CA1127087A - Composition for application to oral cavity and method of preparation thereof - Google Patents

Abstract

ABSTRACT OF THE DISCLOSURE

An innocuous purified extract of Sanguinaria canadensis is compounded at from 0.1% to 40% with a suitable paste or a liquid to be used in an oral cavity fox cleaning teeth, re-freshing the cavity, and conditioning the fleshy parts of the cavity.

Description

-` ~lZ~3B7 1 San~uinaria canadensis, Linne (family Papavaracease) is commonly known as Bloodroot, Redroot, Puccoon, Teterwor-t, etc, is a perennial herb native to North ~merica. The plant and its juices have been used for various purposes during the course of pre-history as well as writ-ten history. It has been used as a natural historic folk remedy medicine~ The plan~ has been generally used whole, either undried (fresh) or dried.
The usual procedure is to powder the dried plant and mix it with a carrier. This olk remedy has been tried for such 13 things as asthma, bronchitis, dysentery, ringworm, and a sub-stantial list of other ailments.
However, the rhizome of the plant has not found favour in more modern times since Sanguinaria is a local ir~itant, which in relatively mild doses, up to toxic quantities, produces epigastxic burning with vomiting, tormenting thirst, faintness, dimness of vision, vertigo, and alarming prostration. In doses of about l gm it is a violent emetic. The present principle use of the Sanguinaria is as a stimulant expectorant in cough syrups.
An early patent, U.S. Patent No. 209,331, describes the use of Bloodroot, zinc chloride and kerosene oil in equal proportions for open sores. U.S. Patent No. 433,257 describes a salve of pulverized bloodroot, armenian bole, powdered rosin, lard and Stockholm tar in a treatment for piles. U.S. Patent No. 2,344,830 describes the use of zinc chloride, stibnite and bloodroot to fix and outline diseased tissue for excising by surgery.
Sanguinarine, chelerythrine and other chemicals are known in Bloodroot, but recovery of these materials has involved fairly elaborate procedures including one or generally more ''~

~LZ7~7 1 chromatographic separation steps. Such is not feasible ~or commercial purposes of producing an innocuous extract from the rhizome of bloodroot.
The present invention relates to oral cleansiny preparations and in particular to toothpaske using a special extract of Sanguinaria canadensis as a portion oE the preparations.
The special extract in the amounts utiliæed does not have the disagreeable properties of the powdered rhizome, and with other ingredients provides an oral cavity and tooth cleansing ayent, an excellent breath freshner and an oral cavity tissue conditioner.
The composition of the present invention, in the form of a toothpaste, provides easily available oral application.
This application may be accomplished by a user. The extract of the bloodroot is compatible with the materials used in the formulation of toothpaste. The composition may be pasty in form (toothpaste) or as a powder.
The Sanguinaria canadensis extract is produced by treating a finely cut or ground bloodroot with an organic solvent, such as methanol. The bloodroot is thoroughly stirred with several volumes of the solvent, and is maintained in the - solvent for 24 hours or more, at a temperature of about 6QC.
Subsequently, the solution is filtered and the methanol evaporated. The residue is dissolved in chloroform, treat~d with concentrated hydrochloric acid, filtered and then dried.
This dried extract is generally taken up in warm glycerin (65C) for mixing with a carrier.
The extract from the bloodroot may be employed in amounts by weights, of from about 0.1~ to about 50%, and pre-ferably from about loOO~ to about 10.0% of the mixture, by weight.

L27~87 1 A toothpaste additi~Je of the extract is prepared from the following:
Amount By Wei~h-t 1. Glycerin 758 g 75.8

2. Water 101 g 10.1~

3. Zinc Chloride136 g 13.6%

4. Bloodroot Extract 5 g 0.5 (as made above) The glycerin is weighed into a vessel and heated to about 65C. The zinc chloride is dissolved in deionized water, and this solution is filtered and added to the bloodroot extract and stirred. This forms a lumpy paste which is placed in a mixing bowl. The remainder of the paste is washed into the vessel with the warmed glycerin. The mixture is then stirred until homogenous. The amount of zinc chloride is useful from 0.1-30% and preferably about 0.1-15% by weight.
A -toothpaste is prepared from the following:
Raw Materials ~mount By Wei~t 1. Vipoint additive 990 g 19.8%

2. Sorbitol (70%) 550 g 10.0%
3~ Polysorbate 80 (tween 80)* 100 g 2.0%
4. Tragacanth 105 g 2.1%

5. Penick mint C-486 31.25 g 0.625%

6. Saccharin/ sodium 15 g 0.3%

7. Me~hylparaben 7O5 g 0.15

8. Propylparaben 0.75 g 0.015

9. Dicalcium phosphate anhyd. 300 g 6.0%

10. Dicalcium phosphate 2H~O 1850 g 37.0%

11. Dionized water 1100.5 g 22.01%

The bloodroot extract additive as prepared above, is placed in a mixing bowl and the sorbitol is added. The polysorbate * Trade Mark `` 11276~7 80 (tween 80) is added and the mixture is stirred. The tragacanth is added in small portions to avoid lumping and the mixture is stirred continuou~ly during the addition. The mint flavouring is added and the mixture stirred until homogenous. At this point, the saccarin and parabens are added with continued stirring. Anhydrous dicalci~n phosphate is aclded in small portions with stirring. The dicalcium phosphate dihydrate is then added in portions with stirring~ Some portions of the water must be added along with the phosphate to maintain a good consistency for thorough mixing. The remaining water is added, and the mixture stirred to the desired consistency of toothpaste. ~ solution made from the paste is about neutral as to PH. The amount of zinc chloride is useful in an amount of 0.1-30% by weight, and in the paste from about 0.1 to 3 weight percent.
The toothpaste is used in the normal manner, one or more times a day. The toothpaste is an excellent cleaning agent, and a breath ~reshener. Use for some 30 days on a regular basis showPd improved tissue condition of the oral cavity. The thirty day application promotes normal tissue and tends to reduce the bleeding associated with vigorous brushing. Other effects are clean teeth and a refreshed breath.

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Claims (5)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. Composition for application to oral cavities consisting;
(a) an extract of Sanguinaria canadensis, produced by treating cut or ground bloodroot with methanol by maintaining the solids with the solvent for about 24 hours at about 60°C, filtering the resultant solvent and evaporating it to dryness and the resulting residue is disssolved in chloroform and adjusted to an acid pH with HC1 and dried, and the resultant residue dissolved in glycerine, in an amount of from 0.1 weight percent to 40.0 weight percent, and from 0.1-30 weight percent of zinc chloride, and (b) an innocuous carrier arranged for application to an oral cavity.

2. The composition of claim 1 wherein said extract is present in amount of 1.0 weight percent to 10 weight percent.

3. The composition of claim 2 wherein said innocuous carrier is a toothpaste base.

4. The composition of claim 1 wherein said extract is present in about 0.5 weight percent.

5. The composition of claim 2 wherein the innocuous carrier is a liquid.