CA1082599A - Method for regulating physiological response in human cells which are growing by the administration of 3- methyl-7-n-pentylaminopyrazolo 4,3-d pyrimidine - Google Patents
Method for regulating physiological response in human cells which are growing by the administration of 3- methyl-7-n-pentylaminopyrazolo 4,3-d pyrimidineInfo
- Publication number
- CA1082599A CA1082599A CA275,336A CA275336A CA1082599A CA 1082599 A CA1082599 A CA 1082599A CA 275336 A CA275336 A CA 275336A CA 1082599 A CA1082599 A CA 1082599A
- Authority
- CA
- Canada
- Prior art keywords
- pyrimidine
- methyl
- pentylaminopyrazolo
- cells
- cytokinin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000005260 human cell Anatomy 0.000 title claims abstract description 11
- 230000001105 regulatory effect Effects 0.000 title claims description 5
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title description 11
- 238000000034 method Methods 0.000 title description 10
- 230000006461 physiological response Effects 0.000 title description 4
- RUZQLRPRQPKGJL-UHFFFAOYSA-N 3-methyl-n-pentyl-2h-pyrazolo[4,3-d]pyrimidin-7-amine Chemical compound CCCCCNC1=NC=NC2=C(C)NN=C12 RUZQLRPRQPKGJL-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000012010 growth Effects 0.000 claims abstract description 14
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 22
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- UQHKFADEQIVWID-UHFFFAOYSA-N cytokinin Natural products C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1CC(O)C(CO)O1 UQHKFADEQIVWID-UHFFFAOYSA-N 0.000 description 42
- 239000004062 cytokinin Substances 0.000 description 42
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 28
- 239000005557 antagonist Substances 0.000 description 23
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 21
- 229960005305 adenosine Drugs 0.000 description 21
- 108010047620 Phytohemagglutinins Proteins 0.000 description 18
- 230000001885 phytohemagglutinin Effects 0.000 description 18
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- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 9
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 8
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
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- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical group N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 description 1
- JKKZIXQBPLMMCW-UHFFFAOYSA-N 3-methyl-7-methylsulfanyl-2h-pyrazolo[4,3-d]pyrimidine Chemical compound CSC1=NC=NC2=C(C)NN=C12 JKKZIXQBPLMMCW-UHFFFAOYSA-N 0.000 description 1
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- ZMJBYMUCKBYSCP-UHFFFAOYSA-N Hydroxycitric acid Chemical compound OC(=O)C(O)C(O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
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- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67400376A | 1976-04-05 | 1976-04-05 | |
| US674,003 | 1976-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1082599A true CA1082599A (en) | 1980-07-29 |
Family
ID=24704944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA275,336A Expired CA1082599A (en) | 1976-04-05 | 1977-04-01 | Method for regulating physiological response in human cells which are growing by the administration of 3- methyl-7-n-pentylaminopyrazolo 4,3-d pyrimidine |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS52122633A (en, 2012) |
| CA (1) | CA1082599A (en, 2012) |
| FR (1) | FR2347045A1 (en, 2012) |
| GB (1) | GB1530747A (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
| ES2351624T3 (es) * | 2003-05-06 | 2011-02-08 | Ústav Experimentálni Botaniky Av Cr, V.V.I. (Institute Of Experimental Botany Academy Of Sciences Of The Czech Republic, Pro) | Pirazolo[4,3-d]pirimidinas, procedimiento para su preparación y uso. |
-
1977
- 1977-03-28 GB GB12899/77A patent/GB1530747A/en not_active Expired
- 1977-04-01 CA CA275,336A patent/CA1082599A/en not_active Expired
- 1977-04-04 JP JP3843877A patent/JPS52122633A/ja active Granted
- 1977-04-04 FR FR7710129A patent/FR2347045A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1530747A (en) | 1978-11-01 |
| JPS52122633A (en) | 1977-10-15 |
| FR2347045B1 (en, 2012) | 1980-06-13 |
| FR2347045A1 (fr) | 1977-11-04 |
| JPS5627495B2 (en, 2012) | 1981-06-25 |
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