CA1083572A - Process for the preparation of 4-hydroxy-3-(5-methyl- 3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1, 1-dioxide and intermediates used in the production thereof - Google Patents

Process for the preparation of 4-hydroxy-3-(5-methyl- 3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1, 1-dioxide and intermediates used in the production thereof

Info

Publication number
CA1083572A
CA1083572A CA252,912A CA252912A CA1083572A CA 1083572 A CA1083572 A CA 1083572A CA 252912 A CA252912 A CA 252912A CA 1083572 A CA1083572 A CA 1083572A
Authority
CA
Canada
Prior art keywords
compound
formula
methyl
reacting
dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA252,912A
Other languages
English (en)
French (fr)
Inventor
Arthur C. Fabian
Harold Zinnes
Jerome D. Genzer
Charles F. Kasulanis
John Shavel, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of CA1083572A publication Critical patent/CA1083572A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CA252,912A 1975-05-21 1976-05-20 Process for the preparation of 4-hydroxy-3-(5-methyl- 3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1, 1-dioxide and intermediates used in the production thereof Expired CA1083572A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US577,568 1975-05-21
US05/577,568 US3957772A (en) 1975-05-21 1975-05-21 Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
US05/644,986 US4022796A (en) 1975-05-21 1975-12-29 2,3-Dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzothiazole-2-acetamide 1,1-dioxide
US05/697,595 US4018762A (en) 1975-05-21 1976-06-18 Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide

Publications (1)

Publication Number Publication Date
CA1083572A true CA1083572A (en) 1980-08-12

Family

ID=27416273

Family Applications (1)

Application Number Title Priority Date Filing Date
CA252,912A Expired CA1083572A (en) 1975-05-21 1976-05-20 Process for the preparation of 4-hydroxy-3-(5-methyl- 3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1, 1-dioxide and intermediates used in the production thereof

Country Status (11)

Country Link
US (3) US3957772A (US20110158925A1-20110630-C00042.png)
JP (4) JPS51143682A (US20110158925A1-20110630-C00042.png)
AU (1) AU511134B2 (US20110158925A1-20110630-C00042.png)
BE (1) BE842079A (US20110158925A1-20110630-C00042.png)
CA (1) CA1083572A (US20110158925A1-20110630-C00042.png)
CH (1) CH629204A5 (US20110158925A1-20110630-C00042.png)
DE (1) DE2618999C2 (US20110158925A1-20110630-C00042.png)
FR (3) FR2333802A1 (US20110158925A1-20110630-C00042.png)
GB (3) GB1492719A (US20110158925A1-20110630-C00042.png)
LU (1) LU74936A1 (US20110158925A1-20110630-C00042.png)
NL (1) NL7605246A (US20110158925A1-20110630-C00042.png)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957772A (en) * 1975-05-21 1976-05-18 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
US4074048A (en) * 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
US4082757A (en) * 1976-12-10 1978-04-04 Warner-Lambert Company Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide
GB2095671B (en) * 1981-03-27 1985-04-11 Lilly Co Eli Acyloxadiazole derivatives useful as intermediates in a process for preparing isoxazol-3-ylcarboxamides
JPS59146207U (ja) * 1983-03-23 1984-09-29 富士重工業株式会社 自動車用空調装置の吹出口部構造
DE3311165A1 (de) * 1983-03-26 1984-09-27 Gödecke AG, 1000 Berlin Feinkristallines isoxicam
ES8604948A1 (es) * 1984-12-28 1986-02-16 Uriach Cia S A J Procedimiento para la obtencion del 1,1-dioxido de 4-hidroxi-3-(5-metil-o-isoxazolocarbamil)-2-metil-2h-1,2-benzotiazina
JPS61238785A (ja) * 1985-04-16 1986-10-24 Taito Pfizer Kk １、２―ベンゾチアジン類
JP2543498Y2 (ja) * 1992-05-22 1997-08-06 日機装株式会社 キャンドモータポンプ
KR960022489A (ko) * 1994-12-30 1996-07-18 김준웅 방사성동위원소 표지화합물로서의 피록시캄 중간체[¹⁴c]의 제조방법
RS49867B (sr) * 1999-12-06 2008-08-07 Ad. Zdravlje, Postupak za sintezu 4-hidroksi-2h-1,2-benzotiazin-3-karboksamida

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3704298A (en) * 1971-06-22 1972-11-28 Warner Lambert Co 4-acyloxy-3-(2-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,1-dioxides
US3821211A (en) * 1972-03-10 1974-06-28 Warner Lambert Co Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
US3868367A (en) * 1974-04-11 1975-02-25 Warner Lambert Co 4-Hydroxy-3-(5-isoxazolylcarbamoyl)-2H-1,2-benzothiazine 1,1-dioxides
US3957772A (en) * 1975-05-21 1976-05-18 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide

Also Published As

Publication number Publication date
BE842079A (fr) 1976-09-16
JPS5421336B2 (US20110158925A1-20110630-C00042.png) 1979-07-30
FR2333802B1 (US20110158925A1-20110630-C00042.png) 1980-02-08
JPS5421350B2 (US20110158925A1-20110630-C00042.png) 1979-07-30
JPS53108969A (en) 1978-09-22
JPS53111065A (en) 1978-09-28
US3957772A (en) 1976-05-18
FR2320744B1 (US20110158925A1-20110630-C00042.png) 1978-12-15
FR2320744A1 (fr) 1977-03-11
GB1492719A (en) 1977-11-23
LU74936A1 (US20110158925A1-20110630-C00042.png) 1977-01-17
FR2313387B1 (US20110158925A1-20110630-C00042.png) 1980-03-14
AU1412976A (en) 1977-11-24
JPS5420495B2 (US20110158925A1-20110630-C00042.png) 1979-07-23
NL7605246A (nl) 1976-11-23
US4018762A (en) 1977-04-19
DE2618999A1 (de) 1976-12-09
GB1492717A (en) 1977-11-23
FR2313387A1 (fr) 1976-12-31
GB1492718A (en) 1977-11-23
DE2618999C2 (de) 1985-01-03
AU511134B2 (en) 1980-07-31
JPS51143682A (en) 1976-12-10
JPS5421351B2 (US20110158925A1-20110630-C00042.png) 1979-07-30
FR2333802A1 (fr) 1977-07-01
JPS53105482A (en) 1978-09-13
CH629204A5 (de) 1982-04-15
US4022796A (en) 1977-05-10

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