CA1124749A - Production of 2,6-dimethyl aniline from cyclohexyl amine - Google Patents
Production of 2,6-dimethyl aniline from cyclohexyl amineInfo
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- CA1124749A CA1124749A CA341,895A CA341895A CA1124749A CA 1124749 A CA1124749 A CA 1124749A CA 341895 A CA341895 A CA 341895A CA 1124749 A CA1124749 A CA 1124749A
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- phenol
- amine
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- dimethyl aniline
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Abstract
Case 4080-A
PRODUCTION OF 2,6-DIMETHYL ANILINE
FROM CYCLOHEXYL AMINES
Abstract A process for making 2,6-dimethyl aniline is shown comprising heating a mixture of phenol and cyclohexyl amine at about 200 to 400° C. in contact with a palladium catalyst and under sufficient pressure to maintain the reactants in a liquid phase.
PRODUCTION OF 2,6-DIMETHYL ANILINE
FROM CYCLOHEXYL AMINES
Abstract A process for making 2,6-dimethyl aniline is shown comprising heating a mixture of phenol and cyclohexyl amine at about 200 to 400° C. in contact with a palladium catalyst and under sufficient pressure to maintain the reactants in a liquid phase.
Description
"` 9L~L%~74~
1 Case 4080-A
PRODUCTION OF 2,6-DIMETHYL ANILINE
FROM CYCLOHEXYL ~INES
This invention relates to the production of 2,6-dimethyl aniline. More particularly the invention comprises an improved process for generating this compound from cyclo-hexyl amines. It is known to produce aromatic amines by contacting a cyclohexyl amine with a Group VIII metal cata-lyst preferably in the presence of ammonia and hydrogen.
However, when this technique is applied to producing 2,6-di-methyl aniline, it is found that forma`tion of the desiredproduct is very slow. The present invention provides sub-stantial improvement in the rate of formation. It comprises heating a mixture of 2,6-dimethylcyclohexylamine and a phenol in contact with a palladium catalyst, maintaining the reac-- 15 tantsin a liquid phase and at an elevated temperature of about 200 to 400 C.
Various methods have been used in the past to pre-pare aromatic amines. According to one method, an aromatic compound is nitrated to form a nitroaromatic which is then hydrogenated to the corresponding aromatic amine. This method is used commercially to make aniline from benzene.
Van Verth et al, U. S. 3,219,702, describes a pro-cess in which a cyclohexanone îs reacted with ammonia in the presence of a hydrogen acceptor (e.g. nitrobenzene) and a dehydrogenation catalyst.
Wilder et al, U. S. 3,219,704, describes a similar process in which the hydrogen acceptor is eliminated and the - amount of cyclohexanone is at least equivalent to the amount of ammonia used.
Barker, U. S. 3,272,865, describes the production of anilines by reaction of phenols with ammonia in contact with a silica-alumina, titania-alumina, zirconia-alumina, phosphoric acid or tungsten oxide catalyst. The process is similar to that described by Neuroessen, U. S. 1,935,209, - 35 and Lowy et al, U. S. 1,449,423.
~2-~749 Barker, U. S. 3,361,818, describes the production of aromatic amines by passing cyclohexyl amine through a Group VIII metal catalyst. Preferably hydrogen and ammonia are included.
Barker, U. S. 3,442,950, describes the reaction of a cyclohexanol with an aminating agent (e.g. ammonia) in contact with a metal catalyst to form the corresponding aromatic amine. If cyclohexanone is present, hydrogen is added initially in an amount at least equivalent to the amount of cyclohexanone.
Wollensak, U. S. 3,931,298, describes the production of aromatic amines by the reaction of a phenol with ammonia in contact with a Group VIII metal catalyst and a promoter amount of a cyclohexanone.
Other processes for making aromati~c amines are taught by Ballard, U. S. 2,413,598; Vogt, U. S. 2,013,873;
Groggins, I'Unite Processes in Organic Synthesis," 5th Ed.;
and Houben-Weyl, "Methoden der Organische Chemi," Vol. 11/1, pp. 117-122.
According to the present process, 2,6-dimethyl aniline is formed from 2,6-dicyclohexyl amine by reaction with a hydroxy aromatic at elevated temperatures, in contact with a palladium catalyst. The 2,6-dimethylcyclohexyl amine can be initially made by reacting 2,6-dimethylphenol with hydrogen and ammonia either sequentially or concurrently in contact with any of a variety of hydrogenation catalysts, e.g. Ni.
A preferred embodiment o the invention is a pro-cess for making 2,6-dimethyl aniline, said process comprising heating a mixture of 1 to 10 mole parts of a 2,6-dimethyl-cyclohexyl amine and 1 to 10 mole parts of a phenol at a temperature of about 200 to 400 C. in contact with a palla-dium catalyst and under sufficient pressure to maintain the reactants in a liquid phase and recovering said aromatic amine from the resultant mixture.
The phenol used in the process can be any phenol .
~ 4 ~
which does not adversely affect the reaction. It is not necessary that the phenol correspond in structure with the cyclohexyl amine. The phenol may be unsubstituted or sub-- stituted with such groups as alkyl, cycloalkyl, aryl, araIkyl, haol, alkoxy and the like~ Some examples o~ such phenols are:
phenol ~-cresol o-cresol
1 Case 4080-A
PRODUCTION OF 2,6-DIMETHYL ANILINE
FROM CYCLOHEXYL ~INES
This invention relates to the production of 2,6-dimethyl aniline. More particularly the invention comprises an improved process for generating this compound from cyclo-hexyl amines. It is known to produce aromatic amines by contacting a cyclohexyl amine with a Group VIII metal cata-lyst preferably in the presence of ammonia and hydrogen.
However, when this technique is applied to producing 2,6-di-methyl aniline, it is found that forma`tion of the desiredproduct is very slow. The present invention provides sub-stantial improvement in the rate of formation. It comprises heating a mixture of 2,6-dimethylcyclohexylamine and a phenol in contact with a palladium catalyst, maintaining the reac-- 15 tantsin a liquid phase and at an elevated temperature of about 200 to 400 C.
Various methods have been used in the past to pre-pare aromatic amines. According to one method, an aromatic compound is nitrated to form a nitroaromatic which is then hydrogenated to the corresponding aromatic amine. This method is used commercially to make aniline from benzene.
Van Verth et al, U. S. 3,219,702, describes a pro-cess in which a cyclohexanone îs reacted with ammonia in the presence of a hydrogen acceptor (e.g. nitrobenzene) and a dehydrogenation catalyst.
Wilder et al, U. S. 3,219,704, describes a similar process in which the hydrogen acceptor is eliminated and the - amount of cyclohexanone is at least equivalent to the amount of ammonia used.
Barker, U. S. 3,272,865, describes the production of anilines by reaction of phenols with ammonia in contact with a silica-alumina, titania-alumina, zirconia-alumina, phosphoric acid or tungsten oxide catalyst. The process is similar to that described by Neuroessen, U. S. 1,935,209, - 35 and Lowy et al, U. S. 1,449,423.
~2-~749 Barker, U. S. 3,361,818, describes the production of aromatic amines by passing cyclohexyl amine through a Group VIII metal catalyst. Preferably hydrogen and ammonia are included.
Barker, U. S. 3,442,950, describes the reaction of a cyclohexanol with an aminating agent (e.g. ammonia) in contact with a metal catalyst to form the corresponding aromatic amine. If cyclohexanone is present, hydrogen is added initially in an amount at least equivalent to the amount of cyclohexanone.
Wollensak, U. S. 3,931,298, describes the production of aromatic amines by the reaction of a phenol with ammonia in contact with a Group VIII metal catalyst and a promoter amount of a cyclohexanone.
Other processes for making aromati~c amines are taught by Ballard, U. S. 2,413,598; Vogt, U. S. 2,013,873;
Groggins, I'Unite Processes in Organic Synthesis," 5th Ed.;
and Houben-Weyl, "Methoden der Organische Chemi," Vol. 11/1, pp. 117-122.
According to the present process, 2,6-dimethyl aniline is formed from 2,6-dicyclohexyl amine by reaction with a hydroxy aromatic at elevated temperatures, in contact with a palladium catalyst. The 2,6-dimethylcyclohexyl amine can be initially made by reacting 2,6-dimethylphenol with hydrogen and ammonia either sequentially or concurrently in contact with any of a variety of hydrogenation catalysts, e.g. Ni.
A preferred embodiment o the invention is a pro-cess for making 2,6-dimethyl aniline, said process comprising heating a mixture of 1 to 10 mole parts of a 2,6-dimethyl-cyclohexyl amine and 1 to 10 mole parts of a phenol at a temperature of about 200 to 400 C. in contact with a palla-dium catalyst and under sufficient pressure to maintain the reactants in a liquid phase and recovering said aromatic amine from the resultant mixture.
The phenol used in the process can be any phenol .
~ 4 ~
which does not adversely affect the reaction. It is not necessary that the phenol correspond in structure with the cyclohexyl amine. The phenol may be unsubstituted or sub-- stituted with such groups as alkyl, cycloalkyl, aryl, araIkyl, haol, alkoxy and the like~ Some examples o~ such phenols are:
phenol ~-cresol o-cresol
2,6,-dimethylphenol 2,6-diethylphenol 2-methyl-6-isopropylphenol 2,6-diisopropylphenol 2-methyl-6-tert-butylphenol 2,6-di-tert-butylphenol 2-sec-butylphenol 2,6-di-sec-butylphenol 2,4-dimethylphenol 4-sec-octylphenol 2-sec-dodecyl-4-methylphenol 2-sec-eicosylphenol 4-cyclohexylphenol 4-phenylphenol l-naphthol 2-naphthol 2-(a,a-dimethylbenzyl)phenol 2,6-di-(a-methylbenzyl)phenol 4-(a,a-dimethylbenzyl~phenol 2,4-di-(~,a-dimethylbenzyl)phenol 4-chlorophenol 2,4-dichlorophenol 2,4,6-trichlorophenol 4-bromophenol 2,6-dibromophenol ; 35 4-fluorophenol 4-iodophenol ~. ~
2,6-dichlorophenol 4-methyoxyphenol 2-ethyoxyphenol ~-dodecoxyphenol and the like.
In a more preferred embodiment the phenol corres-ponds in structure with the cyclohexyl amine. In other words the preferred phenol is 2,6-dimethylphenol.
The reaction can be carried out by merely mixing the 2,6-dimethylcyclohexyl amine with the phenol and heating the mixture at about 200 to 400 C. in contact with the catalyst. Preferably the palladium is on a suitable catalyst support such a~s alumina, silica-alumina, magnesia, zirconia, or the like. The preferred catalyst support is charcoal. The amount of catalys* can vary over a wide range. Reaction rate is dependent on the amount of catalyst used. A useful range is from about 0.0001 to 0.01 mole parts of palladium excludi~g support per mole part of reaction mixture. A preferred range is 0.0005 to 0.001 mole of palladium per mole of reaction mixture.
The amount of each reactant can vary over a wide range. A useful range is from about 1 to 10 mole parts of 2,6-dimethylcyclohexyl amine for each 1 to 10 mole parts of phenolic reactant. More preferably, the process is carried out with 1 to 2 mole parts of a 2,6-dimethyl-cyclohexyl amine for each 1 to 2 mole parts of a phenol.
Most preferably equal mole amounts are used.
The reaction is effected by heating the mixture to about 200 to 400 C. A more preferred temperature range is about 225 to 300 C. The reaction is preferably carried out at autogenous pressure in a closed vessel such as an 11Z~7~9 autoclave to maintain the reactants in the liquid phase.
The reaction is conducted for a time sufficient to convert a substantial amount of the cyclohexyl amine to aromatic amine. A useful reaction time is from about 30 minutes to 8 hours. Generally, good results are achieved in about 1 to 4 hours.
The reaction will proceed without the necessity of adding hydrogen or ammonia to the autoclave. It is highly preferred that the process be conducted without adding hydrogen or ammonia. Preferably an inert atmosphere such as nitrogen is placed over the reactants at the start of the reaction.
The 2,6-dimethylcyclohexyl amine is believed to be converted to the corresponding aromatic amine according 15 to the following equation: -H3C ~ CH3 ~ 3C` ~ ~ 3 ., ~`:
Some cyclohexanone forms. The aromatic amine can be readi-ly recovered from the mixture by distillation. When 2,6-dimethylphenol is used the 2,6-dimethylcyclohexanol and cyclohexanone (referred to collectively herein as "reduced ` products") which form are not waste products but can be recycled to the process after being converted to the cor-responding 2,6-dimethylcyclohexyl amine. This can be accomplished by known methods such as by reacting the re-duced products with ammonia in the presence of a dehydration catalyst such as activated alumina at temperatures of about 200 to 500 C. Alternatively, the reduced products can be reacted with a mixture of hydrogen and ammonia in thepresence of a hydrogenation catalyst at about 200 to 500 C. to form 2,6-dimethylcyclohexyl amine. The hydrogenation catalyst need not be palladium but can be any of the metal catalysts ; , known to catalyze hydrogenation such as the transition l~LZ~749 metal catalysts, especially the less costly catalysts made from metals of the First Transition Series, viz., V, Cr, Mn, Fe, Co, Ni, Cu, and the like. Preferably the hydrogenation catalyst is a Group VIII metal catalyst. I~hen a metal hy-drogenation catalyst is used to convert the reduced productsto 2,6-dimethylcyclohexyl amine it is preferably removed from the cyclohexyl amine product and replaced with the preferred palladium catalyst for the reaction of the 2,6-dimethylcyclohexyl amine with the phenol in the manner pre-viously described.
The method according to which the process is con-ducted is illustrated by the following examples.
Example 1 In an autoclave was placed 60 grams of a mixture consisting essentially fo 52 grams of 2,6-dimethylcyclo-hexyl amine and 8 grams of 2,6-dimethyl aniline. To this was added 13 grams of 5 percent palladium on charcoal catalyst and 90 grams of 2,6-dimethylphenol. The autoclave was sealed and heated to 250 C. and maintained at that temperature for 2 hours. It was then cooled~and analyzed by vapor phase chromatography (VPC). It contained 48.5 grams of 2,6-dimethyl aniline, recoverable by distillation.
Barker, U. S. 3,361,818, discloses a process for converting cyclohexyl amines to anilines by merely heating 25 the cyclohexyl amine to 180 to 500 C. in contact with a catalyst such as palladium. That process appears to work well in converting cyclohexyl amine to aniline. However, ; it is not very effective in converting 2,6-dimethylcyclo-hexylamine to 2,6-dimethylaniline.
Comparative tests were conducted which show the significant effect of the phenol on the reaction of 2,6-dimethylcyclohexylamine in contact with a palladium catalyst.
The first test was conducted by heating 2,6-dimethylcyclo-hexylamine in contact with a palladium catalyst without adding a phenol. The following example describes this test.
112474~
Example 2 In an autoclave was placed 87 grams of 2,6-dimethyl-cyclohexylamine and 14.6 grams of wet 5 percent Pd on char-coal. The autoclave was flushed with hdyrogen. It was then pressurized with hydrogen to 1,000 psig ~70.3 kg.'/sq. cm.) and heated to 50 C. as a standard method of activatLng the Pd catalyst. The autoclave was cooled and vented and 18 grams of ammonia was added. It was sealed. and heated to 300 C. considered the "start" of the reaction. It was necessary to vent 8 grams of ammonia to keep the pressure within the limit of the autoclave. The autoclave was maintained at 300 C. for three hours with samples taken at the start and hourly. The sampels analyzed as follows:
Area Percent VPC Analysis of Reaction Mixture , . _ ~5 ~ 2,6-dimethyl-A B C D E aniline initial 6.2 1.9 - 88.5 - 1.0 "start" 3.3 1.8 - 74.3 ~0.04 9.0 1 hour - 10.6 1.570.4 0.3 15.3 2 hours - 18.8 1.960.3 0.2 17.8
2,6-dichlorophenol 4-methyoxyphenol 2-ethyoxyphenol ~-dodecoxyphenol and the like.
In a more preferred embodiment the phenol corres-ponds in structure with the cyclohexyl amine. In other words the preferred phenol is 2,6-dimethylphenol.
The reaction can be carried out by merely mixing the 2,6-dimethylcyclohexyl amine with the phenol and heating the mixture at about 200 to 400 C. in contact with the catalyst. Preferably the palladium is on a suitable catalyst support such a~s alumina, silica-alumina, magnesia, zirconia, or the like. The preferred catalyst support is charcoal. The amount of catalys* can vary over a wide range. Reaction rate is dependent on the amount of catalyst used. A useful range is from about 0.0001 to 0.01 mole parts of palladium excludi~g support per mole part of reaction mixture. A preferred range is 0.0005 to 0.001 mole of palladium per mole of reaction mixture.
The amount of each reactant can vary over a wide range. A useful range is from about 1 to 10 mole parts of 2,6-dimethylcyclohexyl amine for each 1 to 10 mole parts of phenolic reactant. More preferably, the process is carried out with 1 to 2 mole parts of a 2,6-dimethyl-cyclohexyl amine for each 1 to 2 mole parts of a phenol.
Most preferably equal mole amounts are used.
The reaction is effected by heating the mixture to about 200 to 400 C. A more preferred temperature range is about 225 to 300 C. The reaction is preferably carried out at autogenous pressure in a closed vessel such as an 11Z~7~9 autoclave to maintain the reactants in the liquid phase.
The reaction is conducted for a time sufficient to convert a substantial amount of the cyclohexyl amine to aromatic amine. A useful reaction time is from about 30 minutes to 8 hours. Generally, good results are achieved in about 1 to 4 hours.
The reaction will proceed without the necessity of adding hydrogen or ammonia to the autoclave. It is highly preferred that the process be conducted without adding hydrogen or ammonia. Preferably an inert atmosphere such as nitrogen is placed over the reactants at the start of the reaction.
The 2,6-dimethylcyclohexyl amine is believed to be converted to the corresponding aromatic amine according 15 to the following equation: -H3C ~ CH3 ~ 3C` ~ ~ 3 ., ~`:
Some cyclohexanone forms. The aromatic amine can be readi-ly recovered from the mixture by distillation. When 2,6-dimethylphenol is used the 2,6-dimethylcyclohexanol and cyclohexanone (referred to collectively herein as "reduced ` products") which form are not waste products but can be recycled to the process after being converted to the cor-responding 2,6-dimethylcyclohexyl amine. This can be accomplished by known methods such as by reacting the re-duced products with ammonia in the presence of a dehydration catalyst such as activated alumina at temperatures of about 200 to 500 C. Alternatively, the reduced products can be reacted with a mixture of hydrogen and ammonia in thepresence of a hydrogenation catalyst at about 200 to 500 C. to form 2,6-dimethylcyclohexyl amine. The hydrogenation catalyst need not be palladium but can be any of the metal catalysts ; , known to catalyze hydrogenation such as the transition l~LZ~749 metal catalysts, especially the less costly catalysts made from metals of the First Transition Series, viz., V, Cr, Mn, Fe, Co, Ni, Cu, and the like. Preferably the hydrogenation catalyst is a Group VIII metal catalyst. I~hen a metal hy-drogenation catalyst is used to convert the reduced productsto 2,6-dimethylcyclohexyl amine it is preferably removed from the cyclohexyl amine product and replaced with the preferred palladium catalyst for the reaction of the 2,6-dimethylcyclohexyl amine with the phenol in the manner pre-viously described.
The method according to which the process is con-ducted is illustrated by the following examples.
Example 1 In an autoclave was placed 60 grams of a mixture consisting essentially fo 52 grams of 2,6-dimethylcyclo-hexyl amine and 8 grams of 2,6-dimethyl aniline. To this was added 13 grams of 5 percent palladium on charcoal catalyst and 90 grams of 2,6-dimethylphenol. The autoclave was sealed and heated to 250 C. and maintained at that temperature for 2 hours. It was then cooled~and analyzed by vapor phase chromatography (VPC). It contained 48.5 grams of 2,6-dimethyl aniline, recoverable by distillation.
Barker, U. S. 3,361,818, discloses a process for converting cyclohexyl amines to anilines by merely heating 25 the cyclohexyl amine to 180 to 500 C. in contact with a catalyst such as palladium. That process appears to work well in converting cyclohexyl amine to aniline. However, ; it is not very effective in converting 2,6-dimethylcyclo-hexylamine to 2,6-dimethylaniline.
Comparative tests were conducted which show the significant effect of the phenol on the reaction of 2,6-dimethylcyclohexylamine in contact with a palladium catalyst.
The first test was conducted by heating 2,6-dimethylcyclo-hexylamine in contact with a palladium catalyst without adding a phenol. The following example describes this test.
112474~
Example 2 In an autoclave was placed 87 grams of 2,6-dimethyl-cyclohexylamine and 14.6 grams of wet 5 percent Pd on char-coal. The autoclave was flushed with hdyrogen. It was then pressurized with hydrogen to 1,000 psig ~70.3 kg.'/sq. cm.) and heated to 50 C. as a standard method of activatLng the Pd catalyst. The autoclave was cooled and vented and 18 grams of ammonia was added. It was sealed. and heated to 300 C. considered the "start" of the reaction. It was necessary to vent 8 grams of ammonia to keep the pressure within the limit of the autoclave. The autoclave was maintained at 300 C. for three hours with samples taken at the start and hourly. The sampels analyzed as follows:
Area Percent VPC Analysis of Reaction Mixture , . _ ~5 ~ 2,6-dimethyl-A B C D E aniline initial 6.2 1.9 - 88.5 - 1.0 "start" 3.3 1.8 - 74.3 ~0.04 9.0 1 hour - 10.6 1.570.4 0.3 15.3 2 hours - 18.8 1.960.3 0.2 17.8
3 hours - 24.1 3.051.7 0.5 20.0 A = water; B = 2,6-dimethylcyclohexane; C = m-xylene;
D = 2,6-dimethylcyclohexylamine; E = 2,6-dimethylphenol.
In this experiment carried out without adding 2,6-dimethylphenol, the formation of 2,6-dimethylaniline was very slow. The major products after three hours were (B) 2,6-dimethylcyclohexane and (C) m-xylene.
The following example shows the effect of including 2,6-dimethylphenol in the above reaction.
Example 3 In an autoclave was placed 40 grams of 2,6-di-methylcyclohexylamine, 38.5 grams 2,6-dimethylphenol and 13.4 grams wet 5 percent Pd on charcoal. The autoclave was flushed with hydrogen and then pressurized with hydrogen to 1,000 psig (70.3 kg./sq. cm.) and heated to 50 ~. to r, 112~74~
activate the catalyst. The autoclave was cooled and vented and 9 grams of ammonia added. The autoclave was heated to 300 C., which was considered the "start" of the reaction.
Samples were taken at the start and hourly for VPC analysis.
The following table shows the results of the above reaction:
' .
112-~749 ~^
~o ~ rl a~ ~ oo ~ D
~. . . . .
.,, ~ o ~ oo ~ oo ra ~ U~ U~
a~
~ ~ .
X
~D
o ~ o o o o 11 ~ ...
a) Oo ~ ~ u~ Q) o .. ..
D = 2,6-dimethylcyclohexylamine; E = 2,6-dimethylphenol.
In this experiment carried out without adding 2,6-dimethylphenol, the formation of 2,6-dimethylaniline was very slow. The major products after three hours were (B) 2,6-dimethylcyclohexane and (C) m-xylene.
The following example shows the effect of including 2,6-dimethylphenol in the above reaction.
Example 3 In an autoclave was placed 40 grams of 2,6-di-methylcyclohexylamine, 38.5 grams 2,6-dimethylphenol and 13.4 grams wet 5 percent Pd on charcoal. The autoclave was flushed with hydrogen and then pressurized with hydrogen to 1,000 psig (70.3 kg./sq. cm.) and heated to 50 ~. to r, 112~74~
activate the catalyst. The autoclave was cooled and vented and 9 grams of ammonia added. The autoclave was heated to 300 C., which was considered the "start" of the reaction.
Samples were taken at the start and hourly for VPC analysis.
The following table shows the results of the above reaction:
' .
112-~749 ~^
~o ~ rl a~ ~ oo ~ D
~. . . . .
.,, ~ o ~ oo ~ oo ra ~ U~ U~
a~
~ ~ .
X
~D
o ~ o o o o 11 ~ ...
a) Oo ~ ~ u~ Q) o .. ..
4~ o ~
o C~
~ ~ ~ o X
~o ~o ~J ~ ~ C`J ~o 3 ~, ~, ~ ~ O 0 ,. P
. ~, ~ .....
h c~
C~
~ , C~ ~ U~ ~ 11 Sl ~O
¢
~ C`~ ~ . _ FqIOOOOO
~ O
~1 I r~ -¢ .
~ c~ ll ~- ~
a~ ~
h ~ td td O O O ~
,, , ':
'~ , ' ,':
, li;i: ~749 The above results show that when the same reaction as in Example 2 is carried out in the presence of 2,6-di-methylphenol, the 2,6-dimethylaniline forms very rapidly giving a reaction mixture analyzing over 50 percent 2,6-dimethylaniline.
o C~
~ ~ ~ o X
~o ~o ~J ~ ~ C`J ~o 3 ~, ~, ~ ~ O 0 ,. P
. ~, ~ .....
h c~
C~
~ , C~ ~ U~ ~ 11 Sl ~O
¢
~ C`~ ~ . _ FqIOOOOO
~ O
~1 I r~ -¢ .
~ c~ ll ~- ~
a~ ~
h ~ td td O O O ~
,, , ':
'~ , ' ,':
, li;i: ~749 The above results show that when the same reaction as in Example 2 is carried out in the presence of 2,6-di-methylphenol, the 2,6-dimethylaniline forms very rapidly giving a reaction mixture analyzing over 50 percent 2,6-dimethylaniline.
Claims (2)
Canada THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A process for making 2,6-dimethyl aniline, said process comprising heating a mixture of 1 to 10 mole parts of 2,6-dimethylcyclohexyl amine and 1 to 10 mole parts of a phenol at a temperature of about 200 to 400° C. in con-tact with a palladium catalyst and under sufficient pressure to maintain the reactants in a liquid phase and then recovering 2,6-dimethyl aniline from the resultant mixture.
2. A process of Claim 1 wherein said phenol is 2,6-dimethylphenol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA341,895A CA1124749A (en) | 1979-12-13 | 1979-12-13 | Production of 2,6-dimethyl aniline from cyclohexyl amine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA341,895A CA1124749A (en) | 1979-12-13 | 1979-12-13 | Production of 2,6-dimethyl aniline from cyclohexyl amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1124749A true CA1124749A (en) | 1982-06-01 |
Family
ID=4115830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA341,895A Expired CA1124749A (en) | 1979-12-13 | 1979-12-13 | Production of 2,6-dimethyl aniline from cyclohexyl amine |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1124749A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5072044A (en) * | 1990-11-30 | 1991-12-10 | E. I. Du Pont De Nemours And Company | Preparation of ortho-phenylenediamine |
-
1979
- 1979-12-13 CA CA341,895A patent/CA1124749A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5072044A (en) * | 1990-11-30 | 1991-12-10 | E. I. Du Pont De Nemours And Company | Preparation of ortho-phenylenediamine |
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