CA1144482A - Corticosteroid in nail polish - Google Patents
Corticosteroid in nail polishInfo
- Publication number
- CA1144482A CA1144482A CA000361772A CA361772A CA1144482A CA 1144482 A CA1144482 A CA 1144482A CA 000361772 A CA000361772 A CA 000361772A CA 361772 A CA361772 A CA 361772A CA 1144482 A CA1144482 A CA 1144482A
- Authority
- CA
- Canada
- Prior art keywords
- corticosteroid
- composition
- nail polish
- psoriasis
- lotion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Abstract An improved composition for treating psoriasis of the nails comprising applying nail polish containing an anti-psoriasis effective amount of a topical steroid.
Description
11~4~2 This application relates to a composition for treating psoriasis of the fingernails~
` Psoriasis is a chronic relapsing papulosquamous skin disease which can also affect nails. Nail involve-ment resembles a fungus infection with stipping, separa-tion of the distal margin, nail loss, scales under the nail plate, thickening and discolora~ion and is seen in any~here from ten to fifty percent of psoriasis patients.
While there are a limited number of effective anti-psoriasis agents, it is far more difficult to treat psoriasis of the nails than that of the skin.
Treatment of psoriasis (skin) can include daily removal of the scales by applying soap and water and scrub-bing gently with a soft brush, followed by the application of a keratolytic ointment.
Topical steroids, particularly 0.01 to 0.025% of fluocinolene acetonide, 0.25% fluorandrenolide and 0.05%
triamcinolene acetonide creams have replaced many previous local treatments. The topical steroids are most effective if covered with a polyethylene film, Saran Wrap (R.T.M.) or Handi-Wrap (R.T.M.), which preferably are sealed with tape.
Thin polyethylene gloves are used for treating the hands and fingers.
Another method involving topical steroids are the use of an inconspicuous, transparent, plastic surgical tape containing fluorandrenolide, Cordrant (R.T.M.) tape sold by Dista Products Company, Division of Eli Lilly and . ~
114448:~
Company, Indianapolis, Indiana 46206.
Generally speaking, while there are methods which are effective in treating psoriasis of the skin,attempts to treat nail involvement have failed miserably. Topically applied steroids are generally without effect.
Accordingly, the present invention provides an antipsoriatic nail polish composition comprising nail pol-ish containing an effective amount of a topically active corticosteroid effective against psoriasis.
I have found that excellent results are obtained when this composition is used for treatment of psoriasis of the fingernails.
- In the practice of the present invention, topical steroids such as betamethasone valerate is sold under the trademark Valisone (R.T.M.) by Schering Corporation, Galloping Hill Road, Kenilworth, New Jersey 07033. Vali-sone is available in aerosol 0.15% w/w reduced strength cream (0.01~) and 0.1% cream, ointment and lotion. In the practice of the present invention, when Valisone is used 20 as the topical steroid, it is preferred to use the 0.1%
lotion which contains in each gram betamethasone valerate equivalent to 1.0 mg. of betamethasone (9-fluoro-11~, 17,21-trihydroxy-16~-methylpregna-1,4-diene-3,20-diene 17 valerate) in a vehicle consisting of isopropyl alcohol (47.5%) and water slightly thickened with carboxy vinyl polymer, the pH adjusted to approximately 4.7 with sodium hydroxide.
Betamethasone valerate is effective in relieving the inflammatory manifestations of corticoid-responsive 30 dermatoses because of its anti-inflammatory, antipruretic and vasoconstrictive actions.
Fluorondrenolide (6~a-fluoro-16a-hydroxycortisone 16,17-acetonide) is sold by Dista Products Company, Divi-sion of Eli Lilly and Company, P.O. Box 1407, Indianapolis, Indiana 46206 and is available as a cream, ointment or lotion in full (O.Q5~) or half (0.025%) preparations.
Cordran also is primarily effective as a topical cortico-steroid because of its anti-flammatory, antipruretic and A
1~44482 -3_ vasoconstrictive actions.
Generally speaking, in the practice of the present invention, a topically effective corticosteroid having anti-inflammatory, anti-pruretic and vasoconstrict-ive actions, preferably in lotion form, is mixed with com-mercially available nail polish such as Revlon clear nail polish in an anti-psoriasis effective amount, preferably in a 50:50 mixture and said mixture is periodically applied to the affected nails preferably at least once daily and more often in severe, intractable cases.
The following examples further illustrate the present invention.
Example 1 A nail polish composition useful in treating psoriatic nails was prepared by mixing 0.1% Valisone lotion with Revlon clear nail polish in a 50:50 mixture.
Example 2 The composition of Example 1 was applied twice daily to the nails of a 36 year old male psoriasis patient with psoriatic nail involvement with noticeable improvement after 8 weeks.
Example 3 ~
The composition of Example l was applied twice daily to the psoriatic nails of a 50 year~old patient.
There was complete clearing of the nail involvement within ~; eight weeks.
Example 4 The composition of Example 1 was applied;once daily to a 55 year old female patient with psoriatic nails with noticeable improvement after~6 weeks.
Example 5 A nail polish composition was prepared as in Example 1, using 0.05~ Cordran lotion instead of Valisone lotion. The composition was applied to the psoriatic nails of psoriasis p~tients with similar results to Examples 2-4.
It will be understood by those skilled in the art th~t any commercial nail polish, colored or clear, can be :.
1~44~2 -4~
used in the practice of the invention and while Cordran and Valisone lotions have been used by way of example, any top-ical steroid having anti-inflammatory, antipruretic and vasoconstructive activities normally used in the treatment of psoriasis can be employed in the practice of this invention.
:
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` Psoriasis is a chronic relapsing papulosquamous skin disease which can also affect nails. Nail involve-ment resembles a fungus infection with stipping, separa-tion of the distal margin, nail loss, scales under the nail plate, thickening and discolora~ion and is seen in any~here from ten to fifty percent of psoriasis patients.
While there are a limited number of effective anti-psoriasis agents, it is far more difficult to treat psoriasis of the nails than that of the skin.
Treatment of psoriasis (skin) can include daily removal of the scales by applying soap and water and scrub-bing gently with a soft brush, followed by the application of a keratolytic ointment.
Topical steroids, particularly 0.01 to 0.025% of fluocinolene acetonide, 0.25% fluorandrenolide and 0.05%
triamcinolene acetonide creams have replaced many previous local treatments. The topical steroids are most effective if covered with a polyethylene film, Saran Wrap (R.T.M.) or Handi-Wrap (R.T.M.), which preferably are sealed with tape.
Thin polyethylene gloves are used for treating the hands and fingers.
Another method involving topical steroids are the use of an inconspicuous, transparent, plastic surgical tape containing fluorandrenolide, Cordrant (R.T.M.) tape sold by Dista Products Company, Division of Eli Lilly and . ~
114448:~
Company, Indianapolis, Indiana 46206.
Generally speaking, while there are methods which are effective in treating psoriasis of the skin,attempts to treat nail involvement have failed miserably. Topically applied steroids are generally without effect.
Accordingly, the present invention provides an antipsoriatic nail polish composition comprising nail pol-ish containing an effective amount of a topically active corticosteroid effective against psoriasis.
I have found that excellent results are obtained when this composition is used for treatment of psoriasis of the fingernails.
- In the practice of the present invention, topical steroids such as betamethasone valerate is sold under the trademark Valisone (R.T.M.) by Schering Corporation, Galloping Hill Road, Kenilworth, New Jersey 07033. Vali-sone is available in aerosol 0.15% w/w reduced strength cream (0.01~) and 0.1% cream, ointment and lotion. In the practice of the present invention, when Valisone is used 20 as the topical steroid, it is preferred to use the 0.1%
lotion which contains in each gram betamethasone valerate equivalent to 1.0 mg. of betamethasone (9-fluoro-11~, 17,21-trihydroxy-16~-methylpregna-1,4-diene-3,20-diene 17 valerate) in a vehicle consisting of isopropyl alcohol (47.5%) and water slightly thickened with carboxy vinyl polymer, the pH adjusted to approximately 4.7 with sodium hydroxide.
Betamethasone valerate is effective in relieving the inflammatory manifestations of corticoid-responsive 30 dermatoses because of its anti-inflammatory, antipruretic and vasoconstrictive actions.
Fluorondrenolide (6~a-fluoro-16a-hydroxycortisone 16,17-acetonide) is sold by Dista Products Company, Divi-sion of Eli Lilly and Company, P.O. Box 1407, Indianapolis, Indiana 46206 and is available as a cream, ointment or lotion in full (O.Q5~) or half (0.025%) preparations.
Cordran also is primarily effective as a topical cortico-steroid because of its anti-flammatory, antipruretic and A
1~44482 -3_ vasoconstrictive actions.
Generally speaking, in the practice of the present invention, a topically effective corticosteroid having anti-inflammatory, anti-pruretic and vasoconstrict-ive actions, preferably in lotion form, is mixed with com-mercially available nail polish such as Revlon clear nail polish in an anti-psoriasis effective amount, preferably in a 50:50 mixture and said mixture is periodically applied to the affected nails preferably at least once daily and more often in severe, intractable cases.
The following examples further illustrate the present invention.
Example 1 A nail polish composition useful in treating psoriatic nails was prepared by mixing 0.1% Valisone lotion with Revlon clear nail polish in a 50:50 mixture.
Example 2 The composition of Example 1 was applied twice daily to the nails of a 36 year old male psoriasis patient with psoriatic nail involvement with noticeable improvement after 8 weeks.
Example 3 ~
The composition of Example l was applied twice daily to the psoriatic nails of a 50 year~old patient.
There was complete clearing of the nail involvement within ~; eight weeks.
Example 4 The composition of Example 1 was applied;once daily to a 55 year old female patient with psoriatic nails with noticeable improvement after~6 weeks.
Example 5 A nail polish composition was prepared as in Example 1, using 0.05~ Cordran lotion instead of Valisone lotion. The composition was applied to the psoriatic nails of psoriasis p~tients with similar results to Examples 2-4.
It will be understood by those skilled in the art th~t any commercial nail polish, colored or clear, can be :.
1~44~2 -4~
used in the practice of the invention and while Cordran and Valisone lotions have been used by way of example, any top-ical steroid having anti-inflammatory, antipruretic and vasoconstructive activities normally used in the treatment of psoriasis can be employed in the practice of this invention.
:
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:
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Claims (6)
1. An antipsoriatic nail polish composition comprising nail polish containing an effective amount of a topically active corticosteroid effective against psoriasis.
2. The composition of Claim 1, wherein said corticosteroid comprises 50% by volume of said composi-tion.
3. The composition of Claim 1, wherein said topical corticosteroid is a fluorinated steroid.
4. The composition of Claim 1, wherein said corticosteroid is selected from the group consisting of fluorandrenolide or betamethasone valerate.
5. The composition of Claim 4, wherein said corticosteroid is 0.1% betamethasone valerate lotion.
6. The composition of Claim 4, wherein said corticosteroid is 0.05% fluorandrenolide lotion.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000361772A CA1144482A (en) | 1980-10-08 | 1980-10-08 | Corticosteroid in nail polish |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000361772A CA1144482A (en) | 1980-10-08 | 1980-10-08 | Corticosteroid in nail polish |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1144482A true CA1144482A (en) | 1983-04-12 |
Family
ID=4118085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000361772A Expired CA1144482A (en) | 1980-10-08 | 1980-10-08 | Corticosteroid in nail polish |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA1144482A (en) |
-
1980
- 1980-10-08 CA CA000361772A patent/CA1144482A/en not_active Expired
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Legal Events
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MKEX | Expiry |