetrahydro-24 furan (THF) l-lithio -l-hexene was obtained from lithium and l-hexene at boiling temperatures, at 9% yield.
27 A procedure for the preparation of organolithium compounds 28 from lithium and ethylene in dimethoxymethane or THF in the 29 presence of biphenyl and, if the ca~e, naphLha~ene ~as recently 30 ~1 mzde o~n (V P~autenstrauch of Firmenich 5 A., Geneva, Swiss .
, . Patent 585, 760, May 20, 1974; V. Rautenstrauch, Angew, Chem., 2 ¦ 87, 254, 1975). The yields of organolithium compounds according
- 3 j to these procedures are at very low levels. Since the reaction
4 I products furthermore occur in the form of a mlxture of vinyl-
5 ¦ lithium and 1,4-dilithiobutane, this procedure hardly seems
6 I suitable for technical purposes.
7 I
8 1 SUMMARY OF THE INVENTION
9 l
10 ¦ The present invention provides a catalyst comprising
11 ¦ a composition of the formula
12 ¦ /A B \
4 ¦ ~ \D~ ~ ~ Men(L)p~L )q (*
16 ¦ wherein A and B are sulfur or oxygen 17 ¦ G is a carbon atom bonded to 18 ¦ a radical Rl l9 ¦ D is a carbon atom bonded to a 20 ¦ radical R2 and there is a double bond 21 ¦ between the carbon atom of G and of D;
22 ¦ E is carbon 23 ¦ F is oxygen, 24 ¦ sulfur, 26 = CR3 - CR4, or 23 = CR3 - CR4 Me is an alkaline metal n is an integer from 2 to 20;
~ L and L' are mono or poly-functional i . A
; ll 11~4S33 .
1 ~ ethers or amines;
2 ¦ p and q are integers from O to 4;
4 ~ Rl, R2, R3 and R are-independently hydrogen, .
5 ¦ alkyl, cycloalkyl, 6 ¦ aralkyl or aryl groups 7 ¦ and/or two or more of such groups are closed into ¦ an aliphatic or aromatic ring system; and 8 ~ .
10 ¦ a metal compound of transition metals from group Ib, IIb, 11 ¦ IVb, Vb, VIb, VIIb and VIII of the transition metals of the 12 ¦ periodic system.
4 ¦ ~ \D~ ~ ~ Men(L)p~L )q (*
16 ¦ wherein A and B are sulfur or oxygen 17 ¦ G is a carbon atom bonded to 18 ¦ a radical Rl l9 ¦ D is a carbon atom bonded to a 20 ¦ radical R2 and there is a double bond 21 ¦ between the carbon atom of G and of D;
22 ¦ E is carbon 23 ¦ F is oxygen, 24 ¦ sulfur, 26 = CR3 - CR4, or 23 = CR3 - CR4 Me is an alkaline metal n is an integer from 2 to 20;
~ L and L' are mono or poly-functional i . A
; ll 11~4S33 .
1 ~ ethers or amines;
2 ¦ p and q are integers from O to 4;
4 ~ Rl, R2, R3 and R are-independently hydrogen, .
5 ¦ alkyl, cycloalkyl, 6 ¦ aralkyl or aryl groups 7 ¦ and/or two or more of such groups are closed into ¦ an aliphatic or aromatic ring system; and 8 ~ .
10 ¦ a metal compound of transition metals from group Ib, IIb, 11 ¦ IVb, Vb, VIb, VIIb and VIII of the transition metals of the 12 ¦ periodic system.
13 ¦ Preferably Rl, R2, R3, R4 have less than about 20
14 ¦ carbon atoms. Alkyl groups include methyl, ethyl, isopropyl,
15 ¦ n d~cyl, stearyl.
I : Cycloalkyl groups include cyclopentyl, cyclohexyl, 18 ¦ decahydronaphthyi.
20 I .
l Aralkyl groups include benzyl, phenylethyl and 21 ¦ naphthyl methyl. Aryl groups include pXenyl, tolyl, xylyl, 22 ¦ naphthyl, penanthryl and diphenyl~
~wo groups closed in to an aliphatic ring system include propylene and butylene groups.
28 Two ~roups closed into an aromatic ring system include benzo and naphtho groups.
11~4533 l ¦ Preferably the ratio of moles of the composition of the 2 ~ formula (*) to the moles of transition compound is in the range 4 I from about l:lO to lO:l.
5 ¦ In the formulas (*) above, (**) and (***) below, certain 6 I single bonding lines may represent double bonds and there 7 ¦ can also be a bond between A and B when both A and B are 8 ¦ ¦ sulfur lO I Preferred catalysts of the present invention includ 6 tbose wherein the composition has the fol1Owing formula:
4 . ~ ~ C / ~X~ Men(Llp(L ) 18 and ~herein X is sulfur or oxygen.
21 A more preferred composition has the formula ( I - S
and the metal compound is cuprous chloride of ferric chloride.
3 ¦ Another preferred catalyst has a composition of the 4 ¦ formula 1~ ~ ~1~ \'C ~C~ R~M~ L)p~L ~q 11 I wherein X is sulfur or oxygen.-13 More preferred are catalysts of the formula (II) 14 wherein X is sulfur, R = R is C6H5, and
I : Cycloalkyl groups include cyclopentyl, cyclohexyl, 18 ¦ decahydronaphthyi.
20 I .
l Aralkyl groups include benzyl, phenylethyl and 21 ¦ naphthyl methyl. Aryl groups include pXenyl, tolyl, xylyl, 22 ¦ naphthyl, penanthryl and diphenyl~
~wo groups closed in to an aliphatic ring system include propylene and butylene groups.
28 Two ~roups closed into an aromatic ring system include benzo and naphtho groups.
11~4533 l ¦ Preferably the ratio of moles of the composition of the 2 ~ formula (*) to the moles of transition compound is in the range 4 I from about l:lO to lO:l.
5 ¦ In the formulas (*) above, (**) and (***) below, certain 6 I single bonding lines may represent double bonds and there 7 ¦ can also be a bond between A and B when both A and B are 8 ¦ ¦ sulfur lO I Preferred catalysts of the present invention includ 6 tbose wherein the composition has the fol1Owing formula:
4 . ~ ~ C / ~X~ Men(Llp(L ) 18 and ~herein X is sulfur or oxygen.
21 A more preferred composition has the formula ( I - S
and the metal compound is cuprous chloride of ferric chloride.
3 ¦ Another preferred catalyst has a composition of the 4 ¦ formula 1~ ~ ~1~ \'C ~C~ R~M~ L)p~L ~q 11 I wherein X is sulfur or oxygen.-13 More preferred are catalysts of the formula (II) 14 wherein X is sulfur, R = R is C6H5, and
16 R2 = R3 is hydrogen and
17 Me is lithium and
18 wherein the metal compound is zinc chloride, or palladium
19 chloride or wherein X is sulfur 221 Rl ~ R3 is C6H5, .
22 R = R4 is hydrogen and 23 Me is lLthium, and 24 wherein the metal compound is cupric chloride.
26 The metal compound can be of a metal selected from the 27 groups consisting of copper, gold, zinc, cadmium, titanium, 28 zirconium, vanadium, niobium, tantalum, chromium, molybdenum, 29 tungsten, manganese, iron, cobalt, nickel, ruthenium, rhodium, palladium, osmium, iridium and platinum.
. .
. ~
1 I Preferred metal compounds are of a metal selected from 2 ¦ the group consisting of copper, iron, zinc, palladium, platinum 3 ¦and rhodium.
4 l 5 ¦ Preferred metal compcunds include halides and organic 6 ¦complexes such as acetylacetonites, more preferred are transition 7 ¦metal chlorides.
9 ¦ Exemplary metal compounds include compounds selected from the group consisting of 11 zinc chloride, 12 iron (III) chloride 13 copper (I) chloride .
14 copper .(II) chloride molybdenum (VI) chloride 16 titanium (IV) chloride 17 chromium (III) chloride 18 molybdenum (V) chloride 19 managanese (II) chloride ~.
cobalt (II) chloride 21 nickel (II) chloride 22 nickel (II) acetylacetonate 23 rhodium (III) chloride 24 . platinum (II) chloride palladium (II) chloride 26 . The metal compound is preferably an anhydrous metal 2B compound.
29 In one aspect, the present invention provides a 30 l cata t co=position of metal complexes comprising l ¦ a polycyclic aromatic compound;
2 ¦ an alkali metal; and 3 1 a metal compound of transition metals 4 ¦ from group Ib, IIb, IVb, Vb, VIb, VIIb and 5 ¦ VIIIb of the periodic system.
, 61 7 ¦ The polycyclic aromatic compound has preferably from abou 8 ¦ 10 to 24 carbon atom. Typical aromatic compounds include ¦ naphthalene, lO ¦ anthracene, 11 ¦ phenanthrene, and 12 ¦ diphenyl 14 ¦ The alkaline metal can be lithium, sodium or 15 ¦ otassium and more preferred is lithium.
16 1 .
17 ¦ The present invention also provides a process for 18 ¦ reparation of organo lithium compounds and lithium hydride 19 ¦ comprising contacting lithium with ~ olefin or an a,~ -diolefin
22 R = R4 is hydrogen and 23 Me is lLthium, and 24 wherein the metal compound is cupric chloride.
26 The metal compound can be of a metal selected from the 27 groups consisting of copper, gold, zinc, cadmium, titanium, 28 zirconium, vanadium, niobium, tantalum, chromium, molybdenum, 29 tungsten, manganese, iron, cobalt, nickel, ruthenium, rhodium, palladium, osmium, iridium and platinum.
. .
. ~
1 I Preferred metal compounds are of a metal selected from 2 ¦ the group consisting of copper, iron, zinc, palladium, platinum 3 ¦and rhodium.
4 l 5 ¦ Preferred metal compcunds include halides and organic 6 ¦complexes such as acetylacetonites, more preferred are transition 7 ¦metal chlorides.
9 ¦ Exemplary metal compounds include compounds selected from the group consisting of 11 zinc chloride, 12 iron (III) chloride 13 copper (I) chloride .
14 copper .(II) chloride molybdenum (VI) chloride 16 titanium (IV) chloride 17 chromium (III) chloride 18 molybdenum (V) chloride 19 managanese (II) chloride ~.
cobalt (II) chloride 21 nickel (II) chloride 22 nickel (II) acetylacetonate 23 rhodium (III) chloride 24 . platinum (II) chloride palladium (II) chloride 26 . The metal compound is preferably an anhydrous metal 2B compound.
29 In one aspect, the present invention provides a 30 l cata t co=position of metal complexes comprising l ¦ a polycyclic aromatic compound;
2 ¦ an alkali metal; and 3 1 a metal compound of transition metals 4 ¦ from group Ib, IIb, IVb, Vb, VIb, VIIb and 5 ¦ VIIIb of the periodic system.
, 61 7 ¦ The polycyclic aromatic compound has preferably from abou 8 ¦ 10 to 24 carbon atom. Typical aromatic compounds include ¦ naphthalene, lO ¦ anthracene, 11 ¦ phenanthrene, and 12 ¦ diphenyl 14 ¦ The alkaline metal can be lithium, sodium or 15 ¦ otassium and more preferred is lithium.
16 1 .
17 ¦ The present invention also provides a process for 18 ¦ reparation of organo lithium compounds and lithium hydride 19 ¦ comprising contacting lithium with ~ olefin or an a,~ -diolefin
20 ¦ in the presence of a catalyst comprising:
21 1
22 ¦ a metal organic composition of the formula
23
24 S ~ ~ (**) 1 wherein A and B are sulfur or oxygen, 2 G is carbon bonded to a radical Rl 3 D is carbon bonded to a radicàl R2, 4 and, if A and B are oxygen, also to a hydrogen atom, 6 E is carbon, 7 F.is a member of the group consisting of 8 oxygen, 9 sulfur, hydroxy where B is oxygen, .
11 O .
12 - CHR3 - CR4 where B is oxygen, 13 . 0 14 = CR3 - CR4 where B is sulfur, and 15 . -S
16 = CR3 = CR4 where B is sulfur 17 R , R2, R3, R4 represent hydrogen, 18 alkyl, cycloalkyl, aralkyl or 19 aryl groups and/or two or more .
of such groups are closed into an 21 aliphatic or aromatic ring system, 22 and 23 M* represents a metal compound of metals from groups 24 Ib, IIb, I~, Vb, VIb, VIIb, and VIIIb or the periodic system and/or a group Men (L)p (L')q 26 wherein Me is an alkali metal 27 n is an inte~er from 2 to 20;
2~ L and L' are monofunctional or polyfunctional 29 ethers or amines, and ~0 p and q are integers from 0 to 4;
1 ¦and/or a composition of metal complexes comprising polycyclie 2 ¦ aromatics, an alkali metal, and a metal compound of transition 3 ¦metals from group Ib, IIb, IVb, Vb, VIb, VIIb and VIIIb of the 4 ¦ periodic system.
5 l 6 ¦ If A and B are sulfur in formula (II) there can .
7 I be a bond between A and B and when 8 I F is = CR3 ~ CR4 there is a bond between B and 9 ¦ the sulfur atom of the -S group.
11 ~ -CR4 12 ¦ A preferred metal organic composi~ion employed in 13 ¦ the process has the formula 18 ~ ~ C / ~x~ Me~L)p(L )q (I~
2l9 I , - . ................ .,. . .... . , ' ., 21 ¦wherein X is sulfur or oxygen and more preferred are .
22 ~ catalysts with compositions of the formula
11 O .
12 - CHR3 - CR4 where B is oxygen, 13 . 0 14 = CR3 - CR4 where B is sulfur, and 15 . -S
16 = CR3 = CR4 where B is sulfur 17 R , R2, R3, R4 represent hydrogen, 18 alkyl, cycloalkyl, aralkyl or 19 aryl groups and/or two or more .
of such groups are closed into an 21 aliphatic or aromatic ring system, 22 and 23 M* represents a metal compound of metals from groups 24 Ib, IIb, I~, Vb, VIb, VIIb, and VIIIb or the periodic system and/or a group Men (L)p (L')q 26 wherein Me is an alkali metal 27 n is an inte~er from 2 to 20;
2~ L and L' are monofunctional or polyfunctional 29 ethers or amines, and ~0 p and q are integers from 0 to 4;
1 ¦and/or a composition of metal complexes comprising polycyclie 2 ¦ aromatics, an alkali metal, and a metal compound of transition 3 ¦metals from group Ib, IIb, IVb, Vb, VIb, VIIb and VIIIb of the 4 ¦ periodic system.
5 l 6 ¦ If A and B are sulfur in formula (II) there can .
7 I be a bond between A and B and when 8 I F is = CR3 ~ CR4 there is a bond between B and 9 ¦ the sulfur atom of the -S group.
11 ~ -CR4 12 ¦ A preferred metal organic composi~ion employed in 13 ¦ the process has the formula 18 ~ ~ C / ~x~ Me~L)p(L )q (I~
2l9 I , - . ................ .,. . .... . , ' ., 21 ¦wherein X is sulfur or oxygen and more preferred are .
22 ~ catalysts with compositions of the formula
25 ~ ~ ~ ~ ) Lin ~ 2 Cu Cl 4~S33 .
I . ' -. .
2 land of the formula -~ L~n ~ Fe ~13 9 ¦ The metal organic composition can have the formula ',,'10 I . .
2 \~ ~'C I ~1M n( P q (Il) 16 1 .
17 ¦wherein X is sulfur or oxygen, and preferably 18 wherein X is sulfur, 19 ¦ R ' = R4 is phenyl, 2 0 I R - R is hydrogen and .
21 I Me is lithium, and 22 ¦wherein the metal compound is zinc chloride or palladium 23 I chloride or 24 ¦wherein X is sulfur 25 I Rl = R3 is phenyl
I . ' -. .
2 land of the formula -~ L~n ~ Fe ~13 9 ¦ The metal organic composition can have the formula ',,'10 I . .
2 \~ ~'C I ~1M n( P q (Il) 16 1 .
17 ¦wherein X is sulfur or oxygen, and preferably 18 wherein X is sulfur, 19 ¦ R ' = R4 is phenyl, 2 0 I R - R is hydrogen and .
21 I Me is lithium, and 22 ¦wherein the metal compound is zinc chloride or palladium 23 I chloride or 24 ¦wherein X is sulfur 25 I Rl = R3 is phenyl
26 ¦ R2 = R4 is hydrogen, and
27 ¦ Me is lithium, and
28 ~herein the metal compound is cupric chloride.
29 I .
~0 ¦ The metal compound of the catalyst employed in the 11~4533 1 ~ proces~ can be the metal compound of a metal selected from the 2 ¦ ~roup consistin~ of copper, gold, zinc, cadmium, titanium, 3 I zirconium, vanadium, niobium, t~ntalu~, chromium, molybdenum, 4 tungsten, manganese, iron, cobalt, nickel, ruthenium, rhodium, 5 ¦ palladium, osmium iridium and platinum, and preferably 6 ¦ the metal compound is of a metal selected from the group consist-7 ¦ ing of copper, iron, zinc, palladium, platinum and rhodium.
8 .
9 Typical metal compounds include those selected from the group cor.sisting of 11 zinc chloride, 12 iron (III) chloride, .
13 copper (I) chloride, 14 copper (II) chloride, molybdenum (VI) chloride, 16 titanium (IV) chloride, 17 chromium (III) chloride, 18 molybdenum (V) chloride, 19 manganese (II) chloride, cobalt (II) chloride, 21 nickel (II) chloride, 22 nickel (II) acetylacetonate, 23 rhodium (III) chloride, 24 platinum (II) chloride and palladium (II) chloride.
27 Preferably the metal compound is an anhydrous metal 28 compound.
A sDlvent can be added to the lithium, to ~he J - or . q 4~33 -~
11 . . .
2 ¦ the ~ diolefin and/or to the catalyst.
4 ¦ The solvents include cyclic or an open-chain monoether 5 ¦or polyethers such as the tetrahydrofuran. The catalyst can be 6 ¦formed in situ, by contacting lithium with compounds of the gen-7 ¦eral formulae III and IV, or V, VI and VII
8 ~
10 I S S , o ~ S --~ S
13 ~ / l c~x ~1' C ~ ~0 Rl~ C ~C ~ ~n~
l6 III .... IV v ''19 .' 2~ S - S o O ' 22 ~ C C ~ ~ R4 1~ C`c~ ~ ~`CH~ C ~ 4 (VI) (VII) 26 wherein X is sulfur or oxygen and alternatively lithium is, contacted with compounds of the general formulae III, IV, V, 28 VI, or VII and with a metal compound of transition metals from 29 groups Ib, IIb, IVb, Vb, VI~, VIIb, and VIII of the periodic system.
1 jAlso lithium can be contacted with a catalyst consisting of 2 ¦isolated adducts between compounds III to VII, and 3 !metal compounds of transition metals from groups Ib, IIb, IVb;
S ~Vb, VIb, VIIb and VIIIb of the periodic system.
6 Prefarably a member of the group consisting of the 7 reaction products of the formulae .
.~o ~ vbS.2cuc, 16 . ' . `~ .
17 , ;' ' , ''''' .,' 20 C6 ~ 2 CuC12 and ~ ~ s . 2 reC13 ¦~
2232. ' .
224 is contacted with lithium.
26 In a further aspect of the invention lithium is contacted 27 with a catalyst, producted from a polycyclic aromatic compound 28 such as anthracene, naphthalene or biphenyl and a metal compound 29 of metals from subgroups I, II, IV, V, VI, VII and VIII of the
~0 ¦ The metal compound of the catalyst employed in the 11~4533 1 ~ proces~ can be the metal compound of a metal selected from the 2 ¦ ~roup consistin~ of copper, gold, zinc, cadmium, titanium, 3 I zirconium, vanadium, niobium, t~ntalu~, chromium, molybdenum, 4 tungsten, manganese, iron, cobalt, nickel, ruthenium, rhodium, 5 ¦ palladium, osmium iridium and platinum, and preferably 6 ¦ the metal compound is of a metal selected from the group consist-7 ¦ ing of copper, iron, zinc, palladium, platinum and rhodium.
8 .
9 Typical metal compounds include those selected from the group cor.sisting of 11 zinc chloride, 12 iron (III) chloride, .
13 copper (I) chloride, 14 copper (II) chloride, molybdenum (VI) chloride, 16 titanium (IV) chloride, 17 chromium (III) chloride, 18 molybdenum (V) chloride, 19 manganese (II) chloride, cobalt (II) chloride, 21 nickel (II) chloride, 22 nickel (II) acetylacetonate, 23 rhodium (III) chloride, 24 platinum (II) chloride and palladium (II) chloride.
27 Preferably the metal compound is an anhydrous metal 28 compound.
A sDlvent can be added to the lithium, to ~he J - or . q 4~33 -~
11 . . .
2 ¦ the ~ diolefin and/or to the catalyst.
4 ¦ The solvents include cyclic or an open-chain monoether 5 ¦or polyethers such as the tetrahydrofuran. The catalyst can be 6 ¦formed in situ, by contacting lithium with compounds of the gen-7 ¦eral formulae III and IV, or V, VI and VII
8 ~
10 I S S , o ~ S --~ S
13 ~ / l c~x ~1' C ~ ~0 Rl~ C ~C ~ ~n~
l6 III .... IV v ''19 .' 2~ S - S o O ' 22 ~ C C ~ ~ R4 1~ C`c~ ~ ~`CH~ C ~ 4 (VI) (VII) 26 wherein X is sulfur or oxygen and alternatively lithium is, contacted with compounds of the general formulae III, IV, V, 28 VI, or VII and with a metal compound of transition metals from 29 groups Ib, IIb, IVb, Vb, VI~, VIIb, and VIII of the periodic system.
1 jAlso lithium can be contacted with a catalyst consisting of 2 ¦isolated adducts between compounds III to VII, and 3 !metal compounds of transition metals from groups Ib, IIb, IVb;
S ~Vb, VIb, VIIb and VIIIb of the periodic system.
6 Prefarably a member of the group consisting of the 7 reaction products of the formulae .
.~o ~ vbS.2cuc, 16 . ' . `~ .
17 , ;' ' , ''''' .,' 20 C6 ~ 2 CuC12 and ~ ~ s . 2 reC13 ¦~
2232. ' .
224 is contacted with lithium.
26 In a further aspect of the invention lithium is contacted 27 with a catalyst, producted from a polycyclic aromatic compound 28 such as anthracene, naphthalene or biphenyl and a metal compound 29 of metals from subgroups I, II, IV, V, VI, VII and VIII of the
30 per ic system.
;-- 1` . 114g533' ' 1 j The contacting can be from about -100 C to ~ 100 C, 2 ¦- and is preferably from about -20C and ~50C. Preferably the partial pressures prevailing in the process are less than 4 about 100 bar. The ~-olefines include those of the general .
formula CH2=CHR , wherein R is H, alkyl, aryl, cycloalkyl 6 or aralkyl, and *he a,w diolefins lnclude those of the 7 formula CH2 = CH - (CHR)n ~ CH = CH2 8 wherein R is hydrogen, alkyl, aryl, cycloalkyl or araikyl and-9 n is an integer from 1 to 6.
., ' 10 11 In a further aspect of the invention, a process is 12 provided for preparation of a catalyst comprising contacting 14 an organic compound of the formula .
16 /A B ~
17 I I \ (***) 18 ~ ~ F
21 wherein A and B are sulfur or oxygen 22 G is a carbon atom bonded to 23 a radical Rl 24 . D is a carbon atom bonded to a 2~ radical R2 and there is a double bond 26 between the carbon atom of G and of D.
27 E is carbo~
28 ~ F ~s oxygen ~ I
4533 ` .
1 - CR3 - CR4, or 2= CR3 - CR4 . . .
4Rl, R2, R3 and R4 are independently hydrogen, alkyl, 5cycloalkyl, aralkyl or aryl groups 6 . a~dlor two or more of such groups are .
7 closed into an aliphatic or aromatic .
B ring system;
an alkaline metal; and 11 .. ,, .
12 mono or poly-functional .
l43 ethers or amines.
lS A metal compound of transition metals from groups Ib, 16 IIb, IVb, Vb, VIb, VIIb and VIII of the periodic system can 18 be added to the resulting composition.
19 . Preferred organic compounds in preparing the catalyst 20 include those of the formulas ~.
~6 / C~ X 1~ /C ~ 1 C ~ ~C ~ C ~ 4 4533 ` ~ .
3 R1~ C ~ ~ 4 _ C ~ C~ ,C ~ F4 6' 1 , 7 I VI VII ' 8 I . , 9 ¦ wherein X is sulfur or oxygen.
,,' 10 I , .
11 ¦DETAILED DESCRIPTION OF THE INVENTION
12' ¦INCLUDING'PRE~ERRED EM~ODIMENTS
14 ¦In accordance with the present invention, it was 15 ¦ surprisingly found that a-~olefins and ,~-diolefins can be 16 ¦ reacted,with metallic,lithium in the presence of appropriate i7 ¦ catalysts, and the reaction products include p~re and stereo-18 ¦specific organolithium compounds and lithium hydride. The 19 ¦ reaction between lithium and olefins is carried out for practical 20 ¦ reasons in solvent such as a cyclic or open-chain monoether or 21 ¦ polyether (preferably tetrahydrofuran, THF) at temperatures from 22 ¦ about -100 to +100C and,preferably from about -20C to +50C and 23 ¦ at partial pressures of preferably below 1 bar and at from about 1 24 ¦ to 100 bar pressure.
26 ¦ Accordingly, the invention relatés to a process 'for 27 ¦ production of organolithium compounds in addition to lithium 28 ¦ hydride, wherein lithium is contacted with a catalyst from the 2 9 ¦ following group:
., :
~
4S33 .
1 (a) an alkali-metal complex compound of the 2 general formulae I or II
4 l C C ~ \
6 ~R1~ ~ C / ~X¦ ~len~L~p~L )q B (I) '-'10 . 11 ~ C ~ ) 16 . II
18 wherein Me is an alkali metal, 19 X is sulfur or oxygen;
n is an integer from 2 to 20; . .
21 L and L' are monofunctional or polyfunctional ethers 22 or amines;
23 p and q are integers from 0 to 4;
24 Rl, R2, R3 and R4 are hydrogen, alkyl, cycloalkyl, aralkyl or aryl groups; and/or 26 where two or more of such groups are 27 closed into an aliphatic or aromatic 28 ring system; or 4S33 `
I
1 ¦ (b) a catalyst according to (a) in the presence of 2 ¦ . . a metal compound of transition metals from 3 ¦ group Ib, IIb, IVb, Vb, Vlb, VIIb, and VIII
4 ¦ of the periodic system; or . ¦ (c) a catalyst, produced from polycyclic aromatics 6 ¦ such as anthracene, naphthalene and biphenyl and 7 ¦ alkali metal in the presence of a metal compound 8 ¦ of transition metals from group Ib, IIb, IVb, Vb, 9 ¦ VIb, VIIb, and VIII of the periodic system; or , 10 (d) adducts between compounds of the general formulae 11 III to VII
12 . .
l3 ~ `O
18 III , ; IV V
l29 . . , . .
21 S - S~ O O
22p1~ C ~ C ~ ~C ~ ~ ~4 ~ C~H~ C~ c ~ R4 23 l2 1l3 l~ b3 26 VI _ VII
27 in which Rl, R2, R3 and-R4 have the meanings indicated 28 under (a), and transition-metal compounds of transition 29 metals from group Ib, Ilb, IVb, Vb, VIb, 'IIb and VIII of the periodic system.in a solvent with an ~-olefin -2(i-533 ~ `
.' I
l ¦or ~ diolefin. - .
2 I .
- 3-The catalysts mentioned above under (a) and their preparation are described in German Patent Disclosure Record S27 22 221.5.
7The invention furthermore relates to catalysts from 9(a) an alkali metal complex compound of the general lOformulae I or II .
13 . I X ~ \
4 ~Rl~ C/ ~X~ Men~L)p(L Iq 16 . .
l8 l .
22 ~ ~ ~ ~ C / ~ C~ ~ n~ .(L)p~LlI
23 Il _ .
24 . . ~
in which Me is an àlkali-metal; X is sulfur or oxygen; n is 26 an integer from.2 to 20; ~ and L' are monofunctional or poly-27 functional ethers or amines; p and g are integers from 0 to 28 4; Rl, R2, R3 and R4 are hydrogen, alkyl, cycloalkyl, aralkyl 29 or aryl groups and/or where two or more of such groups are closed into an aliphatic or aromatic ring system; and 533 - .
1 (b) metal compounds of transition metals from group Ib, 2 ~ IIb, IVb, Vb, VIb, VIIb, and Vlllb of the period 3- ¦ system or from S (c) complexes of polycyclic aromatics such as antracene, 6 ¦ naphthalene and biphenyl, and an alkali-metal 7 with 8 I .
(d) a metal compound of transition metals of group lB, Ilb, IVb, Vb, VIb, VIIb, and VIlIb of the 11 ¦ periodic system.
12 I .
13 Among the metals from the group Ib, IIb, IVb, Vb, VIb, 14 VIIb and VlIIb of the periodic system are included copper, gold, zinc, cadmium, titanium, zirconium vanadium,niobium, 16 tantalum, chromium, molybdenum, tungsten, manganese, iron, 17 cobalt, nickel, ruthenium, rhodium, palladium osmium, iridium 18 or platinum. Of these, we prefer copper, iron, zinc, palladium, 19 platinum and rhodium.
21 Examples for the monofunctional or polyfunctional ethers 22 or amines designated by an L or L', in general formulae I and II, 23 are as follows: Cyclic ethers such as tetrahydrofuran or 24 glycol ether, and amines such as tetramethylethylene diamine or morpholine. The monofunctional or polyfunctional ethers or 26 amines have preferably less than about 10 carbon atom. Catalyst 27 formation may also be carried out in a manner such that compounds 28 of the general formulae III, IV, V, VI, and VII -- which are 29 also described in German Patent Disclosure Record No. 27 22 221.5 -- are mixed with alkali metals, preferably , 533 .
.
l lithium, and, if appropriate, with a metal compound of metals from subgroups I, II, IV, V, VI, VII and VIII of 3 ¦ the periodic system, in an appropriate solvent; and, if 4 ¦ appropriate, in the presence of ~ -olefins or ~ diolefins.
A particularly active and selectively operating catalyst 6 ¦ system, in the sense of the present procedure, is produced, 7 1 if 2,5-diphenyl-1,6,6a-trithiapentalene (V, R1=R4=C6H5, 8 R2=R3=H) is converted in combination with zinc chloride I in the presence of ~ -olefines or ~ diolefins in THF
lO ¦ with lithium (see Examples 40 - 42).
.11 12 Finally, it is also possible to let isolatable adducts 13 ¦ between compounds of the general formulae III - VTI, listed 14 above under (d), and trasition-metal compounds of subgroups I, II, IV, V, VI, VII or VIII of the periodic system 16 I operate as catalysts on the lithium and olefin or diolefin.
17 ¦ Thus, for instance, iron (III) chloride, copper (I) chloride, 18 ¦ and copper (II) chloride, as well as molybdenum (V) chloride 19 ¦ form, with 1,2-dithiol-3-thiones or 1,6,6a-trithia-pentalenes, 2 : 1 adducts which may be used instead of 21 ¦ a mixture of both components to produce the catalystfi. By 22 ~ the same token, the complex ortho-chloropalladio-2,5-diphenyl-23 ! 1,6,6a-trithiapentalene(6) which can be produced from 24 ¦1 2,5-diphenyl-1,6,6a-trithiapentalene and PdCl2 yields with 25 1' lithium in THF an active catalyst for the lithiation of olefins:, ' . , ,~
27 i1 - .
- 22 a -~ ~ S
2 ¦ 5 6 ~ ~ ' ~dC12 __ HCl ~ .
C~ \ ( c ~ l6 llThe catalytic lithiation of ethylene.with the aid of 12the catalysts according to the inve~tion, in for instance .
13 THF, lead to vinylIithium and lithium hydride:
. Cat/THF
152 2 ~ CH2=CHLi + LiH (7) 17 IThe vinyllithium soluble in THF may be separated from .
l8 ¦ the insoluble lithium hydride and may be further used in l9 solution or isolated in crystalline form. Depending on the 20 I catalyst, the yields of vinyllithium range from 60 to ~ore than 21 70 % of the amount calculated according to (7).
22 l 23 In the catalytic lithiation of propene according to the 24 ¦, procedure of the invention, there are generally produced four 25 j, isomeric organolithium compounds: Trans-1-propenyllithium ~9)~
2~ ci~ ropen~llithium (10), isopropenyl~ithiu~i (11) and 27 ! allyllithium (12), in addition to lithium hydride:
2.
- _3 -Cat/THF
CH2=CI~CH3 + 2 Li -1 jf~; \
( }'`C=C~ 3 `C-C .3 `C-C' 3 C~2-~n 2,~ ~,iH
\ ~ 10 ~ 8) , The selectivity of this reaction in relation to the formation of individual isomers may be controlled through the selection of the catalysts. Thus, in the presence of catalysts produced with the u~e of iron, copper, cobalt or zinc compounds, trans-l-propenylithium 9 is produced at high selectivity. On the other hand, the catalytic lithiation of propene may be controlled by using palladium, platinum or rhodium compounds in a manner such that predominantly allYllithium 12 is produced. One catalyst tha~
operates in a particularly selective fashion in this sense was found to be the palladium complex (6), with the aid of ~:hich allyllithium may be obtained with a selectivity of 85-90%. In the example of lithiation of l-butene with this palladium complex as a catalyst it is shown that higher ~ -olefins may also be selectively lithiated in the allyl position. On the other hand, using catalysts produced with the utilization of zinc, iron or copper compounds,higher 1 alkenes such as l-butene, l-pentene, l-octene and l,7-octadiene may also be selectively lithiated in the trans -1 position. Thus, for instance, l-octene may be lithiated with the aid of above-mentioned catalyst from 2,5-diphenyl-1,6,6a-trlthiapentalene and ZnC12, with a selectivity of more than 96% in the l-trans position.
H R H R
C=C / + 2 Li Cat./Solv. ~ ~ C=C ~ ~ LiH (9 H / H ' Li H
R = CH3, C2H5, n-C3H7, n-C6H~ (CH2)n- etc-If appropriate, the trans-l-lithio-l-alkenes may be isolated in analytically pure crystalline form. By means of crystallization, the ratio of trans-l-lithio-l-alkene is generally raised. The present procedure thus permits a selective preparation of trans-l-alkenyl or allyllithium compounds from ~-olefins or diolefins and lithium.
In the catalytic lithiation of 1,4-pentadiene in the presence of the 4,5-benzodithiol-3-thione 2CuC12 complex there is produced a heretofore unknown organolithium compound with the following structure:
~ ~ 5 ~C~C12 1~ > <~ (9 The starting point materials for the preparation of organolithium compounds in accordance with the present inven-tion are preferably ~ - olefins and ~,~ olefins having up to about 40 carbon atoms. They include those ~14~533 Gf the general formulae CH2=C~R, in which R = H, alkyl, aryl, cycloalkyl or aralkyl; or diolefins of the general formulae CH2=CH-(C~R)"-CH=CH2, in which R has the same significance as above,and n = 1 - 6.
.
The catalytic lithiation of ~-olefins or ~,~ -diolefins in accordance with the invention represents a new method of preparation of organolithium compounds which cannot be produced in any other way or can only be produced with great difficulty.
In lieu of the expensive and often toxic as well as hard-to-procure organohalogen compounds, the present procedure uses commercially available olefins. Moreover, when the conventional method is used, one-half of the lithium that is used winds up as a lithium halide, and is thus lost for further conversion. The procedure according to the invention supplies, besides the organolithium compound,highly reactive and technically valuable lithium hydride.
The entire amount of lithium applied is converted into valuable lithium compounds.
The present procedure permits a regioselective or stereo-selective synthesis of organolithium compounds, providing the capability of controlling the reaction by the proper choice of the catalyst or the reaction conditions, in a manner such that, depending on the need, different organolithium compounds may be obtained from the same starting-poin~ olefin.
_ _ _ 1~4533 The organolithium compounds that can be prepared by the present procedure may be used as in~tiators for anionic polymerisations of mono- olefins or diolefins, or as reagents for the introduction of organic unsaturated groups, as well as for reduction in organic svnthesis.
The followin~ examples represent preferred embodiments of the present invention.
Exam~
All experiments for the preparation of organolithium compounds are carried out in a protective gas atmosphere, such as argon.
Example 1 ~ S _ S
1 (o 1~ ~ 5 Z CuC12J 13 For the preparation of the 4,5-benzo-1,2-dithiol-3 -thione ~
2CuC12- complex (13), 2.83 g (21.05 mMoles)of anhydrous copper(II) chloride are suspended in 100 ml of benzene, are added to 2.00 g (10.85 mMoles) of 4,5-benzo-1,2-dithiol-3-thione, and the mixture is stirred for 18 hours at room temperature. The suspension is filtered, the precipitate is washed with benzene and dried at 10 3 Torr. This yields 3.58 g (7~% of theoretical) of the complex 13.C7H4S3Cu2C14 (453.16);
, . . _ , . _ .
i 11~4S33 calc. C 18.55, l~ 0.89, S 21.22, Cu 28.04, Cl 31.29;
found C 17.50, H 1.00, S 20.90, Cu 27.60, Cl 32.70.
A solution of 1.40 g (3.09 mMoles) of complex 13 in 100 ml of absolute THF is saturated with propene tl bar) at 0C;
immediately thereafter, 5.07 g (0.73 Moles) of lithium sand is added to the solution in a propene atmosphere at 0C and under stirrlng (molar ratio 13:Li = 1:236).~fter a temporary temperature rise, the absorption of propene starts after 10-15 minutes; the rate of propene absorption can be measured with the aid of a gas burette connected to the reaction vessel.
During the propene absorption, the suspension is stirred, wlth propene pressure kept st 1.1-1.2 bar and temperature kept at 0C to+2C. The dark brown reaction mixture absorbs 6.0 liters of propene (1 bar, 20C) until it is saturated within 49 hours (68.5% of theoretical). The suspension is filtered at OOr~ the precipitate is washed with THF and dried at 0.2 Torr. This yields 4.41 g !'" ~ of lithium hYdride ~ixed with a little lithium (0.135g of the mixture yield with ~2 257 ml of gas (1 bar, 20 C), consisting of 13D (70~), D2 (19%) and H2 (11%). For the purpose of analyzing the organolithiu~
compound in the solution, an aliquot of the solution (8.0 ml of a total of 142.0 ml) is concentrated under vacuum (0 2 torr) and the solid residue is hydrolyzed. The amount of ~as produced thereby is 335.5 ml (1 bar, 20C) and consists of propene (84.9~), THF (4.6~), 332 (3.5%) and acetylene (1.4%). From the amount of -'8-1~4533 propene, ~qu.8 permits calculation of a yield in organolithium compounds LiC3135 of 57.7~. In order to determine the distribution of isomers, 58.0 ml of the solution ar~ concentrated under vacuum (0.2 torr), the residue is dissolved in 60 ml of ether, mixed at 0C w1th 18.9 9 (174 m~]oles)of trimethylchlorosilane, and the mixture is stirred 12 hours at 20C. Hydrolysis or processing and distillation produces, in addition .to hexamethyldisiloxane, 7.3 g of a mixture of the isomeric silanes(CH3)3SiC3H5 (B.P.
87-89C/760 torr), consisting of trans -l- propenyltrimethylsilane 74.5~, cis -l- propenyltrimethylsilanc 1.7%, isopropenyltrimethylsilarl -8.1%; and allyltrimethylsilane 15.3%.
.
In order to isolate the trans -l- propenyllithium (9), 74.0 ml of the solution are concentrated under vaccuum (0.2 torr) to 33.0 ml, added to 50 ml pentane, mixed for lO minutes and filtered. For the purpose of crystalizing (9~ the filtrate is kept for 3 hours at -40C and for 12 hours at -78C. The crystals of (9) are filtered at -78C, are wash~d three times with 40 ml of cold pentane each, dried for one-half hour at -30C, one-half hour at 0C and one hour at.20C under vacuum (0.2 torr). This yields 9.25 9 of the trans -l- propenyllithium-tetrahydrofuran adduct, in the form of light brown crystals (Li-.content 6.51; yields 45.6~ of th~oretical, referred to lithium). The l}3-NI~R spectrum of the product (80 M13z, 10 % in (C2D5)20;
'~= 3.39 ~ (H~), 3.78 m (~
Li K ~ 6.17 m (~), 8.10 m (~ , 8.~8 d H ~ ~ C13 ~ (HC~; J~2 = 21 Hz) (9) - 2q 11~4533 agrees with that of D. Seyferth and L.G. Vaughan (J. Organomet.
Chem.1,-201, 1963) prepared from trans-l-chloro-l-propene and lithium (9).
For further purification, 9.0 g o~ the raw material are re-crystalized from a mixture of 18 ml of THF and 32 ml of pentane, as described above. This yields 6.5 g trans-l- propenyllithium-tetrahydrofuran adduct, in the form of colorless crystals.
C3H5Li-C4H8O (M.W. = 120.0); calc. 5.78~ Li; found 5.75 Li. The conversion of 6.0 g (49.7 mMole) of this product with trimethyl-chlorosilane, as described above, yields 5.43 g of (CH3)3SiC3H5 with the following composition: trans -l- propenyltrimethylsilane, 93.4%; cis-l- propenyltrimethylsilane, 0.4%; isopropenyltrimethyl-silane, 1.3%; and allyltrimethylsilane, 4.9~.
Example 2 ~ - S
~~~S
(3a) `~
.
A solution of 0.90 g (4.9 mMole) of 4.5-benzo-1,2-dithiol-3-thione (BDT) (3a) and 1.63 g (9.8 mMole) of FeC13 in 100 ml of THF are saturated with propene (1 bar) at 0C; immediately afterwards 4.87 g (0.70 Moles) of lithium sand are added to the solution in propene atmosphere at 0C and with mixing (molar ratio 3a:FeC13:Li = 1:2:143). After a temporary temperature .
.. 1144533 rise, the propene absorption starts after 10-15 minutes.
During the propene absorption,the suspension is stirred, the propene pressure is kept at 1.1-1.2 bar and the temperature is kept at 0C to+2C. Tlle reaction mixture absorbs until saturation within 71 hours, 3.8 liters of propene (1 bar,20C).
The suspension is filtered and the lithium hydride is washed with THF. Of the total of 114.0 ml of the filtrates, 8.0 ml are hydrolyzed as described in example 1 whereby 351 ml of gas ~1 bar, 20C) with the composition propene, 75.7%; THF, 7.8%; H2, 8.7~, and acetylene 2.i% are released. From the amount of propene, a total yield of LiC3H5 of 45% is calculated accordiny to Equ. 8. In the silylation of an aliquot of filtrate, as described in example 1, one obtains a mixture of isomeric silanes ~CH3)35iC3H5, of the following composition:
trans -1- propenyltrimethylsilane, 83.8%; cis-l-propenyltrimethyl-silane, 1.3%; isopropenyltrimethylsilane, 10.3%; and allyltri-methylsilane, 4.6%. This result means that in the present case the catalytic lithiation of propene occurs with a selectlvity of 83.8~ in the trans -l-position of the propene;
Examples 3 to 12 For the preparation o~ the 2,4-diphenyl-1,6,6a-trithiapentalene ~
2CuC12- complex (15) Example 6, 3.09 9 (23.0 mMoles) of anhydrous copper(II)chloride are suspended in 100 ml of toluene, added to
;-- 1` . 114g533' ' 1 j The contacting can be from about -100 C to ~ 100 C, 2 ¦- and is preferably from about -20C and ~50C. Preferably the partial pressures prevailing in the process are less than 4 about 100 bar. The ~-olefines include those of the general .
formula CH2=CHR , wherein R is H, alkyl, aryl, cycloalkyl 6 or aralkyl, and *he a,w diolefins lnclude those of the 7 formula CH2 = CH - (CHR)n ~ CH = CH2 8 wherein R is hydrogen, alkyl, aryl, cycloalkyl or araikyl and-9 n is an integer from 1 to 6.
., ' 10 11 In a further aspect of the invention, a process is 12 provided for preparation of a catalyst comprising contacting 14 an organic compound of the formula .
16 /A B ~
17 I I \ (***) 18 ~ ~ F
21 wherein A and B are sulfur or oxygen 22 G is a carbon atom bonded to 23 a radical Rl 24 . D is a carbon atom bonded to a 2~ radical R2 and there is a double bond 26 between the carbon atom of G and of D.
27 E is carbo~
28 ~ F ~s oxygen ~ I
4533 ` .
1 - CR3 - CR4, or 2= CR3 - CR4 . . .
4Rl, R2, R3 and R4 are independently hydrogen, alkyl, 5cycloalkyl, aralkyl or aryl groups 6 . a~dlor two or more of such groups are .
7 closed into an aliphatic or aromatic .
B ring system;
an alkaline metal; and 11 .. ,, .
12 mono or poly-functional .
l43 ethers or amines.
lS A metal compound of transition metals from groups Ib, 16 IIb, IVb, Vb, VIb, VIIb and VIII of the periodic system can 18 be added to the resulting composition.
19 . Preferred organic compounds in preparing the catalyst 20 include those of the formulas ~.
~6 / C~ X 1~ /C ~ 1 C ~ ~C ~ C ~ 4 4533 ` ~ .
3 R1~ C ~ ~ 4 _ C ~ C~ ,C ~ F4 6' 1 , 7 I VI VII ' 8 I . , 9 ¦ wherein X is sulfur or oxygen.
,,' 10 I , .
11 ¦DETAILED DESCRIPTION OF THE INVENTION
12' ¦INCLUDING'PRE~ERRED EM~ODIMENTS
14 ¦In accordance with the present invention, it was 15 ¦ surprisingly found that a-~olefins and ,~-diolefins can be 16 ¦ reacted,with metallic,lithium in the presence of appropriate i7 ¦ catalysts, and the reaction products include p~re and stereo-18 ¦specific organolithium compounds and lithium hydride. The 19 ¦ reaction between lithium and olefins is carried out for practical 20 ¦ reasons in solvent such as a cyclic or open-chain monoether or 21 ¦ polyether (preferably tetrahydrofuran, THF) at temperatures from 22 ¦ about -100 to +100C and,preferably from about -20C to +50C and 23 ¦ at partial pressures of preferably below 1 bar and at from about 1 24 ¦ to 100 bar pressure.
26 ¦ Accordingly, the invention relatés to a process 'for 27 ¦ production of organolithium compounds in addition to lithium 28 ¦ hydride, wherein lithium is contacted with a catalyst from the 2 9 ¦ following group:
., :
~
4S33 .
1 (a) an alkali-metal complex compound of the 2 general formulae I or II
4 l C C ~ \
6 ~R1~ ~ C / ~X¦ ~len~L~p~L )q B (I) '-'10 . 11 ~ C ~ ) 16 . II
18 wherein Me is an alkali metal, 19 X is sulfur or oxygen;
n is an integer from 2 to 20; . .
21 L and L' are monofunctional or polyfunctional ethers 22 or amines;
23 p and q are integers from 0 to 4;
24 Rl, R2, R3 and R4 are hydrogen, alkyl, cycloalkyl, aralkyl or aryl groups; and/or 26 where two or more of such groups are 27 closed into an aliphatic or aromatic 28 ring system; or 4S33 `
I
1 ¦ (b) a catalyst according to (a) in the presence of 2 ¦ . . a metal compound of transition metals from 3 ¦ group Ib, IIb, IVb, Vb, Vlb, VIIb, and VIII
4 ¦ of the periodic system; or . ¦ (c) a catalyst, produced from polycyclic aromatics 6 ¦ such as anthracene, naphthalene and biphenyl and 7 ¦ alkali metal in the presence of a metal compound 8 ¦ of transition metals from group Ib, IIb, IVb, Vb, 9 ¦ VIb, VIIb, and VIII of the periodic system; or , 10 (d) adducts between compounds of the general formulae 11 III to VII
12 . .
l3 ~ `O
18 III , ; IV V
l29 . . , . .
21 S - S~ O O
22p1~ C ~ C ~ ~C ~ ~ ~4 ~ C~H~ C~ c ~ R4 23 l2 1l3 l~ b3 26 VI _ VII
27 in which Rl, R2, R3 and-R4 have the meanings indicated 28 under (a), and transition-metal compounds of transition 29 metals from group Ib, Ilb, IVb, Vb, VIb, 'IIb and VIII of the periodic system.in a solvent with an ~-olefin -2(i-533 ~ `
.' I
l ¦or ~ diolefin. - .
2 I .
- 3-The catalysts mentioned above under (a) and their preparation are described in German Patent Disclosure Record S27 22 221.5.
7The invention furthermore relates to catalysts from 9(a) an alkali metal complex compound of the general lOformulae I or II .
13 . I X ~ \
4 ~Rl~ C/ ~X~ Men~L)p(L Iq 16 . .
l8 l .
22 ~ ~ ~ ~ C / ~ C~ ~ n~ .(L)p~LlI
23 Il _ .
24 . . ~
in which Me is an àlkali-metal; X is sulfur or oxygen; n is 26 an integer from.2 to 20; ~ and L' are monofunctional or poly-27 functional ethers or amines; p and g are integers from 0 to 28 4; Rl, R2, R3 and R4 are hydrogen, alkyl, cycloalkyl, aralkyl 29 or aryl groups and/or where two or more of such groups are closed into an aliphatic or aromatic ring system; and 533 - .
1 (b) metal compounds of transition metals from group Ib, 2 ~ IIb, IVb, Vb, VIb, VIIb, and Vlllb of the period 3- ¦ system or from S (c) complexes of polycyclic aromatics such as antracene, 6 ¦ naphthalene and biphenyl, and an alkali-metal 7 with 8 I .
(d) a metal compound of transition metals of group lB, Ilb, IVb, Vb, VIb, VIIb, and VIlIb of the 11 ¦ periodic system.
12 I .
13 Among the metals from the group Ib, IIb, IVb, Vb, VIb, 14 VIIb and VlIIb of the periodic system are included copper, gold, zinc, cadmium, titanium, zirconium vanadium,niobium, 16 tantalum, chromium, molybdenum, tungsten, manganese, iron, 17 cobalt, nickel, ruthenium, rhodium, palladium osmium, iridium 18 or platinum. Of these, we prefer copper, iron, zinc, palladium, 19 platinum and rhodium.
21 Examples for the monofunctional or polyfunctional ethers 22 or amines designated by an L or L', in general formulae I and II, 23 are as follows: Cyclic ethers such as tetrahydrofuran or 24 glycol ether, and amines such as tetramethylethylene diamine or morpholine. The monofunctional or polyfunctional ethers or 26 amines have preferably less than about 10 carbon atom. Catalyst 27 formation may also be carried out in a manner such that compounds 28 of the general formulae III, IV, V, VI, and VII -- which are 29 also described in German Patent Disclosure Record No. 27 22 221.5 -- are mixed with alkali metals, preferably , 533 .
.
l lithium, and, if appropriate, with a metal compound of metals from subgroups I, II, IV, V, VI, VII and VIII of 3 ¦ the periodic system, in an appropriate solvent; and, if 4 ¦ appropriate, in the presence of ~ -olefins or ~ diolefins.
A particularly active and selectively operating catalyst 6 ¦ system, in the sense of the present procedure, is produced, 7 1 if 2,5-diphenyl-1,6,6a-trithiapentalene (V, R1=R4=C6H5, 8 R2=R3=H) is converted in combination with zinc chloride I in the presence of ~ -olefines or ~ diolefins in THF
lO ¦ with lithium (see Examples 40 - 42).
.11 12 Finally, it is also possible to let isolatable adducts 13 ¦ between compounds of the general formulae III - VTI, listed 14 above under (d), and trasition-metal compounds of subgroups I, II, IV, V, VI, VII or VIII of the periodic system 16 I operate as catalysts on the lithium and olefin or diolefin.
17 ¦ Thus, for instance, iron (III) chloride, copper (I) chloride, 18 ¦ and copper (II) chloride, as well as molybdenum (V) chloride 19 ¦ form, with 1,2-dithiol-3-thiones or 1,6,6a-trithia-pentalenes, 2 : 1 adducts which may be used instead of 21 ¦ a mixture of both components to produce the catalystfi. By 22 ~ the same token, the complex ortho-chloropalladio-2,5-diphenyl-23 ! 1,6,6a-trithiapentalene(6) which can be produced from 24 ¦1 2,5-diphenyl-1,6,6a-trithiapentalene and PdCl2 yields with 25 1' lithium in THF an active catalyst for the lithiation of olefins:, ' . , ,~
27 i1 - .
- 22 a -~ ~ S
2 ¦ 5 6 ~ ~ ' ~dC12 __ HCl ~ .
C~ \ ( c ~ l6 llThe catalytic lithiation of ethylene.with the aid of 12the catalysts according to the inve~tion, in for instance .
13 THF, lead to vinylIithium and lithium hydride:
. Cat/THF
152 2 ~ CH2=CHLi + LiH (7) 17 IThe vinyllithium soluble in THF may be separated from .
l8 ¦ the insoluble lithium hydride and may be further used in l9 solution or isolated in crystalline form. Depending on the 20 I catalyst, the yields of vinyllithium range from 60 to ~ore than 21 70 % of the amount calculated according to (7).
22 l 23 In the catalytic lithiation of propene according to the 24 ¦, procedure of the invention, there are generally produced four 25 j, isomeric organolithium compounds: Trans-1-propenyllithium ~9)~
2~ ci~ ropen~llithium (10), isopropenyl~ithiu~i (11) and 27 ! allyllithium (12), in addition to lithium hydride:
2.
- _3 -Cat/THF
CH2=CI~CH3 + 2 Li -1 jf~; \
( }'`C=C~ 3 `C-C .3 `C-C' 3 C~2-~n 2,~ ~,iH
\ ~ 10 ~ 8) , The selectivity of this reaction in relation to the formation of individual isomers may be controlled through the selection of the catalysts. Thus, in the presence of catalysts produced with the u~e of iron, copper, cobalt or zinc compounds, trans-l-propenylithium 9 is produced at high selectivity. On the other hand, the catalytic lithiation of propene may be controlled by using palladium, platinum or rhodium compounds in a manner such that predominantly allYllithium 12 is produced. One catalyst tha~
operates in a particularly selective fashion in this sense was found to be the palladium complex (6), with the aid of ~:hich allyllithium may be obtained with a selectivity of 85-90%. In the example of lithiation of l-butene with this palladium complex as a catalyst it is shown that higher ~ -olefins may also be selectively lithiated in the allyl position. On the other hand, using catalysts produced with the utilization of zinc, iron or copper compounds,higher 1 alkenes such as l-butene, l-pentene, l-octene and l,7-octadiene may also be selectively lithiated in the trans -1 position. Thus, for instance, l-octene may be lithiated with the aid of above-mentioned catalyst from 2,5-diphenyl-1,6,6a-trlthiapentalene and ZnC12, with a selectivity of more than 96% in the l-trans position.
H R H R
C=C / + 2 Li Cat./Solv. ~ ~ C=C ~ ~ LiH (9 H / H ' Li H
R = CH3, C2H5, n-C3H7, n-C6H~ (CH2)n- etc-If appropriate, the trans-l-lithio-l-alkenes may be isolated in analytically pure crystalline form. By means of crystallization, the ratio of trans-l-lithio-l-alkene is generally raised. The present procedure thus permits a selective preparation of trans-l-alkenyl or allyllithium compounds from ~-olefins or diolefins and lithium.
In the catalytic lithiation of 1,4-pentadiene in the presence of the 4,5-benzodithiol-3-thione 2CuC12 complex there is produced a heretofore unknown organolithium compound with the following structure:
~ ~ 5 ~C~C12 1~ > <~ (9 The starting point materials for the preparation of organolithium compounds in accordance with the present inven-tion are preferably ~ - olefins and ~,~ olefins having up to about 40 carbon atoms. They include those ~14~533 Gf the general formulae CH2=C~R, in which R = H, alkyl, aryl, cycloalkyl or aralkyl; or diolefins of the general formulae CH2=CH-(C~R)"-CH=CH2, in which R has the same significance as above,and n = 1 - 6.
.
The catalytic lithiation of ~-olefins or ~,~ -diolefins in accordance with the invention represents a new method of preparation of organolithium compounds which cannot be produced in any other way or can only be produced with great difficulty.
In lieu of the expensive and often toxic as well as hard-to-procure organohalogen compounds, the present procedure uses commercially available olefins. Moreover, when the conventional method is used, one-half of the lithium that is used winds up as a lithium halide, and is thus lost for further conversion. The procedure according to the invention supplies, besides the organolithium compound,highly reactive and technically valuable lithium hydride.
The entire amount of lithium applied is converted into valuable lithium compounds.
The present procedure permits a regioselective or stereo-selective synthesis of organolithium compounds, providing the capability of controlling the reaction by the proper choice of the catalyst or the reaction conditions, in a manner such that, depending on the need, different organolithium compounds may be obtained from the same starting-poin~ olefin.
_ _ _ 1~4533 The organolithium compounds that can be prepared by the present procedure may be used as in~tiators for anionic polymerisations of mono- olefins or diolefins, or as reagents for the introduction of organic unsaturated groups, as well as for reduction in organic svnthesis.
The followin~ examples represent preferred embodiments of the present invention.
Exam~
All experiments for the preparation of organolithium compounds are carried out in a protective gas atmosphere, such as argon.
Example 1 ~ S _ S
1 (o 1~ ~ 5 Z CuC12J 13 For the preparation of the 4,5-benzo-1,2-dithiol-3 -thione ~
2CuC12- complex (13), 2.83 g (21.05 mMoles)of anhydrous copper(II) chloride are suspended in 100 ml of benzene, are added to 2.00 g (10.85 mMoles) of 4,5-benzo-1,2-dithiol-3-thione, and the mixture is stirred for 18 hours at room temperature. The suspension is filtered, the precipitate is washed with benzene and dried at 10 3 Torr. This yields 3.58 g (7~% of theoretical) of the complex 13.C7H4S3Cu2C14 (453.16);
, . . _ , . _ .
i 11~4S33 calc. C 18.55, l~ 0.89, S 21.22, Cu 28.04, Cl 31.29;
found C 17.50, H 1.00, S 20.90, Cu 27.60, Cl 32.70.
A solution of 1.40 g (3.09 mMoles) of complex 13 in 100 ml of absolute THF is saturated with propene tl bar) at 0C;
immediately thereafter, 5.07 g (0.73 Moles) of lithium sand is added to the solution in a propene atmosphere at 0C and under stirrlng (molar ratio 13:Li = 1:236).~fter a temporary temperature rise, the absorption of propene starts after 10-15 minutes; the rate of propene absorption can be measured with the aid of a gas burette connected to the reaction vessel.
During the propene absorption, the suspension is stirred, wlth propene pressure kept st 1.1-1.2 bar and temperature kept at 0C to+2C. The dark brown reaction mixture absorbs 6.0 liters of propene (1 bar, 20C) until it is saturated within 49 hours (68.5% of theoretical). The suspension is filtered at OOr~ the precipitate is washed with THF and dried at 0.2 Torr. This yields 4.41 g !'" ~ of lithium hYdride ~ixed with a little lithium (0.135g of the mixture yield with ~2 257 ml of gas (1 bar, 20 C), consisting of 13D (70~), D2 (19%) and H2 (11%). For the purpose of analyzing the organolithiu~
compound in the solution, an aliquot of the solution (8.0 ml of a total of 142.0 ml) is concentrated under vacuum (0 2 torr) and the solid residue is hydrolyzed. The amount of ~as produced thereby is 335.5 ml (1 bar, 20C) and consists of propene (84.9~), THF (4.6~), 332 (3.5%) and acetylene (1.4%). From the amount of -'8-1~4533 propene, ~qu.8 permits calculation of a yield in organolithium compounds LiC3135 of 57.7~. In order to determine the distribution of isomers, 58.0 ml of the solution ar~ concentrated under vacuum (0.2 torr), the residue is dissolved in 60 ml of ether, mixed at 0C w1th 18.9 9 (174 m~]oles)of trimethylchlorosilane, and the mixture is stirred 12 hours at 20C. Hydrolysis or processing and distillation produces, in addition .to hexamethyldisiloxane, 7.3 g of a mixture of the isomeric silanes(CH3)3SiC3H5 (B.P.
87-89C/760 torr), consisting of trans -l- propenyltrimethylsilane 74.5~, cis -l- propenyltrimethylsilanc 1.7%, isopropenyltrimethylsilarl -8.1%; and allyltrimethylsilane 15.3%.
.
In order to isolate the trans -l- propenyllithium (9), 74.0 ml of the solution are concentrated under vaccuum (0.2 torr) to 33.0 ml, added to 50 ml pentane, mixed for lO minutes and filtered. For the purpose of crystalizing (9~ the filtrate is kept for 3 hours at -40C and for 12 hours at -78C. The crystals of (9) are filtered at -78C, are wash~d three times with 40 ml of cold pentane each, dried for one-half hour at -30C, one-half hour at 0C and one hour at.20C under vacuum (0.2 torr). This yields 9.25 9 of the trans -l- propenyllithium-tetrahydrofuran adduct, in the form of light brown crystals (Li-.content 6.51; yields 45.6~ of th~oretical, referred to lithium). The l}3-NI~R spectrum of the product (80 M13z, 10 % in (C2D5)20;
'~= 3.39 ~ (H~), 3.78 m (~
Li K ~ 6.17 m (~), 8.10 m (~ , 8.~8 d H ~ ~ C13 ~ (HC~; J~2 = 21 Hz) (9) - 2q 11~4533 agrees with that of D. Seyferth and L.G. Vaughan (J. Organomet.
Chem.1,-201, 1963) prepared from trans-l-chloro-l-propene and lithium (9).
For further purification, 9.0 g o~ the raw material are re-crystalized from a mixture of 18 ml of THF and 32 ml of pentane, as described above. This yields 6.5 g trans-l- propenyllithium-tetrahydrofuran adduct, in the form of colorless crystals.
C3H5Li-C4H8O (M.W. = 120.0); calc. 5.78~ Li; found 5.75 Li. The conversion of 6.0 g (49.7 mMole) of this product with trimethyl-chlorosilane, as described above, yields 5.43 g of (CH3)3SiC3H5 with the following composition: trans -l- propenyltrimethylsilane, 93.4%; cis-l- propenyltrimethylsilane, 0.4%; isopropenyltrimethyl-silane, 1.3%; and allyltrimethylsilane, 4.9~.
Example 2 ~ - S
~~~S
(3a) `~
.
A solution of 0.90 g (4.9 mMole) of 4.5-benzo-1,2-dithiol-3-thione (BDT) (3a) and 1.63 g (9.8 mMole) of FeC13 in 100 ml of THF are saturated with propene (1 bar) at 0C; immediately afterwards 4.87 g (0.70 Moles) of lithium sand are added to the solution in propene atmosphere at 0C and with mixing (molar ratio 3a:FeC13:Li = 1:2:143). After a temporary temperature .
.. 1144533 rise, the propene absorption starts after 10-15 minutes.
During the propene absorption,the suspension is stirred, the propene pressure is kept at 1.1-1.2 bar and the temperature is kept at 0C to+2C. Tlle reaction mixture absorbs until saturation within 71 hours, 3.8 liters of propene (1 bar,20C).
The suspension is filtered and the lithium hydride is washed with THF. Of the total of 114.0 ml of the filtrates, 8.0 ml are hydrolyzed as described in example 1 whereby 351 ml of gas ~1 bar, 20C) with the composition propene, 75.7%; THF, 7.8%; H2, 8.7~, and acetylene 2.i% are released. From the amount of propene, a total yield of LiC3H5 of 45% is calculated accordiny to Equ. 8. In the silylation of an aliquot of filtrate, as described in example 1, one obtains a mixture of isomeric silanes ~CH3)35iC3H5, of the following composition:
trans -1- propenyltrimethylsilane, 83.8%; cis-l-propenyltrimethyl-silane, 1.3%; isopropenyltrimethylsilane, 10.3%; and allyltri-methylsilane, 4.6%. This result means that in the present case the catalytic lithiation of propene occurs with a selectlvity of 83.8~ in the trans -l-position of the propene;
Examples 3 to 12 For the preparation o~ the 2,4-diphenyl-1,6,6a-trithiapentalene ~
2CuC12- complex (15) Example 6, 3.09 9 (23.0 mMoles) of anhydrous copper(II)chloride are suspended in 100 ml of toluene, added to
-31-~W~J 2 CuC1 . , .
_ 15 3.73 g ~12.0 n~oles) of 2,4-diphenyl-1,6,6a-trithiapentalene, and the mixture is stirred for 18 hours at room temperature.
The suspension is filtered, the precipitate is washed.with toluene, and dried at 10-3 torr. One obtains 4.0 g (60% of theoretical) of the complex (15). C17~12S3Cu2C14 (580.8).
calc. C 35.12, H 2.07, S 16.56, Cu 21.88, Cl 24.41. Found C 34.85, H 2.55, S 16.34, Cu 21.78, Cl 24.35.
~. ', . .
Implementation of the examples 3 to 12 (.Table 1): the components of the catalysts are previously added to THF, the suspension is stirred if appropriate for 12 hours at 20C; immediately thereafter, the preparations are saturated at respective reaction temperature with.propene (1 bar), and lithium sand is added in a propene atmosphere under stlrring. The amounts of propene absorbed after specific reaction times (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (9:10:11:12) are indicated in Table 1. The determination of the yields and the isomer ratios are carried out as described in Example 1.
.
_ 15 3.73 g ~12.0 n~oles) of 2,4-diphenyl-1,6,6a-trithiapentalene, and the mixture is stirred for 18 hours at room temperature.
The suspension is filtered, the precipitate is washed.with toluene, and dried at 10-3 torr. One obtains 4.0 g (60% of theoretical) of the complex (15). C17~12S3Cu2C14 (580.8).
calc. C 35.12, H 2.07, S 16.56, Cu 21.88, Cl 24.41. Found C 34.85, H 2.55, S 16.34, Cu 21.78, Cl 24.35.
~. ', . .
Implementation of the examples 3 to 12 (.Table 1): the components of the catalysts are previously added to THF, the suspension is stirred if appropriate for 12 hours at 20C; immediately thereafter, the preparations are saturated at respective reaction temperature with.propene (1 bar), and lithium sand is added in a propene atmosphere under stlrring. The amounts of propene absorbed after specific reaction times (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (9:10:11:12) are indicated in Table 1. The determination of the yields and the isomer ratios are carried out as described in Example 1.
.
-32-11~4533 _ o~ r N ~ o r~
u~ O ~ r- o r~
~:-- ~ ~ ~r a~ ~D O ~ O
~,-1 ~ ~I ~ O r~
o_ ~ ~ -I
O
.,1 _ CD ~ ~ ~
~ O . , . ~ .
!r O ~
C o_ ~ ~D ~ 1"1 0 C~ a~ ~D r u~
.~ ~ S
O ~ dO U~
. ._, I~
O -,~ ~ ~ ~U~ o ~ ~~
3 h 0 ,~ ~ _I `1 0 :~1 ~
,1 ~I E ~ ~ o~
E~ 3 O
O r ~ o o o o o +
~ _ _ -- ,~ ô
.,~ ~ ~ o o o :~ o . _ o o o u~ ~
~ E~ o o o o o ..
~ Q ~ Q
.--1 .IJ E ~ N ~ + ` ~ N
_ ~
aJ O O O
E~ O
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11'~4533 o u~ N
:~1 U--~ C-, . ~
co ~ Vo' .0 'vol ~ O, E ~ N
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a~ o N
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.
aJ O V~
~a . ~a O h r~ _~ CO
h O ~1 N . ~J N
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.
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1:
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t, o o ~ U~
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c~ . ~a / ~
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O
O ~ 3 h OQ.
v \
a) Q1 Q~
o c~l m D C) , , .
_ _ _ _ _ _ 114~533 Examples 13 to 24 Implementation of Examples 13 to 24 (Table 2):
4,5-Benzo-1,2-dithiol-3-thione (BDT) (3a) and respective metal salt (molar ratio BDT:metal salt = 1:2) are stirred in 60 ml of THF for 12 hours at 20C; immediately afterwards, the prepara-tion is saturated at 0C with propene (1 bar), and lithium sand is added in a propene atmosphere and under stirring. The amounts of propene absorbed after specific reactiontimes (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (_:10:11:12) are indicated in Table 2. The determination_ _ of the yields and the isomer ratios are carried out as described in Example 1.
Examples 25 to 27 Preparation of the ortho-chloropalladio-2,5-diphenyl-1,6,6a-trithiapentalene complex (8) (Example 25):
To the suspension of 3.10 g (9.94 mMole) of 2,5-diphenyl-1,6,6a-trithiapentalene in a mixture of 230 ml of methanol and 25 ml of benzene, one adds 1.76 g ~9.92 mMoles) of PdC12 followed by 1.33 g (31.3 mMoles) of LiCl dissolved in 20 ml methanol.
The suspension is boiled for 3 hours under stirring, with reflux, and after cooling to room temperature it is filtered through a G-3 glass filter crucible. In the mother liquor, 93.6% of the split-off HCl was determined acidimetrically. The precipitate was washed with methanol and ether and was dried at 10 torr. The yield of (8) (M.P. 304C, decomp.) amounts to 4.38 g (97~).
C17Hl1S3PdCl (453.8);
Calc. C 44.94, H 2.64, S 21.15, Pd 23.44, Cl 7.82;
Fd. C 44.92, H 2.90, S 21.08, Pd 23.21, Cl 7.86.
Implementation of Examples 25 to 27 (Table 3):
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The solution or suspension of the catalyst in THF is saturated at 0C with propene (1 bar) and immediately thereafter lithium sand is added in a propene atmosphere and under stirring. The amounts of propene absorbed at the specific times (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (9:10:11:12) are indicated in Table 3. The determina-tion of the yields and of the isomer ratios was carried out as described in Example 1.
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Examples 28 to 33 L ~ s 2 FeCl~
(16) preparation of 4,5-benzo-1,2-dithiol-3-thione 2 FeC13- complex (16) (Example 29):
To the suspension of 1.89 g (11.6 mMoles) of the anhydrous FeC13 in 80 ml of benzene, the solution of 1.07 g (5.8 mMoles) of 4,5-benzo-1,2-dithiol-3-thione (3a) in 70 ml of benzene is added in dropwise fashion with stirring; immediately thereafter, the mixture is stirred for 24 hours at 20C. The suspension is filtered, the precipitate is washed with benzene and dried at 10 3 torr. One obtains 2.36 g (80% of theoretical) of the complex (16). C7H4S3Fe2C16 (508.7);
calc. C 16.52, H 0.78, Fe 21.97, S 18.90, Cl 41.84;
fd. C 16.55, H 0.82, Fe 21.91, S 18.84, Cl 41.76.
Implementation of Examples 28 to 33 (Table 4):
The catalysts are previously added to THF, the solution is saturated with ethylene (1 bar) at 0C; immediately thereafter, lithium sand is added at 0C under stirring, in an ethylene atmosphere. The amounts of ethylene absorbed after specific reaction times (in liters, 1 bar and 20C) are indicated in Table 4. The suspensions were filtered and the lithium hydride was washed with THF. In order to determine the yield of vinyllithium ~7 ~4533 in the filtrate, aliquots of the filtrate were concentrated under vacuum and the residues were hydrolyzed. From the amounts of ethylene developed and on the basis of Equ. 7, the yields of vinyllithium indicated in Table 4 were calculated.
In order to isolate the vinyllithium, in Example 28, 85 ml of a total of 90 ml of the filtrate were concentrated under vacuum (0.2 torr), the residue was stirred with 50 ml of pentane for 30 minutes, the suspension was filtered and the solid was washed four times with 10 ml of pentane each. Upon cooling the filtrate to -40 C, the vinyllithium-tetrahydrofuran adduct crystalize~
(2.72 g) in the form of colorless crystals.
C6H11OLi (106.1);
calc. 6.60 % Li;
fd. 6.60% Li.
In order to determine the lithium hydride, in Example 32, the lithium hydride obtained upon filtration was dried at 0.2 torr, yielding 4.1 g of a gray powder with 46.7% Li. Of this powder, 0.158 g yielded upon hydrolysis the following: HD 75.0%;
D2 6.3%; H2 6.3%; C2H3D 2.1%; and THF 1.3~. From the amount of HD, a yield of LiH of 69~ was calculated according to Equ. 7.
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~44S33 Example 34 ln 100 ml of absolute THF, the following are consecutively dissolved: 0.78 g (4.2 mMoles) of 4,5-benzo-1,2-dithiol-3-thione (3a); 1.38 g (8.5 ml~oles) of anhydrous FeC13; and, at 0C, 24.2 g (0.43 Moles) of 1 butene; immediately thereafter, the solution was mixed at 0C and under stirring, with 7.30 g (1.05 l~ole) of lithium sand. The reaction mixture was stirred a total of 7 days at 0C. During this period, 5.0-ml samples of the solution were withdrawn, filtered, and their lithium content was determined acidimetrically. After 17 and 70 hours of reaction time, the samples were found to contain 6.75 and 10.6 g-atoms of lithium, corre;sponding to a lithium conversion to lithiumbutenyl and 3ithium hydride,according to Equ. 9, of 26 and 40%. After 7 days of reaction time, the reaction mixture was separated by filtration from the lithium hYdrideand the un-converted lithium, and the precipitate was washed with THF. A
4!5-ml sample of the filtrate (of a total of 138 ml) yielded upon hydrolysis 218 ml of gas (at 20C, l bar), with 62.5~ vol.
of butene-l. From this, a yield of LiC4~17 of 40~ was calculated according to Equ. 9 In order to characterize the lithium butenyl, the remaining amount was mixed with an excess of trimethylchlorosilane in ether, as described in Example l. This yields 26.2 g of a mixture of the _ _ four isomeric compounds (CH3)3SiC4H7 (B.P. 95-109 C/760 torr), of which the main component is represented at 87.9%, according to the gas chromatogram. According to the lH-NMR-spectrum, H(~ (100 Mhz, 15 ~ in C6H6, ~ =
(~)(H3C)3Si ,~(~) / CH3 (~) 3.89 m (H(~;)), 4.34d (H(~)), \~' CH2 7.98 m (H(~)), 9.08t (~)) and H (~ 9.91 s (H~)); I12 = 18.5 Hz) (17) the major component is trans-l-trimethylsilyl-l-butené (17), which means that the lithiation occurs with a selectivity of 87.9%
in the l-trans position of l-butene.
Example 35 In a manner analogous to that of Example 34, 41.4 g (0.74 Mole) of l-butene are allowed to react in the presence of 2.15 g (4.75 mMoles) of complex (13) (Example 1) as catalyst, with 5.60 g (0.81 Mole) of lithium sand in 150 ml of THF for 10 days at 0 C.
The mixture is f.ltered and the solid (LiH + Li) is washed with THF. Of the filtrate (totalling 186 ml), 5.0 ml yield, after evaporation of the THF and subsequent hydrolysis, 191 ml of gas (at 20C, 1 bar), with 80% l-butene (balance: THF, H2 and C2~2).
On that basis, and following Equ. 9, one calculates a yield of LiC4H7 of 58% (referred to Li). In order to isolate the trans-l-lithio-l-butene, 110 ml of THF is distilled off from the remaining filtrate under vacuum (0.2 torr), 100 ml of pentane are added, -` 1144533 and the mixture is filtered ~free of~ catalyst remnants at O C.
Upon letting the filtrate stand at -78C overnight, further remnants of the catalyst are separated. The supernatant solution is fully evaporated under vacuum (0.2 torr), the residue is dried for several hours at 10 3 torr, taken up in 120 ml of pentane, stirred for a short time and filtered. The white frit residue is washed with pentane and dried under 0.2 torr. One obtains 7.8 g of trans-l-lithium-l-butene, containing 9.48% Li.
After the silylation of this product with trimethylchlorosilane, processing and distillation, as descirbed in Example 1, this yields trans-l-trimethylsilyl-l-butene at 97% taccording to GC analysis), which was identified by lH-NMR-spectroscopy.
Example 36 In a suspension of 0.58 g (1.28 mMoles) of 8 (see Examples 25 to 27) in 20 ml of THF, 1.81 liters (76 mMoles) of gaseous l-butene are dissolved, which is followed by mixing the suspension at 0 C under stirring with 0.92 g (0.13 Mole) of lithium sand. After stirring for 50 hours at 0C it is filtered and the lithium hydride is washed with THF. An aliquot of the solution (4.0 ml of a total of 43.6 ml) yields after evaporation of the THF and hydrolysis, 200 ml of gas (at 20C, 1 bar) with a total of 30.0% butenes. On the basis of the amount of butene one calculates a yield of ~iC4H7 of 40.7%. Upon mixing an aliquot of the solution with trimethyl-chlorosilane, as described in Example 1, one obtains a mixture of ~.
`` 11~4533 the isomeric silanes (H3C)3SiC4~37, which are, according to the lH-~r~R-spectrum or GC analysis, predominantly a mixture of cis-and trans-l-trimethylsilyl-2-butene.
E~ample 37 Tl~ a suspension of 6..29 g (0.91 Mole)of lithium sand in 100 ml of TH~ are added at 0C and under stirring, in consecutive order,
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_ _ _ _ _ _ 114~533 Examples 13 to 24 Implementation of Examples 13 to 24 (Table 2):
4,5-Benzo-1,2-dithiol-3-thione (BDT) (3a) and respective metal salt (molar ratio BDT:metal salt = 1:2) are stirred in 60 ml of THF for 12 hours at 20C; immediately afterwards, the prepara-tion is saturated at 0C with propene (1 bar), and lithium sand is added in a propene atmosphere and under stirring. The amounts of propene absorbed after specific reactiontimes (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (_:10:11:12) are indicated in Table 2. The determination_ _ of the yields and the isomer ratios are carried out as described in Example 1.
Examples 25 to 27 Preparation of the ortho-chloropalladio-2,5-diphenyl-1,6,6a-trithiapentalene complex (8) (Example 25):
To the suspension of 3.10 g (9.94 mMole) of 2,5-diphenyl-1,6,6a-trithiapentalene in a mixture of 230 ml of methanol and 25 ml of benzene, one adds 1.76 g ~9.92 mMoles) of PdC12 followed by 1.33 g (31.3 mMoles) of LiCl dissolved in 20 ml methanol.
The suspension is boiled for 3 hours under stirring, with reflux, and after cooling to room temperature it is filtered through a G-3 glass filter crucible. In the mother liquor, 93.6% of the split-off HCl was determined acidimetrically. The precipitate was washed with methanol and ether and was dried at 10 torr. The yield of (8) (M.P. 304C, decomp.) amounts to 4.38 g (97~).
C17Hl1S3PdCl (453.8);
Calc. C 44.94, H 2.64, S 21.15, Pd 23.44, Cl 7.82;
Fd. C 44.92, H 2.90, S 21.08, Pd 23.21, Cl 7.86.
Implementation of Examples 25 to 27 (Table 3):
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The solution or suspension of the catalyst in THF is saturated at 0C with propene (1 bar) and immediately thereafter lithium sand is added in a propene atmosphere and under stirring. The amounts of propene absorbed at the specific times (in liters, at 1 bar, 20C), as well as the yields of LiC3H5 and the isomer ratios (9:10:11:12) are indicated in Table 3. The determina-tion of the yields and of the isomer ratios was carried out as described in Example 1.
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Examples 28 to 33 L ~ s 2 FeCl~
(16) preparation of 4,5-benzo-1,2-dithiol-3-thione 2 FeC13- complex (16) (Example 29):
To the suspension of 1.89 g (11.6 mMoles) of the anhydrous FeC13 in 80 ml of benzene, the solution of 1.07 g (5.8 mMoles) of 4,5-benzo-1,2-dithiol-3-thione (3a) in 70 ml of benzene is added in dropwise fashion with stirring; immediately thereafter, the mixture is stirred for 24 hours at 20C. The suspension is filtered, the precipitate is washed with benzene and dried at 10 3 torr. One obtains 2.36 g (80% of theoretical) of the complex (16). C7H4S3Fe2C16 (508.7);
calc. C 16.52, H 0.78, Fe 21.97, S 18.90, Cl 41.84;
fd. C 16.55, H 0.82, Fe 21.91, S 18.84, Cl 41.76.
Implementation of Examples 28 to 33 (Table 4):
The catalysts are previously added to THF, the solution is saturated with ethylene (1 bar) at 0C; immediately thereafter, lithium sand is added at 0C under stirring, in an ethylene atmosphere. The amounts of ethylene absorbed after specific reaction times (in liters, 1 bar and 20C) are indicated in Table 4. The suspensions were filtered and the lithium hydride was washed with THF. In order to determine the yield of vinyllithium ~7 ~4533 in the filtrate, aliquots of the filtrate were concentrated under vacuum and the residues were hydrolyzed. From the amounts of ethylene developed and on the basis of Equ. 7, the yields of vinyllithium indicated in Table 4 were calculated.
In order to isolate the vinyllithium, in Example 28, 85 ml of a total of 90 ml of the filtrate were concentrated under vacuum (0.2 torr), the residue was stirred with 50 ml of pentane for 30 minutes, the suspension was filtered and the solid was washed four times with 10 ml of pentane each. Upon cooling the filtrate to -40 C, the vinyllithium-tetrahydrofuran adduct crystalize~
(2.72 g) in the form of colorless crystals.
C6H11OLi (106.1);
calc. 6.60 % Li;
fd. 6.60% Li.
In order to determine the lithium hydride, in Example 32, the lithium hydride obtained upon filtration was dried at 0.2 torr, yielding 4.1 g of a gray powder with 46.7% Li. Of this powder, 0.158 g yielded upon hydrolysis the following: HD 75.0%;
D2 6.3%; H2 6.3%; C2H3D 2.1%; and THF 1.3~. From the amount of HD, a yield of LiH of 69~ was calculated according to Equ. 7.
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~44S33 Example 34 ln 100 ml of absolute THF, the following are consecutively dissolved: 0.78 g (4.2 mMoles) of 4,5-benzo-1,2-dithiol-3-thione (3a); 1.38 g (8.5 ml~oles) of anhydrous FeC13; and, at 0C, 24.2 g (0.43 Moles) of 1 butene; immediately thereafter, the solution was mixed at 0C and under stirring, with 7.30 g (1.05 l~ole) of lithium sand. The reaction mixture was stirred a total of 7 days at 0C. During this period, 5.0-ml samples of the solution were withdrawn, filtered, and their lithium content was determined acidimetrically. After 17 and 70 hours of reaction time, the samples were found to contain 6.75 and 10.6 g-atoms of lithium, corre;sponding to a lithium conversion to lithiumbutenyl and 3ithium hydride,according to Equ. 9, of 26 and 40%. After 7 days of reaction time, the reaction mixture was separated by filtration from the lithium hYdrideand the un-converted lithium, and the precipitate was washed with THF. A
4!5-ml sample of the filtrate (of a total of 138 ml) yielded upon hydrolysis 218 ml of gas (at 20C, l bar), with 62.5~ vol.
of butene-l. From this, a yield of LiC4~17 of 40~ was calculated according to Equ. 9 In order to characterize the lithium butenyl, the remaining amount was mixed with an excess of trimethylchlorosilane in ether, as described in Example l. This yields 26.2 g of a mixture of the _ _ four isomeric compounds (CH3)3SiC4H7 (B.P. 95-109 C/760 torr), of which the main component is represented at 87.9%, according to the gas chromatogram. According to the lH-NMR-spectrum, H(~ (100 Mhz, 15 ~ in C6H6, ~ =
(~)(H3C)3Si ,~(~) / CH3 (~) 3.89 m (H(~;)), 4.34d (H(~)), \~' CH2 7.98 m (H(~)), 9.08t (~)) and H (~ 9.91 s (H~)); I12 = 18.5 Hz) (17) the major component is trans-l-trimethylsilyl-l-butené (17), which means that the lithiation occurs with a selectivity of 87.9%
in the l-trans position of l-butene.
Example 35 In a manner analogous to that of Example 34, 41.4 g (0.74 Mole) of l-butene are allowed to react in the presence of 2.15 g (4.75 mMoles) of complex (13) (Example 1) as catalyst, with 5.60 g (0.81 Mole) of lithium sand in 150 ml of THF for 10 days at 0 C.
The mixture is f.ltered and the solid (LiH + Li) is washed with THF. Of the filtrate (totalling 186 ml), 5.0 ml yield, after evaporation of the THF and subsequent hydrolysis, 191 ml of gas (at 20C, 1 bar), with 80% l-butene (balance: THF, H2 and C2~2).
On that basis, and following Equ. 9, one calculates a yield of LiC4H7 of 58% (referred to Li). In order to isolate the trans-l-lithio-l-butene, 110 ml of THF is distilled off from the remaining filtrate under vacuum (0.2 torr), 100 ml of pentane are added, -` 1144533 and the mixture is filtered ~free of~ catalyst remnants at O C.
Upon letting the filtrate stand at -78C overnight, further remnants of the catalyst are separated. The supernatant solution is fully evaporated under vacuum (0.2 torr), the residue is dried for several hours at 10 3 torr, taken up in 120 ml of pentane, stirred for a short time and filtered. The white frit residue is washed with pentane and dried under 0.2 torr. One obtains 7.8 g of trans-l-lithium-l-butene, containing 9.48% Li.
After the silylation of this product with trimethylchlorosilane, processing and distillation, as descirbed in Example 1, this yields trans-l-trimethylsilyl-l-butene at 97% taccording to GC analysis), which was identified by lH-NMR-spectroscopy.
Example 36 In a suspension of 0.58 g (1.28 mMoles) of 8 (see Examples 25 to 27) in 20 ml of THF, 1.81 liters (76 mMoles) of gaseous l-butene are dissolved, which is followed by mixing the suspension at 0 C under stirring with 0.92 g (0.13 Mole) of lithium sand. After stirring for 50 hours at 0C it is filtered and the lithium hydride is washed with THF. An aliquot of the solution (4.0 ml of a total of 43.6 ml) yields after evaporation of the THF and hydrolysis, 200 ml of gas (at 20C, 1 bar) with a total of 30.0% butenes. On the basis of the amount of butene one calculates a yield of ~iC4H7 of 40.7%. Upon mixing an aliquot of the solution with trimethyl-chlorosilane, as described in Example 1, one obtains a mixture of ~.
`` 11~4533 the isomeric silanes (H3C)3SiC4~37, which are, according to the lH-~r~R-spectrum or GC analysis, predominantly a mixture of cis-and trans-l-trimethylsilyl-2-butene.
E~ample 37 Tl~ a suspension of 6..29 g (0.91 Mole)of lithium sand in 100 ml of TH~ are added at 0C and under stirring, in consecutive order,
33.8 g (0.48 t~ole) of l-pentene and 1.45 g (2.85 mMole) of complex 16 (Examples 28 to 33). The mixture is stirred for 5 days at 0C, followed by filtration and washing of the solid (LiH) with THF.
Of the total of 169 ml of filtrate, 2.50 ml contain, according to the aciaimetric lithium determination, 4.30 g-atoms of Li, which corresponds to a yield in LiC5Hg of 64%.
In order to chara~terize the ~rganolithium compound LiC5Hg, 86.5 ml of the filtrate are mixed with excess trimethylchlorosilane, as described in Example 1. Procéssing or distillation yields, among others, 10.6 9 of a fraction (B.P. 133C/760 torr), which is trans-l-trimethylsilyl-l-pentene (18), according to the l~-Nt~R-spectrum.
(80 tlH2, 15 ~ in CDC13; ~ 3 =.96 m (H1~, 4.39 d (l~, 7.90 m 0 (l13~, 8.57 m (H~), 9.09 t 3 )3 ~ Cl ~ l2 ~ Cl~ 18 5 l~z) (lB) In order to isolate the trans-l-lithio-l-pentene, 80 ml of the ~1~4S33 filtrate are concentrated under vacuum to 20 ml, are mixed with 80 ml of pentane and filtered. The filtrate is kept for 12 hours at -78C, and is then syphoned off at -78C from the catalyst remnants that separated. The solution so obtained is completely evaporated under vacuum, the residue is dried at 20C and 10-3 torr to constant weight, is taken up in 100 ml pentane, stirred for one-half hour and filtered. The white precipitate is washed with pentane and dried at 0.2 torr. One obtains 3.14 g of trans-l-lithio-l-pentene in the form of white powder. LiC5Hg (MW = 75.9);calc. 9.32 ~ Li; fd. 9.29% Li.
.
Example 38 In a manner analogous to Example 34, 21.6 g (0.20 Mole) of 1,7-octadie~e are left to react in the presence of 1.25 g (2 76 mMoles) of complex 13 (Example 1) as catalyst, with 5.~2 g (0.84 Mole) of lithium sand in 150 ml of THF for 11 days at 0C. The suspension is filtered and lithium hydride is washed with THF.
Of a total of 17 ml of the filtrate, 5.0 ml contain, according to the acidimetric determination, 6.94 g-atoms of lithium, corresponding to a total yield of organolithium compounds of 57%.
The orqanolithium compounds in solution are characterized in the form of their trimethysilyl derivatives. For that purpose, 77 ml (of a total of 172 ml) of the solution, are mixed with trimethyl-chlorosilane as described in Example 1. The processing or distillation yields 7.67 g of a fraction with B.P. 55-63 C/0.7 torr, as well as 1.55 g of a fraction of B.P.54-55 C/10 torr.
According to the H-NMR-spectrum, the first fraction consists of trans-l-trimethylsilyl-1,7-octadiene (19), and the second fraction essentially of bis-1,8-(trans-trimethylsilyl)-1,7-octadiene (20), i.e., (CH3)3Si ~ (C 2)4CH CH2(CH3)3Si ~ CH2CH2-H H . 2 (19) _ in the case of 1,7-octadiene, the lithiation also occurs with high selectivity in the trans-l position.
Example 39 In 150 ml of absolute THF there are suspended or dissolved con-secutively 1.79 g (3.95 mMoles) of complex 13 (Example 1), as well as 13.0 g (0.19 Moles) of 1,4-pentadiene; immediately thereafter one adds to the suspension, at 0C under stirring, 11.1 g (1.60 Mole) of lithium sand. The reaction mixture is stirred for 74 hours at 0C. After this time period, a 5.0-ml sample of the solution contains 9.42 mg atoms of lithium. The suspension is diluted with 50 ml of THF, filtered at 0 C and the LiH is washed with THF. During the 48-hour standing of the solution at -78C, 11~4533 the organolithium compound 14 crystalizes out in the form of brown-color, coarse crystal. The crystals are separated from the mother liquor at -78C, are washed with a little T~F cooled to -78C and dried for one-half hour at 0C and one-half hour at 20C under vacuum (0.2 torr). One obtains 11.1 g of product with a ratio of 9.61% lithium (calc. for C4H5Li3(THF)2 9 0~ Li).
On the basis of the H-NMR or C-NMR-spectra in combination with spin-spin-decoupling experiments, as well as on the basis of the silylation (see below), the organolithium compound is assigned structure 14. In oxder to record the H-NMR-spectrum, the product, with 9.61 % Li, is recrystalized twice from an 1:1 THF-tetramethyl-ethylenediamine mixture (crystalization respectively at -78C).
The H-NMR-spectrum of 14 (15% in d8-THF; 270 MHz; 27 Ci d-THF
as internal standard ): ~ = 7.54 dd (Hl), 5.37 d(H3), 4.79 d (H4), 3.03 d (H5), 2.95 d (H ), 3.54 m and 1.68 m (THF), 2.21 s and 2.06 s (tetramethylenediamine); I12 - 16.3 Hz, I13 = 5.4 Hz, I45 = 4.2 Hz.
~ Li ¦ ~
In order to record the 3C-NMR-spectrum, the raw product is recrystalized from THF (crystalization at -78 C). The C-N~R-- ,j spectrum of 14 (100 MHz; 10% in d8-THF, at 25 C); ~ (ppm)=
84.6 t (C5), 97.6 (wide) (Cl), 100.4 d (C3), 153.9 d (C2), 187.7 (wide) (C4). The widening of the signals of the Cl and 13C4 nuclei indicates the presence of two Li-C bonds. In the reaction of 1.07 g of 14 with trimethylchlorosilane, as described in Example 1, one obtains, after processing or dis-tillation, 0.85 g of a fraction of B.P. 45-47 C/10 torr, which, according to the H-NMR-spectrum, is a mixture of the three stereoisomeric 1,4,5-tris (trimethylsilyl)-1,3-pentadienes (21) (65%), (22) (33~), and (23) (2%).
SiMe3 SiMe3 Me351 ~ ~e35i Si~e3 SiMe3 SiMe3 Me3Si ~
SiMe3 ~n It was shown in a parallel experiment that in the reaction of pentadiene-1,4 with lithium, under the same conditions of reaction but in the absence of the catalyst, the formation of 14 occurs at best in trace quantities only.
Example 40 S_ S _S
H5C6 ~ C6H5 A solution of 0.34 g (1.1 mMoles) of 2,5-diphenyl-1~6,6a-trithia-pentalene 24 and 0.30 g (2.2 mMoles) of NzC12 (anhydrous) in 50 ml of absolute THF, is saturated at 0C with ethylene (1 bar);
immediately thereafter the preparation is mixed in an ethylene atmosphere at 0C and under stirring, with 1.45 g (0.21 Moles) of lithium sand. After a slight rise in temperature, ethylene absorption starts after 10-15 minutes, the rate of absorption being measured with the aid of a gas burette attached to the reaction vessel.
During the ethylene absorption, the suspension is vigorously stirred and the temperature is kept at 0C. Up to the end of the reaction, the reaction mixture absorbs within 6 hours 2.28 liters of ethylene (1 bar, 20C). The suspension is filtered to separate the lithium hydride, and the lithium hydride is washed with THF.
Of the total of 81.0 ml of the filtrate, 50 ml yield after evaporation ~7 - ` 114~533 of the THF, upon hydrolysis, 126 ml of gas (at 20C, 1 bar), which, according to MS analysis consists of 84.8 Mole% of ethylene. On the basis of the amount of ethylene obtained during hydrolysis, the vinyllithium yield is calculated according to Equ. 7 at 76% (referred to ethylene).
Example 41 A solution of 1.61 g (5.2 mMoles) of 2,5-diphenyl-1,6,6a-tri-thizpentalene (24) and 1.21 g (8.9 mMoles) of ZnC12 (anhydrous) in 100 ml of absolute THF is saturated at 0C with propene tl bar);
immediately thereafter the preparation is mixed in a propene atmosphere at 0C and under stirring with 5.47 g (0.79 Moles) of lithium sand. The further pe~rformance of the experiment followed Example 40 as described for ethylene. Up to the end of the reaction, the reaction mixture absorbed within 12 hours 7.9 liters of propene (at 20C, 1 bar). The suspension was filtered and the lithiumhydride washed with THF. Of the total of 167.0 ml of filtrate, 7.0 ml yielded upon hydrolysis 372 ml of gas (20~C, 1 bar), consisting of 88.8 Mole~ of propene(balance: THF, H2).
From the amount of propene obtained upon hvdrolysis, the yield of organolithium compounds LiC3H5 was calculated according to Equ. 8 at 99.7% (referred to propene). The mixing of 40 ml of the filtrate with trimethylchlorosilane,and thesubsequent processing and distillation, as described in Example 1, yielded 11.9 g of the isomeric silanes (CH3)35iC3l~5, with the composition: trans-l-pro-penyltrimethylsilane, 80.0%; cis-l-propenyl-trimethylsilane, 0.4~;
S3;~
isopropenyltrimethylsilane, 15.0%; and allyltrimethylsilane, 4.6%. The isolation of the organolithium compounds LiC3H5 from the THF solution, as described in Example l, yields a product that consists of 91.3% trans-propenyllithium.
.
EY.ample 42 To a solution of 25.1 g (0.22 Mole)of l-octene and 1.23 g (4.0 mMoles) of 2,5-diphenyl-1,6,6a-trithiapentalene (24)in 100 ml of absolute THF, there are added consecutively at 0C and under stirring,1.15 g (8.5 mMoles) of ZnC12 (anhydrous) and, in small portions, 3.09 g (0.45 Moles) of lithium sand. The preparation was stirred for a total of 22 hours at 0C. During this period, 2.5-ml samples were withdrawn from the solution, filtered, and the lithium content in the filtrates determined acidimetrically. After 3.5, 6, and 22 hours, the lithium content in the samples is 4.2, 4.6 and 5.4 mMoles, respectively, corresponding to a lithium conversion to lithium octenyl and lithiumhydride, according toFqu. 9, of 75, 83 and 97%.
The ?reparation is filtered and the lithiumhydride is washed with THF. Of the total of 167.0 ml of the filtrate, 47.0 ml are mixed, as described in Example 1, with 11.0 g (0.10 ~oles) of trimethyl-chlorosilane. The processing or distillation yields 6.13 g of a fraction of B.P. 35-43C/0.2 torr, which, according to GC analysis or GC-MS-coupling analysis and lH-NMR-spectrum, consists of 96.6%
of trans-l-trimethysilyl--l-octene (25). According to this result, -~6-11~4533 \ C ~ \ tCH ) CH
.
l-octéne is lithiated according to the method described with a selectivity greater than 96~ in the trans-l position.
.
Herein and in the claims, the catalyst is defined in the manner conventionally used in the art, i.e., in terms of its components, ra~her than attempting to speculate on the nature or structure of an active material which may be formed from these components.
This application is a division of Canadian Patent Application serial number 347,087, filed March 5, 1980.
.. . . _
Of the total of 169 ml of filtrate, 2.50 ml contain, according to the aciaimetric lithium determination, 4.30 g-atoms of Li, which corresponds to a yield in LiC5Hg of 64%.
In order to chara~terize the ~rganolithium compound LiC5Hg, 86.5 ml of the filtrate are mixed with excess trimethylchlorosilane, as described in Example 1. Procéssing or distillation yields, among others, 10.6 9 of a fraction (B.P. 133C/760 torr), which is trans-l-trimethylsilyl-l-pentene (18), according to the l~-Nt~R-spectrum.
(80 tlH2, 15 ~ in CDC13; ~ 3 =.96 m (H1~, 4.39 d (l~, 7.90 m 0 (l13~, 8.57 m (H~), 9.09 t 3 )3 ~ Cl ~ l2 ~ Cl~ 18 5 l~z) (lB) In order to isolate the trans-l-lithio-l-pentene, 80 ml of the ~1~4S33 filtrate are concentrated under vacuum to 20 ml, are mixed with 80 ml of pentane and filtered. The filtrate is kept for 12 hours at -78C, and is then syphoned off at -78C from the catalyst remnants that separated. The solution so obtained is completely evaporated under vacuum, the residue is dried at 20C and 10-3 torr to constant weight, is taken up in 100 ml pentane, stirred for one-half hour and filtered. The white precipitate is washed with pentane and dried at 0.2 torr. One obtains 3.14 g of trans-l-lithio-l-pentene in the form of white powder. LiC5Hg (MW = 75.9);calc. 9.32 ~ Li; fd. 9.29% Li.
.
Example 38 In a manner analogous to Example 34, 21.6 g (0.20 Mole) of 1,7-octadie~e are left to react in the presence of 1.25 g (2 76 mMoles) of complex 13 (Example 1) as catalyst, with 5.~2 g (0.84 Mole) of lithium sand in 150 ml of THF for 11 days at 0C. The suspension is filtered and lithium hydride is washed with THF.
Of a total of 17 ml of the filtrate, 5.0 ml contain, according to the acidimetric determination, 6.94 g-atoms of lithium, corresponding to a total yield of organolithium compounds of 57%.
The orqanolithium compounds in solution are characterized in the form of their trimethysilyl derivatives. For that purpose, 77 ml (of a total of 172 ml) of the solution, are mixed with trimethyl-chlorosilane as described in Example 1. The processing or distillation yields 7.67 g of a fraction with B.P. 55-63 C/0.7 torr, as well as 1.55 g of a fraction of B.P.54-55 C/10 torr.
According to the H-NMR-spectrum, the first fraction consists of trans-l-trimethylsilyl-1,7-octadiene (19), and the second fraction essentially of bis-1,8-(trans-trimethylsilyl)-1,7-octadiene (20), i.e., (CH3)3Si ~ (C 2)4CH CH2(CH3)3Si ~ CH2CH2-H H . 2 (19) _ in the case of 1,7-octadiene, the lithiation also occurs with high selectivity in the trans-l position.
Example 39 In 150 ml of absolute THF there are suspended or dissolved con-secutively 1.79 g (3.95 mMoles) of complex 13 (Example 1), as well as 13.0 g (0.19 Moles) of 1,4-pentadiene; immediately thereafter one adds to the suspension, at 0C under stirring, 11.1 g (1.60 Mole) of lithium sand. The reaction mixture is stirred for 74 hours at 0C. After this time period, a 5.0-ml sample of the solution contains 9.42 mg atoms of lithium. The suspension is diluted with 50 ml of THF, filtered at 0 C and the LiH is washed with THF. During the 48-hour standing of the solution at -78C, 11~4533 the organolithium compound 14 crystalizes out in the form of brown-color, coarse crystal. The crystals are separated from the mother liquor at -78C, are washed with a little T~F cooled to -78C and dried for one-half hour at 0C and one-half hour at 20C under vacuum (0.2 torr). One obtains 11.1 g of product with a ratio of 9.61% lithium (calc. for C4H5Li3(THF)2 9 0~ Li).
On the basis of the H-NMR or C-NMR-spectra in combination with spin-spin-decoupling experiments, as well as on the basis of the silylation (see below), the organolithium compound is assigned structure 14. In oxder to record the H-NMR-spectrum, the product, with 9.61 % Li, is recrystalized twice from an 1:1 THF-tetramethyl-ethylenediamine mixture (crystalization respectively at -78C).
The H-NMR-spectrum of 14 (15% in d8-THF; 270 MHz; 27 Ci d-THF
as internal standard ): ~ = 7.54 dd (Hl), 5.37 d(H3), 4.79 d (H4), 3.03 d (H5), 2.95 d (H ), 3.54 m and 1.68 m (THF), 2.21 s and 2.06 s (tetramethylenediamine); I12 - 16.3 Hz, I13 = 5.4 Hz, I45 = 4.2 Hz.
~ Li ¦ ~
In order to record the 3C-NMR-spectrum, the raw product is recrystalized from THF (crystalization at -78 C). The C-N~R-- ,j spectrum of 14 (100 MHz; 10% in d8-THF, at 25 C); ~ (ppm)=
84.6 t (C5), 97.6 (wide) (Cl), 100.4 d (C3), 153.9 d (C2), 187.7 (wide) (C4). The widening of the signals of the Cl and 13C4 nuclei indicates the presence of two Li-C bonds. In the reaction of 1.07 g of 14 with trimethylchlorosilane, as described in Example 1, one obtains, after processing or dis-tillation, 0.85 g of a fraction of B.P. 45-47 C/10 torr, which, according to the H-NMR-spectrum, is a mixture of the three stereoisomeric 1,4,5-tris (trimethylsilyl)-1,3-pentadienes (21) (65%), (22) (33~), and (23) (2%).
SiMe3 SiMe3 Me351 ~ ~e35i Si~e3 SiMe3 SiMe3 Me3Si ~
SiMe3 ~n It was shown in a parallel experiment that in the reaction of pentadiene-1,4 with lithium, under the same conditions of reaction but in the absence of the catalyst, the formation of 14 occurs at best in trace quantities only.
Example 40 S_ S _S
H5C6 ~ C6H5 A solution of 0.34 g (1.1 mMoles) of 2,5-diphenyl-1~6,6a-trithia-pentalene 24 and 0.30 g (2.2 mMoles) of NzC12 (anhydrous) in 50 ml of absolute THF, is saturated at 0C with ethylene (1 bar);
immediately thereafter the preparation is mixed in an ethylene atmosphere at 0C and under stirring, with 1.45 g (0.21 Moles) of lithium sand. After a slight rise in temperature, ethylene absorption starts after 10-15 minutes, the rate of absorption being measured with the aid of a gas burette attached to the reaction vessel.
During the ethylene absorption, the suspension is vigorously stirred and the temperature is kept at 0C. Up to the end of the reaction, the reaction mixture absorbs within 6 hours 2.28 liters of ethylene (1 bar, 20C). The suspension is filtered to separate the lithium hydride, and the lithium hydride is washed with THF.
Of the total of 81.0 ml of the filtrate, 50 ml yield after evaporation ~7 - ` 114~533 of the THF, upon hydrolysis, 126 ml of gas (at 20C, 1 bar), which, according to MS analysis consists of 84.8 Mole% of ethylene. On the basis of the amount of ethylene obtained during hydrolysis, the vinyllithium yield is calculated according to Equ. 7 at 76% (referred to ethylene).
Example 41 A solution of 1.61 g (5.2 mMoles) of 2,5-diphenyl-1,6,6a-tri-thizpentalene (24) and 1.21 g (8.9 mMoles) of ZnC12 (anhydrous) in 100 ml of absolute THF is saturated at 0C with propene tl bar);
immediately thereafter the preparation is mixed in a propene atmosphere at 0C and under stirring with 5.47 g (0.79 Moles) of lithium sand. The further pe~rformance of the experiment followed Example 40 as described for ethylene. Up to the end of the reaction, the reaction mixture absorbed within 12 hours 7.9 liters of propene (at 20C, 1 bar). The suspension was filtered and the lithiumhydride washed with THF. Of the total of 167.0 ml of filtrate, 7.0 ml yielded upon hydrolysis 372 ml of gas (20~C, 1 bar), consisting of 88.8 Mole~ of propene(balance: THF, H2).
From the amount of propene obtained upon hvdrolysis, the yield of organolithium compounds LiC3H5 was calculated according to Equ. 8 at 99.7% (referred to propene). The mixing of 40 ml of the filtrate with trimethylchlorosilane,and thesubsequent processing and distillation, as described in Example 1, yielded 11.9 g of the isomeric silanes (CH3)35iC3l~5, with the composition: trans-l-pro-penyltrimethylsilane, 80.0%; cis-l-propenyl-trimethylsilane, 0.4~;
S3;~
isopropenyltrimethylsilane, 15.0%; and allyltrimethylsilane, 4.6%. The isolation of the organolithium compounds LiC3H5 from the THF solution, as described in Example l, yields a product that consists of 91.3% trans-propenyllithium.
.
EY.ample 42 To a solution of 25.1 g (0.22 Mole)of l-octene and 1.23 g (4.0 mMoles) of 2,5-diphenyl-1,6,6a-trithiapentalene (24)in 100 ml of absolute THF, there are added consecutively at 0C and under stirring,1.15 g (8.5 mMoles) of ZnC12 (anhydrous) and, in small portions, 3.09 g (0.45 Moles) of lithium sand. The preparation was stirred for a total of 22 hours at 0C. During this period, 2.5-ml samples were withdrawn from the solution, filtered, and the lithium content in the filtrates determined acidimetrically. After 3.5, 6, and 22 hours, the lithium content in the samples is 4.2, 4.6 and 5.4 mMoles, respectively, corresponding to a lithium conversion to lithium octenyl and lithiumhydride, according toFqu. 9, of 75, 83 and 97%.
The ?reparation is filtered and the lithiumhydride is washed with THF. Of the total of 167.0 ml of the filtrate, 47.0 ml are mixed, as described in Example 1, with 11.0 g (0.10 ~oles) of trimethyl-chlorosilane. The processing or distillation yields 6.13 g of a fraction of B.P. 35-43C/0.2 torr, which, according to GC analysis or GC-MS-coupling analysis and lH-NMR-spectrum, consists of 96.6%
of trans-l-trimethysilyl--l-octene (25). According to this result, -~6-11~4533 \ C ~ \ tCH ) CH
.
l-octéne is lithiated according to the method described with a selectivity greater than 96~ in the trans-l position.
.
Herein and in the claims, the catalyst is defined in the manner conventionally used in the art, i.e., in terms of its components, ra~her than attempting to speculate on the nature or structure of an active material which may be formed from these components.
This application is a division of Canadian Patent Application serial number 347,087, filed March 5, 1980.
.. . . _
Claims (28)
OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A catalyst comprising a composition of the formula wherein A and B are sulfur or oxygen;
G is a carbon atom bonded to a radical R1;
D is a carbon atom bonded to a radical R2 and there is a double bond between the carbon atom of G and D;
E is carbon;
F is oxygen, sulfur, , or ;
Me is an alkaline metal;
n is an integer from 2 to 20;
L and L' are mono or poly-functional ethers or amines;
p and q are integers from 0 to 4;
R1, R2, R3 and R4 are independently hydrogen, alkyl, cycloalkyl, aralkyl or aryl groups, and/or two or more of such groups are closed into an aliphatic or aromatic ring system; and a metal compound of transition metals from group Ib, IIb, IVb, Vb, VIb, VIIb, and VIII of the periodic system.
G is a carbon atom bonded to a radical R1;
D is a carbon atom bonded to a radical R2 and there is a double bond between the carbon atom of G and D;
E is carbon;
F is oxygen, sulfur, , or ;
Me is an alkaline metal;
n is an integer from 2 to 20;
L and L' are mono or poly-functional ethers or amines;
p and q are integers from 0 to 4;
R1, R2, R3 and R4 are independently hydrogen, alkyl, cycloalkyl, aralkyl or aryl groups, and/or two or more of such groups are closed into an aliphatic or aromatic ring system; and a metal compound of transition metals from group Ib, IIb, IVb, Vb, VIb, VIIb, and VIII of the periodic system.
2. The catalyst according to claim 1, wherein the composition has the formula in which X is sulfur or oxygen.
3. The catalyst according to claim 2, wherein the composition has the formula
4. The catalyst according to claim 3, wherein the metal compound is cupreous chloride or ferric chloride.
5. The catalyst according to claim 1, wherein the composition has the formula II
in which X is sulfur or oxygen.
in which X is sulfur or oxygen.
6. The catalyst according to claim 5, wherein X is sulfur, R1 = R4 is C6H5, R2 = R3 is hydrogen, and-Me is lithium.
7. The catalyst according to claim 6, wherein the metal compound is zinc chloride or palladium chloride.
8. The catalyst according to claim 5, wherein X is sulfur, R1 = R3 is C6H5, R2 = R4 is hydrogen, and Me is lithium.
9. The catalyst according to claim 8, wherein the metal compound is cupric chloride.
10. The catalyst according to claim 1, wherein the metal compound is of a metal selected from the group consisting of copper, gold, zinc, cadmium, titanium, zirconium, vanadium, niobium, tantalum, chromium, molybdenum, tungsten, manganese, iron, cobalt, nickel, ruthenium, rhodium, palladium, osmium, iridium, and platinum.
11. The catalyst according to claim 1, wherein the metal compound is of a metal selected from the group consisting of copper, iron, zinc, palladium, platinum, and rhodium.
12. The catalyst according to claim 1, wherein the metal compound is selected from the group consisting of zinc chloride, iron (III) chloride, copper (I) chloride, copper (II) chloride, molybdenum (VI) chloride, titanium (IV) chloride, chromium (III) chloride, molybdenum (V) chloride, manganese (II) chloride, cobalt (II) chloride, nickel (II) chloride, nickel (II) acetyl-acetonate, rhodium (III) chloride, platinum (II) chloride, and palladium (II) chloride.
13. The catalyst according to claim 1, wherein the metal compound is an anhydrous metal compound.
14. A catalyst composition of metal complexes comprising a polycyclic aromatic compound, comprising a member of the group consisting of naphthalene, anthracene, phenanthrene, and diphenyl, an alkali metal, and a metal compound of tansition metals from group Ib, IIb, IVb, Vb, VIb, VIIb and VIII of the periodic system.
15. The catalyst composition according to claim 14, wherein the alkaline metal is lithium.
16. The catalyst composition according to claim 14, wherein the alkaline metal is sodium or potassium.
17. The catalyst according to claim 14, wherein the metal compound is a metalselected from the group consisting of zinc chloride, iron (III) chloride,copper(I) chloride, copper (II) chloride, molybdenum (VI) chloride, titanium (III) chloride, titanium (IV) chloride, chromium (III) chloride, molybdenum (V) chloride, manganese (II) chloride, cobalt (II) chloride, nickel (II) chloride, nickel (II) acetylacetonate, rhodium (III) chloride, platinum (II) chloride, and palladium (II) chloride.
18. A process for the preparation of a catalyst comprising contacting:
an organic compound of the formula wherein A and B are sulfur or oxygen, G is a carbon atom bonded to a radical R1, D is a carbon atom bonded to a radical R2 and there is a double bond between the carbon atom of G and D, E is carbon, F is oxygen, sulfur, or R1, R2, R3, and R4 are independently hydrogen, alkyl, cyclo-alkyl, aralkyl or aryl groups and/or two or more of such groups are closed into an aliphatic or aromatic ring system;
lithium; and mono- or poly-functional ethers or amines.
an organic compound of the formula wherein A and B are sulfur or oxygen, G is a carbon atom bonded to a radical R1, D is a carbon atom bonded to a radical R2 and there is a double bond between the carbon atom of G and D, E is carbon, F is oxygen, sulfur, or R1, R2, R3, and R4 are independently hydrogen, alkyl, cyclo-alkyl, aralkyl or aryl groups and/or two or more of such groups are closed into an aliphatic or aromatic ring system;
lithium; and mono- or poly-functional ethers or amines.
19, The process according to claim 18, further comprising adding to the resulting composition a metal compound of transition metals from group Ib, IIb, IVb, Vb, VIb, VIIb, and VIII of the periodic system.
20. The process according to claim 18, wherein the organic compound has the formula III
in which X is sulfur or oxygen.
in which X is sulfur or oxygen.
21. The process according to claim 18, wherein the organic compound has the formula IV
22. The process according to claim 18, wherein the organic compound has the formula V
23. The process according to claim 22 wherein R1 = R4 is C6H5, and R2 = R3 is hydrogen.
24. The process according to claim 23, further comprising adding zinc chloride or palladium chloride to the resulting composition.
25. The process according to claim 22, wherein R1 = R3 is C6H5, and R2 = R4 is hydrogen.
26. The process according to claim 25, further comprising adding cupric chloride to the resulting composition.
27. The process according to claim 18 wherein the organic compound has the formula VI
28. The process according to claim 18, wherein the organic compound has the formula VII
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000404171A CA1144533A (en) | 1979-03-07 | 1982-05-31 | Procedure for the preparation of organolithium compounds together with lithium hydride |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792908928 DE2908928A1 (en) | 1979-03-07 | 1979-03-07 | METHOD FOR PRODUCING ORGANOLITHIUM COMPOUNDS IN ADDITION TO LITHIUM HYDROID |
DEP2908928.9 | 1979-03-07 | ||
CA000347087A CA1148924A (en) | 1979-03-07 | 1980-03-05 | Procedure for the preparation of organolithium compounds together with lithium hydride |
CA000404171A CA1144533A (en) | 1979-03-07 | 1982-05-31 | Procedure for the preparation of organolithium compounds together with lithium hydride |
Publications (1)
Publication Number | Publication Date |
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CA1144533A true CA1144533A (en) | 1983-04-12 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CA000404171A Expired CA1144533A (en) | 1979-03-07 | 1982-05-31 | Procedure for the preparation of organolithium compounds together with lithium hydride |
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CA (1) | CA1144533A (en) |
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1982
- 1982-05-31 CA CA000404171A patent/CA1144533A/en not_active Expired
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